Nitric Oxide synthesis in bacteria. We discovered that Gram-positive bacteria has enzyme highly homologues to eukaryotic NO-synthases. We demonstrated that this enzyme produce NO under physiological conditions and this NO protect bacteria against oxidative stress. Currently we studying the role of NO in interaction between bacteria (Staphylococci and Bacilli) and C. elegance. Studies are on the way to demonstrate that bacterial NO is important for nematode colonization.