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Biosketch / Results /

Naoko Tanese, Ph.D.

Associate Professor;
Department of Microbiology (Microbiology ) [1]

Contact Info

Address
550 First Avenue
Dept of Microbiology Floor 2 Room 258
Medical Science Building
New York, NY 10016

917-696-2234
212-263-8276
tanesn01@med.nyu.edu


[3]

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Education

1988-1993 — University of California at Berkeley, PostDoctoral Training
— Columbia University, Graduate Education

« Back to Results [7]

Research Summary

Huntington disease (HD) is a devastating disease that strikes affected individuals in mid-life with symptoms such as motor neuron dysfunction, cognitive and psychiatric disturbances that worsen with age. There is no cure for HD and currently available therapies are of limited use. Better understanding of the functions of the disease-causing huntingtin protein and the pathogenic mechanisms involved in the early stages of HD would permit identification of new targets for therapeutic intervention. Studies suggest that other neurodegenerative disorders caused by poly-glutamine expansion may share similar disease mechanisms. Thus, research on HD will likely contribute to the molecular understanding of many diseases of the brain. The gene that is mutated in HD is huntingtin (Htt), which encodes a large ubiquitously expressed protein. Expansion of a triplet CAG repeat sequence in the Htt gene generates a protein with poly-glutamine repeat expansion, which is the cause of HD, an autosomal, dominantly inherited neurodegenerative disorder. Although the pathogenic mechanisms of HD remain unclear, current evidence suggests significant dysfunction of neurons leading to progressive neuronal loss initially in the striatum. Wild-type Htt has been implicated in many cellular functions including regulation of gene expression, endocytosis and microtubule-directed vesicular trafficking in axons and dendrites. We recently reported a new role for Htt in post-transcriptional gene regulation and maintenance of processing bodies / neuronal RNA granules (PNAS 2008:105,10820; JBC 2010:285,13142). Endogenous Htt was found to co-localize and co-traffic with mRNA in dendrites. An emerging body of evidence suggests regulated transport and local translation of mRNA in neurons play a critical role in establishing their connectivity. Our findings implicate normal Htt in these important dynamic processes in neurons. It is possible that mutant Htt perturbs them in some way, contributing to the HD pathogenesis. Our ongoing research focuses on the identification and characterization of proteins and RNA that associate with normal and mutant Htt.

Research Interests

Transcriptional and post-transcriptional regulation of gene expression in health and disease

Research Keywords

transcription, chromatin, RNA processing, RNA trafficking, neurodegeneration, Huntington's disease, BDNF

Research Documents

Seven-color segmentation of a composite confocal image (3D projection) to analyze mRNA/protein and protein/protein co-localization in a rat brain slice. [8]

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search [9]

Proteomic Analysis of Wild-type and Mutant Huntingtin-associated Proteins in Mouse Brains Identifies Unique Interactions and Involvement in Protein Synthesis
Culver, Brady P; Savas, Jeffrey N; Park, Sung K; Choi, Jeong H; Zheng, Shuqiu; Zeitlin, Scott O; Yates, John R 3rd; Tanese, Naoko
2012 Jun;287(26):21599-21614, Journal of biological chemistry
— id: 170420, year: 2012, vol: 287, page: 21599, stat: Journal Article,

Quantitative analysis of BDNF/TrkB protein and mRNA in cortical and striatal neurons using alpha-tubulin as a normalization factor
Ma, Bin; Savas, Jeffrey N; Chao, Moses V; Tanese, Naoko
2012 Aug;81(8):704-717, Cytometry A
— id: 173025, year: 2012, vol: 81, page: 704, stat: Journal Article,

Target genes of the largest human SWI/SNF complex subunit control cell growth
Inoue, Hiroko; Giannakopoulos, Stavros; Parkhurst, Christopher N; Matsumura, Tatsushi; Kono, Evelyn A; Furukawa, Takako; Tanese, Naoko
2011 Feb 15;434(1):83-92, Biochemical journal
— id: 138119, year: 2011, vol: 434, page: 83, stat: Journal Article,

Huntingtin mediates dendritic transport of I<super>2</super>-actin mRNA in rat neurons
Ma B; Savas JN; Yu M-S; Culver BP; Chao MV; Tanese N
2011 Nov;1:140-?, Scientific reports
— id: 150540, year: 2011, vol: 1, page: 140, stat: Journal Article,

Huntingtin mediates dendritic transport of beta-actin mRNA in rat neurons
Ma, Bin; Savas, Jeffrey N; Yu, Man-Shan; Culver, Brady P; Chao, Moses V; Tanese, Naoko
2011 ;1:140-140, Scientific reports
— id: 166786, year: 2011, vol: 1, page: 140, stat: Journal Article,

Regulation of Androgen Receptor-Mediated Transcription by RPB5 Binding Protein URI/RMP
Mita, Paolo; Savas, Jeffrey N; Djouder, Nabil; Yates, John R 3rd; Ha, Susan; Ruoff, Rachel; Schafler, Eric D; Nwachukwu, Jerome C; Tanese, Naoko; Cowan, Nicholas J; Zavadil, Jiri; Garabedian, Michael J; Logan, Susan K
2011 Sep;31(17):3639-3652, Molecular & cellular biology
— id: 136514, year: 2011, vol: 31, page: 3639, stat: Journal Article,

Mammalian SWI/SNF-A Subunit BAF250/ARID1 Is an E3 Ubiquitin Ligase That Targets Histone H2B
Li, Xuan Shirley; Trojer, Patrick; Matsumura, Tatsushi; Treisman, Jessica E; Tanese, Naoko
2010 Apr;30(7):1673-1688, Molecular & cellular biology
— id: 107927, year: 2010, vol: 30, page: 1673, stat: Journal Article,

