462 First Avenue
New York, NY 10016
Our research involves clinical studies of immune responses to malignant melanoma. We have developed a method of inducing cellular immune responses to metastatic melanoma that result in frequent durable complete regressions of disease.
We also are interested in immunological and virological aspects of human immunodeficiency virus (HIV) infection. We are investigating HIV-specific cellular immune responses in acute, primary HIV infection and in elite controllers who "spontaneously" control HIV without antiretroviral drugs. We have discovered that individuals treated very early in their HIV infection develop strong CD4 T cell memory responses to HIV antigens, similar but often of smaller magnitude to the memory responses observed in elite controllers. Many individuals treated for one year after the onset of their infection are subsequently able to control their blood levels of HIV for at least 1 to 2 years after stopping their anti-HIV drugs.
Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor
Gornalusse, German G; Mummidi, Srinivas; Gaitan, Alvaro A; Jimenez, Fabio; Ramsuran, Veron; Picton, Anabela; Rogers, Kristen; Manoharan, Muthu Saravanan; Avadhanam, Nymisha; Murthy, Krishna K; Martinez, Hernan; Molano Murillo, Angela; Chykarenko, Zoya A; Hutt, Richard; Daskalakis, Demetre; Shostakovich-Koretskaya, Ludmila; Abdool Karim, Salim; Martin, Jeffrey N; Deeks, Steven G; Hecht, Frederick; Sinclair, Elizabeth; Clark, Robert A; Okulicz, Jason; Valentine, Fred T; Martinson, Neil; Tiemessen, Caroline Tanya; Ndung'u, Thumbi; Hunt, Peter W; He, Weijing; Ahuja, Sunil K. Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2015 Aug 25;112(34):E4762-E4771 (1742172)
Structural Characterization of Two Monoclonal Antibodies Targeting the Fourth Constant Domain in the Bridging Sheet of HIV-1 gp120
Pan, R. ; Chen, Y. ; Vaine, M. ; Wang, S. ; Kelker, H. C. ; Itri, V. R. ; Valentine, F. T. ; Lu, S. ; Kong, X.. Structural Characterization of Two Monoclonal Antibodies Targeting the Fourth Constant Domain in the Bridging Sheet of HIV-1 gp120 [Meeting Abstract]. AIDS research & human retroviruses. 2013 NOV 1;29(11):A61-A62 (657002)
Early Detection of HIV Infection Among Kenyan Infants Using a Reverse Transcriptase Activity Assay
Sivapalasingam, Sumathi; Ahmed, Aabid; Mendillo, Megan; Holzman, Robert; Marshed, Fatuma; Mwamzuka, Musa; Khamadi, Samuel; Mwau, Matilu; Laverty, Maura; Valentine, Fred. Early Detection of HIV Infection Among Kenyan Infants Using a Reverse Transcriptase Activity Assay. Pediatric infectious disease journal. 2012 Jul;31(7):732-735 (169479)
Sex differences in the incidence of peripheral neuropathy among kenyans initiating antiretroviral therapy
Mehta, Sapna A; Ahmed, Aabid; Laverty, Maura; Holzman, Robert S; Valentine, Fred; Sivapalasingam, Sumathi. Sex differences in the incidence of peripheral neuropathy among kenyans initiating antiretroviral therapy. Clinical infectious diseases. 2011 Sep;53(5):490-496 (136612)
Evidence of dysregulation of dendritic cells in primary HIV infection
Sabado, Rachel Lubong; O'Brien, Meagan; Subedi, Abhignya; Qin, Li; Hu, Nan; Taylor, Elizabeth; Dibben, Oliver; Stacey, Andrea; Fellay, Jacques; Shianna, Kevin V; Siegal, Frederick; Shodell, Michael; Shah, Kokila; Larsson, Marie; Lifson, Jeffrey; Nadas, Arthur; Marmor, Michael; Hutt, Richard; Margolis, David; Garmon, Donald; Markowitz, Martin; Valentine, Fred; Borrow, Persephone; Bhardwaj, Nina. Evidence of dysregulation of dendritic cells in primary HIV infection. Blood. 2010 Nov 11;116(19):3839-3852 (114507)