Variable Porosity of the Pipeline Embolization Device in Straight and Curved Vessels: A Guide for Optimal Deployment Strategy
Shapiro M, Raz E, Becske T, Nelson PK
American Journal of Neuroradiology. 2013 September 26
NFκB1 (p50) Suppresses SOD2 Expression via Inhibiting FoxO3a Transactivation in a miR190/PHLPP1/Akt-Dependent Axis
Du K, Yu Y, Zhang D, Luo W, Huang H, Chen J, Gao J, Huang C
Mol Biol Cell. 2013 September 25
Health Insurance Status and the Care of Nursing Home Residents With Advanced Dementia
Goldfeld KS, Grabowski DC, Caudry DJ, Mitchell SL.
JAMA Internal Medicine. 2013 September 23
Inhibition of androgen receptor and β-catenin activity in prostate cancer
Lee E, Madar A, David G, Garabedian MJ, Dasgupta R, Logan SK
Proceedings of the National Academy of Sciences U.S.A. 2013 September 9.
Urinary phthalates are associated with higher blood pressure in children
Trasande L, Sathyanarayana S, Spanier AJ, Trachtman H, Attina TM, Urbina EM
Journal of Pediatrics. 2013 September; 163 (3): 747-753
Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study
Neumeister A, Normandin MD, Pietrzak RH, Piomelli D, Zheng MQ, Gujarro-Anton A, Potenza MN, Bailey CR, Lin SF, Najafzadeh S, Ropchan J, Henry S, Corsi-Travali S, Carson RE, Huang Y
Molecular Psychiatry. 2013 September; 18 (9): 1034-1040
This study suggests that there is a connection between the number of cannabinoid receptors in the brain and the effects of post-traumatic stress disorder (PTSD).
Lipid lowering in patients with treatment-resistant hypertension: an analysis from the Treating to New Targets (TNT) trial
Bangalore S, Fayyad R, Laskey R, Demicco D, Deedwania P, Kostis JB, Messerli FH; Treating to New Targets Steering Committee and Investigators
European Heart Journal. 2013 August 29
A new role for the cellular PABP repressor Paip2 as an innate restriction factor capable of limiting productive cytomegalovirus replication
McKinney C, Yu D, Mohr I
Genes & Development. 2013 August 15; 27 (16): 1809-20
A deficiency in the autophagy gene atg16L1 enhances resistance to enteric bacterial infection
Marchiando AM, Ramanan D, Ding Y, Gomez LE, Hubbard-Lucey VM, Maurer K, Wang C, Ziel JW, van Rooijen N, Nuñez G, Finlay BB, Mysorekar IU, Cadwell K
Cell Host & Microbe. 2013 August 14; 14 (2): 216-24
Long-term continence outcomes in men undergoing radical prostatectomy for clinically localized prostate cancer
Prabhu V, Sivarajan G, Taksler GB, Laze J, Lepor H
European Urology. 2013 August 9. doi: pii: S0302-2838(13)00827-0
Scientific publications on firearms in youth before and after Congressional action prohibiting federal research funding
Ladapo JA, Rodwin BA, Ryan AM, Trasande L, Blustein J
JAMA. 2013 August 7; 310 (5): 532-4
STIM1 and STIM2-mediated Ca2+ influx regulates antitumour immunity by CD8+ T cells
Weidinger C, Shaw PJ, Feske S
EMBO Molecular Medicine. 2013 August 6. doi: 10.1002/emmm.201302989
Adding an unnatural covalent bond to proteins through proximity-enhanced bioreactivity
Xiang Z, Ren H, Hu YS, Coin I, Wei J, Cang H, Wang L
Nature Methods. 2013 August 4. doi: 10.1038/nmeth.2595
Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons
Owen SF, Tuncdemir SN, Bader PL, Tirko NN, Fishell G, Tsien RW
Nature. 2013 August 4. doi: 10.1038/nature12330
The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage
Chaumeil J, Micsinai M, Ntziachristos P, Roth DB, Aifantis I, Kluger Y, Deriano L, Skok JA
Nature Communications. 2013 July 31; 4:2231. doi: 10.1038/ncomms3231
Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling
Chou WC, Takeo M, Rabbani P, Hu H, Lee W, Chung YR, Carucci J, Overbeek P, Ito M
Nature Medicine. 2013 July; 19 (7): 924-9
Wnt activation in nail epithelium couples nail growth to digit regeneration
Takeo M, Chou WC, Sun Q, Lee W, Rabbani P, Loomis C, Taketo MM, Ito M
Nature. 2013 July 11; (449): 228-32
Researchers have discovered the biological chain of events that enable mammals to regenerate a lost fingertip.
