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G16. 1999 -
Scientific Methods: Survival Techniques for Young Investigators
in Biomedical Research
This course is required of all first year Ph.D. and M.D./Ph.D. students
on a non-credit basis. In four sessions, four topics are covered
that a graduate student must master in order to survive and to excel
in doing research.This year we have arranged for Dr. Sun to give
these four lectures in a one-day workshop on Saturday, September
17th. These lectures will cover the following topics: experimental
design; literature analysis; scientific writing; oral presentation.
Course Director: Tung-Tien Sun (212-263-5685)
sunt01@popmail.med.nyu.edu
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G16.2001
- Foundations of Cell and Molecular Biology I
Please see Syllabus for dates and times
This course, offered by the Cell and Molecular Biology Training
Program, provides a broad overview of nucleic acid and protein metabolism
and function. The fall semester begins with five weeks of Basic
Molecular Biology, covering protein and nucleic acid structure,
and fundamental aspects of gene expression. This initial section
features intensive lectures, and weekly discussion groups. This
segment of the course is followed by nine weeks of Selected Topics
in Molecular Biology. The latter segment covers prokaryotic and
eukaryotic transcription, chromatin structure and gene silencing,
telomeres, DNA replication and recombination, protein translation,
and RNA splicing and processing. Selected Topics includes two lectures
and a discussion section per week. Particularly in the Selected
Topics portion of the course, the reading of primary research articles
is heavily emphasized. The course has a total of three in-class
exams.
6 credits
Course Director: James Borowiec (212) 263-8453
borowj01@popmail.med.nyu.edu
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G16.2004 – Principles of Structural Biology
The goals of this course are to provide students with an introduction
to
protein structure and to demonstrate how knowledge of the three-dimensional
structures of proteins affords an in-depth understanding of biological
processes. Two 1.5 hr lectures and one 1.5 hr discussion session
per week.
Classes will be held in the Skirball 3rd floor seminar room. Recommended
text: "Introduction to Protein Structure" by Branden and
Tooze. The book is
available at the NYU Medical Bookstore (also at Amazon.com) and
on reserve
in the library.
http://skirball.med.nyu.edu/research/sb/PSB05/
4 credits
Course Director: Steve Hubbard – (212) 263-8938
hubbard@saturn.med.nyu.edu
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G16.2005/2608 Introduction to Cellular Neuroscience
Introduction to the anatomy, cell biology, molecular structure,
and physiology of neurons and glial cells. The course is structured
to equip students with skills necessary to read contemporary neuroscience
literature, as well as to provide a grounding in the fundamental
concepts of cellular neurobiology. Emphasis is placed on basic cellular
and molecular mechanisms used by neurons to receive, integrate and
transmit information. Subjects covered include the structural anatomy
and electrophysiological properties of neurons and glia, synaptic
transmission and integration, biochemistry, physiology of neurotransmitters,
and regulation of neuronal function by gene expression.
6 credits for G16.2005 and 3 credits for G16.2608
Course Director: Stewart Bloomfield (212) 263-5770
stewart.bloomfield@med.nyu.edu
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G16.2010 Molecular Parasitology
The course will provide an in-depth analysis of
cellular, immunological and molecular mechanisms in parasite biology
and parasite-host interactions. Topics will include mechanisms of
host cell invasion, host innate and adaptative immune response,
parasite genome structure and expression, antigenic variability,
immune evasion and vector-parasite interactions.
The course will cover a variety of parasites and their insect vectors.
Protozoan (Plasmodium, Leishmania, Trypanosoma, Toxoplasma, Entamoeba)
and metazoan (Oncocherca, Schistosoma, Trichinella) parasites which
cause disease in humans will be studied. This course is required
for parasitology students.
4 credits
Course Directors: Ana Rodriguez (212) 263 6757
rodria02@popmail.med.nyu.edu
Photini Sinnis (212) 263 6818
Photini.Sinnis@med.nyu.edu
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G16.2202 Medical
Microbiology
This course, divided into two parts, has been re-engineered this
year for graduate students in their second year and above. Topics
include: concepts in medical bacteriology; E. coli; evasion of host
defenses; viral structure and replication; herpes; HIV; tumor viruses;
host defenses in viral infection. Course begins Thursday, 8/25.
3 Credits
Course Director: Michael Garabedian (212) 263-7662
garabm01@popmail.med.nyu.edu
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G16.2213 Genetics
Transmission genetics in diploid organisms. Principles and methods
of genetic analysis in diploid organisms, including Drosophila,
worms, zebrafish, plants, mice and humans, will be emphasized. Classes
include lectures, problem solving and discussion of primary literature.
Topics include: linkage, gene interactions, mapping, mutagenesis,
clonal analysis, sex determination, transgenic studies, use of mosaics,
imprinting and methods of study in human genetics.First year students
need permission of instructor to enroll.
6 credits
Course director: Hannah Klein (212) 263-5778
kleinh01@popmail.med.nyu.edu
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G16.2308 Advanced Immunology
The course will run on Thursdays, from 12:00 noon to 4 PM between
Sept 8th and Dec 15th. Every Thursday at noon we will have a seminar.
