The work in my laboratory has focused on understanding the genetic basis of disease, including disorders of color vision and sexual differentiation, and most recently, genetic susceptibility to cancer. We are using novel genomic approaches to identify new genes that are involved in testicular development and that either increase or lessen one''s likelihood for developing cancer. To facilitate that use of information about these genes in the clinical setting, we perform case control studies to determine the relative risk of disease that is associated with inheritance of mutations in these genes.