Localization of BDNF mRNA with the Huntington's disease protein in rat brain
Ma, Bin; Culver, Brady P; Baj, Gabriele; Tongiorgi, Enrico; Chao, Moses V; Tanese, Naoko
2010 ;5:22-22, Molecular neurodegeneration
— id: 110078, year: 2010, vol: 5, page: 22, stat: Journal Article,

A role for huntington disease protein in dendritic RNA granules
Savas, Jeffrey N; Ma, Bin; Deinhardt, Katrin; Culver, Brady P; Restituito, Sophie; Wu, Ligang; Belasco, Joel G; Chao, Moses V; Tanese, Naoko
2010 Apr 23;285(17):13142-13153, Journal of biological chemistry
— id: 109209, year: 2010, vol: 285, page: 13142, stat: Journal Article,

A combined immunoprecipitation, mass spectrometric and nucleic acid sequencing approach to determine microRNA-mediated post-transcriptional gene regulatory networks
Savas, Jeffrey N; Tanese, Naoko
2010 Jan;9(1):24-31, Briefings in functional genomics & proteomics
— id: 106497, year: 2010, vol: 9, page: 24, stat: Journal Article,

Acetylation targets mutant huntingtin to autophagosomes for degradation
Jeong, Hyunkyung; Then, Florian; Melia, Thomas J Jr; Mazzulli, Joseph R; Cui, Libin; Savas, Jeffrey N; Voisine, Cindy; Paganetti, Paolo; Tanese, Naoko; Hart, Anne C; Yamamoto, Ai; Krainc, Dimitri
2009 Apr 3;137(1):60-72, Cell
— id: 106025, year: 2009, vol: 137, page: 60, stat: Journal Article,

The role of YY1 in reduced HP1alpha gene expression in invasive human breast cancer cells
Lieberthal, Jason G; Kaminsky, Marissa; Parkhurst, Christopher N; Tanese, Naoko
2009 ;11(3):R42-R42, Breast cancer research
— id: 101285, year: 2009, vol: 11, page: R42, stat: Journal Article,

Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies
Savas, Jeffrey N; Makusky, Anthony; Ottosen, Soren; Baillat, David; Then, Florian; Krainc, Dimitri; Shiekhattar, Ramin; Markey, Sanford P; Tanese, Naoko
2008 Aug 5;105(31):10820-10825, Proceedings of the National Academy of Sciences of the United States of America
— id: 86555, year: 2008, vol: 105, page: 10820, stat: Journal Article,

The Heterochromatin Protein 1 Family is Regulated in Prostate Development and Cancer
Shapiro, Ellen; Huang, Hongying; Ruoff, Rachel; Lee, Peng; Tanese, Naoko; Logan, Susan K
2008 Apr 22;179(6):2435-2439, Journal of urology
— id: 78573, year: 2008, vol: 179, page: 2435, stat: Journal Article,

HP1-mediated silencing targets Pol II coactivator complexes
Smallwood, Andrea; Black, Joshua C; Tanese, Naoko; Pradhan, Sriharsa; Carey, Michael
2008 Mar;15(3):318-320, Nature structural & molecular biology
— id: 94954, year: 2008, vol: 15, page: 318, stat: Journal Article,

The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun
Koyama-Nasu, Ryo; David, Gregory; Tanese, Naoko
2007 Sep;9(9):1074-1080, Nature cell biology
— id: 75366, year: 2007, vol: 9, page: 1074, stat: Journal Article,

Conserved region I of human coactivator TAF4 binds to a short hydrophobic motif present in transcriptional regulators
Wang, Xiaoping; Truckses, Dagmar M; Takada, Shinako; Matsumura, Tatsushi; Tanese, Naoko; Jacobson, Raymond H
2007 May 8;104(19):7839-7844, Proceedings of the National Academy of Sciences of the United States of America
— id: 94955, year: 2007, vol: 104, page: 7839, stat: Journal Article,

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
Cui, Libin; Jeong, Hyunkyung; Borovecki, Fran; Parkhurst, Christopher N; Tanese, Naoko; Krainc, Dimitri
2006 Oct 6;127(1):59-69, Cell
— id: 94956, year: 2006, vol: 127, page: 59, stat: Journal Article,

Activation of the Kaposi's Sarcoma-Associated Herpesvirus Major Latency Locus by the Lytic Switch Protein RTA (ORF50)
Matsumura, Satoko; Fujita, Yuriko; Gomez, Evan; Tanese, Naoko; Wilson, Angus C
2005 Jul;79(13):8493-8505, Journal of virology
— id: 56176, year: 2005, vol: 79, page: 8493, stat: Journal Article,

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease
Dunah, Anthone W; Jeong, Hyunkyung; Griffin, April; Kim, Yong-Man; Standaert, David G; Hersch, Steven M; Mouradian, M Maral; Young, Anne B; Tanese, Naoko; Krainc, Dimitri
2002 Jun 21;296(5576):2238-2243, Science
— id: 48167, year: 2002, vol: 296, page: 2238, stat: Journal Article,

Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors
Inoue, Hiroko; Furukawa, Takako; Giannakopoulos, Stavros; Zhou, Sharleen; King, David S; Tanese, Naoko
2002 Nov 1;277(44):41674-41685, Journal of biological chemistry
— id: 32539, year: 2002, vol: 277, page: 41674, stat: Journal Article,

A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development
Nakashima, M; Tanese, N; Ito, M; Auerbach, W; Bai, C; Furukawa, T; Toyono, T; Akamine, A; Joyner, A L
2002 Nov;119(1):21-34, Mechanisms of development
— id: 32540, year: 2002, vol: 119, page: 21, stat: Journal Article,

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