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For the Psychiatrist - Augmentation Strategies in the Treatment of Depression

1. Factors that can contribute to treatment failure of depression include:
  • a. medical conditions
  • b. substance dependence
  • c. body dysmorphic disorder
  • d. atypical depression
  • e. all of the above
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2. In order to give the patient the best chance of therapeutic response, the antidepressant should be administered for a minimum of:
  • a. 1 week
  • b. 2 weeks
  • c. 4 weeks
  • d. 6 weeks
  • e. 8 weeks
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3. Disadvantages of augmentation/combination compared with substitution include:
  • a. higher risk of relapse
  • b. lower response rate
  • c. increased side effects
  • d. delayed onset of action
  • e. none of the above
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4. Augmentation of antidepressant treatment using Lithium was found to produce response rates from 30% to 65%.
  • a. True
  • b. False
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5. T3 augmentation of TCAs is shown to be effective in approximately:
  • a. 5%-10% of patients
  • b. 10%-20% of patients
  • c. 30%-40% of patients
  • d. 50-60% of patients
  • e. none of the above
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6. Recent use of buspirone as an augmenting agent revealed:
  • a. superior safety profile
  • b. no lab testing required
  • c. 60% response rate to the combination
  • d. none of the above
  • e. all of the above
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