Effect of soy protein isolate supplementation on biochemical recurrence of prostate cancer after radical prostatectomy: a randomized trial
Bosland MC, Kato I, Zeleniuch-Jacquotte A, Schmoll J, Enk Rueter E, Melamed J, Kong MX, Macias V, Kajdacsy-Balla A, Lumey LH, Xie H, Gao W, Walden P, Lepor H, Taneja SS, Randolph C, Schlicht MJ, Meserve-Watanabe H, Deaton RJ, Davies JA
JAMA. 2013 July 10; 310 (2): 170-8
It has been suggested that soy protein can reduce the relapse rate in prostate cancer. This randomized double-blind study found that a daily dose of soy protein did not lead to fewer recurrences.
Abnormal propagation of calcium waves and ultrastructural remodeling in recessive catecholaminergic polymorphic ventricular tachycardia
Liu N, Denegri M, Dun W, Boncompagni S, Lodola F, Protasi F, Napolitano C, Boyden PA, Priori SG
Circulation Research. 2013 July 5; 113 (2):142-52
A spindle-independent cleavage pathway controls germ cell formation in Drosophila
Cinalli RM, Lehmann R
Nature Cell Biology. 2013 July; 15 (7): 839-45
CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluable ligands in sterile inflammation
Sheedy FJ, Grebe A, Rayner KJ, Kalantari P, Ramkhelawon B, Carpenter SB, Becker CE, Ediriweera HN, Mullick AE, Golenbock DT, Stuart LM, Latz E, Fitzgerald KA, Moore KJ
Nature Immunology. 2013 June 30; (14): 812-820
Staphylococcus aureus LukAB cytotoxin kills human neutrophils by targeting the CD11b subunit of the integrin Mac-1
Dumont AL, Yoong P, Day CJ, Alonzo F III, McDonald WH, Jennings MP, Torres VJ
Proceedings of the National Academy of Sciences U.S.A. 2013 June 25; 110 (26): 10794-9
This paper shows that a plentiful surface protein on granulocytes is the receptor for a major toxin from S. aureus and is critical for the targeting and killing of cells by S. aureus.
GPR15-mediated homing controls immune homeostasis in the large intestine mucosa
Kim SV, Xiang WV, Kwak C, Yang Y, Lin XW, Ota M, Sarpel U, Rifkin DB, Xu R, Littman DR
Science. 2013 June 21; 340 (6139): 1456-9
The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability
King B, Trimarchi T, Reavie L, Xu L, Mullenders J, Ntziachristos P, Aranda-Orgilles B, Perez-Garcia A, Shi J, Vakoc C, Sandy P, Shen SS, Ferrando A, Aifantis I
Cell. 2013 June 20; 153 (7): 1552-66
A key oncogene, MYC, was found not to be degraded in T cell leukemia, implying that the leukemia relies on the oncogene's function. A small molecule that blocks this oncogene's activity sent mouse T cell leukemia into remission, suggesting a potential treatment.
Peripheral elevation of TNF-α leads to early synaptic abnormalities in the mouse somatosensory cortex in experimental autoimmune encephalomyelitis
Yang G, Parkhurst CN, Hayes S, Gan WB
Proceedings of the National Academy of Sciences U.S.A. 2013 June 18; 110 (25): 10306-11
This study shows that, in a mouse model that resembles multiple sclerosis, the production of the cytokine TNF in the body increases before any symptoms appear. This TNF crosses the blood-brain-barrier and destabilizes synapses in the cortex.
The autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism
Di Martino A, Yan CG, Li Q, Denio E, Castellanos FX, Alaerts K, Anderson JS, Assaf M, Bookheimer SY, Dapretto M, Deen B, Delmonte S, Dinstein I, Ertl-Wagner B, Fair DA, Gallagher L, Kennedy DP, Keown CL, Keysers C, Lainhart JE, Lord C, Luna B, Menon V, Minshew NJ, Monk CS, Mueller S, Müller RA, Nebel MB, Nigg JT, O'Hearn K, Pelphrey KA, Peltier SJ, Rudie JD, Sunaert S, Thioux M, Tyszka JM, Uddin LQ, Verhoeven JS, Wenderoth N, Wiggins JL, Mostofsky SH, Milham MP
Molecular Psychiatry. 2013 June 18. doi: 10.1038/mp.2013.78
The authors introduce and demonstrate the feasibility and utility of the largest, to date, neuroimaging dataset of individuals with autism and controls, a collection resulting from the Autism Brain Imaging Data Exchange (ABIDE), an international consortium of labs sharing data globally.
