Researchers in NYU Langone’s Leon H. Charney Division of Cardiology conduct clinical trials to advance the care of patients with ischemic heart disease such as coronary artery disease; myocardial infarction, or heart attack; takotsubo syndrome, also known as broken heart syndrome; heart failure; cardiogenic shock; and valvular heart disease, among other cardiovascular conditions.

In addition, we investigate how to best prevent cardiovascular disease, whether through lifestyle changes or medication, and how to improve cardiovascular outcomes in patients with comorbid conditions.

Heart Disease with Open Arteries and Heart Disease in Women Clinical Trials

Not all heart attacks are the same. Some people have heart attacks or chest pain despite having no badly blocked arteries, or arteries that have no plaque at all. We seek to learn about the causes of all types of heart disease, including those for which the problem is not immediately clear. Some of these types of heart disease disproportionately affect women.

Women’s Heart Attack Research Program: Imaging Study (HARP)
Investigator: Harmony R. Reynolds, MD

Women’s Heart Attack Research Program: Platelet Sub-Study (HARP)
Investigators: Jeffrey S. Berger, MD

Women’s Heart Attack Research Program: Stress Ancillary Study (HARP)
Investigator: Tanya M. Spruill, PhD

Coronary Microvascular Disease Study
Investigator: Nathaniel R. Smilowitz, MD

Registry of Pregnancy and Cardiac Disease III (ROPAC III)
Investigator: Dan G. Halpern, MD

Spontaneous Coronary Artery Dissection Registry
Investigator: Harmony R. Reynolds, MD

Takotsubo Syndrome Registry
Investigator: Harmony R. Reynolds, MD

Takotsubo Syndrome Clinical Studies
Investigator: Harmony R. Reynolds, MD

Diabetes and Obesity Clinical Trials

Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity (SELECT)
Investigator: Howard Weintraub, MD

Cholesterol Lowering and Residual Risk in Type 2 Diabetes (CHORD)
Investigator: Jeffrey S. Berger, MD

Heart Rhythm and Electrophysiology Clinical Trials

Evaluation of QDOT MICRO Catheter for Pulmonary Vein Isolation (PVI) in Subjects with Paroxysmal Atrial Fibrillation (PAF) (Q-fficiency)
Investigator: Larry A. Chinitz, MD

Accelerometer Sensing for Micra AV Study (AccelAV)
Investigator: Larry A. Chinitz, MD

Dielectric Tissue Imaging in Cavotricuspid Isthmus Ablation (ERUCA)
Investigator: Larry A. Chinitz, MD

Comparison of Anticoagulation with Left Atrial Appendage Closure After AF Ablation
Investigator: Larry A. Chinitz, MD

Patient Specific Optimized Therapy (PSOT) Study
Medical condition: heart rhythm problem requiring ablation procedure
Investigator: Larry A. Chinitz, MD

Heart Valve Disease Clinical Trials

Transcatheter Mitral Valve Replacement with the Medtronic Intrepid TMVR System in Patients with Severe Symptomatic Mitral Regurgitation APOLLO Trial
Investigator: Mathew R. Williams, MD

The Early Feasibility Study of the Intrepid TMVR Transseptal System
Medical condition: mitral regurgitation
Investigator: Mathew R. Williams, MD

Edwards PASCAL Transcatheter Mitral Valve Repair System Pivotal Clinical Trial (CLASP IID): A Prospective Multicenter Randomized Controlled Pivotal Trial to Evaluate the Safety and Effectiveness of Transcatheter Mitral Valve Repair with the Edwards PASCAL Transcatheter Mitral Valve Repair System Compared to Abbott MitraClip in Patients with Degenerative Mitral Regurgitation (DMR)
Investigator: Mathew R. Williams, MD

Percutaneous MitraClip Device or Surgical Mitral Valve Repair in Patients with Primary Mitral Regurgitation Who Are Candidates for Surgery (REPAIR-MR)
Investigator: Mathew R. Williams, MD

The Half Moon Transcatheter Mitral Valve Repair (TMVr) Pilot Study
Medical condition: mitral regurgitation and high risk for mitral valve surgery
Investigator: Mathew R. Williams, MD

PARTNER 3 Trial: Mitral Valve in Valve
Medical condition: Failing surgically implanted bioprosthetic valve in the mitral position
Investigator: Mathew R. Williams, MD

Evaluation of Transcatheter Aortic Valve Replacement Compared to Surveillance for Patients with Asymptomatic Severe Aortic Stenosis: EARLY TAVR trial
Investigator: Mathew R. Williams, MD

TRiluminate: Treatment of Tricuspid Regurgitation
Investigator: Mathew R. Williams, MD

Center for the Prevention of Cardiovascular Disease Trials

The following studies are being conducted by researchers at the Center for the Prevention of Cardiovascular Disease.

