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Moses V. Chao, Curriculum Vitae

Molecular Neurobiology Program
Skirball Institute of Biomolecular Medicine
Departments of Cell Biology, Physiology and Neuroscience, and Psychiatry
New York University School of Medicine
540 First Avenue
New York, N.Y.  10016
chao@saturn.med.nyu.edu


  Education
1970 -1973  B.A., Pomona College, Claremont, California
1975 -1980  Ph.D., UCLA, Department of Chemistry, Los Angeles, CA
  Postdoctoral
1980 -1983 Fellow, Columbia University College of Physicians & Surgeons
  Experience
1975 -1978   Teaching Assistant, Department of Chemistry, UCLA
1976 -1980   Predoctoral research, UCLA, Los Angeles, California
1980 -1983 Postdoctoral research, Columbia University, New York, New York
1984 -1989   Assistant Professor, Dept. of Cell Biology and Anatomy, Cornell University Medical College, New York
1989 -1991 Associate Professor, Cornell University Medical College
1991-1998   Professor of Cell Biology in Medicine, Cornell Medical College
1997-1998 Joseph C. Hinsey Professor of Cell Biology, Cornell Medical College
1998-2009 Professor and Co-Coordinator, Molecular Neurobiology Program, Skirball Institute, New York University,
School of Medicine
1998 - present

Professor of Cell Biology, Physiology and Neuroscience, Co-Coordinator, Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine

2007 - present Professor of Psychiatry, New York University School of Medicine
2009 - present

Associate of the Center of Neural Science, New York University

2011 - 2012

President of the Society for Neuroscience

  Honors
1980-1983 American Cancer Society Postdoctoral Fellowship
1985-1988 Cornell University Scholars Award
1987-1992 Hirschl/Caulier Faculty Award
1991-1994 Zenith Award, Alzheimer's Association
1993 Presidential Symposium Speaker, Society of Neuroscience Annual Meeting
1994 Guggenheim Fellowship
1995 John Flynn Lecturer, Yale University
1995 Randall Lecturer in Pharmacology, University of Pennsylvania
1996-2003 Javits Neuroscience Investigator Award
1998 UCLA Tenth Annual Neuroscience Distinguished Speaker
1999 Great Lakes Glia Meeting, Keynote Speaker
2000 Helen Wilshire Walsh Lecturer
2000 Grass Foundation Lecturer
2002 Berlin Neuroscience Forum Lecturer
2003 Weizmann Institute Life Science Lecturer
2004 Cajal Institute Lecturer
2007 World Congress on Psychiatric Genetics Plenary Speaker,
2008 Dartmouth University Neuroscience Day Speaker
2008 Fellow, AAAS
2008 Berlin Brain Days, Keynote Speaker
2011 President’s Award, Glaucoma Research Foundation, 2011
2013 Fondazione Premio Galileo Prize
  Professional Duties
  Editorial Board
1991- 1996 Neuron
1991 - Journal of Cellular Biochemistry
1992 - 1997 Journal of Biological Chemistry
1993 - International Journal of Developmental Neuroscience
1994 - 2006 Molecular and Cellular Neuroscience
1995 - Cytokine and Growth Factor Research
1995 - Editor, Journal of Neurobiology
1996 - 2002 Section Editor, Journal of Neuroscience
2002 - 2006 Associate Editor, Experimental Neurology
2002 - 2006 Associate Editor, Molecular and Cellular Neuroscience
2006 - 2011 Senior Editor, Journal of Neuroscience
  Advisory Panels & Study Sections
1988 - 1993 American Cancer Society Personnel Study Section
1988 - 1993 Regeneron Scientific Advisory Board
1989 - 1996 Alzheimer's Association Medical and Scientific Advisory Board
1992 - 1996 NIH Neuroscience Training (NST) Study Section
1991 - 1999 American Paralysis Association Scientific Advisory Board
1994 - 1996 Trophix Scientific Advisory Board
1996 - 1998 NICHD Intramural Review Panel
1996 - 1998 NLS-3 Special Emphasis Panel
1997 NIH Neuroscience Working Group
1998 - Diabetic Neuropathy Study Section
1998 - NSF Developmental Neuroscience Study Section
1999 -  Christopher Reeve Paralysis Foundation Scientific Advisory Board
2000 -  NICHD Board of Scientific Counselors
2000 - 2003 Program Committee, Society of Neuroscience (Chair, 2002)
2001 - 2004 Kirsch Foundation Scientific Advisory Board
2001 - NICHD Laboratory of Mammalian Genes and Development Review Panel
2001 - Chair, New York State Spinal Cord Injury Research Board (SCIRB)
2002 - NIA Special Emphasis Panel
2002 - NINDS Board of Scientific Counselors Intramural Review Panel
2002 - Center for Scientific Review Special Emphasis Panel ZRG FO3A
2002 - Wadsworth Foundation Strategic Scientific Advisory Board
2003 - 2006 National Multiple Sclerosis Society Study Section
2004 -  NIH MCDN-2 (NDBG) Study Section Member
2004 -  Chair, Glaucoma Foundation Scientific Advisory Board
2005 - 2006 Chair, NICHD Board of Scientific Counselors
2005 -  Chair, Christopher and Dana Reeve Foundation Scientific Advisory Board
2006 -  NIH Neuroscience Blueprint Committee
2006 - Secretary, Society of Neuroscience
2007 -  present Simons Foundation Scientific Advisory Board
2007 -  present NIH Genes Cognition and Psychosis Scientific Advisory Board
2007 Hi Q Foundation Workshop on BDNF and Huntington’s Disease
2007 Christopher and Dana Reeve Foundation Workshop on Stem Cells
2008 Center for Scientific Research IRG Review Meeting
2008 - Chair, CMNG Study Section
2009 - 20011 Vollum Institute Scientific Advisory Board
2010 - European Brain Research Institute Scientific Advisory Board
  Meeting Organizer
  Keystone UCLA Symposium, Molecular Biology of Neuronal Signal Transduction
Co-Organizer with Tom Curran, Jim Morgan, and Tom Schwarz
Taos, New Mexico, April 1993
International Society of Neurochemistry, Symposium Chairman, Neurotrophins,
Montpellier, France, August, 1993
Gordon Conference, Neurotrophins, Vice-Chair, Plymouth, New Hampshire, 1993.
International Society of Neurochemistry, Program Committee, Kyoto, 1995
Gordon Conference, Neurotrophins, Co-Chair, 1995
Society of Neuroscience Symposium Chair, Molecular Mechanisms of Cell Death, Miami, 1999
Chair, Society of Neuroscience Program Committee, 2002
Novartis Foundation, Growth Factors and Psychiatric Disorders, Chair, London, 2007
New York State Spinal Cord Research Board Symposium, New York Academy of Sciences,
New York, 2008
NGF2008 Katzir Conference on Life and Death in the Nervous System, Galilee, Israel,
September, 2008
Major Speaker Invitations (Since 2004)

