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G16. 1999 -
Scientific Methods: Survival Techniques for Young Investigators
in Biomedical Research
This course is required of all first year Ph.D. and M.D./Ph.D. students
on a non-credit basis.
Although tremendous scientific progress has been made in recent
times, the way we train our young investigators has remained basically
the same - we practice apprenticeship. We offer our students courses
on selected subjects, but we do not really teach them how to do
research. Rather, by putting a student in a laboratory, we expect
him to learn, perhaps by osmosis, everything there is to know about
doing research. Many students found this process inefficient and
frustrating. Dr. Sun has therefore organized this course, which
deals with practical issues such as: how to get (any) laboratory
techniques to work reproducibly and predictably; how to read a paper
actively, rather than passively; how to pick a research project;
how to write a scientific paper; and how to be an effective seminar
speaker. A graduate student and/or a young scientist will leave
this course knowing the skills they must master in order to survive
and to excel in doing research. In four sessions, four topics are
covered that a graduate student must master in order to survive
and to excel in doing research.This year we have arranged for Dr.
Sun to give these four lectures in a one-day workshop on Saturday,
September 9th. These lectures will cover the following topics: experimental
design; literature analysis; scientific writing; oral presentation.
Course Director: Tung-Tien Sun (212-263-5685)
sunt01@popmail.med.nyu.edu
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G16.2001
- Foundations of Cell and Molecular Biology I
Please see Syllabus for varied dates and times.
This course, offered by the Cell and Molecular Biology Training
Program, provides a broad overview of nucleic acid and protein metabolism
and function. The fall semester begins with five weeks of Basic
Molecular Biology, covering protein and nucleic acid structure,
and fundamental aspects of gene expression. This initial section
features intensive lectures, and weekly discussion groups. This
segment of the course is followed by nine weeks of Selected Topics
in Molecular Biology. The latter segment covers prokaryotic and
eukaryotic transcription, chromatin structure and gene silencing,
telomeres, DNA replication and recombination, protein translation,
and RNA splicing and processing. Selected Topics includes two lectures
and a discussion section per week. Particularly in the Selected
Topics portion of the course, the reading of primary research articles
is heavily emphasized. The course has a total of three in-class
exams.
6 credits
Course Director: James Borowiec (212) 263-8453
borowj01@popmail.med.nyu.edu
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G16.2004 –
Principles of Structural Biology
The goal of this course is to provide students with an introduction
to protein structure and to demonstrate how knowledge of the three-dimensional
structures of proteins affords an in-depth understanding of biological
processes. A primer on structure determination by x-ray crystallography,
electron microscopy and NMR spectroscopy will also be given.
4 credits
Course Director: Steve Hubbard – (212) 263-8938
hubbard@saturn.med.nyu.edu
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G16.2005/2608
Introduction to Cellular Neuroscience
Introduction to the anatomy, cell biology, molecular structure,
and physiology of neurons and glial cells. The course is structured
to equip students with skills necessary to read contemporary neuroscience
literature, as well as to provide a grounding in the fundamental
concepts of cellular neurobiology. Emphasis is placed on basic cellular
and molecular mechanisms used by neurons to receive, integrate and
transmit information. Subjects covered include the structural anatomy
and electrophysiological properties of neurons and glia, synaptic
transmission and integration, biochemistry, physiology of neurotransmitters,
and regulation of neuronal function by gene expression.
6 credits for G16.2005 and 3 credits for G16.2608
Course Director: Stewart Bloomfield (212) 263-5770
stewart.bloomfield@med.nyu.edu
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G16.2202 Medical
Microbiology
This course, for second year graduate students and above, contains
both lectures organized by the medical school and separate graduate
student sessions. Topics include: concepts in medical bacteriology;
E. coli; evasion of host defenses; viral structure and replication;
herpes; HIV; tumor viruses; host defenses in viral infection. Course
begins Thursday, 8/24.
3 Credits
Course Director: Michael Garabedian (212) 263-7662
garabm01@popmail.med.nyu.edu
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G16.2213
Genetics
Transmission genetics in diploid organisms. Principles and methods
of genetic analysis in diploid organisms, including Drosophila,
worms, zebrafish, plants, mice and humans, will be emphasized. Classes
include lectures, problem solving and discussion of primary literature.
Topics include: linkage, gene interactions, mapping, mutagenesis,
clonal analysis, sex determination, transgenic studies, use of mosaics,
imprinting and methods of study in human genetics. First year students
need permission of instructor to enroll.
6 credits
Course director: Hannah Klein (212) 263-5778
kleinh01@popmail.med.nyu.edu
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G16.2401 Principles
in Pharmacology
This course is a combination of lectures, workshops and seminars.
The lectures and workshops are part of the Medical Pharmacology
course for medical students. Topics include: pharmacokinetics, pharmacodynamics,
drug metabolism, drug receptors and drugs affecting the autonomic
nervous system.
