Clinical
Core: Biostatistics and Epidemiology
Patient-based research: epidemiological and biostatistical consultation,
biomathematical modeling, and data management.
Clinical
Core: Specimen Management
Processing and storage of biological samples from HIV-infected
patients and uninfected controls, cataloging and distribution
of information on stored specimens, procurement of fresh biological
samples for HIV/AIDS studies.
Flow Cytometry
Innovative flow measurements, 3-color surface phenotyping of
lymphocytes, training and consultation on phenotyping methods.
Immunology
Core
Immunologic assays; testing of polyclonal sera as well as human,
primate and rodent anti-HIV mAbs for neutralizing activity against
HIV primary isolates and for their ability to bind to intact
virions and to infected cells; provision of human anti-HIV mAbs;
frozen stocks of more than 70 mycoplasma-free cell lines producing
human anti-HIV mAbs.
Virology
Core
Bulk and quantitative HIV culture, measurement, resistance testing,
phenotype analysis , and genotype analysis using heteroduplex
mobility assay and sequencing; HIV RNA in plasma or culture fluids
by the Roche RT-PCR method; and a licensed virology lab which
detects the presence of herpes viruses (HSV, CMV, HHV6, VZV,
and EBV) by culture and/or PCR, as well as other viruses such
as HCV and JC by PCR.
General Clinic Research Center (GCRC)
Research
Nursing Staff/Nursing Services
Trained research nurses with technical expertise including monitoring,
critical assessment, and teaching of patients.
Core
Lab
Molecular biology support for GCRC clinical research protocols,
training of clinical research fellows and medical students in
the laboratory methods of patient-oriented research.
BioInformatics
Core
Consulting and software for data management on GCRC projects
involving DNA or protein sequences, gene expression microarrays,
multilocus genotyping/SNPs, or proteomics.
Biostatistics
Core
Statistical consultation and collaboration to GCRC investigators
in all stages of the clinical research process for approved
protocols. Protocol development and review through conduct, analysis,
and reporting of results.
Informatics
Core
Informatics policies (HIPAA, privacy, security); best practices;
protocol development; accessing services; database design,
development and maintenance and programming for automated data
uploads or extractions; and reporting, coding, un-blinding, de-identifying
and archiving data.
Research
Subject Safety Office
Ensurance of safety and ethical conduct, with protection of human
subjects accorded the highest priority.
Skirball Institute of Biomolecular Medicine
DNA Sequencing
Facility
DNA sequencing performed with Applied Boisystems 3730 DNA Analyzer;
in-person consulting for sequencing strategy planning and troubleshooting.
Image Core Facility
Wide spectrum of microscopy equipment, technical assistance in
sample preparation and image acquisition. CM 12 transmission
electron microscope, CM 200 transmission electron microscope
with cryo holder, Leica Ultracut UCT ultramicrotome, Sorvall
ultramicrotome, Leica glass knife-makers, Denton Vacuum carbon
coating unit, Carl Zeiss inverted microscope, Zeiss light microscope.
Instruction, consultation, assistance and collaboration for the
research involving electron microscopy. Sample preparation, ultramicrotomy,
staining, and immuno-gold electron microscopy.
Digital Media
Services
Professional quality large format posters, digital prints, digital
production services, fabric poster printing.
Protein
Analysis Lab
ALDI-TOF mass spectrometry, Q-TOF mass spectrometry (MS/MS peptide
sequencing), Ion Trap mass spectrometry (MS/MS peptide sequencing), proteolysis
and identification of proteins from SDS-PAGE gels.
Washington Square Advanced Media Studio
Archival printing, laser cutting, rapid prototyping, and other advanced media services to the NYU community.
X-Ray Diffraction
Lab
Two Rigaku X-ray systems for collecting macromolecular single-crystal
diffraction data.
Analytical
Chemistry
Combined mass spectrometry and metals analysis laboratories.