Cancer UK, London, 2004
NIH NINDS Seminar Speaker, March 2004
University of North Carolina School of Medicine, 2004
Juan March Symposium, Madrid, April 2004
Buck Institute for Aging Research, 2004
Institute for the Study of Aging Workshop, New York, 2004
Mechanisms of Protein Activation, Wurzburg, 2004
Wyeth Research, Restoring Function to the Damaged Brain, Perugia, 2004
Neuroplasticity, Neurotrophic Factors and Affective Disorders, Pisa, 2005
Mt Sinai Hospital, Toronto, June 2005
Gordon Conference, Neurotrophins, Newport RI, 2005
International Symposium on Aging and Neurodegneration, Seoul, 2005
Tong Joh Honorary Symposium, Burke Medical Institute, November, 2005
Novartis Foundation, Purinergic Signalling in Neuron-Glia Interactions, London, 2005
King’s College, London, January 2006
Columbia University Center for Neurobiology, January 2006
Cleveland Clinic, February 2006
University of Louisville, 2006
Johns Hopkins School of Medicine, March 2006
University of Louisville School of Medicine, March 2006
UCSD School of Medicine, March 2006
Rockefeller University Seminars in Clinical Research, April 2006
Neurotrophins: Mechanisms in Disease and Therapy, Bristol UK, April, 2006
NGF 2006 Meeting, Lyon, France, May, 2006
Molecular and Cellular Basis of Neuroconnectivity, Leuven, Belgium, May, 2006
Mt. Sinai School of Medicine, June 2006
Society of Neuroscience Symposium on Stem Cells, October 2006
Adler Foundation Symposium on Alzheimer’s Disease, Salk Institute, February, 2007
Emory University School of Medicine, May 2007
USC School of Medicine, September 2007
World Congress on Psychiatric Genetics, Plenary Speaker, New York City, October 2007
Columbia University Motor Neuron Center, January 2008
Dartmouth University Annual Neuroscience Day Keynote Speaker, February 2008
Kavli Institute for Theoretical Physics, UCSB, March 2008
Pasteur Institute, Paris, April 2008
Duke University School of Medicine, May 2008
European Brain Research Institute, Rome, September 2008
University of Alabama, December 2008
Berlin Brain Days, Keynote Speaker, December, 2008
National Congress Italian Neuroscience Society Keynote Speaker, 2009
BrainForum Speaker: New Frontiers in Brain Research, Rome 2010
ISF New Approaches to Neurodegenerative Diseases, Dead Sea Israel, 2010
Neurotrophin Gordon Conference, Newport 2011
CHDI 6th Annual Huntington’s Disease Therapeutics Conference, 2011
Yale University School of Medicine, 2011
International Symposium on Receptors, Channels and Transporters, Wurzburg, Germany, 2011
International Center for Scientific Debate, How Mind Emerges from Brain, Barcelona, 2012
Mechanisms of neurotrophic factors in health and disease, Salamanca, 2013
University of New England, 2013
Hospital Pitie-Salpetriere ICM, Paris, 2013
Brain Forum, Rome, 2013

Bibliography
Recent Publications
Puehringer, D., Orel, N., Luningschror, P., Subramanian, N., Herrmann, T., Chao, M.V. and Sendtner, M. (2013) EGF transactivation of Trk receptors regulates the migration of newborn cortical neurons.  Nature Neuroscience 16, 407-415.
Liston, C., Cichon, J.M., Jeanneteau, F., Jia, Z., Chao, M.V. and Gan, W.B. (2013) Circadian glucocorticoid oscillations promote learning-dependent synapse formation and maintenance. Nature Neurosci 16, 698-705.
Jeanneteau, F., Lambert, W.M., Ismaili, N., Bath, K.G., Lee, F.S., Garabedian, M.J. and Chao, M.V. (2012) BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus.  Proc Natl Acad Sci 109, 1305-1310.
Deinhardt, K., Kim, T., Spellman, D.S., Mains, R.E., Eipper, B.A., Neubert, T.A., Chao, M.V. and Hempstead, B.L. (2011) Neuronal growth cone retraction relies on proneurotrophin receptor signaling through rac.  Science Signaling 4, ra82.
Duffy, A.M., Schaner, M.J., Wu, S.H., Staniszewski, A., Kumar, A., Arevalo, J.C., Arancio, O., Chao, M.V. and Scharfman, H.E. (2011) A selective role for ARMS/Kidins220 scaffold protein in spatial memory and trophic support of entorhinal and frontal cortical neurons.  Exp Neurol 229, 409-420.
Ma, B. Savas, J.N., Yu, M.S., Culver, B.P., Chao, M.V. and Tanese, N. (2011) Huntingtin mediates dendritic transport of ?-actin mRNA in rat neurons.  Science Rep 1, 140.
Pattwell, S.S., Bath, K.G., Perez-Castro, R., Lee, F.S., Chao, M.V. and Ninan, I. (2012) The BDNF Val66Met polymorphism impairs synaptic transmission and plasticity in the infralimbic medial prefrontal cortex.  J Neuroscience 15, 2410-2421. 
Baj, G., Leone, E., Chao, M.V., Tongiorgi, E. (2011) Spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct dendritic compartments. Proc Natl Acad Sci, ahead of print.
Matrone, C., Barbagallo, A.P., La Rosa, L.R., Florenzano, F., Ciotti, M.T., Mercanti, D., Chao, M.V., Calissano, P., D’Adamio, L. (2011) APP is phosphorylated by TrkA and regulates NGF/TrkA signaling. J Neuroscience 31, 11756-11761.
Lu, Y., Ji, Y., Ganesan, S., Schloesser, R., Martinowich, K., Sun, M., Mei, F., Chao, M.V. and Lu, B. (2011) TrkB as a potential synaptic and behavioral tag. J Neuroscience 31, 11762-11771.
Roehm, P.C., Camarena, V., Nayak, S., Gardner, J. , Wilson, A., Mohr, I. and Chao, M.V. (2011) Cultured vestibular ganglion neurons demonstrate latent HSV-1 reactivation. Laryngoscope, ahead of print.

Shroff, S., Mierzwa, A., Scherer, S.S., Peles, E., Arevalo, J.C., Chao, M.V. and Rosenbluth, J. (2011)
Paranodal permeability in “myelin mutants”. Glia, ahead of print.

Zhang, G., Deinhardt, K., Chao, M.V. and Neubert, T.A. (2011) Study of neurotrophin-3 signaling in primary
cultured neurons using multiplex stable isotope labeling with amino acids in cell culture. J Proteome
Res
10, 2546-2554.
Spencer-Segal, J.L., Waters, E.M., Bath, E.G., Chao, M.V., McEwen, B.S. and Milner, T.A. (2011)
Distribution of phospohrylated TrkB receptor in the mouse hippocampal formation depends on sex and estrous cycle stage. J Neuroscience 31, 6780-6790.
Yu, T., Calvo, L., Lopez-Benito, S., Southon, E., Chao, M.V., Tessarollo, L. and Arevalo, J.C. (2011)
Regulation of trafficking of activated TrkA is critical for NGF-mediated functions. Traffic 12, 521-534.
Duffy, A., Schaner, M.J., Wu, S.H., Staniszewski, A., Kumar, A., Arevalo, J.C., Arancio, O., Chao, M.V.,
Scharfman, H.E. (2011) A selective role for ARMS/Kidins220 scaffold protein in spatial memory and trophic support of entorhinal and frontal cortical neurons. Exp Neurology 229, 409-420.
Vaegter, C.B., Jansen, P., Fjorback, A.W., Glerup, S., Skeldal, S., Kjolby, M., Richner, M., Erdmann, B.,
Nyengaard, J.R., Tessarollo, L., Lewin, G.R., Willnow, T.E., Chao, M.V. and Nykjaer A. (2011) Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nature Neurosci 14, 54-61.
Camarena, V., Kobayashi, M, Kim, J.Y., Roehm, P., Perez, R., Garner, J., Wilson, A.C., Mohr, I. and Chao,
M.V. (2010) Nature and duration of growth factor signaling through receptor tyrosine kinases regulates HSV-1 latency in neurons. Cell Host Microbe 8, 320-330.
Wu, S.H., Arevalo, J.C., Neubrand, V.E., Zhang, H., Arancio, O., Chao, M.V. (2010) The ankyrin-rich
membrane spanning (ARMS)/KIDINS220 scaffold protein is regulated by activity-dependent calpain proteolysis and modulates synaptic plasticity. J Biol Chem 285, 40472-40478.
Jeanneteau, F., Deinhardt, K., Miyoshi, G., Bennett, A.M. and Chao, M.V. (2010) The MAP kinase
phosphatase MKP-1 regulates BDNF-induced axon branching. Nature Neurosci 13, 1373-1379.
Chao, M.V. (2010) Increasing the specificity of neurotrophic factors. Proc. Natl. Acad. Sci. 107, 13565
13566.
Sutachan, J.J., Chao, M.V. and Ninan, I. (2010) Regulation of inhibitory neurotransmission by the scaffolding
protein ankyrin-rich membrane spanning/kinase D-interacting substrate of 220 kDa. J Neurosci Res, ahead of print
Mierzwa, A.J., Arevalo, J.C., Schiff, R., Chao, M.V. and Rosenbluth, J. (2010) Role of transverse bands in
maintaining paranodal structure and axolemmal domain organization in myelinated nerve fibers: effect on longevity in dysmyelinated mutant mice. J Comp Neurol 518, 2841-2853.
Arevalo, J.C., Wu, S.H., Takahashi, T., Zhang, H., Yu, T., Yano, H., Milner, T.A., Tessarollo, L., Ninan, I.,
Arancio, O. and Chao, M.V. (2010) The ARMS/Kidins220 scaffold protein modulates synaptic transmission. Mol Cell Neurosci 45, 92-100.
Assaife-Lopes, N., Sousa V.C., Pereira, D.B., Ribeiro, J.A., Chao, M.V. and Sebastiao, A.M. (2010)
Activation of A2A receptors induces TrkB translocation and increases BDNF-mediated phospho-TrkB localization in lipid rafts: Implications for neuromodulation. J Neuroscience 30, 8468-8480
Ma, B., Culver, B.P., Baj, G., Tongiorgi, E., Chao, M.V. and Tanese, N. (2010) Localization of BDNF mRNA
with the Huntington’s disease protein in rat brain protein Mol Neurodegener 5, 22.

