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Notes:
- The monoamine
neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) plays important
roles in many behaviors including sleep, appetite, memory, and mood.
- 5-HT release is
under the tonic inhibitory control of 5-HT1A receptors.
- The highest density
of 5-HT1A receptors among limbic structures is in the hippocampus. The
5-HT1A receptors located in the raphe nuclei correspond to presynaptic
somatodendritic autoreceptors. Shih, 1995:419(4)
- The function of
presynaptic somatodendritic 5-HT1A receptors is to slow down the activity
of serotonergic neurons. Their activation reduces neuronal firing, 5-HT
synthesis, and terminal release. Artigas, 1994:249 (2)
- Thus, under conditions
of excess extracellular 5-HT, these autoreceptors induce a negative
feedback loop that inhibits 5-HT synthesis and release.
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