Richard L. Possemato, PhD

Our laboratory focuses on identifying metabolic pathways that are altered in the transformed state, understanding how those pathways support transformation, and investigating the environmental, genetic and epigenetic contexts in which such pathways act. Of particular interest are investigating iron homeostasis and iron-sulfur cluster metabolism as well as metabolic perturbations that affect nucleotide synthesis and DNA replication. We attack these problems with a combination of approaches that endeavor to push the boundaries of genetic screening, mammalian cell culture, and metabolomic methods. Visit our lab website at: http://possematolab.org