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Publications

Dustin ML. Opening the frontier of the T cell surface: Schlossman and Goldstein. J Immunol. 2013 Jun 1;190(11):5343-5. doi: 10.4049/jimmunol.1300951. PMID: 23687190

Kumari S, Curado S, Mayya V, Dustin ML. T cell antigen receptor activation and actin cytoskeleton remodeling. Biochim Biophys Acta. 2013 May 14. doi:pii: S0005-2736(13)00150-8. 10.1016/j.bbamem.2013.05.004.PMID: 23680625

Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C; Immunological Genome Consortium, Best AJ, Knell J, Goldrath A, Jojic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Rao TN, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S. The transcriptional landscape of αβ T cell differentiation. Nat Immunol. 2013 Jun;14(6):619-32. doi: 10.1038/ni.2590. Epub 2013 May 5. PMID: 23644507

Jojic V, Shay T, Sylvia K, Zuk O, Sun X, Kang J, Regev A, Koller D; Immunological Genome Project Consortium, Best AJ, Knell J, Goldrath A, Jojic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Rao TN, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S. Identification of transcriptional regulators in the mouse immune system. Nat Immunol. 2013 Jun;14(6):633-43. doi: 10.1038/ni.2587. Epub 2013 Apr 28. PMID: 23624555

Cordoba SP, Choudhuri K, Zhang H, Bridge M, Basat AB, Dustin ML, van der Merwe PA. The large ectodomains of CD45 and CD148 regulate their segregation from and Inhibition of ligated T-cell receptor. Blood. 2013 Apr 15. PMID: 23580664

Zinselmeyer BH, Heydari S, Sacristán C, Nayak D, Cammer M, Herz J, Cheng X, Davis SJ, Dustin ML, McGavern DB. PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis. J Exp Med. 2013 Apr 8;210(4):757-74. doi: 10.1084/jem.20121416. Epub 2013 Mar 25. PMID: 23530125

Blair DA, Dustin ML. T cell priming goes through a new phase. Nat Immunol. 2013 Apr;14(4):311-2. doi: 10.1038/ni.2575. PMID: 23507636

Demaria S, Dustin ML. Role of the crosstalk between CTLA-4 and NKG2D in the development of anti-CTLA-4 treatment strategies. Immunotherapy. 2013 Feb;5(2):109-12. doi: 10.2217/imt.12.160. PMID: 23413900

Best JA, Blair DA, Knell J, Yang E, Mayya V, Doedens A, Dustin ML, Goldrath AW; Immunological Genome Project Consortium. Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation. Nat Immunol. 2013 Apr;14(4):404-12. doi: 10.1038/ni.2536. Epub 2013 Feb 10. PMID: 23396170

Kumari S, Vardhana S, Cammer M, Curado S, Santos L, Sheetz MP and Dustin ML. T lymphocyte myosin IIA is required for maturation of the immunological synapse. Front. Immun. 2012 July 14; 3:230. doi: 10.3389/fimmu.2012.00230 PMID: 22626451

Zenclussen AC, Olivieri DN, Dustin ML, Tadokoro CE. In vivo Multiphoton Microscopy Technique to Reveal the Physiology of the Mouse Placenta. Am J Reprod Immunol. 2012 May 24. doi: 10.1111/j.1600-0897.2012.01161.x.

Batista FD, Dustin ML.Cell:cell interactions in the immune system. Immunol Rev. 2013 Jan;251(1):7-12. doi: 10.1111/imr.12025. PMID: 23278736

Weiss JM, Bilate AM, Gobert M, Ding Y, Curotto de Lafaille MA, Parkhurst CN, Xiong H, Dolpady J, Frey AB, Ruocco MG, Yang Y, Floess S, Huehn J, Oh S, Li MO, Niec RE, Rudensky AY, Dustin ML, Littman DR, Lafaille JJ. Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med. 2012 Sep 24;209(10):1723-42, S1. Epub 2012 Sep 10. PMID: 22966001

Ruocco MG, Pilones KA, Kawashima N, Cammer M, Huang J, Babb JS, Liu M, Formenti SC, Dustin ML, Demaria S. Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects. J Clin Invest. 2012 Oct 1;122(10):3718-30. doi: 10.1172/JCI61931. Epub 2012 Sep 4. PMID: 22945631

Christie DA, Kirchhof MG, Vardhana S, Dustin ML, Madrenas J. Mitochondrial and plasma membrane pools of stomatin-like protein 2 coalesce at the immunological synapse during T cell activation. PLoS One. 2012;7(5):e37144. Epub 2012 May 18. PMID: 22623988

Mazzon C, Anselmo A, Soldani C, Cibella J, Ploia C, Moalli F, Burden SJ, Dustin ML, Sarukhan A, Viola A. Agrin is required for survival and function of monocytic cells. Blood. 2012 Jun 7;119(23):5502-11. Epub 2012 Apr 19. PMID: 22517892

