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Biosketch / Results /

Angus C Wilson, Ph.D.

Associate Professor; Asst Dean Research Labs Oper and Facilities
Department of Microbiology (Microbiology ) [1]

Contact Info

Address
540 First Avenue
Floor 5 Room Admin Area
Skirball Institute
New York, NY 10016

212-263-0206
Angus.Wilson@med.nyu.edu


[3]

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Education

— Kings's College University of London, Medical Education
1990 — Dr. Wilson received his Ph.D. from Kings College, University of London, United Kingdom, Graduate Education
1991-1996 — Dr. Wilson was a Postdoctoral Fellow at Cold Spring Harbor Laboratory, New York, PostDoctoral Training

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Research Summary

Viruses encode specific proteins that modify the regulatory machinery of the infected cell, overcoming host antiviral defenses and creating an optimal environment for viral replication. Mechanistic studies of virus-host interactions have provided a unique window into the workings of the cell and the origins of human cancer. We are interested in the ways in which herpesviruses modulate cellular transcription factors involved in control of cell proliferation; studies that will expand our understanding of the mammalian cell cycle and the virus-mediated oncogenesis.We have focused on two important viral regulatoy proteins: VP16 from herpes simplex virus (HSV) and LANA from Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8).

VP16, a potent transcriptional activator encoded by HSV, targets a conserved cellular factor known as HCF-1. Using a temperature-sensitive cell line, we have shown that HCF-1 is required for progression through G1 phase of the cell cycle and acts as a coactivator for a variety of celluar transcription factors. To understand how HCF-1 promotes cell growth we are currently following two major directions: (i) the identification and analysis of other nuclear proteins that interact with HCF-1 or with HCF-2, a related protein identified in our lab and (ii) characterization of HCF function in the fruit fly Drosophila; an attractive model system that combines the power of genetics, biochemistry and developmental biology.

A second area under investigation in the lab is the role of KSHV in the development of Kaposi's sarcoma (KS), the leading tumor seen in AIDS patients and in the less common but more aggressive primary effusion lymphoma (PEL). We are interested in the establishment and maintenance of latent KSHV infection, focusing on the role of LANA in maintaining the viral genome during proliferation of the host cell. We also study the regulation of gene expression during reactivation focusing on viral factors that regulate gene transcription and post-transcriptional events.

These studies will provide new insight into the mechanisms behind the immortalization of latently-infected B cells and endothelial cells - the first step towards development of KS or PEL tumors.

Research Interests

Viral pathogenesis, herpesviruses, latency, reactivation, control of viral and cellular gene expression, Kaposi's sarcoma-associated herpesvirus, KSHV, HHV8, herpes simplex virus, HSV, virus-host interactions, chromatin, Kaposi's sarcoma, effusion lymphoma, transcription.

Research Keywords

viral pathogenesis, herpesviruses, latency, reactivation, Kaposi's sarcoma-associated herpesvirus, KSHV, herpes simplex virus, HSV, virus-host interactions, host cell factor, HCF-1, VP16, RTA, epigenetic regulation, chromatin

Grant Keywords

Cell Lines, Pathogenesis, Gene Regulation, Infectious Diseases/Agents, AIDS, Cancer Biology

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search [8]

Transient Reversal of Episome Silencing Precedes VP16-Dependent Transcription during Reactivation of Latent HSV-1 in Neurons
Kim, Ju Youn; Mandarino, Angelo; Chao, Moses V; Mohr, Ian; Wilson, Angus C
2012 Feb;8(2):e1002540-e1002540 e1002540, PLoS pathogens
— id: 159845, year: 2012, vol: 8, page: e1002540, stat: Journal Article,

A primary neuron culture system for the study of herpes simplex virus latency and reactivation
Kobayashi, Mariko; Kim, Ju-Youn; Camarena, Vladimir; Roehm, Pamela C; Chao, Moses V; Wilson, Angus C; Mohr, Ian
2012 ;(62):?-?, Journal of visualized experiments : JoVE
— id: 164363, year: 2012, vol: , page: ?, stat: Journal Article,

Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor
Kobayashi, Mariko; Wilson, Angus C; Chao, Moses V; Mohr, Ian
2012 Jul;26(14):1527-1532, Genes & development
— id: 174034, year: 2012, vol: 26, page: 1527, stat: Journal Article,