Domeniconi, M. and Chao, M.V. (2010) Transactivation of Trk receptors in spinal motor neurons. Histol
Histopathol
25, 1207-1213.

Ginsberg, S.D., Allred, M.J., Counts, S.E., Cataldo, A.M., Neve, R.L., Jiang, Y., Wuu, J., Chao, M.V., Mufson, E.J., Nixon, R.A. and Che, S. (2010) Microarray analysis of hippocampal CA1 neurons
implicates early endosomal dysfunction during Alzheimer’s disease progression. Biol Psychiatry 68, 885-893.
Ninan, I., Bath, K.G., Dagar, K., Perez-Castro, R., Plummer, M.R., Lee, F.S. and Chao, M.V. (2010)
The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus. J Neuroscience 30, 8866-8870.
Parkhurst, C.N., Zampieri, N. and Chao, M.V. (2010) Nuclear localization of the p75 neurotrophin receptor
intracellular domain. J. Biol. Chem. 285, 5361-5368.
Chao, M.V. (2010). A conversation with Rita Levi-Montalcini. Interview by Moses V. Chao. Ann. Review
Physiology
72, 1-13.
Savas, J.N., Ma, B., Deinhardt, K., Culver, B.P., Restituito, S., Wu, L., Belasco, J.G., Chao, M.V. and Tanese,
N. (2010) A role for Huntington disease protein in dendritic RNA granules. J. Biol. Chem. 285, 13142-13153.
Chao, M.V. and Ip, N.Y. (2010). Trophic factors: 50 years of growth. Dev Neurobiology 70, 269-270.
Read, D. J., Li, Y., Chao, M.V., Cavanagh, J.B. and Glynn, P. (2010) Organophosphates induce distal axonal
damage, but not brain oedema, by inactivating neuropathy target esterase. Toxiol. Appl. Pharmacol., Epub ahead of print.
Schechterson, L.C., Hudson, M.P., Ko, M., Phillippidou, P., Akmentin, W., Wiley, J. Rosenblum, E. Chao,
M.V., Halegoua, S. and Bothwell, M. (2010) Trk activation in the secretory pathway promotes Golgi fragmentation. Mol. Cell. Neurosci 43, 403-413.
Yano, H., Torkin, R., Martin, L.A., Chao, M.V. and Teng, K.K. (2009). Proneurotrophin-3 is a neuronal
apoptotic ligand: evidence for retrograde-directed cell killing. J. Neurosci. 29, 14790-14802.
Read, D.J., Li, Y., Chao, M.V., Cavanagh, J.B. and Glynn, P. (2009) Neuropathy target esterase is required for adult vertebrate axon maintenance. J. Neurosci. 16, 11594-11600.
Rosenbluth, J., Schiff, R., Lam, P., Nuriel, T. and Chao, M.V. (2009) Spongiform pathology in mouse CNS lacking ‘neuropathy target esterase’ and cellular prion protein. Neurobiol Dis, ahead of print.
Huang, S.H., Zhao, L., Sun, Z.P., Li, X.Z., Geng, Z., Zhang, K.D., Chao, M.V. and Chen, Z.Y. (2009) Essential role of Hrs in endocytic recycling of full-length TrkB receptor but not its isoform TrkB.T1. J. Biol. Chem. 284, 15126-15136.
Nagahara, A.H., Merrill, D.A., Coppola, G., Tsukada, S., Schroeder, B.E., Shaked, G.M., Wang, L., Blesch, A., Kim, A., Conner, J.M., Rockenstein, E., Chao, M.V., Koo, E.H., Geschwind, D., Masliah, E., Chiba, A.A. and Tuszynski, M.H. (2009) Nature Med. 15, 331-337.
Wu, S.H., Arevalo, J.C., Sarti, F., Tessarollo, L, Gan. W.B. and Chao, M.V. (2009) Ankryin repeat rich membrane spanning/Kidins220 protein regulates dendritic branching and spine stability in vivo. Dev Neurobiology 69, 547-557
Bath, K.G., Mandairon, N., Jing, D., Rajagopal, R., Kapoor, R., Chen, Z-Y., Khan, T, Proenca, C.C., Kraemer, R., Cleland, T.A., Hempstead, B.L., Chao, M.V. and Lee, F.S. (2008) Variant Brain-derived Neurotrophic Factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination. J. Neuroscience 28, 2383-2393.
Sniderhan, L.F., Stout, A., Lu, Y., Chao, M.V. and Maggiwar, S.B. (2008) Ankyrin-rich membrane spanning protein plays a critical role in nuclear factor-kappa B signaling. Mol. Cell. Neurosci. 38, 404-416.
Spellman, D.S., Deinhardt, Darie, C.C., Chao, M.V. and Neurbert, T.A. (2008) Stable isotopic labeling by amino acids in cultured primary neurons: application to brain-derived neurotrophic factor-dependent phosphotyrosine-associated signaling. Mol Cell Proteomics 7, 1067-1076.
Iwakawa, Y., Nawa, H., Sora, I. and Chao, M.V. (2008) Dopamine D1 receptor-induced signaling through TrkB receptors in striatal neurons. J. Biol. Chem 283, 15799-15806.
Jeanneteau, F., Garabedian, M. and Chao, M.V. (2008) Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect. Proc. Natl. Acad. Sci. 105, 4862-4867.
Wiese, S., Jablonka, S., Holtmann, B., Orel, N., Rajagopal, R., Chao, M.V. and Sendtner, M. (2007) Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB. Proc. Natl. Acad. Sci. 104, 17210-17215.
Pereira, D.B. and Chao, M.V. (2007) The tyrosine kinase Fyn determines the localization of TrkB receptors in lipid rafts.  J. Neuroscience 27, 4859-4869.
Cortes, R.Y., Arevalo, J.C., Magby, J.P., Chao, M.V. and Plummer, M.R. (2007) Developmental and activity-dependent regulation of ARMS/Kidins220 in cultured rat hippocampal neurons.  Dev. Neurobiol., ahead of print.
Sachs, B.D., Baillie, G.S., McCall, J.R., Passino. M.A., Schachtrup, C.,, Wallace, D.A., Dunlop, A.J., MacKenzie, K.F., Klussmann, E., Lynch, M.J., Sikorski, S.L., Nuriel, T., Tsigelny, I., Zhang, J., Houslay, M.D., Chao, M.V. and Akassoglou, K. (2007) p75 neurotrophin receptor regulates tissue fibrosis through inibition of plasminogen activation via a PDE4/cAMP/PKA pathway.  J. Cell Biol. 177, 1119-1132.
Rantamaki, T., Hendolin, P., Kankaanpaa, A., Mijatovic, J., Piepponen, P., Domenici, E., Chao, M.V., Mannisto, P.T. and Castren, E. (2007) Pharmacologically diverse antidepressants rapidly activate BDNF receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brain.  Neuropsychopharm Feb 21, ahead of print.
Domeniconi, M., Hempstead, B.L. and Chao, M.V. (2007) Pro-NGF secreted by astrocytes promotes motor neuron cell death.  Mol. Cell. Neuroscience 34, 271-279.
Urra, S., Escudero, C.A., Ramos, P., Lisbona, F., Allende E., Covarrubias, P., Parraguez, J.I., Zampieri, N., Chao, M.V., Annaert, W. and Bronfman, F.C. (2007) TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intacellular domain.  J. Biol. Chem. 282, 7606-7615.
Zampieri, N. and Chao, M.V. (2006) Mechanisms of neurotrophin receptor signaling.  Biochem. Soc. Trans. 34, 607-611.
Jeanneteau, F. and Chao, M.V. (2006) Promoting neurotrophic effects by GPCR ligands.  Novartis Found. Symp. 276, 181-189.