Dustin ML. Signaling at neuro/immune synapses. J Clin Invest. 2012 Apr 2;122(4):1149-55. doi: 10.1172/JCI58705. PMID: 22466656

Xu C, Shen Y, Littman DR, Dustin ML, Velázquez P. Visualization of mucosal homeostasis via single- and multiphoton intravital fluorescence microscopy. J Leukoc Biol. 2012 Mar 27. PMID: 22457365

Prins KC*, Vasiliver-Shamis G*, Cammer M, Depoil D, Dustin ML, Hioe CE. Imaging of HIV-1 Envelope-induced Virological Synapse and Signaling on Synthetic Lipid Bilayers. J Vis Exp. 2012 Mar 8;(61). pii: 3757. doi: 10.3791/3757. PMID: 22433250

Dustin ML, Groves JT. Receptor Signaling Clusters in the Immune Synapse. Annu Rev Biophys. 2012 Feb 23. PMID: 22404679

Judokusumo E, Tabdanov E, Kumari S, Dustin ML, Kam LC. Mechanosensing in T lymphocyte activation. Biophys J. 2012 Jan 18;102(2):L5-7. PMID: 22339876

Schubert DA, Gordo S, Sabatino JJ Jr, Vardhana S, Gagnon E, Sethi DK, Seth NP, Choudhuri K, Reijonen H, Nepom GT, Evavold BD, Dustin ML, Wucherpfennig KW. Self-reactive human CD4 T cell clones form unusual immunological synapses. J Exp Med. 2012 Feb 13;209(2):335-52. Epub 2012 Feb 6. PMID: 22312112

Zanin-Zhorov A, Lin J, Scher J, Kumari S, Blair D, Hippen KL, Blazar BR, Abramson SB, Lafaille JJ, Dustin ML. Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1625-30. Epub 2012 Jan 17. PMID: 22307621

Dustin ML. Visualization of Cell-Cell Interaction Contacts: Synapses and Kinapses. Self Nonself. 2011 Apr;2(2):85-97. Epub 2011 Apr 1. PMID: 22299060

Dustin ML, Meyer-Hermann M. Immunology. Antigen feast or famine. Science. 2012 Jan 27;335(6067):408-9. PMID: 22282794

Gottschalk RA, Hathorn MM, Beuneu H, Corse E, Dustin ML, Altan-Bonnet G, Allison JP. Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses. Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):881-6. Epub 2012 Jan 5. PMID: 22223661

Springer TA, Dustin ML. Integrin inside-out signaling and the immunological synapse. Curr Opin Cell Biol. 2012 Feb;24(1):107-15. Epub 2011 Nov 28. PMID: 22129583

Dustin ML. PKC-θ: hitting the bull's eye. Nat Immunol. 2011 Oct 19;12(11):1031-2. doi: 10.1038/ni.2141. PMID: 22012436

Dustin ML, Depoil D. New insights into the T cell synapse from single molecule techniques. Nat Rev Immunol. 2011 Sep 9. doi: 10.1038/nri3066. PMID: 21904389

Hioe CE, Tuen M, Vasiliver-Shamis G, Alvarez Y, Prins KC, Banerjee S, Nádas A, Cho MW, Dustin ML, Kachlany SC. HIV Envelope gp120 Activates LFA-1 on CD4 T-Lymphocytes and Increases Cell Susceptibility to LFA-1-Targeting Leukotoxin (LtxA). PLoS One. 2011;6(8):e23202. Epub 2011 Aug 5. PMID: 21850260

Burroughs NJ, Köhler K, Miloserdov V, Dustin ML, van der Merwe PA, Davis DM. Boltzmann Energy-based Image Analysis Demonstrates that Extracellular Domain Size Differences Explain Protein Segregation at Immune Synapses. PLoS Comput Biol. 2011 Aug;7(8):e1002076. Epub 2011 Aug 4. PMID: 21829338

Anandasabapathy N, Victora GD, Meredith M, Feder R, Dong B, Kluger C, Yao K, Dustin ML, Nussenzweig MC, Steinman RM, Liu K. Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain. J Exp Med. 2011 Aug 1;208(8):1695-705. Epub 2011 Jul 25. PMID: 21788405

Zanin-Zhorov A, Dustin ML, Blazar BR. PKC-θ function at the immunological synapse: prospects for therapeutic targeting. Trends Immunol. 2011 Aug;32(8):358-63. Epub 2011 Jul 4. PMID: 21733754

Mazzon C, Anselmo A, Cibella J, Soldani C, Destro A, Kim N, Roncalli M, Burden SJ, Dustin ML, Sarukhan A, Viola A. The critical role of agrin in the hematopoietic stem cell niche. Blood. 2011 Sep 8;118(10):2733-42. Epub 2011 Jun 7. PMID: 21653324

Gutenkunst RN, Coombs D, Starr T, Dustin ML, Goldstein B. A biophysical model of cell adhesion mediated by immunoadhesin drugs and antibodies. PLoS One. 2011;6(5):e19701. Epub 2011 May 18. PMID: 21629715 PMCID: PMC3100730