A cell culture model of facial palsy resulting from reactivation of latent herpes simplex type 1
Kuhn, Maggie A; Nayak, Shruti; Camarena, Vladimir; Gardner, Jimmy; Wilson, Angus; Mohr, Ian; Chao, Moses V; Roehm, Pamela C
2012 Jan;33(1):87-92, Otology & neurotology
— id: 146264, year: 2012, vol: 33, page: 87, stat: Journal Article,

A cultured affair: HSV latency and reactivation in neurons
Wilson, Angus C; Mohr, Ian
2012 Dec;20(12):604-611, Trends in microbiology
— id: 182432, year: 2012, vol: 20, page: 604, stat: Journal Article,

Cooperation between viral interferon regulatory factor 4 and RTA to activate a subset of Kaposi's sarcoma-associated herpesvirus lytic promoters
Xi, Xiangmei; Persson, Linda M; O'Brien, Michael W; Mohr, Ian; Wilson, Angus C
2012 Jan;86(2):1021-1033, Journal of virology
— id: 155938, year: 2012, vol: 86, page: 1021, stat: Journal Article,

Cultured vestibular ganglion neurons demonstrate latent HSV1 reactivation
Roehm, Pamela C; Camarena, Vladimir; Nayak, Shruti; Gardner, James B; Wilson, Angus; Mohr, Ian; Chao, Moses V
2011 Oct;121(10):2268-2275, Laryngoscope
— id: 137886, year: 2011, vol: 121, page: 2268, stat: Journal Article,

Nature and duration of growth factor signaling through receptor tyrosine kinases regulates HSV-1 latency in neurons
Camarena, Vladimir; Kobayashi, Mariko; Kim, Ju Youn; Roehm, Pamela; Perez, Rosalia; Gardner, James; Wilson, Angus C; Mohr, Ian; Chao, Moses V
2010 Oct 21;8(4):320-330, Cell Host & Microbe
— id: 113951, year: 2010, vol: 8, page: 320, stat: Journal Article,

LANA interacts with MeCP2 and nucleosomes through separate domains
Matsumura, Satoko; Persson, Linda M; Wong, LaiYee; Wilson, Angus C
2010 Mar;84(5):2318-2330, Journal of virology
— id: 106026, year: 2010, vol: 84, page: 2318, stat: Journal Article,

Wide-scale use of Notch-signaling factor CSL/RBP-J{kappa} in RTA-mediated KSHV lytic gene activation
Persson, Linda M; Wilson, Angus C
2010 Feb;84(3):1334-1347, Journal of virology
— id: 106027, year: 2010, vol: 84, page: 1334, stat: Journal Article,

Activation of host translational control pathways by a viral developmental switch
Arias, Carolina; Walsh, Derek; Harbell, Jack; Wilson, Angus C; Mohr, Ian
2009 Mar;5(3):e1000334-e1000334, PLoS pathogens
— id: 98991, year: 2009, vol: 5, page: e1000334, stat: Journal Article,

Association of C-terminal ubiquitin hydrolase BAP1 with cell cycle regulator HCF-1
Misaghi, Shahram; Ottosen, Soren; Izrael-Tomasevic, Anita; Arnott, David; Lamkanfi, Mohamed; Lee, James; Liu, Jinfeng; O'Rourke, Karen; Dixit, Vishva M; Wilson, Angus C
2009 Apr;29(8):2181-2192, Molecular & cellular biology
— id: 94315, year: 2009, vol: 29, page: 2181, stat: Journal Article,

Setting the stage for S phase
Wilson, Angus C
2007 Jul 20;27(2):176-177, Molecular cell
— id: 73584, year: 2007, vol: 27, page: 176, stat: Journal Article,

Activation of the Kaposi's Sarcoma-Associated Herpesvirus Major Latency Locus by the Lytic Switch Protein RTA (ORF50)
Matsumura, Satoko; Fujita, Yuriko; Gomez, Evan; Tanese, Naoko; Wilson, Angus C
2005 Jul;79(13):8493-8505, Journal of virology
— id: 56176, year: 2005, vol: 79, page: 8493, stat: Journal Article,

Transcripts encoding K12, v-FLIP, v-cyclin, and the microRNA cluster of Kaposi's sarcoma-associated herpesvirus originate from a common promoter
Pearce, Michael; Matsumura, Satoko; Wilson, Angus C
2005 Nov;79(22):14457-14464, Journal of virology
— id: 62365, year: 2005, vol: 79, page: 14457, stat: Journal Article,

Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induces a strong bend on binding to terminal repeat DNA
Wong, Lai-Yee; Wilson, Angus C
2005 Nov;79(21):13829-13836, Journal of virology
— id: 58978, year: 2005, vol: 79, page: 13829, stat: Journal Article,

Transcriptional activation by the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen is facilitated by an N-terminal chromatin-binding motif
Wong, Lai-Yee; Matchett, Gerald A; Wilson, Angus C
2004 Sep;78(18):10074-10085, Journal of virology
— id: 45302, year: 2004, vol: 78, page: 10074, stat: Journal Article,

HCF-1 functions as a coactivator for the zinc finger protein Krox20
Luciano, Randy L; Wilson, Angus C
2003 Dec 19;278(51):51116-51124, Journal of biological chemistry
— id: 48178, year: 2003, vol: 278, page: 51116, stat: Journal Article,

Molecular cloning of Drosophila HCF reveals proteolytic processing and self-association of the encoded protein
Mahajan, Shahana S; Johnson, Kristina M; Wilson, Angus C
2003 Feb;194(2):117-126, Journal of cellular physiology
— id: 35188, year: 2003, vol: 194, page: 117, stat: Journal Article,

An activation domain in the C-terminal subunit of HCF-1 is important for transactivation by VP16 and LZIP
Luciano, Randy L; Wilson, Angus C
2002 Oct 15;99(21):13403-13408, Proceedings of the National Academy of Sciences of the United States of America
— id: 39588, year: 2002, vol: 99, page: 13403, stat: Journal Article,

Interaction of HCF-1 with a cellular nuclear export factor
Mahajan, Shahana S; Little, Markus M; Vazquez, Rafael; Wilson, Angus C
2002 Nov 15;277(46):44292-44299, Journal of biological chemistry
— id: 39404, year: 2002, vol: 277, page: 44292, stat: Journal Article,

Transcription
Tanese N; Wilson AC
2001 ;2001:?-?, McGraw-Hill yearbook of science & technology
— id: 19699, year: 2001, vol: 2001, page: ?, stat: Journal Article,

N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the Host Cell Factor-1 binding motif
Luciano RL; Wilson AC
2000 Sep 26;97(20):10757-10762, Proceedings of the National Academy of Sciences of the United States of America
— id: 11503, year: 2000, vol: 97, page: 10757, stat: Journal Article,

Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP
Mahajan SS; Wilson AC
2000 Feb;20(3):919-928, Molecular & cellular biology
— id: 11872, year: 2000, vol: 20, page: 919, stat: Journal Article,

Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies
Schwam DR; Luciano RL; Mahajan SS; Wong L; Wilson AC
2000 Sep;74(18):8532-8540, Journal of virology
— id: 11534, year: 2000, vol: 74, page: 8532, stat: Journal Article,

HCF-1 amino- and carboxy-terminal subunit association through two separate sets of interaction modules: involvement of fibronectin type 3 repeats
Wilson AC; Boutros M; Johnson KM; Herr W
2000 Sep;20(18):6721-6730, Molecular & cellular biology
— id: 19696, year: 2000, vol: 20, page: 6721, stat: Journal Article,

Herpes simplex virus transactivator VP16 discriminates between HCF-1 and a novel family member, HCF-2
Johnson KM; Mahajan SS; Wilson AC
1999 May;73(5):3930-3940, Journal of virology
— id: 6081, year: 1999, vol: 73, page: 3930, stat: Journal Article,

A single-point mutation in HCF causes temperature-sensitive cell-cycle arrest and disrupts VP16 function
Goto H; Motomura S; Wilson AC; Freiman RN; Nakabeppu Y; Fukushima K; Fujishima M; Herr W; Nishimoto T
1997 Mar 15;11(6):726-737, Genes & development
— id: 8394, year: 1997, vol: 11, page: 726, stat: Journal Article,

VP16 targets an amino-terminal domain of HCF involved in cell cycle progression
Wilson AC; Freiman RN; Goto H; Nishimoto T; Herr W
1997 Oct;17(10):6139-6146, Molecular & cellular biology
— id: 17836, year: 1997, vol: 17, page: 6139, stat: Journal Article,

The gene encoding the VP16-accessory protein HCF (HCFC1) resides in human Xq28 and is highly expressed in fetal tissues and the adult kidney
Wilson AC; Parrish JE; Massa HF