The lectures that graduate students must attend are as follows:
Metabolism: A. Wood; Friday, 9/1
Pharmacokinetics I & II - A Grossman; Tues./Thurs, 9/26 and
9/27
Drug Receptors - F Stanley; Thurs., 9/28
Pharmaco-distribution I & II - F Stanley; Wed./Thurs. 10/4 and
10/5
(See attached schedule for lecture times.)
The seminars (for graduate students only) are designed to introduce
the students to the use of molecular pharmacology in drug development.
A seminar on G-protein receptor function in inflammatory signaling
will highlight how understanding G-protein signaling has led to
discovery of drugs for inflammation and immune disorders. The second
seminar focuses on the development of drugs that affect growth factor
receptor tyrosine kinases for the treatment of cancer and developmental
disorders. Another seminar will focus on enzymes as drug targets.
Finally, the use of partial agonists/antagonists for nuclear hormone
receptors will be discussed in relation to their importance for
cancer and metabolic disease. Each session will consist of a 30-45
minute seminar followed by a 45 minute discussion of a seminal paper
in the field. Instructors/Times/Locations will be announced later
in the semester.
3 credits
Course Directors:
Arnold Stern (212)-263-7118
sterna01@popmail.med.nyu.edu
(Medical School portion)
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Frederick Stanley (212) 263-7927
stanlf01@popmail.med.nyu.edu
(Graduate school portion)
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G16.2406
- Molecular Pharmacology of Receptors
This course gives an overview of the principles in pharmacology,
modern approaches to studying pharmacology and molecular aspects
of receptors and signal transduction. The course is divided into
three parts. The first part, introduction to molecular pharmacology,
will focus on some of the basic concepts in signaling and drug-receptor
interactions. The second part, modern approaches to pharmacological
research, will emphasize methods such as expression profiling, computational
approaches to receptor structor and function, imaging live cells,
mass spectrometry, and genetic studies with Drosophila as a pharmacological
tool. The third part, applications of pharmacology research, will
focus on the structure and function of tyrosine kinase receptors,
insulin receptors, insulin receptors, potassium channels, steroid/thyroid
hormone nuclear receptor gene family, glycoproteins and proteoglycans
of the nervous system, the role of histone code in receptor signalling,
and proteolytic processing of receptors. Classes include lectures
as well as weekly discussions on selected papers.
3 credits
Course Directors:
Efrat Levy 845 398 5540
levye01@med.nyu.edu
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G16.2511 Tutorial
in Structural Biology
Graduate Students will be paired with Structural Biology faculty
members and a specific topic for the semester will be researched
by the student and discussed with the faculty member during weekly
sessions.
1.5 credits
Course Director: David Stokes (212) 263-1580
stokes@saturn.med.nyu.edu
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G16.2605 Research
Presentations in CMB
Seminar required of all students in the CMB program.
1.5 Credits
Course Director: Lynette Wilson (212) 263-7684
wilsoe01@popmail.med.nyu.edu
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G16.2606 Tutorial
in Developmental Genetics
Required of all students in the Developmental Genetics Program.
1.5 Credits
Course Director: Ruth Lehmann (212) 263-8071
lehmann@saturn.med.nyu.edu
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G16.2607 Readings in Physiology/Neuroscience
Seminar required of all 2nd and 3rd graduate students in the Physiology
& Neuroscience training program.
1.5 credits
Course Director: Stewart Bloomfield (212) 263-5770
stewart.bloomfield@med.nyu.edu
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G16.2610
Developmental Genetics I
This course is an introduction into Developmental Genetics. Fundamental
questions, concepts and methodologies of modern inquiry into the
genetic and cellular mechanisms of development will be explored
through lectures and discussion of primary literature. Topics include
embryonic axis determination and the establishment of cellular asymmetry,
cell specification through cell-cell interaction and region-specific
gene expression, morphogenesis and organogenesis in different species.
Each week two instructors will discuss current topics in developmental
biology. Each session includes a lecture and discussion part. In
the discussion part students will discuss research articles related
to the topic. Students will read 2 research articles as well as
a review or book chapter for each session. Each student is expected
to have read the articles before each session and to be able to
present a summary, a detailed description of the data, underlying
techniques and figures, and a critique of the research papers.
To facilitate discussion, students will meet in small groups Wednesday
or Thursday to discuss the papers.
6 credits
Course Director: Ruth Lehmann (212) 263-8071
lehmann@saturn.med.nyu.edu
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G16.2611,
Section 001, Tutorial in Cell Biology
Required seminar for graduate students in the Cell and Molecular
training program (second year and beyond)
1.5 credits
Course Director: Alan Frey (212) 263-8129
freya01@popmail.med.nyu.edu
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G16.2617, Tutorial
in Biomedical Imaging
Students who register for G16.4404, Fundamental Concepts in Magnetic
Resonance Imaging must register for this tutorial. For a course
sumary, see G16.4404.