Manz BN, Jackson BL, Petit RS, Dustin ML, Groves J. T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters. Proc Natl Acad Sci U S A. 2011 May 31;108(22):9089-94. Epub 2011 May 16. PMID: 21576490

Schwickert TA, Victora GD, Fooksman DR, Kamphorst AO, Mugnier MR, Gitlin AD, Dustin ML, Nussenzweig MC. A dynamic T cell-limited checkpoint regulates affinity- dependent B cell entry into the germinal center. J Exp Med. 2011 May 16. PMID: 21576382

Waite JC, Leiner I, Lauer P, Rae CS, Barbet G, Zheng H, Portnoy DA, Pamer EG, Dustin ML. Dynamic imaging of the effector immune response to listeria infection in vivo. PLoS Pathog. 2011 Mar;7(3):e1001326. Epub 2011 Mar 24.

Tang W, Lu Y, Tian QY, Zhang Y, Guo FJ, Liu GY, Syed NM, Lai Y, Lin EA, Kong L, Su J, Yin F, Ding AH, Zanin-Zhorov A, Dustin ML, Tao J, Craft J, Yin Z, Feng JQ, Abramson SB, Yu XP, Liu CJ. The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice. Science. 2011 Mar 10. [Epub ahead of print]

Kang SS, Herz J, Kim JV, Nayak D, Stewart-Hutchinson P, Dustin ML, McGavern DB. Migration of cytotoxic lymphocytes in cell cycle permits local MHC I–dependent control of division at sites of viral infection. J. Exp. Med. 2011;0 201012951-20101295, Published online Apr 4 2011, 10.1084/jem.20101295.

Victora GD, Schwickert TA, Fooksman DR, Kamphorst AO, Meyer-Hermann M, Dustin ML, Nussenzweig MC. Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell. 2010 Nov 12;143(4):592-605.PMID: 21074050

Milstein O, Hagin D, Lask A, Reich-Zeliger S, Shezan E, Ophir E, Eidelstein Y, Afik R, Antebi YE, Dustin ML, Reisner Y. CTLs respond with activation and granule secretion when serving target for T cell recognition. Blood. 2011 Jan 20;117(3):1042-52. Epub 2010 Nov 2. PMID: 21045195

Choudhuri K, Dustin ML. Signaling microdomains in T cells. FEBS Lett. 2010 Dec 15;584(24):4823-31. Epub 2010 Oct 19. PMID: 20965175

Vasiliver-Shamis G, Dustin ML, Hioe CE. HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse. Viruses. 2010 May 1;2(5):1239-1260.PMID: 20890395

Dustin ML, Chakraborty AK, Shaw AS. Understanding the Structure and Function of the Immunological Synapse. Cold Spring Harbor Perspectives in Biology. 2010 Oct 1;2(10):a002311. Epub 2010 Sep 15. PMID: 20890395.

Fooksman DR, Schwickert TA, Victora GD, Dustin ML, Nussenzweig MC, Skokos D. Development and Migration of Plasma Cells in the Mouse Lymph Node. Immunity. 2010 July 7. Epub ahead of print.

Vasiliver-Shamis G, Dustin ML, Hioe CE.HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse. Viruses. 2010 May 1;2(5):1239-1260. PMID: 20890395

Dustin ML, Long, EO. Cytotoxic Immunological Synapse. Immunological Reviews. 2010 April 28. Vol. 235: 24-34

Owen DM, Oddos S, Kumar S, Davis DM, Neil MAA, French PMW, Dustin ML, Magee AI, Cebecauer M. High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells. Molecular Membrane Biology. 2010 April. Early Online, 1-12.

Fooksman DR, Dustin ML.Affinity measured by microcluster. J. Exp. Med. 2010 May 3 . [Epub ahead of print]

Shi C, Velázquez P, Hohl TM, Leiner I, Dustin ML, Pamer EG.Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression. J. Immunology 2010 Apr 30. [Epub ahead of print]

Vardhana S, Choudhuri K, Varma R, Dustin ML.Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster. Immunity. 2010 Apr 23. 32(4):531-40.

Zanin-Zhorov A, Ding Y, Kumari S, Attur M, Hippen KL, Brown M, Blazar BR, Abramson SB, Lafaille JJ, Dustin ML.Protein Kinase C-{theta} Mediates Negative Feedback on Regulatory T Cell Function. Science.2010 April 16. 328(5976):372-6. Epub 2010 Mar 25.

Dustin ML. Modular design of immunoloical synapses and kinapses. Cold Spring Harbor Perspect Biol. 2009 jul; 1(1):a002873

Fooksman DR, Vardhana S, Vasiliver-Shamis G, Liese J, Blair D, Waite J, Sacristán C, Victora G, Zanin-Zhorov A, Dustin ML. Functional Anatomy of T Cell Activation and Synapse Formation. Annu Rev Immunol.2010 Apr 23.Epub 2009 Nov 10.

