New Elective in Clinical Pharmacology
Title: Clinical Pharmacology
Course Code: 04-39
Preceptor: Bruce N. Cronstein, MD
Telephone #: 263-6404
Email: cronsb01@med.nyu.edu
Prerequisites: None

Description:

During this elective students will have the opportunity to review the basics of pharmacology in the light of their recent clinical experiences in a small group/lecture setting. In addition, the students will have the opportunity to study in greater detail the process of new drug development and licensing as it occurs in the United States. As drugs have been introduced for an increasing number of novel indications the proportion of the cost of medical care spent on pharmacologic agents has increased; students will be introduced to the principles of pharmacoeconomics as well. In general, the elective will consist of small group sessions held over a period of two weeks and a presentation by the student to faculty and staff of a plan for development of a new drug.

Objectives:

Students will have the opportunity to review the basics of therapy in various areas of medicine and pediatrics. In addition, students will be given the opportunity to review the mechanism by which new drugs are developed and the effect of pricing on use of and compliance with therapeutic regimens.

Key responsibilities of the student:

Each student will be expected to attend small group sessions and participate in discussions of the topics presented. In addition, over the course of the elective students will be expected to develop a plan for development of a hypothetical new drug ranging from pre-clinical to clinical trials of the agent for the desired indication and to present this plan to the remainder of the participating students and faculty. Each student will work on this plan with a mentor.

Didactic Program:

The classes will be given during the day over a two week period with the final day being devoted to student presentations.

Other information:

Dates offered: Wednesday, January 30 ˜ Tuesday, February 12, 2002

Number of Students: 8

Clinical Pharmacology Elective

Ultimate assignment: A plan for the development of a new drug from pre-clinical to Phase III studies. This can and should be taken from the literature.

Day I
Principles of Clinical Pharmacology I
Principles of Clinical Pharmacology II
Health Care Policy: What is the real cost of a drug?

Day II
New Drugs released (2000-2001)
FDA Licensing - What is a phase?
Generic Drugs and their equivalents
Clinical Pharmacology Rounds

Day III
Drug Interactions
Medication Errors
Alternative therapies
Developing a clinical trial

Day IV
Overview of biological therapies - New therapies, new challenges
Pharmacogenomics and Pharmacogenetics
Principles of Oncology Therapy
An Overview of Pharmacology in Pediatrics

Day V
Overview of nonsteroidal anti-inflammatory drugs (NSAIDs)
Overview of therapy of Rheumatic Diseases
Journal Club

Day VI
Overview of Geriatric Therapeutics
Polypharmacy in the Elderly
Overview of antihypertensive therapy

Day VII
Overview of anti-arrhythmic therapy
Overview of the therapy of ischemia
Overview of AIDS therapy
Overview of antibiotic therapy and development

Day VIII
Overview of asthma therapy
Overview of GI medications
Medicating the peri-operative patient

Day IX
Journal Club

Day X
Student Presentations

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