Associate Professor of Biochemistry and Medicine
Research SummaryRelated Images
Assay for Ranbp1, a cytosolic protein that binds strongly to Ran complexed with GTP. The top panel shows the specificity of binding; the binding of radioactive Ran-GTP is blocked by excess unlabelled Ran-GTP and unaffected by excess unlabelled Ran-GDP. The bottom panel shows that Ranbp1 is very well conserved evolutionarily. The binding assay detects homologs in extracts from frog (Xenopus), yeast (Schizosaccharomyces pombe) and human (HeLa) cells.
Research Information
Research Interests
Linkage Genetics in the Mouse; Molecular Biology of the ras Oncogene Family
Research Keywords
cell cycle, GTPases, mammalian genetics
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