Goodwin M Breinin M.D.
Goodwin M Breinin M.D.
Professor Emeritus of Ophthalmology; Clinical Professor
Department of Ophthalmology

Research Summary

For several summers, I have been working in the Reese Laboratory of Neurobiology of the Marine Biological Laboratory at Woods Hole, MA and at the NYU School of Medicine to establish a Laser Trapping Unit which can move cells and organelles of nanometer dimensions within cells. This technique also lends itself to pico tensiometry enabling the measurement of force-velocity relations at pico-newton dimensions. Studies of molecular motor (kinesin-myosin) activity in axons and cells are also ongoing.



For many years, we have studied the electrophysiology and structure of extraocular muscle. This unique muscle type involves both fast twitch and slow tonic fibers of a very special kind (fibrillenstruktur and felderstruktur).



Currently, we are developing a laboratory for laser intervention in tissues using laser trapping and laser inactivation of protein techniques, which are new approaches to analyzing intracellular organelles in the optic nerve, extraocular muscle, and visual cells. These techniques will extend work done at the Reese Laboratory of Neurobiology of the Marine Biological Laboratories. We now anticipate using confocal microscopy techniques with these studies.






For manyyears my colleagues and I have investigated the physiology of ocular motility utilizing the technique of electromyography and ultrastructure of extraocular muscle.
as well as the physiology of accommodation. vide monograph "The Electrophysiology of Exraocular Muscle;GMBreinin



Research Information
Research Interests
,Laser Intervention in Biologic Tissues, ocular motility, visual science

Research Keywords
kinesin, laser protein inactivation, laser trapping (tweezers), molecular motors, myosin