Yano, H., Ninan, I., Zhang, H., Milner, T.A., Arancio, O., Chao, M.V. (2006) BDNF-mediated neurotransmission relies upon a myosin VI motor complex.  Nature Neurosci 9, 1009-1018.

Arevalo, J.C., Waite, J., Rajagopal, R., Beyna, M., Chen, Z-Y., Lee, F.S. and Chao, M.V. (2006) Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination. Neuron 50, 549-559.
Rajagopal, R. and Chao, M.V. (2006) A role for Fyn in Trk receptor transactivation by G-protein-coupled receptor signaling.  Mol. Cell. Neurosci 33, 36-46.
Arevalo, J.C., Waite, J., Rajagopal, R., Beyna, M., Chen, Z-Y., Lee, F.S. and Chao, M.V. (2006) Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination. Neuron 50, 549-559.
Kenchappa, R.S., Zampieri, N., Chao, M.V., Barker, P.A., Teng, H.K., Hempstead, B.L. and Carter, B.D. (2006) Ligand-dependent cleavage of the p75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons.  Neuron 50, 219-232.
Arevalo, J.C., Pereira, D., Yano, H., Teng, K.K. and Chao, M.V. (2006) Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylation, J. Biol Chem.281, 1001-1007.

Zampieri, N., Xu, C., Neubert, T.A., Chao, M.V. (2005) Cleavage of p75 neurotrophin receptor by alpha secretase and gamma-secretase requires specific receptor domains.  J Biol Chem 280, 14563-14571.

Taveggia, C., Zanazzi, G. Petrylak, A., Yano, H., Rosenbluth, J., Einheber, S., Xu, X., Esper, R.M.,, Loeb, J.A., Shrager, P., Chao, M.V., Falls, D.L., Role, L. and Salzer, J.L. (2005) Neuregulin-1 Type III determines the ensheathment fate of axons.  Neuron 47, 681-694.

Luo, S., Chen, Y., Lai, K.O., Arevalo, J.C., Froehner, S.C., Adams, M.E., Chao, M.V. and Ip, N.Y. (2005) alpha-syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner.  J Cell Biol 169, 813-824.

Arevalo, J.C. and Chao, M.V. (2005) When neurotrophins meet Wnts. Current Opinion Cell Biol 7, 112- 115
Domeniconi, M., Zampieri, N., Spencer, T., Hilaire, M., Mellado, W., Chao, M.V., Filbin, M.T. (2005) MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth.  Neuron 46, 849-855.
Chang, M.S., Arevalo, J.C. and Chao, M.V. (2004) Ternary complex with Trk, p75 and an ankyrin-rich membrane spanning protein.  J Neurosci Res 78, 186-192.
Rajagopal, R., Chen, Z-Y., Lee, F.S. and Chao, M.V. (2004) Transactivation of Trk neurotrophin receptors by G-protein-coupled receptor ligands occurs on intracellular membranes.  J. Neuroscience 24, 6650-6658.
Murray, S., Perez, P., Lee, R., Hempstead, B.L. and Chao, M.V. (2004) A novel p75 neurotrophin receptor related protein, NRH2, regulates NGF binding to the TrkA receptor.  J Neuroscience 24, 2742=2749.
Arevalo, J.C., Yano, H., Teng, K.K., Chao, M.V. (2004) A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane spanning protein.  EMBO J 23, 2358-2368.
Akassoglou, K., Malester, B., Xu, J., Tessarollo, L., Rosenbluth, J. and Chao, M.V. (2004) Brain-specific deletion  of Neuropathy Target Esterase/swisscheese results in neurodegeneration.  Proc Natl Acad Sci USA 101, 5075-5080.
Murray, S., Perez, P., Lee, R., Hempstead, B.L. and Chao, M.V. (2004) A novel p75 neurotrophin receptor related protein, NRH2, regulates NGF binding to the TrkA receptor.  J Neuroscience 24, 2742 - 2749.
Chittka, S., Arevalo, J.C., Rodriguez-Guzman, M., Perez, P., Chao, M.V. and Sendtner, M. (2004) The p75NTR interacting protein SC1 inhibits cell cycle progression by transcriptional repression of cyclin E,  J Cell Biology 164, 985-996.
Kim, D.H, Zhao, X., Tu, CH, Casaccia-Bonnefil, P and Chao, M.V. (2004) Prevention of apoptotic but not necrotic cell death following neuronal injury by neurotrophin signaling through the  tyrosine kinase receptor.  J Neurosurgery 100, 79-87.
Yano, H. and Chao, M.V. (2004) Mechanisms of neurotrophin receptor vesicular transport.  J. Neurobiology 58, 244-257.
Jung, K.M., Tan, S., Landsman, N., Petrova, K., Murray, S., Lewis, R., Kim, P.K., Kim, D.S., Ryu, S.H., Chao, M.V. and Kim, T.W. (2003) Regulated intramembraneous proteolysis of the p75 receptor modulates its association with the TrkA receptor.  J Biol Chem 278, 42161-42169.

Caporaso, G., Lim, D.A., Alvarez-Buyyla, A. and Chao, M.V. (2003).  Telomerase activity in the subventricular zone of adult mice.  Mol Cell Neuroscience. 4, 693-702.  

Shonukan, O., Bagayogo, I., McCrea, P., Chao, M. and Hempstead, B. (2003) Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin. Oncogene 22, 3616-3623.
Kim, A.H., Sasaki, T and Chao, M.V. (2003) JNK interacting protein 1 promotes Akt1 activation.  J BiolChem 279, 29830-29836.
Chao, M.V. (2003) Neurotrophins and their receptors: A convergence point for many signaling pathways. Nature Rev Neuroscience 4, 299-309.
Kim, A.H., Yano, H., Cho, H., Meyer, D., Monks, B., Margolis, B., Birnbaum, M.J. and Chao, M.V. (2002) Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron 35, 697-709.

Harroch, S., Furtado, G.C., Beueck, W., Rosenbluth, J., Lafaille, J., Chao, M., Buxbaum, J.D. and Schlessinger, J. (2002)  A critical role for the protein tyrosine phosphatase receptor type beta in functional recovery from demyleinating lesions.  Nature Genetics 32, 411-414.

Doetsch, F., Verdugo, J M-G., Caille, I., Alvarez-Buylla, A., Chao, M.V. and Casaccia-Bonnefil, P. (2002) Lack of the cell cycle inhibitor p27Kip1 results in selective increase of transit-amplifying cells for adult neurogenesis.  J. Neuroscience 22, 2255-2264.
Lee, F.S., Rajagopal, R., Kim, A.H., Chang, P.C. and Chao, M.V. (2002) Activation of Trk neurotrophin receptor signaling by pituitary adenylate cyclase-activating polpeptides. J. Biol. Chem. 277, 9096-9102.
Okuse, K., Malik-Hall, M., Baker, M.D., Poon, W.Y., Kong, H., Chao, M.V. and Wood, J.N. (2002) Annexin II light chain regulates sensory neuron-specific sodium channel expression.  Nature 417, 653-656.
Legrier, M.E., Ducray, A., Propper, A., Chao, M. and Kastner, A. (2001) Cell cycle regulation during  mouse olfactory neurogenesis.  Cell Growth Differentiation 12, 591-601.

Esposito, D., Patel, P., Stephens, R.M., Perez, P., Chao, M.V., Kaplan, D.R. and Hempstead, B.L. (2001). The cytoplasmic and transmembrane domains of the p75 and TrkA receptors regulate high affinity binding to NGF.  J. Biol. Chem. 276, 32687-32695.

Wolf, R.M., Wilkes, J.J., Chao, M.V. and Resh, M.D. (2001) Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation.  J. Neurobiology 49, 62-78.
Chuang, H., Prescott, E.D., Kong, H., Shields, S., Jordt, S.E., Basbaum, A.I., Chao, M.V. and Julius, D. (2001) Bradykinin and nerve growth factor release the capsaicin receptor from PIP2-mediated inhibition.  Nature 411, 957-962.
Caporaso, G.L. and Chao, M.V. (2001) Telomerase and oligodendrocyte differentiation.  J. Neurobiology. 49, 224-234.
Lee, C.J., Kong, H., Manzini, M.C., Albuquerque, C., Chao, M.V. and MacDermott, A.B. (2001) Kainate receptors expressed by a subpopulation of developing nociceptors rapidly switch from high to low Ca2+ permeability.  J Neuroscience 21, 4572-4581.
Lee, F.S. and Chao, M.V. (2001) Activation of Trk neurotrophin receptors in the absence of neurotrophins. Proc. Natl. Acad. Sci. USA 98, 3555-3560.
Khursigara, G., Bertin, J., Yano, H., Moffett, H., Stefano, P.S. and Chao, M.V. (2001) A pro-survival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor interacting protein 2. J. Neuroscience 21, 5854-5863.

