Pindolol Summary

• Animal studies showed antagonistic effects of pindolol at 5-HT1A sematodentritic autoreceptors and lack of antagonism at postsynaptic 5-HT 1A receptors in the hippocampus.
• Pindolol was shown to prevent the inhibitory effect of paroxetine on the firing activity of 5-HT neurons.
• Pindololís safety and therapeutic potential as an augmenting agent was corroborated by investigators.