Dustin ML .Insights into function of the immunological synapse from studies with supported planar bilayers. Curr Top Microbiol Immunol. 2010;340:1-24.

Beal AM, Anikeeva N, Varma R, Cameron TO, Vasiliver-Shamis G, Norris PJ, Dustin ML, Sykulev Y. Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain. Immunity. 2009 Oct 16;31(4):632-42.

Kim JV, Jiang N., Tadokoro CE, Liu L, Ransohoff RM, Lafaille JJ, Dustin ML. Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites. J. Immunol. Methods 2010 Jan 31. 352(1-2):89-100. Epub 2009 Oct.

Vasiliver-Shamis G, Cho MW, Hioe CE, Dustin ML.HIV-1 envelope gp120-induced partial T-cell receptor signaling creates an F-actin-depleted zone in the virological synapse. J Virol. 2009 Nov. 83(21):11341-55. Epub Aug 26.

Chen HY, Fermin A, Vardhana S, Weng IC, Lo KF, Chang EY, Maverakis E, Yang RY, Hsu DK, Dustin ML, Liu FT. Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14496-501. Epub 2009 Aug 12.

Darrasse-Jèze G, Deroubaix S, Mouquet H, Victora GD, Eisenreich T, Yao K-H, Masilamani RF, Dustin ML, Rudensky A, Liu K, Nussenzweig MC. .Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J. Exp. Med. 2009 Aug 10; DOI: 10.1084/jem.20090746.

Liu D, Bryceson YT, Meckel T, Vasiliver-Shamis G, Dustin ML, Long EO.Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses. Immunity. 2009 Jul 17;31(1):99-109.

Srivastava S, Di L, Zhdanova O, Li Z, Vardhana S, Wan Q, Yan Y, Varma R, Backer J, Wulff H, Dustin ML, Skolnik EY.The Class II Phosphatidylinositol 3 kinase C2 Beta Is Required for the Activation of the K+ Channel KCa3.1 and CD4 T-Cells. Mol Biol Cell. 2009 Jul 8. [Epub ahead of print]

Buonamici S, Trimarchi T, Ruocco MG, Reavie L, Cathelin S, Mar BG, Klinakis A, Lukyanov Y, Tseng JC, Sen F, Gehrie E, Li M, Newcomb E, Zavadil J, Meruelo D, Lipp M, Ibrahim S, Efstratiadis A, Zagzag D, Bromberg JS, Dustin ML, Aifantis I.CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia. Nature. 2009 Jun 18;459(7249):1000-4.

Dustin ML. Multiscale analysis of T cell activation: correlating in vitro and in vivo analysis of the immunological synapse. Curr Top Microbiol Immunol. 2009;334:47-70. (Review article)

Dustin ML. Supported bilayers at the vanguard of immune cell activation studies. J Struct Biol. 2009 Jun 11.(Review article)

Dustin ML. Visualizing Immune System Complexity. Science Signaling 2 (66) mr4 [DOI: 10.1126/scisignal.266mr4] April 14, 2009. EMBO workshop report from Centre d'immunologie Marseille-Luminy,Marseille, France in Jan 2009.

Kaizuka Y, Douglass AD, Vardhana S, Dustin ML, and Vale RD The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells. JCB published April 27, 2009, 10.1083/jcb.200809136

Dustin ML .The cellular context of T cell signalling. Immunity 2009 Apr 30(4):482-492. (review)

Ilani T, Vasiliver-Shamis G, Vardhana S, Bretscher A*, Dustin ML* .T cell antigen receptor signaling and immunological synapse stability require myosin IIA. Nat Immunol. 2009 Apr 6.doi:10.1038/ni.1723

Velázquez P, Dustin ML, Nelson PJ.Renal Dendritic Cells: An Update. Nephron Exp Nephrol. 2009 Mar 10;111(3):e67-e71.

Dehan E, Bassermann F, Guardavaccaro D, Vasiliver-Shamis G, Cohen M, Lowes KN, Dustin M, Huang DC, Taunton J, Pagano M. betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.Mol Cell. 2009 Jan 16;33(1):109-16.

Vardhana S, Dustin ML. Supported planar bilayers for the Formation of Study of Immunological Synapses and Kynapse. J. Vis Exp. 2008Sep 15;(19). pii: 947. doi: 10.3791/947 (Method- video)

Dustin ML.Visualization of cell-cell interaction contacts-synapses and kinapses. Adv. Exp. Med. Biol. 2008. 640: 164-82 (Review)

Kim JV*, Kang SS*, Dustin ML, McGavern DB. Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature. 2008 Nov 16.doi: 10.1038

Yokosuka T, Kobayashi W, Sakata-Sogawa K, Takamatsu M, Hashimoto-Tane A, Dustin ML, Tokunaga M, Saito T. Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation. Immunity. 2008 Oct;29(4):589-601.