Arevalo, J.C., Conde, B., Hempstead, B.L., Chao, M.V., Martin-Zanca, D. and Perez, P. (2001) A novel mutation within the extrcellular domain of TrkA causes constitutive receptor activation. Oncogene 20, 1229-1234. 

Lou, X, Yano, H., Lee, F.S., Chao, M.V. and Farquhar, M (2001)  GIPC amd GAIP form a complex with TrkA: a putative link between G-protein and receptor tyrosine kinase pathways.  Mol Biol Cell 12, 615-627.
Yano, H., Lee, F., Kong, H., Chuang, J-Zen, Arevalo, J.C., Perez, P., Sung, C.H. and Chao, M.V. (2001) Association of Trk neurotrophin receptors with  components of the cytoplasmic dynein motor.  J. Neuroscience 21, RC125.
Kim, A., Khursigara, G., Sun, X., Franke, T. and Chao, M.V. (2001) Akt phosphorylates and negatively regulates apoptosis signal regulating kinase 1.  Mol Cell Biol 21, 893-901.
Kong, H., Boutler, J., Weber, J.L., Lai, C. and Chao, M.V. (2001) An evolutionarily conserved transmembrane protein that serves as a downstream target for neurotrophins and ephrin receptors.  J. Neuroscience 21, 170-185
Zezula, J., Casaccia-Bonnefil, P., Ezhevsky, S.A., Osterhout, D.J., Levine, J.M., Dowdy, S.F., Chao, M.V. and Koff, A. (2001) p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal.  EMBO Reports 21, 27-34.
Yano, H. and Chao, M.V. (2000) Neurotrophin receptor structure and interactions.  Pharm Acta Helv 74, 253-260.
Tikoo, R., Zanazzi, G., Shiffman, D., Salzer, J. and Chao, M.V. (2000)  Cell cycle control of Schwann cell proliferation:  Role of cyclin-dependent kinase-2.   J. Neuroscience 20, 4627-4634.
Gu, C., Ma, Y-C., Benjamin, J., Littman, D., Chao, M.V. and Huang, X-Y. (2000) Apoptotic signaling through the b-adrenergic receptor.  J. Biol. Chem. 275, 20726-20733.
Arevalo, J.C., Conde, B., Hempstead, B.L., Chao, M.V., Martin-Zanca, D. and Perez, P. (2000) TrkA immunoglobulin-like binding domains inhibit spontaneous activation of the receptor.  Mol. Cell. Biol. 20, 5908-5916.
Chao, M.V. (2000) Trophic factors: An evolutionary cul-de-sac or door into higher neuronal function? J. Neurosci. Res. 59, 353-355
Yano, H., Cong, F., Birge, R.B., Goff, S.P. and Chao, M.V. (2000) Association of the Abl tyrosine kinase with the Trk nerve growth factor receptor.  J. Neurosci. Res. 59, 356-364.
Dowling, P., Ming, X., Raval, S., Husar, W., Casaccia-Bonnefil, P., Chao, M., Cook, S. and Blumberg, B. (1999) Up-regulated p75NTR neurotrophin receptor on glial cells in MS plaques.  Neurology 53, 1676.
Kong, H., Kim, A.H., Orlinick, J.R. and Chao, M.V. (1999) A comparison of the death domains of the Fas receptor and the p75 neurotrophin receptor.  Cell Death and Differentiation 6, 1134-1143.

Chittka, A. and Chao, M.V.  (1999) Identification of a novel zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor.  Proc Natl Acad Sci USA 96, 10705-10710.

Casaccia-Bonnefil, P., Hardy, R.J., Teng, K.K., Levine, J.M., Koff, A. and Chao, M.V. (1999) Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation.  Development 126, 4027-4037.
Osterhout, D.J., Wolven, A., Wolf, R.M., Resh, M.D. and Chao, M.V. (1999) Morphological differentiation of oligodendrocytes requires activation of Fyn tyrosine kinase.  J Cell Biol 145, 1209-1218.
Gu, C., Casaccia-Bonnefil, P., Srinivasan, A. and Chao, M.V. (1999) Oligodendrocyte apoptosis mediated by caspase activation.  J Neuroscience 19, 3043-3049.
Castellino, A.M. and Chao, M.V. (1999) Differential association of phosphatidylinositol-5-phosphate 4 kinase with the EGF/ErbB family of receptors.  Cell Signaling 11, 171-177.

Vaishnaw, A.K., Orlinick, J.R., Chu, J.L., Krammer, P.H., Chao, M.V. and Elkon, K.B. (1999) The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1)  mutations.  J Clinical Invest 103, 355-363.

Khursigara, G., Orlinick, J.R. and Chao, M.V. (1999)  Association of TRAF6 with the p75 neurotrophin receptor.  J Biol Chem 274, 2597-2600.
Aibel, L., Martin-Zanca, D., Perez, P. and Chao, M.V. (1998) Functional expression of TrkA receptors in hippocampal neurons.  J  Neurosci Res 54, 424-431.
Chao, M., Casaccia-Bonnefil, P., Carter, B., Chittka, A., Kong, H. and Yoon, S.O. (1998) Neurotrophin receptors: mediators of life and death.  Brain Res Rev 26, 295-301.
Gu, C., Castellino, A., Chan, J-H. and Chao, M.V. (1998) BRE: a modulator of TNF-a action.  FASEB J 12, 1101-1108
Orlinick, J.R. and Chao, M.V. (1998) TNF-related ligands and their receptors.  Cell Signaling 10, 543-551.

Tikoo, R., Osterhout, D., Casaccia-Bonnefil, P., Seth, P., Koff, A. and Chao, M.V. (1998) Ectopic expression of p27Kip in oligodendrocyte progenitor cells results in cell cycle growth arrest.  J Neurobiology 36, 431-440. 

Yoon, S.O. Casaccia-Bonnefil, P., Carter, B. and Chao, M.V. (1998)  Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival.  J Neuroscience 18, 3273-3281.
Casaccia-Bonnefil, P., Kong, H. and Chao, M.V.  (1998)  Neurotrophins: the biological paradox of survival factors eliciting apoptosis.  Cell Death and Differentiation 5, 357-364.
Orlinick, J.R., Elkon, K. and Chao, M.V. (1997) Separate domains of the human Fas ligand dictate self association and receptor binding.  J Biol Chem 272, 32221-32229.
Yoon, S.O., Soltoff, S.P. and Chao, M.V. (1997) A dominant role of the juxtamembrane region of the trkA NGF receptor during neuronal cell differentiation.  J Biol Chem 272, 23231-23238.
Orlinick, J.R., Vaishnaw, A., Elkon, K. and Chao, M.V. (1997) Requirement of cysteine-rich repeats of the Fas receptor for binding by the Fas ligand.  J Biol Chem 272, 28889-28894.
Casaccia-Bonnefil, P., Tikoo, R., Kiyokawa, H., Friedrich, V., Chao, M.V. and Koff, A. (1997). Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1.  Genes and Development 11, 2335-2346.
Wong, B.R., Rho, J., Arron, J., Robinson, E., Orlinick, J., Chao, M., Kalachikov, S., Cayani, E., Bartlett, F.S., Frankel, W.N., Lee, S.Y. and Choi, Y.  (1997) TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells.  J Biol Chem 272, 25190-25194.
Castellino, A., Parker, G.J., Boronenkov, I.V., Anderson, R.A. and Chao, M.V. (1997) A novel interaction between the juxtamembrane region of the p55 TNF receptor and phosphatidyinositol-4-phosphate 5-kinase.  J Biol Chem 272, 5861-5874.
Tikoo, R., Casaccia-Bonnefil, P., Chao, M. and Koff, A. (1997) Changes in CDK2 and p27Kip during differentiation of CG-4 cells.  J Biol Chem 272, 442-447.

