The following projects are currently ongoing or completed during the last three years at the NYU School of Medicine Sleep Disorders Center.

• Sleep Heart Health Study (NY Cohort)
• Development of Computer Controlled Nasal CPAP
• NRSA- "Kinetics of whole body CO2 balance during sleep in
• OSAS"
• Sleep in Coronary Artery Bypass Patients
• ALA of NY- Grant in Aid
• Clinical Trial of SR46349B in OSAS

Sleep Heart Health Study (NY Cohort)
Agency: PHS-NIH-NHLBI HL U01HL53931

PI: David M. Rapoport, MD
Co-PI: Joyce Walsleben, PhD, Thomas Pickering, MD

This 6 center collaborative study proposes to establish the epidemiological link between sleep disordered breathing and cardiovascular outcomes (CVA, MI, hypertension). SDB is measured in home polysomnography and correlated with long term followup in established cardiovascular cohorts of subjects. Subjects are chosen from existing cohorts at Cornell Hypertension Center.

Development of Computer Controlled Nasal CPAP
Agency: Nellcor Puritan Bennett

PI: David M. Rapoport, MD

This project is to develop a device which will automatically adjust nasal CPAP in patients with OSAS through feedback from computerized analysis of the inspiratory airflow waveform (using detection of flow limitation). Subjects are chosen from clinical laboratory.

NRSA- "Kinetics of whole body CO2 balance during sleep in OSAS"
Agency: NIH-NHLBI 5 F32 HL 09686

PI: Kenneth I. Berger, MD
Co-Sponsor: David M. Rapoport, MD

This is a career development (fellowship) award for Dr. Berger in the area of sleep physiology and control of breathing. The project addresses the kinetics of CO2 accumulation and elimination during sleep in patients with ventilatory sleep disorders in order to gain insights into the mechanisms by which obstructive sleep apnea syndrome may lead to the chronic hypercapnic state. Study has ended.

Sleep in Coronary Artery Bypass Patients
Agency: National Institute of Nursing Research 1 K01 NR 00101-01A1

PI: Nancy S. Redeker, PhD
Sponsor: David M. Rapoport, MD

This is a grant to allow training and research experience in sleep and circadian rhythms in cardiovascular patients. The project evaluates sleep in post coronary artery bypass patients (CABS) and conducts a feasibility study for sleep interventions in recovering CABS patients. Study is performed at Rutgers, NJ.

ALA of NY- Grant in Aid (Indu Ayappa, PhD)
Agency: American Lung Asociation of NY

PI: Indu Ayappa, MD
Consultant: David M. Rapoport, MD

This project will develop the use of cardiogenic oscillations in central apnea and validate their relationship to airway resistance. Data is obtained from laboratory setting.

Clinical Trial of SR46349B in OSAS
Agency: Sonafi Research, Inc.

PI: David M. Rapoport, MD

This project is to study the safety and efficacy of a new serotonin H2 receptor blocker vs placebo in patients with OSAS. The NYU Sleep Disorders Center will serve both in recruiting subjects and as one of two central reading centers for respiratory portion of the polysomnography. Study is open to patients with apnea who are naive to CPAP.