Representative
Publications:
N. Kam, H. Kugler, R. Marelly, L. Appleby, J. Fisher, A. Pnueli, D. Harel, M.J. Stern, E.J.A Hubbard. A scenario-based approach to modeling development: A Prototype Model of C. elegans Vulval Cell Fate Specification. Developmental Biology (in press)
R. Voutev, and E. J. A. Hubbard. A “FLP-out” system for controlled gene expression in C. elegans. Genetics (in press)
A. Sadot, J. Fisher, D. Barak, Y. Admanit, M.J. Stern, E.J.A. Hubbard, and D. Harel (2008) Towards Verified Biological Models. IEEE/ACM Trans Comput Biol BioinformApr-Jun;5(2):223-34 [featured cover article]
E. J. A. Hubbard (2007) “Model organisms as powerful tools for biomedical research” in: Science without Laws: Model systems, cases and exemplary Narratives. Duke University Press
H. Kugler, M.J. Stern, and E.J.A. Hubbard (2007) Testing Scenario-Based Models. International Conference on Fundamental Approaches to Software Engineering (FASE), Braga, Portugal March 24-April 1 (accepted for publication; to appear as part of the Springer "Lecture Notes in Computer Science" (LNCS) series)
E. J. A. Hubbard (2007) The C. elegans germ line: a model for stem cell biology. Developmental Dynamics 236:3343-3357.
J. Maciejowski, N. Ugel, B. Mishra, M. Isopi, E.J.A. Hubbard (2006) Quantitative analysis of germline mitosis in adult C. elegans. Developmental Biology 292:142-151.
R. Voutev, D.J. Killian, J.H. Ahn, and E.J.A. Hubbard (2006) Alterations in ribosome biogenesis cause specific defects in C. elegans hermaphrodite gonadogenesis. Developmental Biology 298:45-58.
E. J. Hubbard and D. Greenstein (2005) Introduction to the germ line. WormBook. 2005 Sep 1:1-4. Review.
J. Maciejowski, J.H. Ahn, D.J. Killian, P.G. Cipriani, A.L. Chaudhary, J.I. Lee, R. Voutev, R.C. Johnsen, D.L. Baillie, K.C. Gunsalus, D.H.A. Fitch, and E.J.A. Hubbard (2005). Autosomal genes of autosomal/X-linked duplicated gene pairs and germline proliferation in C. elegans. Genetics Apr;169(4):1997-2011.
D.J. Killian and E.J.A. Hubbard (2005) C. elegans germline patterning requires coordinated development of the somatic gonadal sheath and the germ line. Developmental Biology Mar 15;279(2):322-35.
J. Fisher, N. Piterman, E.J.A. Hubbard, M. Stern, D. Harel (2005) Computational insights into C. elegans vulval development. PNAS Feb 8;102(6):1951-6.
D.J. Killian and E.J.A. Hubbard (2004) C. elegans pro-1 activity is required for soma/germline interactions that influence proliferation and differentiation in the germ line Development 131, 1267-1278.
D. Hansen, E. J. A. Hubbard and T. Schedl (2004) Multi-pathway control of the proliferation versus meiotic development decision in the Caenorhabditis elegans germline, Developmental Biology, 268:342-357.
N. Kam, D. Harel, H. Kugler, R. Marelly, A. Pnueli, E.J.A Hubbard, and M.J. Stern (2004) “Formal Modeling of C. elegans Development: A Scenario Based Approach”, G.Ciobanu (Ed.): Modeling in Molecular Biology, Natural Computing Series, Springer.
A. S.-R. Pepper, T.-W. Lo, D. J. Killian, D. Hall and E. J. A. Hubbard (2003) The establishment of C. elegans germline pattern is controlled by overlapping proximal and distal somatic gonad signals Developmental Biology 259:336-350.
A. S.-R. Pepper, D. J. Killian and E. J. A. Hubbard (2003) Genetic analysis of Caenorhabditis elegans glp-1 mutants suggests receptor interaction or competition. Genetics 163: 115-132
Research is supported by the National Institutes of Health and March of Dimes
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