Papandreou, C., Bogenrieder, T., Loganzo, F., Chao, M.V., Nanus, D.M. and Albino, A.P.  (1996). Mutation and expression of the low affinity neurotrophin receptor in human malignant melanoma. Melanoma Res 6, 373-378.

Casaccia-Bonnefil, P., Aibel, L. and Chao, M.V. (1996) Central glial and neuronal populations display differential sensitivity to ceramide-dependent cell death.  J Neurosci Res 43, 382-289.

Castellino, A.M. and Chao, M.V. (1996) Trans-signaling by cytokine and growth factor receptors. Cytokine & Growth Factor Reviews  7, 297-302. 

Yoon, S.O., Lois, C., Alvarez-Buylla, A., Falck-Pederson, E. and Chao, M.V. (1996) Adenovirus-mediated gene delivery into neuronal precursors in the adult mammalian brain.  Proc Natl Acad Sci USA. 93, 11974-11979.
Orlinick, J. and Chao, M.V. (1996)  Interactions of cellular polypeptides with the cytoplasmic domain of the mouse Fas antigen.  J Biol Chem 271, 8627-8632.
Casaccia-Bonnefil, P., Carter, B., Dobrowsky, R. and Chao, M.V. (1996)  Death of oligodendrocytes mediated by an interaction of nerve growth factor and its receptor p75.  Nature 383, 716-718.
Perez, P., Coll, P.M., Hempstead, B.L., Martin-Zanca, D. and Chao, M.V. (1995) NGF binding to the trk tyrosine kinase receptor requires the extracellular immunoglobulin-like domains.   Mol Cell Neurosci 6, 97-105.
Einarson, M. and Chao, M.V. (1995) Regulation of Id1 and its association with basic helix-loop-helix proteins during NGF-induced differentiation of PC12 cells.  Mol Cell Biol 15, 4175-4183.
Monlauzeur, L., Rajasekaran, A., Chao, M., Rodriguez-Boulan, E. and LeBivic, A. (1995) A cytoplasmic tyrosine is essential for the basolateral localization of mutants of the human nerve growth factor receptor in Madin-Darby Canine kidney cells.  J Biol Chem 270, 12219-12225.
Huber, L.J. and Chao, M.V. (1995) A potential interaction of p75 and trkA NGF receptors revealed by affinity crosslinking and immunoprecipitation.  J  Neurosci  Res 40, 557-563.
Muragaki, Y., Timothy, N., Leight, S., Hempstead, B., Chao, M., Trojanowski, J. and Lee, V. (1995). Expression of Trk receptors in the developing and adult human central and peripheral nervous system.  J  Comp  Neurol. 356, 387-397.
Rao, P., Hsu, K.C. and Chao, M.V. (1995) Upregulation of NFkB dependent gene expression mediated by the p75 tumor necrosis factor receptor.  Lymphokine and Cytokine Res 15, 171-177.

Curtis, R., Adryan, K.M., Stark, J.L., Park, J.S., Compton, D.L., Weskamp, G., Huber, L.J., Chao, M.V., Jaenisch, R., Lee, K.F., Lindsay, R.M. and DiStefano. P.S. (1995) Differential role of the low affinity neurotrophin receptor (p75) in retrograde axonal transport of the neurotrophins. Neuron 14, 1201-1211. 

Chao, M.V. and Hempstead, B.L. (1995) Trk and p75: A two receptor system.  Trends Neurosci 18, 321-326.

Van Zee, K.J., Stackpole, S.A., Montegut, W.J., Rogy, M.A., Calvano, S.E., Hsu, K.C., Chao, M., Meschter, C.L., Loetscher, H., Stuber, D., Ettlin, R., Wipf, B., Lesslauer, W., Lowry, S.F. and Moldawer, L.L. (1994) A human tumor necrosis factor (TNF) a mutant that binds exclusively to the p55 TNF receptor produces toxicity in the baboon.  J Exp Med 179, 1185-1191.

Huber, L.J. and Chao, M.V. (1995) Mesenchymal and neuronal cell expression of the p75 neurotrophin receptor are distinguished during morphogenesis of transgenic animals.  Developmental Biology167, 227-238.
Samtambrogio, L., Bendetti, M., Chao, M.V., Muzaffar, R., Kulig, K., Gabellini, N. and Hochwald, G. (1994)  Nerve growth factor production by lymphocytes.  J Immunology 152, 4488-4489.
Donovan, M.J., Hempstead, B., Huber, L.J., Kaplan, D., Tsoulfas, P., Chao, M., Parada, L. and Schofield, D. (1994)  Identification of the neurotrophin receptors p75 and trk in a series of Wilms' tumors. Am. J Pathology 145, 792-801.
Dobrowsky, R.T., Werner, M., Castellino, A.M., Chao, M.V. and Hannun, Y.A. (1994) Activation of the sphingomyelin cycle by the low affinity neurotrophin receptor.  Science 265, 1596-1599.
Verdi, J., Birren, S., Ibanez, C., Persson, H., Kaplan, D.R., Benedetti, M., Chao, M.V. and Anderson, D. (1994) p75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells. Neuron 12, 733-745.
Mahadeo, D., Kaplan, L., Chao, M.V. and Hempstead, B.L. (1994) High affinity NGF binding displays a faster rate of association than p140trk binding: Implications for multi-subunit polypeptide receptors.  J Biol Chem  269, 6884-6990.
Donovan, M.J, Hempstead, B.L., Horvath, C., Chao, M.V. and Schofield, D. (1993)  Immunohistochemical localization of trk receptor protein in pediatric small round blue cell tumors.  Am J Pathology 143,1560-1567.
Benedetti, M., Levi, A. and Chao, M.V. (1993) Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness.  Proc  Natl  Acad. Sci USA 90, 7859-7863.

Horvath, C.M., Wolven, A., Machedo, D., Huber, L.J., Benedetti, M., Hempstead, B.L. and Chao, M.V.Analysis of the trk NGF receptor tyrosine kinase using recombinant fusion proteins. J Cell Science 17, 223-228.