Milstein O, Tseng SY, Starr T, Llodra J, Nans A, Liu M, Wild MK, van der Merwe PA, Stokes DL, Reisner Y, Dustin ML. Nanoscale increases in CD2-CD48 mediated intermembrane spacing decrease adhesion and reorganize the immunological synapse. J Biol Chem. 2008 Dec; 283(49):34414-22.

Kim, N, Stiegler, AL., Cameron, TO, Hallock, PT, Gomez, AM, Huang, JH, Hubbard, SR, dustin, ML, Burden, SJ. Lrp4 is a receptor for Agrin and forms a complex with MuSK. Cell. 2008 Oct 17;135(2):334-42. Epub 2008 Oct 9.

Tseng SY, Waite JC, Liu M, Vardhana S, Dustin ML. T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase Ctheta. J Immunol. 2008 Oct 1;181(7):4852-63.

Beal AM, Anikeeva N, Varma R, Cameron TO, Norris PJ, Dustin ML, Sykulev Y.Protein kinase Ctheta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL. J Immunol. 2008 Oct 1;181(7):4815-24.

Kirchhof MG, Chau LA, Lemke CD, Vardhana S, Darlington PJ, Márquez ME, Taylor R, Rizkalla K, Blanca I, Dustin ML, Madrenas J.Modulation of T cell activation by stomatin-like protein 2. J Immunol. 2008 Aug 1;181(3):1927-36.

Vasiliver-Shamis G, Tuen M, Wu TW, Starr T, Cameron TO, Thomson R, Kaur G, Liu J, Visciano ML, Li H, Kumar R, Ansari R, Han DP, Cho MW, Dustin ML, Hioe CE. Human immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cells. J Virol. 2008 Oct;82(19):9445-57.

Shen K, Thomas VK, Dustin ML, Kam LC. Micropatterning of costimulatory ligands enhances CD4+ T cell function. Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7791-6

Dustin ML. Synaptic asymmetry to go. Cell. 2008 Mar 7;132(5):733-4.

Velázquez P, Cameron TO, Kinjo Y, Nagarajan N, Kronenberg M, Dustin ML. Cutting edge: activation by innate cytokines or microbial antigens can cause arrest of natural killer T cell patrolling of liver sinusoids. J Immunol. 2008 Feb 15;180(4):2024-8.

DeMond AL, Mossman KD, Starr T, Dustin ML, Groves JT. T cell receptor microcluster transport through molecular mazes reveals mechanism of translocation. Biophys J. 2008 Apr 15;94(8):3286-92. Epub 2008 Jan 16.

Dustin ML, Chakraborty AK. Immunity. Tug of war at the exit door. 2008 Jan;28(1):15-7.

Kaizuka Y, Douglass AD, Varma R, Dustin ML, Vale RD.Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20296-301.

Velázquez P, Waite JC, Dustin ML. Dynamics of host defense: the view at the front lines. Nat Immunol. 2007 Nov;8(11):1153-7. Review.

Dustin ML.Cell adhesion molecules and actin cytoskeleton at immune synapses and kinapses.Curr Opin Cell Biol. 2007 Oct;19(5):529-33. Epub 2007 Oct 17. Review

Dustin ML, Starr T, Coombs D, Majeau GR, Meier W, Hochman PS, Douglass A, Vale R, Goldstein B, Whitty A. Quantification and modeling of tripartite CD2-, CD58FC chimera (alefacept)-, and CD16-mediated cell adhesion.J Biol Chem. 2007 Nov 30;282(48):34748-57.

Skokos D, Shakhar G, Varma R, Waite JC, Cameron TO, Lindquist RL, Schwickert T, Nussenzweig MC, Dustin ML.Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes.Nat Immunol. 2007 Aug;8(8):835-44.

Huang JH, Cárdenas-Navia LI, Caldwell CC, Plumb TJ, Radu CG, Rocha PN, Wilder T, Bromberg JS, Cronstein BN, Sitkovsky M, Dewhirst MW, Dustin ML. Requirements for T lymphocyte migration in explanted lymph nodes. J Immunol. 2007 Jun 15;178(12):7747-55.

Sims, T.N., T.J. Soos, H.S. Xenias, B. Dubin-Thaler, J.M. Hofman, J.C. Waite, T.O. Cameron, V.K. Thomas, R. Varma, C.H. Wiggins, M.P. Sheetz, D.R. Littman, and M.L. Dustin. Opposing Effects of PKCtheta and WASp on Symmetry Breaking and Relocation of the Immunological Synapse. Cell 2007; 129, 773-785.

Mor, A., G. Campi, G. Du, Y. Zheng, D.A. Foster, M.L. Dustin, and M.R. Philips. 2007. The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2. Nat Cell Biol 2007; ncb1592.