Mass spectrometry (MS) and atomic absorption (AA) spectroscopy;
consultative services to NYU investigators in physical and inorganic
chemistry, separations science, and spectral interpretation (MS,
NMR, UV); training of students and researchers in the use of
MS, NMR, and AA.
Biostatistics
Statistical collaboration and consultation in clinical and translational
oncology, basic science, cancer epidemiology and prevention,
and the core research services. Statistical expertise in research
study design, conduct, analysis, interpretation, and reporting
of results for clinical trials, laboratory experiments, and
observational studies.
Core
Clinical Laboratory
Support of immune-modulating antineoplastic agents and cytotoxic
therapies, specialized clinical correlates to monitor novel approaches
to cancer treatment. Laboratory support for institutional cancer
clinical trials, logistical support for trials that require
specimen collection and assessment of multiple parameters ranging
from specialized tests for patient eligibility to quality control
of specialized therapeutic modalities.
Experimental
Animal and Exposure Core
Facilities, animal care, technical assistance for experiments
with rodent species involving delivery of carcinogenic
and toxic chemicals, infectious agents, or intervention compounds,
using inhalation, systemic, dermal, and oral administration
routes of exposure; experimental design and conduct for cancer-related
animal studies; segregated housing and health monitoring of animals;
necropsy services for animal experiments.
Experimental
Pathology
Anatomic pathology: tissues acquisition and banking, histopathology,
acquisition of human pathological specimens, processing of human
and murine tissues; resources and guidance for investigators;
access to immunohistochemistry, murine cytogenetics, laser
capture, quantitative morphometry, and the preparation of tissue
arrays.
Flow
Cytometry & Cell Sorting
DakoCytomation MoFlo, Becton Dickinson LSR system, Becton Dickinson
FACScan.
Genomics
Facility
Affymetrix Genechip system for gene expression and DNA genotyping
analyses, manufacturing of spotted DNA arrays, pyrosequencing
and high-throughput quantitative PCR. Experimental designs, standards
for DNA array procedures, guidance in data management and
analysis.
Histopathology
Histology and comparative pathology service: paraffin, plastic,
and cryostat sectioning, preparation of slides for conventional
and specialized staining, immunohistochemistry, and in situ
hybridization; conventional and specialized slide staining
and immunohistochemistry; necropsy services including appropriate
tissue fixation required for animal experiments; comprehensive
consultation and collaboration on comparative and experimental
pathology; basic photomicroscopy services.
Immunohistochemistry
State-of-the-art computer-controlled immunohistochemical system,
extensive menu of antibodies (Angiogenesis - CD34, CD31,
Factor VIII, FAK, VEGF, HIF-1 alpha; apoptosis - bcl-2, CD30,
MDM2, TUNEL, activated caspase 3; cell cycle and related -
cyclins D1, E, p16, p21, p27, p53, p57; hematopoietic - CD1a,
CD3, CD4, CD8, CD5, CD61, CD99, TIA-1, CD117; hormone and related
- estrogen, progesterone, erb-B2, MIB-1; thymidine phosphorylase,
CD44, cytokeratins 7, 19, 17, E-cadherin, FHIT, Cox-2, TTF-1,
TGF-b, MDR, EGF-R, green fluorescent protein). Development
of preliminary data as well as staining of funded research.
Mouse
Imaging
Magnetic resonance micro-imaging (µMRI) and ultrasound
biomicroscopy (UBM) services to detect and follow tumor progression
in mouse models.
NYUCI Protemics Core Facility
Assists scientists at NYU with their research by helping them to characterize proteins of interest.
Tissue
Acquisition & Banking Services
Human tissue sample procurement (collected from excess surgical
material) and tissue banking for investigators involved in peer-reviewed
grants or institutionally funded projects.
Transgenic
Mouse/ES Cell Chimera Facility
Production of transgenic (Tg) mice by zygote injection, production
of embryonic stem (ES) cell chimeras, and rederivation of mouse
strains.
Vaccine & Cell Therapy Laboratory
Production and monitoring of experimental immunotherapies for patients with cancer or chronic viral infections.