3 credits
Course Director: Glyn Johnson (212) 263-8746
glyn.johnson@med.nyu.edu
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G16.3211 Seminar
in Microbiology
Required seminar for graduate students in the Microbiology training
program (second year and beyond)
1.5 credits
Course Director: Michael Garabedian (212) 263-7662
garabm01@popmail.med.nyu.edu
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G16.3311 Seminar
in Pathology
Required seminar for graduate students in the Molecular Oncology
and Immunology training program (second year and beyond)
1.5 credits
Course Director: David Levy (212) 263-8192
del243@popmail.med.nyu.edu
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G16.3404 Seminar
in Developmental Genetics
Required seminar for graduate students in the Developmental Genetics
program (second year and beyond)
1.5 credits
Course Director: Ruth Lehmann (212) 263-8071 lehmann@saturn.med.nyu.edu
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G16.3411 Seminar
in Pharmacology
Required seminar for graduate students in the Pharmacology program
(second year and beyond)
1.5 credits
Course Director: Erika Bach (212) 263-5963
sapj01@popmail.med.nyu.edu
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G16.3715 Seminar
in Structural Biology
Required seminar for graduate students in the Structural Biology
program (second year and beyond)
1.5 credits
Course Director: David Stokes (212) 263-1580
stokes@saturn.med.nyu.edu
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G16.4012 -
G16.4402 Readings in Biomedical Sciences
Students may opt to take Readings courses for a variable
amount of credits in order to study a specific area complementary
to their thesis research under the guidance of a Sackler faculty
member. Contact the graduate advisor for your program for assistance
in selecting a faculty member and area of study.
Variable 1 - 4 credits
Course Director: Staff
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G16.4404 Fundamental
Concepts in Magnetic Resonance Imaging
In conjunction with this course, students must simultaneously
register for G16.2617, Tutorial in Biomedical Imaging for 3 credits.
This course will provide a largely non-mathematical introduction
to the principles of MRI, and is therefore accessible to students
with varied backgrounds. Topics covered include the basics of nuclear
magnetic resonance, image formation and the properties of images,
contrast mechanisms and how to exploit them, basic instrumentation
for MRI, and an introduction to clinical and biological applications.
Several advanced topics such as angiography, diffusion and perfusion
imaging, covered more fully in the “Advanced MRI” course,
will be introduced. This course includes weekly lectures, discussion
sessions revolving around assigned research articles, and practical
labs pertinent to material covered in the lectures.
3 credits
Course Director:Glyn Johnson (212) 263-8746
glyn.johnson@med.nyu.edu
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G16.4405 Independent
Study in Structural Biology
Students concentrating in Structural Biology can register
for an independent study in a variable amount of credits when their
research and coursework requires them to pursue academic research
and/or coursework at the NIH.
Variable 1 - 6 credits
Course Director: David Stokes (212) 263-1580
stokes@saturn.med.nyu.edu
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G16.4406 Introduction
to Tissues and Organ Systems
This survey course and its accompanying laboratory will be
the cornerstone for the newly developed graduate training program
in pathobiology. The specific goal of this course is to provide
an overview of the basic development and physiology of mammalian
tissues and organs and introduce the tools, techniques and strategies
important in the study of in vivo model systems for human disease.
4 credits
Course Director:Cynthia Loomis (212) 263-6827
loomic01@med.nyu.edu
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G16.4407 Introduction
to Histopathobiology Laboratory
This introductory laboratory course must be taken in conjunction
with the lecture course "Tissues and Organ Systems." The
specific goal of this laboratory course is to introduce students
to the tools, techniques and strategies necessary for the study
of in vivo model systems for human disease.
4 credits
Course Director:Cynthia Loomis (212) 263-6827
loomic01@med.nyu.edu
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G16.4408 Cryoelectron
Microscopy of Macromolecular Assemblies
CryoEM in combination with image analysis is increasingly powerful
in producing 3D structures of individual molecules and large macromolecular
complexes that are unapproachable by other methods. This comprehensive
course will cover the theory and practice of solving molecular structures
by electron microscopy. We will start with optics, sample preparation
and a basic mathematical description of diffraction before moving
into a detailed exploration of the three main methods of structure
determination: electron crystallography, single particle analysis,
and electron tomography. We will end with a discussion of map interpretation
and molecular fitting.
This will predominantly be a lecture course involving one 2-hour
lecture per week accompanied by a discussion session and an occasional
practical session using facilities at the New York Structural Biology
Center. Lecturers will be given by expert electron microscopists
from around NYC and students from various campuses will be encouraged
to attend.
3 credits
Course Director: David Stokes 212-263-1580
stokes@saturn.med.nyu.edu
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