Dafna Bar-Sagi

Biosketch / Results /

Dafna Bar-Sagi

Professor, Department of Biochemistry and Molecular Pharmacology
Professor, Department of Medicine


Contact Info

Address
522 First Avenue
New York, NY 10016

212/263-2095
Dafna.Bar-Sagi@nyumc.org

Research Summary

The transformation of normal cells to cancer cells is tightly linked to alterations in signaling cascades that control cell proliferation, differentiation and motility. The research in our laboratory focuses a signaling axis that is deregulated in more than 30% of human cancers due to the mutational activation of the GTP-binding protein Ras. We are interested in defining the contribution of specific molecular perturbations in this signaling axis to cancer initiation and progression with the ultimate goal of utilizing this information for the development of novel diagnostic and therapeutic strategies. Ongoing projects in the laboratory include the development of cell- and animal-based models to study the role of inflammation in Ras-driven tumorigenesis, the characterization of feedback mechanisms that control the functional output of the Ras signaling axis and the use of chemical biology approaches to identify new modalities for therapeutic targeting.

One-way membrane trafficking of SOS in receptor-triggered Ras activation
Christensen, Sune M; Tu, Hsiung-Lin; Jun, Jesse E; Alvarez, Steven; Triplet, Meredith G; Iwig, Jeffrey S; Yadav, Kamlesh K; Bar-Sagi, Dafna; Roose, Jeroen P; Groves, Jay T. One-way membrane trafficking of SOS in receptor-triggered Ras activation. Nature structural & molecular biology. 2016 Aug 8;23(9):838-846 (2213552)

gammadelta T Cells Support Pancreatic Oncogenesis by Restraining alphabeta T Cell Activation
Daley, Donnele; Zambirinis, Constantinos Pantelis; Seifert, Lena; Akkad, Neha; Mohan, Navyatha; Werba, Gregor; Barilla, Rocky; Torres-Hernandez, Alejandro; Hundeyin, Mautin; Mani, Vishnu Raj Kumar; Avanzi, Antonina; Tippens, Daniel; Narayanan, Rajkishen; Jang, Jung-Eun; Newman, Elliot; Pillarisetty, Venu Gopal; Dustin, Michael Loran; Bar-Sagi, Dafna; Hajdu, Cristina; Miller, George. gammadelta T Cells Support Pancreatic Oncogenesis by Restraining alphabeta T Cell Activation. Cell. 2016 Aug 25;166(6):1485-1499.e15 (2232382)

Antitumor activity and immune reponse in CD40 immunotherapy with gemcitabine and nab-paclitaxel in an orthotopic pancreatic cancer mouse model
Siolas, D; Cullis, J; Avanzi, A; Byrne, K; Leichman, L P; Vonderheide, R H; Bar-Sagi, D. Antitumor activity and immune reponse in CD40 immunotherapy with gemcitabine and nab-paclitaxel in an orthotopic pancreatic cancer mouse model [Meeting Abstract]. Journal of clinical oncology. 2016 01 Feb 2016;34(4):- (2068182)

Histological Image Processing Features Induce a Quantitative Characterization of Chronic Tumor Hypoxia
Sundstrom, Andrew; Grabocka, Elda; Bar-Sagi, Dafna; Mishra, Bud. Histological Image Processing Features Induce a Quantitative Characterization of Chronic Tumor Hypoxia. PLoS one. 2016 Apr 19;11(4):e0153623-e0153623 e0153623 (2079342)

Nab-paclitaxel and agonist CD40 mAb combination therapy induces tumor-associated macrophage polarization switching in pancreatic cancer
Collis, Jane E; Siolas, Despina; Maitra, Anirban; Bar-Sagi, Dafna. Nab-paclitaxel and agonist CD40 mAb combination therapy induces tumor-associated macrophage polarization switching in pancreatic cancer [Meeting Abstract]. Cancer research. 2015 AUG 1;75:?-? (2064392)