Before the seminar, all students should read carefully the two-three
"papers of the week," which will be sent by e-mail a week
in advance. Students will be selected to present the papers to fellow
classmates and faculty. The papers will be discussed for their significance
(questions addressed and their relevance), techniques utilized,
analysis of data and perspectives. Basically, the students are expected
to know the papers before the discussion starts. All students will
take turns and will be called to present aspects of the papers.
Unless there is confusion among students, the faculty members will
try not to cut the students' discussion, and will let the students
come to an agreement. During the discussion, the students will have
access to the papers and any other material that they wish (i.e.
other papers which contain nice schemes that could be drawn for
classmates, textbooks). The grades will depend upon 1) class participation
(discussion of the weekly papers); 2) a short (4-6 page typed) paper
to be delivered to Dr. Lafaille by January 10th, 2004. Seminar attendance
is mandatory.
4 credits
Course Director: Juan Lafaille (212) 263-1489
lafaille@saturn.med.nyu.edu
G16.2401
Principles in Pharmacology
This course is a combination of lectures, workshops and seminars.
The lectures and workshops are part of the Medical Pharmacology
course for medical students. Topics include: pharmacokinetics, pharmacodynamics,
drug metabolism, drug receptors and log dose response curves and
autonomics.
The seminars, for graduate students only, are designed to illustrate
how the general principles of pharmacology apply to clinically important
areas. Example, since the function of the cardiovascular system
is dependent on the autonomic system and a number of cardiovascular
diseases are responsive to autonomic drugs, it will be possible
to provide an in-depth understanding of the mechanism of action
of autonomic drugs. Topics covered are: cardiovascular pharmacology,
endocrine pharmacology and oncologic pharmacology. Each seminar
will last 1 and a half hours. Instructors/Times/Locations will be
announced later in the semester. First years must get permission
to take this course from Dr. Frederick Stanley.
3 credits
Course Directors:
Arnold Stern (212)-263-7118
sterna01@popmail.med.nyu.edu
(Medical School portion)
Frederick Stanley (212) 263-7927
stanlf01@popmail.med.nyu.edu
(Graduate school portion)
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G16.2406
- Molecular Pharmacology of Receptors
This course gives an overview of the principles in pharmacology,
modern approaches to studying pharmacology and molecular aspects
of receptors and signal transduction. The course is divided into
three parts. The first part, introduction to molecular pharmacology,
will focus on some of the basic concepts in signaling and drug-receptor
interactions. The second part, modern approaches to pharmacological
research, will emphasize methods such as imaging live cells, mass
spectrometry, and genetic studies with C. elegans as a pharmacological
tool. The third part, applications of pharmacology research, will
focus on the structure and function of tyrosine kinase receptors,
receptor phosphatases, G protein receptors, insulin receptors, steroid/thyroid
hormone nuclear receptor gene family, glycoproteins and proteoglycans
of the nervous system, recycling and internalization of receptors,
exocytosis and receptors for neurotransmitters, and proteolytic
processing of receptors and ligands. Classes include lectures as
well as weekly discussions on selected papers.
3 credits
Course Directors:
Efrat Levy 845 398 5540
levye01@med.nyu.edu
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G16.2511 Tutorial in Structural Biology
Graduate Students will be paired with Structural Biology faculty
members and a specific topic for the semester will be researched
by the student and discussed with the faculty member during weekly
sessions.
1.5 credits
Course Director: David Stokes (212) 263-1580
stokes@saturn.med.nyu.edu
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G16.2605 Research Presentations in CMB
Seminar required of all students in the CMB program.
1.5 Credits
Course Director: Lynette Wilson (212) 263-7684
wilsoe01@popmail.med.nyu.edu
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G16.2606 Tutorial in Developmental Genetics
Required of all students in the Developmental Genetics Program.
1.5 Credits
Course Director: Ruth Lehmann (212) 263-8071
lehmann@saturn.med.nyu.edu
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G16.2607 Readings in Physiology/Neuroscience
Seminar required of all 2nd and 3rd graduate students in the Physiology
& Neuroscience training program.
1.5 credits
Course Director: Stewart Bloomfield (212) 263-5770
stewart.bloomfield@med.nyu.edu
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G16.2610 Developmental Genetics I
This course is an introduction into Developmental Genetics. Fundamental
questions, concepts and methodologies of modern inquiry into the
genetic and cellular mechanisms of development will be explored
through lectures and discussion of primary literature. Topics include
embryonic axis determination and the establishment of cellular asymmetry,
cell specification through cell-cell interaction and region-specific
gene expression, morphogenesis and organogenesis in different species.
Each week two instructors will discuss current topics in developmental
biology. Each session includes a lecture and discussion part. In
the discussion part students will discuss research articles related
to the topic. Students will read 2 research articles as well as
a review or book chapter for each session. Each student is expected
to have read the articles before each session and to be able to
present a summary, a detailed description of the data, underlying
techniques and figures, and a critique of the research papers.