Schwickert, T. A., Lindquist, R. L., Shakhar, G., Livshits, G., Kosco-Vilbois, M. H., Dustin*, M. L., and Nussenzweig*, M. C. Germinal center imaging reveals a dynamic open structure. Nature 2007; 446:83-7.

Alon, R., and M.L. Dustin. Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells. Immunity 2007; 26:17-27.

Zhu, D.M., M.L. Dustin, C.W. Cairo, and D.E. Golan. Analysis of two-dimensional dissociation constant of laterally mobile cell adhesion molecules. Biophys J 2007; 92:1022-23.

Zhu, D. M., Dustin, M. L., Cairo, C. W., Thatte, H. S., and Golan, D. E. Mechanisms of Cellular Avidity Regulation in CD2-CD58-Mediated T Cell Adhesion. ACS Chem Biol 2006; 1:649-658.

Demond, A. L., Starr, T., Dustin, M. L., and Groves, J. T. Control of antigen presentation with a photoreleasable agonist Peptide. J Am Chem Soc 2006; 128:15354-15355.

Anikeeva, N., Lebedeva, T., Clapp, A. R., Goldman, E. R., Dustin, M. L., Mattoussi, H., and Sykulev, Y. Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response. Proc Natl Acad Sci U S A 2006; 103:16846-16851.

Döbereiner, H. G., B. J. Dubin-Thaler, J. Hofman, H. S. Xenias, T. N. Sims, G. Giannone, M. L. Dustin, C. Wiggins and M. P. Sheetz. Lateral Membrane Waves Constitute a Universal Dynamic Pattern of Motile Cells. Phys. Rev. Letters, 2006; 97, 38102-1-4.

>Kim, J.V., and M.L. Dustin. Innate response to focal necrotic injury inside the blood brain barrier. J. Immunol., 2006; 177:5269-5277.

Varma, R., G. Campi, T. Yokosuka, T. Saito and M.L. Dustin. T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity, 2006; 25, 117-127.

Dustin, M.L. Immunology. When F-actin becomes too much of a good thing. Science, 2006; 313, 767-768.

Dustin, M.L. Impact of the immunological synapse on T cell signaling. Results Probl Cell Differ 2006; 43:175-198.

Dustin, M.L., and C. Zhu. T cells like a firm molecular handshake. Proc Natl Acad Sci U S A, 2006; 103, 4335-4336.

Soos, T.J., T.N. Sims, L. Barisoni, K. Lin, D.R. Littman, M.L. Dustin, and P.J. Nelson. CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney. Kidney Int, 2006; 70, 591-596.

Dustin, M.L., S.Y. Tseng, R. Varma, and G. Campi. T cell-dendritic cell immunological synapses. Curr Opin Immunol, 2006; 18, 512-516.

Germain, R. N., M. J. Miller, M.l L. Dustin, and M C. Nussenzweig. Dynamic Imaging of the Immune System: Progress, Pitfalls, and Promise. Nat. Rev. Immunol., 2006; 6, 497-507.

Tadokoro, C.E., G. Shakhar, S. Shen, Y. Ding, A.C. Lino, A. Maraver, J.J. Lafaille*, and M.L. Dustin*. Regulatory T cell inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. J. Exp. Med. 2006; 203:505-511.

Mossman, K., G. Campi, J.T. Groves* and M.L. Dustin*. Altered TCR signaling from geometrically repatterned immunological synapses. Science. 2005; 310, 1191-1193.

Tseng, S.Y., M. Liu, and M.L. Dustin. CD80 cytoplasmic domain controls the localization of CD28, CTLA-4 and PKC-q in the immunological synapse. J.Immunol. 2005; 175, 7829-7836.

Shakhar G*, Lindquist RL*, Skokos D, Dudziak D, Huang JH, Nussenzweig MC, Dustin ML Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivo. . Nat Immunol. 2005 Jul;6(7):707-14.

Campi G, Varma R, Dustin ML. Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J Exp Med. 2005 Oct 17;202(8):1031-6.

Lindquist RL*, Shakhar G*, Dudziak D, Wardemann H, Eisenreich T, Dustin ML, Nussenzweig MC. (2004). Visualizing dendritic cell networks in vivo. Nat Immunol. 5(12):1243-50.

Dustin ML. Stop and go traffic to tune T cell responses. Immunity. 2004 Sep;21(3):305-14. Review.

Somersalo, K., Anikeeva, N., Sims, T.N., Thomas, V.K., Strong, R.K., Spies, T., Lebedeva, T., Sykulev, Y., and Dustin, M.L. (2004). Cytotoxic T lymphocytes form an antigen-independent ring junction. J Clin Invest 113, 49-57.

Heissmeyer, V., Macian, F., Im, S.H., Varma, R., Feske, S., Venuprasad, K., Gu, H., Liu, Y.C., Dustin, M.L., and Rao, A. (2004). Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol 5, 255-265.

Dustin, M.L., Bivona, T.G., and Philips, M.R. (2004). Membranes as messengers in T cell adhesion signaling. Nat Immunol 5, 363-372.