Assessing the Impact of Lipoprotein(a) Lowering with TQJ230 on Major Cardiovascular Events in Patients with CVD (Lp(a)HORIZON)
Investigator: Howard Weintraub, MD

Arsenic, Disordered Glucose Homeostasis, and Atherosclerosis (EMERALD-D)
Investigator: Jonathan Newman, MD, MPH

Lipoprotein(a) in Patients with Cardiovascular Disease (CVD)
Investigator: Howard Weintraub, MD

Platelet Activity and Thrombosis Registry and Prevention Biorepository
Investigator: Jeffrey S. Berger, MD

Trial to Assess Chelation Therapy 2 (TACT2)
Investigators: Dennis A. Goodman, MD, and Jonathan Newman, MD, MPH

Effects of Bariatric Surgery on HDL and Platelet Function
Investigator: Sean P. Heffron, MD

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of AMG 890 in Subjects with Elevated Plasma Lipoprotein(a)
Investigator: Howard Weintraub, MD

Catheterization Laboratory and Coronary Artery Disease Clinical Trials

Prospective Randomized 1:1 Multi-Center Clinical Trial Designed to Evaluate Orbital Atherectomy (OA) Vessel Preparation Compared to Conventional Angioplasty Technique for the Treatment of Severely Calcified Coronary Artery Lesions
Medical condition: coronary artery disease
Investigator: Claudia C. Serrano-Gomez, MD

LIFE-BTK Randomized Controlled Trial
Medical condition: narrowed infrapopliteal lesions
Investigator: Anvar Babaev, MD, PhD

CLEAR SYNERGY (OASIS 9): A 2x2 Factorial Randomized Controlled Trial of Colchicine and Spironolactone in Patients with ST Elevation Myocardial Infarction/SYNERGY Stent Registry Organization to Assess Strategies for Ischemic Syndromes 9
Investigator: Binita Shah, MD

CLEAR SYNERGY Neutrophil Substudy
Medical condition: heart attack
Investigator: Binita Shah, MD

Catheterization Laboratory Clinical Studies

CLEAR SYNERGY (OASIS 9): A 2x2 Factorial Randomized Controlled Trial of Colchicine and Spironolactone in Patients with ST Elevation Myocardial Infarction/SYNERGY Stent Registry Organization to Assess Strategies for Ischemic Syndromes 9
Investigator: Binita Shah, MD

CLEAR SYNERGY Neutrophil Substudy
Medical condition: heart attack
Investigator: Binita Shah, MD

Heart Failure Trials

Hemodynamic-Guided Management of Heart Failure (GUIDE-HF)
Investigator: Tajinderpal Saraon, MD

Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects with Heart Failure (METEORIC-HF)
Investigator: Stuart D. Katz, MD

CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of AKCEA-TTR-LRx in Participants with Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)
Investigator: Alex Reyentovich, MD

Randomized Controlled Pivotal Trial of Autologous Bone Marrow Mononuclear Cells Using the CardiAMP Cell Therapy system in Patients with Post Myocardial Infarction Heart Failure (CardiAMP Heart Failure Trial)
Investigator: Stuart D. Katz, MD

A Phase 3 Multinational Randomized Placebo-Controlled Study of ARRY-371797 in Patients with Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation
Investigator: Stuart D. Katz, MD

Ferric Carboxymaltose to Improve Skeletal Muscle Metabolism in Heart Failure Patients with Functional Iron Deficiency
Investigator: Stuart D. Katz, MD

Open Label Single Arm Pilot Study to Assess Feasibility and Safety of Iron Repletion with Feraheme in Iron-Deficient Patients with Durable Ventricular Assist Device Support
Medical condition: heart failure
Investigator: Stuart D. Katz, MD

Clinical Study to Evaluate Mavacamten (MYK-461) in Adults with Symptomatic Obstructive Hypertrophic Cardiomyopathy (EXPLORER-HCM)
Investigator: Mark V. Sherrid, MD

Randomized Evaluation of Dosing with CK-3773274 in Obstructive Outflow Disease in HCM (REDWOOD-HCM)
Investigator: Mark V. Sherrid, MD

Rehabilitation at Home Using Mobile Health in Older Adults After Hospitalization for Ischemic Heart Disease (RESILIENT)
Investigator: John A. Dodson, MD, MPH

Behavioral Economics Trial to Enhance Regulation of Blood Pressure (BETTER-BP)
Medical condition: hypertension
Investigator: John A. Dodson, MD, MPH

COVID-19 Cardiology Clinical Trials

COVID-19 and Adult Congenital Heart Disease (ACHD) Patients, Multicenter Study
Investigator: Dan G. Halpern, MD

Cardiovascular Effects of COVID-19
Investigator: Stuart D. Katz, MD

Colchicine Coronavirus SARS-CoV2 Trial (COLCORONA)
Investigator: Binita Shah, MD

Incidence of Major Bleeding Among Critically Ill Patients with COVID-19
Investigator: Eugene Yuriditsky, MD

Features and Outcomes of In-Hospital Cardiac Arrest Due to COVID-19
Investigator: Eugene Yuriditsky, MD

A Phase II and III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of the Safety, Tolerability, and Efficacy of Bardoxolone Methyl in Hospitalized Patients with COVID-19 (BARCONA Trial)
Investigator: Sripal Bangalore, MD

Medications and Risk of COVID-19
Investigator: Harmony R. Reynolds, MD

Clinical Manifestations of COVID-19: A Collaborative Study
Investigator: Judith S. Hochman, MD

Anti-Thrombotics for Adults Hospitalized with COVID-19 (ACTIV-4)
Investigator: Jeffrey S. Berger, MD

Cardiovascular Clinical Research Center Trials

The following trials are conducted within the Cardiovascular Clinical Research Center at NYU Langone.

Changes in Ischemia and Angina Over 1 Year Among ISCHEMIA Trial Screen Failures with No Obstructive CAD on Coronary CT Angiography (CIAO)
Investigator: Harmony R. Reynolds, MD

Coronary Artery Bypass Surgery vs. Percutaneous Coronary Intervention to Improve Outcomes in Systolic Heart Failure: A Pilot Feasibility Study
Medical condition: coronary artery disease and heart failure
Investigators: Stuart D. Katz, MD, and Judith S. Hochman, MD