Huber, L.J. and Chao, M.V. (1993) Transgenic expression of neurotrophic factors and their receptors.  In Neuromethods, Vol. 25, Neurotrophic Factors (A. Boulton, G. Baker, F. Hefti, Editors) The Humana Press, pp. 231-245.
Hsu, K.C. and Chao, M.V. (1993)  Differential expression and ligand binding properties of tumor necrosis factor receptor chimera mutants. J Biol Chem  268, 16430-16436.
Battleman, D.S., Geller, A.I. and Chao, M.V. (1993) HSV-1 vector mediated gene transfer of the human NGF receptor p75hNGFR defines high affinity NGF binding.  J  Neurosci  13, 941-951. 
Lee, K-F., Li, E., Huber, L.J., Landis, S.C., Sharpe, A.H., Chao, M.V. and Jaenisch, R. (1992) Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 69, 737-749.
Berg, M.M., Sternberg, D., Parada, L.F. and Chao, M.V. (1992) K-252a inhibits NGF-induced trk proto-oncogene tyrosine phosphorylation and kinase activity.  J Biol Chem 267, 13-16.
LeBivic, A., Sambuy, Y., Patzak, A., Patil, N., Chao, M. and Rodriguez-Boulan, E. (1991) An internal deletion in the cytoplasmic tail reverses the apical localization of human NGF receptor in transfected MDCK cells.  J Cell Biology 115, 607-618.
Yan, H. and Chao, M.V. (1991) Disruption of cysteine rich repeats of the NGF receptor leads to loss of ligand binding. J Biol Chem 266, 12099-12104.
Loeb, D.M., Maragos, J., Martin-Zanca, D., Chao, M.V., Parada, L.F. and Greene, L.A. (1991) The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines.  Cell 66, 961-966.
Yan, H., Schlessinger, J. and Chao, M.V. (1991) Chimeric NGF and EGF receptors define domains responsible for neuronal differentiation.  Science 252, 561-563.
Hempstead, B.L., Martin-Zanca, D., Kaplan, D.R., Parada, L.F. and Chao, M.V. (1991) High affinity binding requires co-expression of the trk proto-oncogene and the low affinity NGF receptor.  Nature 350, 678-683.
Kaplan, D.R., Hempstead, B.L., Martin-Zanca, D., Chao, M.V. and Parada, L.F. (1991)  The trk proto-oncogene product: a signal transducing receptor for nerve growth factor.  Science 252, 554-558.
Berg, M.M., Sternberg, D., Hempstead, B. and Chao, M.V. (1991) The low affinity p75 NGF receptor mediates NGF-induced tyrosine phosphorylation.  Proc Natl Acad Sci USA 88, 7106-7110.
Gibbs, R.B., Chao, M.V. and Pfaff, D.W. (1991) Effects of fimbria-fornix and angular bundle transection on expression of p75NGFR mRNA by cells in the medial septum and diagonal band of Broca: correlations with cell survival, synaptic reorganization and sprouting.  Mol Brain Res 11, 207-219.
Clagett-Dame, M., Chung, C., Chao, M.V. and DiStefano, P.S. (1990) Monoclonal antibodies to the cell surface and a soluble form of the human nerve growth factor receptor.  J Neurosci Res 27, 642-650.
Escandon, E. and Chao, M.V. (1990) Identification of high and low affinity NGF receptors during development of the chicken central nervous system.  Dev Biol 142, 293-300.
Patil, N., Lacy, E. and Chao, M.V. (1990) Specific neuronal expression of human NGF receptors in the basal forebrain and cerebellum of transgenic mice.  Neuron 4, 437-447.
Hempstead, B.L., Patil, N., Thiel, B. and Chao, M.V. (1990)  Deletion of cytoplasmic sequences of the NGF receptor leads to a loss of high affinity ligand binding.  J Biol Chem 265, 9595-9598.
Miyasaka, T., Chao, M.V., Sherline, P. and Saltiel, A.R. (1990) Nerve growth factor stimulates a protein kinase in PC12 cells that phosphorylates microtubule associated protein-2.   J Biol Chem 265, 4730-4735.
Gibbs, R.B., McCabe, J.T., Buck, C.R., Chao, M.V. and Pfaff, D.W. (1989) Expression of NGF receptor in the rat forebrain detected with in situ hybridization and immunohistochemistry.  Mol Brain Res 6, 275-287.
Sehgal, A., Bothwell, M. and Chao, M.V. (1989) Gene transfer of truncated NGF receptor clones leads to cell surface expression in mouse fibroblasts.  Nucl Acids Res  17, 5623-5632
Escandon, E. and Chao, M.V. (1989)  Developmental expression of the chicken nerve growth factor receptor gene during brain morphogenesis.  Devl. Brain Res  47, 187-196.
Hempstead, B.L. and Chao, M.V. (1989) The nerve growth factor receptor: Biochemical and structural analysis. Rec Prog Hormone Res  45, 441-466.
Chan, B.L., Chao, M.V., Saltiel, A.R. (1989) Nerve growth factor stimulates the hydrolysis of glycosylphosphatidylinositol in PC12 cells: A novel mechanism of protein kinase C regulation.  Proc Natl Acad Sci USA 86, 1756-1760.
Goedert, M, Fine, A., Dawbarn, D., Wilcock, G.K. and Chao, M.V. (1989) Nerve growth factor receptor mRNA distribution in human brain: normal levels in basal forebrain in Alzheimer's disease. Mol Brain Res 5, 1-7.
Hempstead, B.L., Schleifer, L.S. and Chao, M.V. (1989) Expression of functional NGF receptors after gene transfer.  Science 243, 373-375.
Wright, E.C., Fain, P.R., Barker, D.F. and Chao, M.V. (1989) A moderately frequent HindIII polymorphism at the human NGFR locus (17q12-17q22).  Nucleic Acids Res. 5, 825.
Buck, C.R., Martinez, H., Chao, M.V. and Black, I.B. (1988) Differential expression of the nerve growth factor receptor gene in multiple brain areas.  Dev Brain Res  44, 259-268.
Hempstead, B.L., Patil, N., Olson, K. and Chao, M.V. (1988)  Molecular analysis of the nerve growth factor receptor.  Cold Spring Harbor Symposium 53, 477-486.
Sehgal, A., Wall, D. and Chao, M. (1988) Efficient processing and expression of human NGF receptors in Xenopus oocytes: Effects on maturation.  Mol. Cell Biol 8, 2242-2246.
Peacocke, M., Yaar, M., Mansur, C.P., Chao, M.V. and Gilchrest, B.A. (1988) Induction of nerve growth factor receptors on cultured human melanocytes.  Proc Natl. Acad Sci.USA 85, 5282-5286.
Sehgal, A., Patil, N. and Chao, M. (1988) A constitutive promoter directs expression of the nerve growth factor receptor gene.  Mol Cell Biol  8, 3160-3167.
Hotta, H., Ross, A.H., Heubner, K. Isobe, M., Chao, M.V. Ricciardi, R.P., Tsujimoto, Y., Croce, C.M. and Koprowski, H. (1988) Molecular cloning and characterization of a melanoma-associated antigen (ME491) expressed at the early stages of tumor progression.  Cancer Res 48, 2955-2962.
Lemke, G. and Chao, M. (1988) Axons regulate Schwann cell expression of major myelin and NGF receptor genes.  Development 102, 499-504.
Seizinger, B., Rouleau, G.A., Ozelius, L.J., Lane, A.H., Farnyniarz, A.G., Chao, M.V., Huson, S., Korf, B.R., Parry, D.M., Pericak-Vance, M.A., Collins, F.S., Hobbs, W.J., Falcone, B.G., Iannazzi, J.A., Roy, J.C., St. George-Hyslop, P.H., Tanzi, R.E., Bothwell, M.A., Upadhyaya, M., Harper, P., Goldstein, A.E., Hoover, D.L., Bader, J.L., Spence, M.A., Mulvihill, J.J., Aylsworth, A.S., Vance, A.S., Rossenwasser, G.O.D., Gaskell, P.C., Roses, A.D., Martuza, R.L., Breakefield, X.O. and Gusella, J.F. (1987) Genetic linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene.  Cell 49, 589-594.
Buck, C.R., Martinez, H., Black, I.B. and Chao, M.V. (1987) Developmentally regulated expression of the NGF receptor gene in the periphery and brain.  Proc. Natl. Acad. Sci. USA 84, 3060-3063.
Breakefield, X.O., Ozelius, L., Bothwell, M.A., Chao, M.V., Axelrod, F., Kramer, P. L., Lanahan, A., Johnson, D.E., Ross, A.H. and Gusella, J.F. (1986) DNA polymorphisms for the nerve growth factor receptor gene exclude its role in familial dysautonomia.  Molecular Biol. and Medicine 3, 483-494.
Huebner, K., Isobe, M., Chao, M. Bothwell, M. Ross, A.H., Finan, J., Hoxie, J.A., Sehgal, A., Buck, C.R., Lanahan, A., Nowell, P.C., Koprowski, H. and Croce, C.M. (1986) The nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias.  Proc Natl Acad Sci USA 83, 1403-1407.
Johnson, D., Lanahan, A., Buck, C.R., Sehgal, A., Morgan, C., Mercer, E., Bothwell, M. and Chao, M. (1986) Expression and structure of the human NGF receptor.  Cell 47, 545-554.
Chao, M.V., Bothwell, M.A., Ross, A.H., Koprowski, H., Lanahan, A.A., Buck, C.R. and Sehgal, A. (1986). Gene transfer and molecular cloning of the human NGF receptor.  Science 232, 518-521.
