Dafna Bar-Sagi

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Dafna Bar-Sagi

Professor, Department of Biochemistry and Molecular Pharmacology
Professor, Department of Medicine


Contact Info

Address
522 First Avenue
New York, NY 10016

212-263-2095
Dafna.Bar-Sagi@nyumc.org

Research Summary

The transformation of normal cells to cancer cells is tightly linked to alterations in signaling cascades that control cell proliferation, differentiation and motility. The research in our laboratory focuses a signaling axis that is deregulated in more than 30% of human cancers due to the mutational activation of the GTP-binding protein Ras. We are interested in defining the contribution of specific molecular perturbations in this signaling axis to cancer initiation and progression with the ultimate goal of utilizing this information for the development of novel diagnostic and therapeutic strategies. Ongoing projects in the laboratory include the development of cell- and animal-based models to study the role of inflammation in Ras-driven tumorigenesis, the characterization of feedback mechanisms that control the functional output of the Ras signaling axis and the use of chemical biology approaches to identify new modalities for therapeutic targeting.

Research Keywords

oncogene function in pancreatic cancer, signal transduction, ras function, inflammation, ras signaling

Macropinocytosis of nab-paclitaxel drives macrophage activation in pancreatic cancer
Cullis, Jane E; Siolas, Despina; Avanzi, Antonina; Barui, Sugata; Maitra, Anirban; Bar-Sagi, Dafna. Macropinocytosis of nab-paclitaxel drives macrophage activation in pancreatic cancer. Cancer immunology research. 2017 Jan 20;:?-? (2414102)

Simulating Heterogeneous Tumor Cell Populations
Sundstrom, Andrew; Bar-Sagi, Dafna; Mishra, Bud. Simulating Heterogeneous Tumor Cell Populations. PLoS one. 2016 Dec 28;11(12):e0168984-e0168984 e0168984 (2383312)

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors
Davidson, Shawn M; Jonas, Oliver; Keibler, Mark A; Hou, Han Wei; Luengo, Alba; Mayers, Jared R; Wyckoff, Jeffrey; Del Rosario, Amanda M; Whitman, Matthew; Chin, Christopher R; Condon, Kendall J; Lammers, Alex; Kellersberger, Katherine A; Stall, Brian K; Stephanopoulos, Gregory; Bar-Sagi, Dafna; Han, Jongyoon; Rabinowitz, Joshua D; Cima, Michael J; Langer, Robert; Vander Heiden, Matthew G. Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors. Nature medicine. 2016 Dec 26;23(2):235-241 (2383492)

Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules
Grabocka, Elda; Bar-Sagi, Dafna. Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules. Cell. 2016 Dec 15;167(7):1803-1813.e12 (2363772)

gammadelta T Cells Support Pancreatic Oncogenesis by Restraining alphabeta T Cell Activation
Daley, Donnele; Zambirinis, Constantinos Pantelis; Seifert, Lena; Akkad, Neha; Mohan, Navyatha; Werba, Gregor; Barilla, Rocky; Torres-Hernandez, Alejandro; Hundeyin, Mautin; Mani, Vishnu Raj Kumar; Avanzi, Antonina; Tippens, Daniel; Narayanan, Rajkishen; Jang, Jung-Eun; Newman, Elliot; Pillarisetty, Venu Gopal; Dustin, Michael Loran; Bar-Sagi, Dafna; Hajdu, Cristina; Miller, George. gammadelta T Cells Support Pancreatic Oncogenesis by Restraining alphabeta T Cell Activation. Cell. 2016 Sep 08;166(6):1485-1499.e15 (2232382)