To discover factors that cause or contribute to or that can prevent the development of prostate cancer and to elucidate the mechanisms of action of these factors serve as our longterm research objectives. Ultimately, we want to prevent this major human malignancy.

Current investigations include: 1) Clinical trials with men that have or have been surgically treated for prostate cancer to dertemine whether supplementation with soy protein isolate can prevent cancer recurrence or modify intermediate end-points such as serum PSA; 2) Laboratory studies of green tea, soy protein isolate, and selenium compounds to determine their chemopreventive activity against prostate cancer; 3) Mechanisms of genotoxic activity of estrogens which cause prostate carcinomas in rats also treated with androgen; 4) Studies of genotoxic activity of estrogens in human prostate tissue; 5) Cellular and molecular mechanisms whereby perinatal exposure to androgen and diethystilbestrol influences prostate cancer risk; 6) The role of mesenchymal cells in malignant transformation of prostate epithelium and development of the hormone-independent phenotype; and 7) Identification of specific genes involved in malignant transformation and development of a metastatic phenotype in prostate epithelium.