Lung-Chi Chen B.S., Ph.D., M.S.
Professor
Department of Environmental Medicine
Inhalation toxicology; exposure-response relations
Research Summary
Dr. Chen is an internationally recognized expert on inhalation toxicology and has extensive experience in the measurement of cardiopulmonary effects of inhaled pollutants. He is also an expert in the generation and characterization of exposure atmospheres, and in the performance of toxicology studies using all routes of exposure, primarily those involving pulmonary exposure. He has served on a number of national and international committees and study sections in his areas of expertise.
Dr. Chen is the author of over 120 research papers and book chapters dealing with the mechanisms underlying the adverse cardiopulmonary effects resulting from inhalation exposure to occupational and environmental air pollutants. His research approach is to systematically dissect the role that physico-chemical properties of these pollutants play in the exposure, uptake at sites of deposition in the respiratory tract and translocation to the heart, as well as in the development, progression, and resolution of cardiopulmonary diseases.
Dr. Chen is the author of over 120 research papers and book chapters dealing with the mechanisms underlying the adverse cardiopulmonary effects resulting from inhalation exposure to occupational and environmental air pollutants. His research approach is to systematically dissect the role that physico-chemical properties of these pollutants play in the exposure, uptake at sites of deposition in the respiratory tract and translocation to the heart, as well as in the development, progression, and resolution of cardiopulmonary diseases.
Research Information
Research Interests
1. Nanoparticle Toxicity and functional utilization.
2. The role of health disparity in air pollution-induced cardiopulmonary diseases
3. Gene-environment interactions in environmentally induced diseases
4. Effects of particulate air pollution in the pathogenesis of atherosclerosis
5. Mechanisms of air pollution induced asthma
6. Pollutant-induced alterations in biological response modifiers and associated membrane receptors
7. Signal transduction pathways associated with oxidative stress



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