Investigations of neuronal ion channels led to the discovery of a new class of voltage-dependent calcium channel named the P-type for the Purkinje cell where it was first detected. We now study the structure and function of this channel using various biochemical methods and the lipid-bilayer technique.

Using cell transplant methods, we recently found that adult cells implanted into the brain show longterm viability and maintain function if they are adhered to micro-carriers before implantation. Our results suggest this method is far superior to fetal transplants, and we are actively pursuing this exciting area for treatment of neurodegenerative disease, including Parkinson disease.

Another interest is identification and isolation of compounds from natural products with potential therapeutic utility. One such compound isolated from oats functions as a potassium channel activator and thus lowers blood pressure.