Inflammatory Bowel Disease Research Program | NYU Langone Health

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Inflammatory Bowel Disease Research Program

Our work turns basic science discoveries into treatments for inflammatory bowel diseases.

The Inflammatory Bowel Disease Research Program at NYU Langone Health bridges basic, clinical, and educational disciplines and brings together faculty who build on the breadth of our immunology, microbiology, and cell biology research to foster cross-disciplinary collaborations and studies. Our mission is to build on our institution’s tradition of turning basic science discoveries into treatments for inflammatory bowel diseases (IBD) including Crohn’s disease and ulcerative colitis.

Following their research on immune signaling molecules, NYU Langone microbiologists worked with pharmaceutical companies to develop the drug infliximab, which blocks one such molecule called TNF-α. It remains among the most commonly used therapies for IBD.

Faculty at the Inflammatory Bowel Disease Research Program work hand-in-hand with gastroenterologists and surgeons at NYU Langone’s clinical Inflammatory Bowel Disease Center with the goal of discovering new treatment strategies and how best to apply them to improve patient care.

Our Leadership

Ken H. Cadwell, PhD, the Recanati Family Professor of Microbiology and professor in the Departments of Microbiology and Medicine is our program director. Dr. Cadwell is recognized for his research on how our immune system is regulated by the diverse microbes we encounter throughout our lives. His discoveries have contributed to our understanding of how imbalances in our relationship with microbes in the gut can lead to inflammation, as seen in patients with IBD.

Dr. Cadwell works together with other members of the leadership team to integrate basic and clinical research with training objectives of the Inflammatory Bowel Disease Research Program. Jordan E. Axelrad, MD, MPH, directs our clinical and translational inflammatory bowel disease research efforts and oversees the gastrointestinal diseases biorepository. Dr. Axelrad is recognized for his research on malignant and infectious complications of IBD, specifically, in elucidating how exposures such as gastrointestinal infections may complicate IBD or trigger it to develop.

David P. Hudesman, MD, and Feza Remzi, MD, are co-directors of our Inflammatory Bowel Disease Center. Together with Dr. Cadwell and Dr. Axelrad, they manage IBD research studies and clinical trials representing partnerships among clinicians, scientists, and industry.

Available Positions

We are hiring research scientists to join our team. Learn more about our available positions.

Select Faculty Publications

Use of Phage Display and Other Molecular Display Methods for the Development of Monobodies

Koide, Akiko; Koide, Shohei

Cold Spring Harbor protocols. 2024 May 02; 2024:pdb.over107982

Histological remission in inflammatory bowel disease and female fertility: A nationwide study

Mårild, Karl; Söderling, Jonas; Stephansson, Olof; Axelrad, Jordan; Halfvarson, Jonas; ,; Bröms, Gabriella; Marsal, Jan; Olén, Ola; Ludvigsson, Jonas F

Gastroenterology. 2024 May ; 166:802-814.e18

Improving Sleep Using Mentored Behavioral and Environmental Restructuring (SLUMBER)

Martin, Jennifer L; Cadogan, Mary; Brody, Abraham A; Mitchell, Michael N; Hernandez, Diana E; Mangold, Michael; Alessi, Cathy A; Song, Yeonsu; Chodosh, Joshua

Journal of the American Medical Directors Association. 2024 May ; 25:925-931.e3

Implementation Outcomes for the SLUMBER Sleep Improvement Program in Long-Term Care

Chodosh, Joshua; Cadogan, Mary; Brody, Abraham A; Mitchell, Michael N; Hernandez, Diana E; Mangold, Michael; Alessi, Cathy A; Song, Yeonsu; Martin, Jennifer L

Journal of the American Medical Directors Association. 2024 May ; 25:932-938.e1

Real-World Surgical and Endoscopic Recurrence Based on Risk Profiles and Prophylaxis Utilization in Postoperative Crohn's Disease

Shah, Ravi S; Bachour, Salam; Joseph, Abel; Xiao, Huijun; Lyu, Ruishen; Syed, Hareem; Li, Terry; Pothula, Shravya; Vinaithirthan, Vall; Ali, Adel Hajj; Contreras, Sussel; Hu, Jessica H; Barnes, Edward L; Axelrad, Jordan E; Holubar, Stefan D; Regueiro, Miguel; Cohen, Benjamin L; Click, Benjamin H

Clinical gastroenterology & hepatology. 2024 Apr ; 22:847-857.e12

Histologic Activity in Inflammatory Bowel Disease and Risk of Serious Infections: A Nationwide Study

Mårild, Karl; Söderling, Jonas; Axelrad, Jordan; Halfvarson, Jonas; Forss, Anders; ,; Olén, Ola; Ludvigsson, Jonas F

Clinical gastroenterology & hepatology. 2024 Apr ; 22:831-846

SHORT CHAIN FATTY ACIDS MITIGATE OSTEOCLAST-MEDIATED ARTHRITIC BONE REMODELLING

Yang, Katharine Lu; Mullins, Briana J; Lejeune, Alannah; Ivanova, Ellie; Shin, Jong; Bajwa, Sofia; Possemato, Richard; Cadwell, Ken; Scher, Jose U; Koralov, Sergei B

Arthritis & rheumatology. 2024 Apr ; 76:647-659

Role of Antigenic Stimulation in Cutaneous T-Cell Lymphomas

Gumina, Megan E; Hooper, Madeline J; Zhou, Xiaolong A; Koralov, Sergei B

Journal of investigative dermatology. 2024 Apr ; 144:755-763