Davis, D.M., and Dustin, M.L. (2004). What is the importance of the immunological synapse? Trends Immunol 25, 323-327.

Carrasco, Y.R., Fleire, S.J., Cameron, T., Dustin, M.L., and Batista, F.D. (2004). LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation. Immunity 20, 589-599.

Lee, K.H., Dinner, A.R., Tu, C., Campi, G., Raychaudhuri, S., Varma, R., Sims, T.N., Burack, W.R., Wu, H., Wang, J., Kanagawa, O., Markiewicz, M., Allen, P.M., Dustin, M.L., Chakraborty, A.K., and Shaw, A.S. (2003). The immunological synapse balances T cell receptor signaling and degradation. Science 302, 1218-1222.

Groves, J.T., and Dustin, M.L. (2003). Supported planar bilayers in studies on immune cell adhesion and communication. J Immunol Methods 278, 19-32.

Dustin, M.L. (2003). Coordination of T cell activation and migration through formation of the immunological synapse. Ann N Y Acad Sci 987, 51-59.

Dustin, M.L. (2003). In vivo imaging approaches in animal models of rheumatoid arthritis. Arthritis Res Ther 5, 165-171.

Chakraborty, A.K., Dustin, M.L., and Shaw, A.S. (2003). In silico models for cellular and molecular immunology: successes, promises and challenges. Nat Immunol 4, 933-936.

Hailman, E., Burack, W.R., Shaw, A.S., Dustin, M.L., and Allen, P.M. (2002). Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation. Immunity 16, 839-848.

Dustin ML and Colman DR: Neural and immunological synaptic relations.Science 2002, 298: 785-789.

Hailman E, Burack WR, Shaw AS, Dustin ML, and Allen PM: Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation. Immunity 2002, 16: 839-848.

Dustin ML: Shmoos, rafts, and uropods- the many facets of cell polarity. Cell 2002, 110: 13-18

Burack WR, Lee KH, Holdorf AD, Dustin ML, and Shaw AS: Cutting edge: quantitative imaging of raft accumulation in the immunological synapse. J Immunol 2002, 169: 2837-2841.

Sims TN and Dustin ML: The immunological synapse: integrins take the stage. Immunol Rev 2002, 186: 100-117.

Dustin ML: Membrane domains and the immunological synapse: keeping T cells resting and ready. J Clin Invest 2002, 109: 155-160.

Savage ND, Kimzey SL, Bromley SK, Johnson KG, Dustin ML, and Green JM: Polar redistribution of the sialoglycoprotein CD43: implications for T cell function. J Immunol 2002, 168: 3740-3746.

Lee S, Hori Y, Groves J, Dustin ML, and Chakraborty A: Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation. Trends Immunol 2002, 23: 492.

Lee S, Hori Y, Groves J, Dustin M, and Chakraborty A: The synapse assembly model Trends Immunol 2002, 23: 500.

Tseng S and Dustin M: T-cell activation: a multidimensional signaling network. Curr Opin Cell Biol 2002, 14: 575.

Bromley, S. K. and M. L. Dustin (2002). Stimulation of naive T cell adhesion and immunological synapse formation by chemokine dependent and independent mechanisms. Immunology. 2002 Jul;106(3):289-98.

Antón, I. M., M. A. de la Fuente, et al. (2002). WIP Deficiency Reveals a Differential Role for WIP and the Actin Cytoskeleton in T and B Cell Activation.Immunity 16: 193-204

Lee, K.-H., A. D. Holdorf, et al. (2002). "T Cell Receptor signaling precedes formation of the immunological synapse." Science 295: 1539-1542.

Wulfing, C., C. Sumen, et al. (2002). "Costimulation and endogenous MHC ligands contribute to T cell recognition." Nat Immunol 3(1): 42-7.

Bromley, S. K., A. Iaboni, et al. (2001). "The immunological synapse and CD28-CD80 interactions." Nat. Immunol. 2: 1159-1166.

Dustin, M. L., S. K. Bromley, et al. (2001). "Identification of "self" through two-dimensional chemistry and synapses." Annu.Rev.Cell Dev.Biol. 17: 133-157.

Bromley, S.K., W.R. Burack, K.G. Johnson, K. Somersalo, T.N. Sims, C. Sumen, M.M. Davis, A.S. Shaw, P.M. Allen, and M.L. Dustin. 2001. The immunological synapse. Annu Rev Immunol. 19:375-96.

Dustin, M.L., P.M. Allen, and A.S. Shaw. 2001. Environmental control of immunological synapse formation and duration. Trends Immunol. 22:192-4.

Dustin, M.L., and A.R. De Fougerolles. 2001. Reprograming T cells: the role of extracellular matrix in coordination of T cell activation and migration. Curr.Opin.Immunol. 13:286-290.