Control of cholesterol metabolism and plasma high-density lipoprotein levels by microRNA-144
Ramírez CM, Rotllan N, Vlassov AV, Dávalos A, Li M, Goedeke L, Aranda JF, Cirera-Salinas D, Araldi E, Salerno A, Wanschel A, Zavadil J, Castrillo A, Kim J, Suárez Y, Fernández-Hernando C
Circulation Research. 2013 June 7; 112(12): 1592-601
Association of tattooing and hepatitis C virus infection: a multicenter case-control study
Carney K, Dhalla S, Aytaman A, Tenner CT, Francois F
Hepatology. 2013 June; 57 (6): 2117-23
Circadian glucocorticoid oscillations promote learning-dependent synapse formation and maintenance
Liston C, Cichon JM, Jeanneteau F, Jia Z, Chao MV, Gan WB
Nature Neuroscience. 2013 June; 16 (6): 698-705
Glucocorticoids are produced excessively under stress, but normally follow a rhythmic cycle. This endogenous process is shown to help motor-skill memory formation and retention, through the controlled creation and maintenance of new synapses.
Mild traumatic brain injury: longitudinal regional brain volume changes
Zhou Y, Kierans A, Kenul D, Ge Y, Rath J, Reaume J, Grossman RI, Lui YW
Radiology. 2013 June; 267 (3): 880-90
This study is the first to show that a single concussion can cause lasting structural damage to the brain in the form of measurable brain volume loss.
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.
Commisso C, Davidson SM, Soydaner-Azeloglu RG, Parker SJ, Kamphorst JJ, Hackett S, Grabocka E, Nofal M, Drebin JA, Thompson CB, Rabinowitz JD, Metallo CM, Vander Heiden MG, Bar-Sagi D
Nature. 2013 May 30; 497 (7451): 633-7
The unraveling of a longstanding mystery about how pancreatic tumor cells feed themselves may open up new therapeutic possibilities for a notoriously lethal disease with few treatment options.
Specificity of RppH-dependent RNA degradation in Bacillus subtilis
Hsieh PK, Richards J, Liu Q, Belasco JG
Proceedings of the National Academy of Sciences U.S.A. 2013 May 28; 110 (22): 8864-8869
Robust measurement of telomere length in single cells
Wang F, Pan X, Kalmbach K, Seth-Smith ML, Ye X, Antumes DM, Yin Y, Liu L, Keefe DL, Weissman SM
Proceedings of the National Academy of Sciences U.S.A. 2013 May 21; 110 (21): E1906-12.
Taste-independent nutrient selection is mediated by a brain-specific Na+/solute co-transporter in Drosophila
Dus M, Ai M, Suh GS
Nature Neuroscience. 2013 May; 16 (5): 526-8
In food-deprived flies, the nutritional value of sugar can be ascertained without taste differences. This paper shows that a Drosophila gene designated cupcake, which encodes a solute transporter, is key for flies to behave as if they are hungry and choose foods rich in calories.
FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade
Kuchay S, Duan S, Schenkein E, Peschiaroli A, Saraf A, Florens L, Washburn MP, Pagano M
Nature Cell Biology. 2013 May; 15 (5): 472-80
T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy
Zhong S, Malecek K, Johnson LA, Yu Z, Vega-Saenz de Miera E, Darvishian F, McGary K, Huang K, Boyer J, Corse E, Shao Y, Rosenberg SA, Restifo NP, Osman I, Krogsgaard M
Proceedings of the National Academy of Sciences U.S.A. 2013 April 23; 110 (17): 6973-8
Is it possible to create safe anti-tumor T cells? This paper shows that the T cell receptor's affinity for its ligand in tumor immunity is critical. It needs to be moderate to fight tumors, but cannot be too high, as that induces autoimmune damage.
Cortical response tracking the conscious experience of threshold duration visual stimuli indicates visual perception is all or none
Sekar K, Findley WM, Poeppel D, Llinás RR
Proceedings of the National Academy of Sciences U.S.A. 2013 April 2; 110 (14): 5642-7
Dedicated olfactory neurons mediating attraction behavior to ammonia and amines in Drosophila
Min S, Ai M, Shin SA, Suh GS
Proceedings of the National Academy of Sciences U.S.A. 2013 April 2; 110 (14): E1321-9