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Drew R. Jones

Drew R. Jones, PhD

Assistant Professor, Department of Biochemistry and Molecular Pharmacology

Assistant Professor, Department of Radiation Oncology

Summary

Dr. Jones’ laboratory is focused on the development and application of metabolomics technology for global untargeted analyses with mass spectrometry. Reliable identification of metabolites in untargeted experiments is a major bottle neck for the field. To address this challenge, Dr. Jones has developed a method called Metabolome Identification by Systematic Stable Isotope Labeling Experiments (MISSILE) which can determine the chemical formula of any metabolite de novo, greatly improving the confidence of such annotations. Biologically, this method is being applied to the study of stress response in yeast and in disease states such as Alzheimer’s.

Phone

646-501-2054

Academic office

430 East 29th Street

West Tower 6th Floor, Room 635A/B

New York, NY 10016

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Positions

Assistant Professor, Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine

Assistant Professor, Department of Radiation Oncology at NYU Grossman School of Medicine

Director, Metabolomics Core Resource Laboratory

Graduate Education

PhD from University of Arkansas for Medical Sciences

Postdoctoral Training

St. Jude Children's Research Hospital, Peng Laboratory

SAMPLE (Specimen and Matched Phenotype Linked Evaluation)

See All Studies (1)

Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation

Tiniakou, Ioanna; Hsu, Pei-Feng; Lopez-Zepeda, Lorena S; Garipler, Görkem; Esteva, Eduardo; Adams, Nicholas M; Jang, Geunhyo; Soni, Chetna; Lau, Colleen M; Liu, Fan; Khodadadi-Jamayran, Alireza; Rodrick, Tori C; Jones, Drew; Tsirigos, Aristotelis; Ohler, Uwe; Bedford, Mark T; Nimer, Stephen D; Kaartinen, Vesa; Mazzoni, Esteban O; Reizis, Boris

Science immunology. 2024 Apr 12; 9(94):eadi1023

Chemosensory detection of polyamine metabolites guides C. elegans to nutritive microbes

Brissette, Benjamin; Ficaro, Lia; Li, Chenguang; Jones, Drew R; Ramanathan, Sharad; Ringstad, Niels

Science advances. 2024 Mar 22; 10(12):eadj4387

Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson's disease model

Morrone Parfitt, Gustavo; Coccia, Elena; Goldman, Camille; Whitney, Kristen; Reyes, Ricardo; Sarrafha, Lily; Nam, Ki Hong; Sohail, Soha; Jones, Drew R; Crary, John F; Ordureau, Alban; Blanchard, Joel; Ahfeldt, Tim

Nature communications. 2024 Jan 10; 15(1):447

Targeting pancreatic cancer metabolic dependencies through glutamine antagonism

Encarnación-Rosado, Joel; Sohn, Albert S W; Biancur, Douglas E; Lin, Elaine Y; Osorio-Vasquez, Victoria; Rodrick, Tori; González-Baerga, Diana; Zhao, Ende; Yokoyama, Yumi; Simeone, Diane M; Jones, Drew R; Parker, Seth J; Wild, Robert; Kimmelman, Alec C

Nature cancer. 2024 Jan; 5(1):85-99

Intestinal microbiome and metabolome signatures in patients with chronic granulomatous disease

Chandrasekaran, Prabha; Han, Yu; Zerbe, Christa S; Heller, Theo; DeRavin, Suk See; Kreuzberg, Samantha A; Marciano, Beatriz E; Siu, Yik; Jones, Drew R; Abraham, Roshini S; Stephens, Michael C; Tsou, Amy M; Snapper, Scott; Conlan, Sean; Subramanian, Poorani; Quinones, Mariam; Grou, Caroline; Calderon, Virginie; Deming, Clayton; Leiding, Jennifer W; Arnold, Danielle E; Logan, Brent R; Griffith, Linda M; Petrovic, Aleksandra; Mousallem, Talal I; Kapoor, Neena; Heimall, Jennifer R; Barnum, Jessie L; Kapadia, Malika; Wright, Nicola; Rayes, Ahmad; Chandra, Sharat; Broglie, Larisa A; Chellapandian, Deepak; Deal, Christin L; Grunebaum, Eyal; Lim, Stephanie Si; Mallhi, Kanwaldeep; Marsh, Rebecca A; Murguia-Favela, Luis; Parikh, Suhag; Touzot, Fabien; Cowan, Morton J; Dvorak, Christopher C; Haddad, Elie; Kohn, Donald B; Notarangelo, Luigi D; Pai, Sung-Yun; Puck, Jennifer M; Pulsipher, Michael A; Torgerson, Troy R; Kang, Elizabeth M; Malech, Harry L; Segre, Julia A; Bryant, Clare E; Holland, Steven M; Falcone, Emilia Liana

Journal of allergy & clinical immunology. 2023 Dec; 152(6):1619-1633.e11

The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability

Ravn-Boess, Niklas; Roy, Nainita; Hattori, Takamitsu; Bready, Devin; Donaldson, Hayley; Lawson, Christopher; Lapierre, Cathryn; Korman, Aryeh; Rodrick, Tori; Liu, Enze; Frenster, Joshua D; Stephan, Gabriele; Wilcox, Jordan; Corrado, Alexis D; Cai, Julia; Ronnen, Rebecca; Wang, Shuai; Haddock, Sara; Sabio Ortiz, Jonathan; Mishkit, Orin; Khodadadi-Jamayran, Alireza; Tsirigos, Aris; Fenyö, David; Zagzag, David; Drube, Julia; Hoffmann, Carsten; Perna, Fabiana; Jones, Drew R; Possemato, Richard; Koide, Akiko; Koide, Shohei; Park, Christopher Y; Placantonakis, Dimitris G

Cell reports. 2023 Nov 28; 42(11):113374

Modulation of GluA2-γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2

Gangwar, Shanti Pal; Yen, Laura Y; Yelshanskaya, Maria V; Korman, Aryeh; Jones, Drew R; Sobolevsky, Alexander I

Nature structural & molecular biology. 2023 Oct; 30(10):1481-1494

In vivo metabolomics identifies CD38 as an emergent vulnerability in LKB1 -mutant lung cancer

Deng, Jiehui; Peng, David H; Fenyo, David; Yuan, Hao; Lopez, Alfonso; Levin, Daniel S; Meynardie, Mary; Quinteros, Mari; Ranieri, Michela; Sahu, Soumyadip; Lau, Sally C M; Shum, Elaine; Velcheti, Vamsidhar; Punekar, Salman R; Rekhtman, Natasha; Dowling, Catríona M; Weerasekara, Vajira; Xue, Yun; Ji, Hongbin; Siu, Yik; Jones, Drew; Hata, Aaron N; Shimamura, Takeshi; Poirier, John T; Rudin, Charles M; Hattori, Takamitsu; Koide, Shohei; Papagiannakopoulos, Thales; Neel, Benjamin G; Bardeesy, Nabeel; Wong, Kwok-Kin

bioRxiv.org : the preprint server for biology. 2023 Apr 20;

See All Publications (54)

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