Mill, J.F., Chao, M.V. and Ishii, D.N. (1985) Insulin, insulin-like growth factor II, and nerve growth factor effects on tubulin mRNA synthesis and neurite formation.  Proc Natl Acad. Sci USA 82, 7126-7130.
Charney, P., Treisman, R., Mellon, P., Chao, M., Axel, R. and Maniatis (1984) Differences in the expression of cloned human a- and b-globin genes introduced into mouse erythroleukemia cells.  Cell 38, 251-263.
Chao, M.V., Mellon, P., Charney, P., Maniatis, T. and Axel. R. (1983) Introduction and expression of beta-globin genes in murine erythroleukemic cells.  Gene Amplification Anal. 3, 215-231.
Chao, M.V., Mellon, P., Charney, P., Maniatis, T. and Axel, R. (1983) The regulated expression of globin genes in mouse erythroleukemia cells.  Cell 32, 483-493.
Sweet, R.W., Chao, M.V. and Axel, R. (1982) The structure of the tk gene promoter: Nuclease hypersensitivity correlates with expression.  Cell 31, 347-353 (1982).
Chao, M.V., Gralla, J.D. and Martinson, H.G. (1980) Lac operator nucleosomes.  II. Lac nucleosomes can change conformation to strengthen binding by lac repressor. Biochemistry 19, 3260-3269.
Chao, M.V., Martinson, H.G and Gralla, J.D. (1980) Lac operator nucleosomes.  I. Repressor binds specifically to operator within the nucleosome core.  Biochemistry 19, 3254-3260.
Chao, M.V., Gralla, J.D. and Martinson, H.G. (1979) DNA sequence directs the placement of histone cores on restriction fragments.  Biochemistry 18, 1068-1074.
Recent Review Articles and Book Chapters
Chao, M.V. and Calissano, P. (2013) Rita Levi-Montalcini: In memoriam. Neuron 6, 385-387.
Deinhardt, K. and Chao, M.V. (2013) Shaping neurons: Long and short range effects of mature and proBDNF signaling upon neuronal structure.  Neuropharmacology, Epub ahead of print.
Jeanneteau, F. and Chao, M.V. (2012) Are BDNF and glucocorticord activities calibrated?  Neuroscience 239, 173-195.
Arancio, O. and Chao, M.V. (2007) Neurotrophins, synaptic plasticity, and dementia.  Current Opinion in Neurobiol, 17,  325-330.
Chao, M.V., Rajagopal, R. and Lee, F.S. (2005) Neurotrophin signaling in health and disease.  Clinical Science 110, 167-173.
Arevalo, J.C. and Chao, M.V. (2005) When neurotrophins meet Wnts.  Current Opinion Cell Biol 7, 112-115.
Chao, M.V. and Lee, F.S. (2004) Neurotrophin survival signaling mechanisms.  J Alzheimers Disease, S7-S11.
Zampieri, N. and Chao, M.V. (2004) The p75 NGF receptor exposed.  Science 304, 833-834.
Schiavo, G. and Chao, M.V. (2004) Motors, adaptors, and receptors: Key elements of neuronal transport.  J   Neurobiology 58, 161-163.
Chao, M.V. (2003) Dependence receptors: what is the mechanism?  Science STKE, PE38.
Chao, M.V. (2003).  Retrograde transport redux.  Neuron 39, 1-2.
Chao, M.V. (2003) Neurotrophins and their receptors: A convergence point for many signaling pathways. Nature Rev Neuroscience 4, 299-309.
Lee, F.S., Rajagopal, R. and Chao, M.V. (2002) Distinctive features of Trk neurotrophin transactivation by G protein-coupled receptors.  Cytokine Growth Factor Rev 13, 11-17.
Chao, M.V. and Bothwell, M. (2002) Neurotrophins: To cleave or not to cleave.  Neuron 33, 9-12.
Lee, F.S., Kim, A.H., Khursigara, G. and Chao, M.V. (2001) The uniqueness of being a neurotrophin receptor.  Current Opinion in Neurobiology 11, 281-286.
Yano, H. and Chao, M.V. (2000) Neurotrophin receptor structure and interactions.  Pharm Acta Helv 74,  253-260.
Chao, M.V. (2000) Trophic factors: An evolutionary cul-de-sac or door into higher neuronal function?  J. Neurosci. Res. 59, 353-355.
Casaccia-Bonnefil, P., Gu, C., Khursigara, G. and Chao, M.V. (1999) p75 neurotrophin receptor as a modulator of survival and death decisions.  Microscopy Res and Tech 45, 217-224.
Casaccia-Bonnefil, P., Kong, H. and Chao, M.V.  (1998)  Neurotrophins: the biological paradox of survival factors eliciting apoptosis.  Cell Death and Differentiation 5, 357-364.
Hempstead, B.L. and Chao, M.V. (1997) Entering the domain of neurotrophin binding.  Nature Biotech 15, 506-507.
Castellino, A.M. and Chao, M.V. (1996) Trans-signaling by cytokine and growth factor receptors. Cytokine & Growth Factor Reviews  7, 297-302.
Chao, M.V. and Huber, L.J. (1996)  Interactions between NGF receptors, TrkA and p75.   In Life and death in the nervous system.  Elsevier, Oxford, England.
McDonald, N. and Chao, M.V. (1995) Structural determinants of neurotrophin action.  J Biol. Chem 270, 19669-19672.
Chao, M.V. (1995) Ceramide: A potential second messenger in the nervous system.  Mol Cell Neurosci 6, 91-96.
Chao, M.V. and Hempstead, B.L. (1995) Trk and p75: A two receptor system.  Trends Neurosci 18, 321 326.
Huber, L.J. and Chao, M.V. (1993) Transgenic expression of neurotrophic factors and their receptors.  In Neuromethods, Vol. 25, Neurotrophic Factors (A. Boulton, G. Baker, F. Hefti, Editors) The Humana Press, pp. 231-245.
Chao, M.V., Battleman, D.S. and Benedetti, M. (1992) Receptors for nerve growth factor.  Int Rev Cytology 137, 169-180.
Patil, N., Lacy, E. and Chao, M.V. (1990) Human NGF receptor expression in the CNS of transgenic mice.  In: Growth Factors and Alzheimer's Disease (Y. Christen, Editor), Springer-Verlag, Berlin, pp. 62-72.
Chao, M.V. (1990) Nerve growth factor.  In: Peptide Growth Factors and their Receptors (M. Sporn and A. Roberts, Editors).  Handbook of Experimental Pharmacology, vol. 95, Springer-Verlag, Berlin, pp. 135-165.
Chao, M.V. (1988) Gene transfer and expression of mammalian cell receptors.  In: Endocrine Genes: Analytical methods, experimental approaches, and selected systems (Y-F. Lau, Editor) Oxford University Press, New York, pp. 3-18.
Littman, D.R. and Chao, M.V. (1987) Use of gene transfer in the isolation of cell surface receptor genes.  In: Genetic Engineering, volume 9 (Jane Setlow, Editor), pp. 89-105.
Ross, A.H., Meryln, M., Maul, G.G., Koprowski, H., Bothwell, M., Chao, M., Pleasure, D. and Sonnenfeld, K.H. (1986) The nerve growth factor receptor in normal and transformed neural crest cells.  In: Neurofibromatosis, Ann. New York Academy of Sciences, pp. 115-123.
Chao, M.V. (1986) Expression of transfected genes.  In: Gene Transfer (R. Kucherlapati, editor) Plenum Press, New York, pp. 223-241.
Chao, M.V., Mellon, P., Wold, B., Maniatis, T. and Axel, R. (1984) Regulation of globin genes introduced into murine erythroleukemia cells.  In: Cell Fusion: Gene Transfer and Transformation, volume 14 (R. Beers and W. Bassett, Editors) Raven Press, New York, pp. 89-100.
Chao, M.V., Mellon, P., Charney, P., Maniatis, T. and Axel. R. (1983) Introduction and expression of beta-globin genes in murine erythroleukemic cells.  Gene Amplification Anal. 3, 215-231.
Chao, M.V., Mellon, P., Wold, B., Maniatis, T. and Axel, R. (1982) The structure and function of a eukaryotic promoter.  In: Tumor Cell Heterogeneity: Origins and Implications (A.H. Owens, D.S. Coffey, and S.B. Baylin, Editors) Academic Press, New York, pp. 425-440.
McKnight, S.L., Chao, M.V., Sweet, R.W., Silverstein, S. and Axel, R. (1981) The structure and function of a eukaryotic promoter.  In: Primary and Tertiary Structure of Nucleic Acids and Cancer Research (M.Miwa, S. Nishimura, A. Rich, D. Soll, and T. Suginura, Editors) Japan Sci. Soc. Press, Tokoyo, pp. 73- 85.
McKnight, S.L., Chao, M.V., Sweet, R.W., Silverstein, S. and Axel, R. (1981) The structure and function of a  eukaryotic promoter.  In: Primary and Tertiary Structure of Nucleic Acids and Cancer Research (M. Miwa, S. Nishimura, A. Rich, D. Soll, and T. Suginura, Editors) Japan Sci. Soc. Press, Tokoyo, pp. 73- 85.
McKnight, S.L., Chao, M.V., Sweet, R.W., Silverstein, S. and Axel, R. (1981) Transcriptional control of transformed  genes.  Oncodev. Biol. and Medicine 4, 81-95.
 
   
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