Johnson, K.G., S.K. Bromley, M.L. Dustin, and M.L. Thomas. 2000. A supramolecular basis for CD45 regulation during T cell activation. Proc.Natl.Acad.Sci.USA. 97:10138-10143.

Dustin, M.L., and A.C. Chan. 2000. Signaling takes shape in the immune system. Cell. 103:283-294.

Dustin, M.L., and J.A. Cooper. 2000. The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. Nature Immunology. 1:23-29.

Bromley, S.K., D.A. Peterson, M.D. Gunn, and M.L. Dustin. 2000. Cutting Edge: Hierarchy of Chemokine Receptor and TCR Signals Regulating T Cell Migration and Proliferation. J Immunol. 165:15-19.

Anton van der Merwe, P., S.J. Davis, A.S. Shaw, and M.L. Dustin. 2000. Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition. Semin Immunol. 12:5-21.

Shih, N.Y., J. Li, V. Karpitskii, A. Nguyen, M.L. Dustin, O. Kanagawa, J.H. Miner, and A.S. Shaw. 1999. Congenital Nephrotic Syndrome in Mice Lacking CD2-Associated Protein. Science. 286:312-315.

Mordue, D.G., N. Desai, M. Dustin, and L.D. Sibley. 1999. Invasion by Toxoplasma gondii establishes a moving junction that selectively excludes host cell plasma membrane proteins on the basis of their membrane anchoring. J Exp Med. 190:1783-92.

Grakoui, A., S.K. Bromley, C. Sumen, M.M. Davis, A.S. Shaw, P.M. Allen, and M.L. Dustin. 1999. The immunological synapse: A molecular machine controlling T cell activation. Science. 285:221-227.

Dustin, M.L. and Shaw, A.S. 1999. Costimulation: Building an immunological synapse. Science. 283:649-650.

Ding, Z.M., J.E. Babensee, S.I. Simon, H. Lu, J.L. Perrard, D.C. Bullard, X.Y. Dai, S.K. Bromley, M.L. Dustin, M.L. Entman, C.W. Smith, and C.M. Ballantyne. 1999. Relative contribution of LFA-1 and mac-1 to neutrophil adhesion and migration. J Immunol. 163:5029-38.

Davis, M.M., C. Wulfing, M.F. Krummel, P.A. Savage, J. Xu, C. Sumen, M.L. Dustin, and Y.H. Chien. 1999. Visualizing T-cell recognition. Cold Spring Harb Symp Quant Biol. 64:243-51.

Dustin, M.L. 1998. Making a little affinity go a long way: a topological view of LFA-1 regulation. Cell Adhes.Commun. 6:255-62.

Dustin, M.L., M.W. Olszowy, A.D. Holdorf, J. Li, S. Bromley, N. Desai, P. Widder, F. Rosenberger, P.A. van der Merwe, P.M. Allen, and A.S. Shaw. 1998. A novel adapter protein orchestrates receptor patterning and cytoskeletal polarity in T cell contacts. Cell. 94:667-677.

Shaw, A.S., and M.L. Dustin. 1997. Making the T cell receptor go the distance: a topological view of T cell activation. Immunity. 6:361-369.

Knorr, R., and M.L. Dustin. 1997. The LFA-1 I domain is a transient binding module for ICAM-1 and ICAM-3 in hydrodynamic flow. Journal of Experimental Medicine. 186:719-730.

Ganpule, G., R. Knorr, J.M. Miller, C.P. Carron, and M.L. Dustin. 1997. Low affinity of cell surface LFA-1 generates selectivity for cell-cell interactions. Journal of Immunology. 159:2685-2692.

Dustin, M.L., D.E. Golan, D.M. Zhu, J.M. Miller, W. Meier, E.A. Davies, and P.A. van der Merwe. 1997. Low affinity interaction of human or rat T cell adhesion molecule CD2 with its ligand aligns adhering membranes to achieve high physiological affinity. J.Biol.Chem. 272:30889-30898.

Dustin, M.L. 1997. Adhesive bond dynamics in contacts between T lymphocytes and glass supported planar bilayers reconstituted with the immunoglobulin related adhesion molecule CD58. J.Biol.Chem. 272:15782-15788.

Dustin, M.L., S.K. Bromely, Z. Kan, D.A. Peterson, and E.R. Unanue. 1997. Antigen receptor engagement delivers a stop signal to migrating T lymphocytes. Proc.Natl.Acad.Sci.USA. 94:3909-3913.

Baorto, D.M., Z. Gao, R. Malaviya, M.L. Dustin, A. van der Merwe, D. Lublin, and S.N. Abraham. 1997. Survival of FIMH-expressing Escherichia coli in macrophages after co-opting glycolipid trafficking pathways Nature. 389:636-639.

Rothlein R, Dustin ML, Marlin SD, Springer TA. A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J. Immunol. 1986. 137: 1270-1274. J Immunol. 2011 May 1;186(9):5021-3. PMID: 21505215

Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA. Induction by IL 1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 1986. 137: 245-254. PMID: 21505214

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