Current CT technology allows radiologists to interact with imaging data in creative ways which facilitate diagnosis, improve therapeutic decisions, and efficiently communicate findings. This is accomplished through the adaptation of 3-D reading. Development of platforms facilitating the transition is Dr. Megibow''s major research interest. Imaging of the pancreas is the clinical test site for these innovations. Currently, he is investigating non-invasive pancreatico-biliary 3-D CT ductography. They have developed a new oral contrast agent which has specific utility for multidetector-row CT scanning. Use of this contrast optimizes 3-D imaging. The second volume of a four volume text written in conjunction with pancreatic radiologists in Verona Italy is in preparation. Dr. Megibow participates with other members of his section in evaluation of Computer Assisted Diagnosis in CT colonography. They have launched multiple studies evaluating 3-D image compression techniques.