To facilitate discussion, students will meet in small groups Wednesday
or Thursday to discuss the papers.
6 credits
Course Director: Ruth Lehmann (212) 263-8071
lehmann@saturn.med.nyu.edu
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G16.2611,
Section 001, Tutorial in Cell Biology
Required seminar for graduate students in the Cell and Molecular
training program (second year and beyond)
1.5 credits
Course Director: Alan Frey (212) 263-8129
freya01@popmail.med.nyu.edu
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G16.2611, Section 002, Tutorial in Neuroanatomy
This course presents the central and peripheral nervous systems
in terms of anatomical localization, connectivity and functional
relevance of NS organization. We will analyze sensory systems and
their topographical projections into the CNS together with output
as fundamental controls of behavior. The presentations will include
the hierarchy of integrative centers that act to generate simple
to complex reflexes and the formulation of consciousness. Thirty
sessions will include a two hour lecture and a two hour lab each
week that includes practical and didactic examinations. The sessions
will begin in on September 7th and end in December 2005. The laboratories
will utilize human brain specimens to reinforce lecture presentations.
Upon completion, students should be able to: conceptualize the human
nervous system from a structural and general functional point of
view that includes anatomical localization of structures and centers
throughout the human brain; formulation of a philosophical understanding
of relationships between input and output systems and how they are
bound in integrative connectivity; and describe functional connectivity
in relationship to lesions and disease processes.
3.0 credits
Course Director: Dean Hillman (212) 263-7430
hillmd01@popmail.med.nyu.edu
Kalman Rubinson (212) 263 6792
kr4@nyu.edu
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G16.2617 Cryoelectron Microscopy of Macromolecular Assemblies
CryoEM in combination with image analysis is increasingly powerful
in producing 3D structures of individual molecules and large macromolecular
complexes that are unapproachable by other methods.This comprehensive
course will cover the theory and practice of solving molecular structures
by electron microscopy. We will start with optics, sample preparation
and a basic mathematical description of diffraction before moving
into a detailed exploration of the three main methods of structure
determination: electron crystallography, single particle analysis,
and electron tomography. We will end with a discussion of map interpretation
and molecular fitting.
This will predominantly be a lecture course involving one 2-hour
lecture per week accompanied by a discussion session and an occasional
practical session using facilities at the New York Structural Biology
Center. Lecturers will be given by expert electron microscopists
from around NYC and students from various campuses will be encouraged
to attend.
3 credits
Course Director: David Stokes (212) 263-1580
stokes@saturn.med.nyu.edu
http://www.nysbc.org/seminars/CryoEM%20Courses/CemGraduateCourse.html
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G16.3211 Seminar in Microbiology
Required seminar for graduate students in the Microbiology training
program (second year and beyond)
1.5 credits
Course Director: Michael Garabedian (212) 263-7662
garabm01@popmail.med.nyu.edu
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G16.3311 Semianr in Pathology
Required seminar for graduate students in the Molecular Oncology
and Immunology training program (second year and beyond)
1.5 credits
Course Director: David Levy (212) 263-8192
del243@popmail.med.nyu.edu
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G16.3404 Seminar in Developmental Genetics
Required seminar for graduate students in the Developmental Genetics
program (second year and beyond)
1.5 credits
Course Director: Ruth Lehmann (212) 263-8071 lehmann@saturn.med.nyu.edu
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G16.3411 Seminar in Pharmacology
Required seminar for graduate students in the Pharmacology program
(second year and beyond)
1.5 credits
Course Director: Jan Sap (212) 263-7120
sapj01@popmail.med.nyu.edu
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G16.3715 Seminar in Structural Biology
Required seminar for graduate students in the Structural Biology
program (second year and beyond)
1.5 credits
Course Director: David Stokes (212) 263-1580
stokes@saturn.med.nyu.edu
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G16.4012 - G16.4402 Readings in Biomedical Sciences
Students may opt to take Readings courses for a variable amount
of credits in order to study a specific area complementary to their
thesis research under the guidance of a Sackler faculty member.
Contact the graduate advisor for your program for assistance in
selecting a faculty member and area of study.
Variable 1 - 4 credits
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G16.4404 Fundamental Concepts in Magnetic Resonance Imaging
Fundamental physical, mathematical and computational principles
governing the data acquisition and image reconstruction of magnetic
resonance imaging (MRI). The course consists of three parts: (1)
An in-depth explanation of the fundamental concepts of magnetic
resonance imaging; (2) an introduction to the latest advances in
this rapidly growing field and (3) the application of MRI to biomedicine.
3 credits
Course Director: Qun Chen (212) 263-3308
qun.chen@med.nyu.edu
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G16.4405 Independent Study in Structural Biology
Students concentrating in Structural Biology can register
for an independent study in a variable amount of credits when their
research and coursework requires them to pursue academic research
and/or coursework at the NIH.
3 credits
Course Director: David Stokes (212) 263-1580
stokes@saturn.med.nyu.edu
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