Dr. Sadowski graduated from Medical University of Gdansk in Gdansk, Poland in 1995 and received Ph.D. in neuroanatomy from the same institution in 1996. Between 1996 and 1998 he completed post-doctoral fellowship in experimental neuropathology in the New York State Institute for Basic Research. Following an internship in general medicine, Dr. Sadowski completed a neurology residency in New York Medical College and NYU School in Medicine and joined NYU faculty as an Assistant Professor in 2002. Dr. Sadowski research focuses on Alzheimer?s disease, the most common form of dementia, and on prion diseases, which although relatively rare grasp a broad attention of the general public. Both Alzheimer?s disease and prion disease belong to a group of conformational disorders where pathological mechanism lies upon conversion of physiological proteins into insoluble and toxic conformers accumulating in the brain during the course of the disease. Dr. Sadowski is using cell culture and transgenic animal models to study various aspects of pathological mechanisms of these diseases. He is also using these models to test various diagnostic and treatment approaches which may be applicable for human use. In particular Dr. Sadowski is working on inhibition an interaction between amyloid-? peptide and apolipoprotein E which chaperones conformational transformation of amyloid-? and facilitates its deposition in the brain of Alzheimer?s patients. Developed by Dr. Sadowski ligands that block the apolipoprotein E/amyloid-? interaction were shown to successfully lower amount of amyloid-? deposited in brains of Alzheimer?s transgenic mice. Dr. Sadowski is also developing new MRI and PET ligands allowing detection of accumulation of abnormal prion protein in infected but presymptomatic patients. Dr. Sadowski is recipient of a career development award from the National Institute on Aging and the Paul B. Beeson Career Development Award in Studies on Aging Clinical research of Dr. Sadowski focuses on memory dysfunction during normal aging, mild cognitive impairment and its conversion to Alzheimer?s disease. As a Director of Neurological Service Dr. Sadowski is also responsible for neurological care of patients evaluated in the Center for Brain Health, which is a research program focusing on development and validation biomarkers for Alzheimer?s disease, clinical drug trials, and on longitudinal studies on memory changes during normal aging, mild cognitive impairment and its conversion to Alzheimer?s disease. Dr. Sadowski is an author of a book directed to patients and their caregivers entitled ?100 Questions and Answers About Alzheimer?s Disease?.