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Biosketch / Results /

Daniel B. Rifkin, Ph.D.

Professor; Charles Aden Poindexter Professor of Medicine; Interim Chair & Professor; Interim Chair of the Department of Cell Biology; Dir Cell& MoleBio Pgm Instrc& Lecturer-Cell Bio
Departments of Cell Biology (Chair) [1] and Medicine (GIM Div) [2]

Contact Info

Address
550 First Avenue
Dept. of Cell Biology Floor 6 Room 638
Medical Science Building
New York, NY 10016

Phone: 212-263-5109
Fax: 212-263-0595
Email: Daniel.Rifkin@nyumc.org

[3]

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Education

1968 — Dr. Rifkin received his Ph.D. in Biochemistry from The Rockefeller University, Graduate Education
1968-1970 — Dr. Rifkin was a postdoctoral fellow at the Rockefeller University, PostDoctoral Training

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Research Summary

The Rifkin lab's major interest is in understanding transfer of information in the extracellular environment and the impact of this process on diseases such as cancer. As a model to study how extracellular molecular cues are processed, we have chosen to examine the manner in which growth factors are presented to their receptors. While at first thought this may appear to be straight forward, the interaction of a growth factor with its receptor occurs only under specific conditions: growth factor diffusion must be controlled to ensure that sufficiently high concentrations are reached, many growth factors must be activated before binding to their cognate receptor, and growth factors function is highly contextual. These facts make the problem of understanding growth factor availability in both time and space interesting and challenging. Indeed, improper growth factor presentation may be the cause of a number of pathologies including tumor growth, fibrosis, and autoimmunity.

Our research is focused on elucidating how transforming growth factor-ß (TGF-ß) is regulated. The TGF-ßs (ß1, ß2, ß3) are 25kD dimeric cytokines derived from larger precursors by intracellular processing by furins. However, even though the bonds between the TGF-ß dimer and the propeptide dimer are cleaved within the trans Golgi, the propeptide remains tightly associated with the growth factor by non covalent interactions. This association renders the TGF-ß unable to interact with its receptor. Thus, TGF-ß is normally secreted in a latent form and to act must be liberated from interaction with its propeptide, also known as the latency associated protein (LAP). The extracellular forms of latent TGF-ß are also associated with a second gene product, the latent TGF-ß binding protein (LTBP). LTBPs are complex proteins consisting of multiple EGF-like domains and signature 8-cysteine-containing modules. LTBPs are joined to LAP via a pair of disulfide bonds that form between cysteine residues near the amino terminus of LAP and a pair of cysteines in the third 8-cysteine domains of LTBP-1, 3 or 4

The research efforts of the laboratory are focused on several themes that relate to the fundamental biology of TGF-ß and its activation. First, we are interested in elucidating the mechanisms that convert latent to active TGF-ß. We have described activation by proteases and by the integrin alpha vß6. We are currently performing molecular experiments to establish the role of LTBP in this process, the regions of LTBP that are involved, and the biochemical constituents that are part of the activation reaction. We have also developed a genetic screen for molecules that activate latent TGF-ß. We have isolated several cell clones that may express novel activators and are in the process of characterizing these activators. Our ultimate goal is to understand latent TGF-ß activation in a way that will permit the design of inhibitors for specific activation pathways.

Second, we are studying LTBP function by creating mouse mutants in which either null mutations have been introduced into the LTBP genes, mutations have been made that affect LTBP function, or point mutations in LAP have been generated that will block binding to LTBP. These mutations have revealed several interesting phenotypes in bone, lung, and fat differentiation are informative with respect to aspects of TGF-ß biology.

Third, we are interested in the role of the LTBPs during early development. We have found that these proteins may participate in patterning of the dorsal ventral axes in early embryos. We think that this occurs via interactions with the TGF-ß superfamily members activin and nodal. We are interested in understanding the developmental consequences of these interactions as well as the biochemical parameters that control them.

Research Interests

Extracellular Control of Growth Factor Action<br>

Research Keywords

cell signaling, extracellular matrix, growth factors, metastasis, proteases, development<br><br>

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search [8]

GPR15-Mediated Homing Controls Immune Homeostasis in the Large Intestine Mucosa
Kim, Sangwon V; Xiang, Wenkai V; Kwak, Changsoo; Yang, Yi; Lin, Xiyao W; Ota, Mitsuhiko; Sarpel, Umut; Rifkin, Daniel B; Xu, Ruliang; Littman, Dan R
2013 May;:?-?, Science
— id: 357322, year: 2013, vol: , page: ?, stat: Journal Article,

Latent TGF-beta binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5
Noda, Kazuo; Dabovic, Branka; Takagi, Kyoko; Inoue, Tadashi; Horiguchi, Masahito; Hirai, Maretoshi; Fujikawa, Yusuke; Akama, Tomoya O; Kusumoto, Kenji; Zilberberg, Lior; Sakai, Lynn Y; Koli, Katri; Naitoh, Motoko; von Melchner, Harald; Suzuki, Shigehiko; Rifkin, Daniel B; Nakamura, Tomoyuki
2013 Feb;110(8):2852-2857, Proceedings of the National Academy of Sciences of the United States of America
— id: 249442, year: 2013, vol: 110, page: 2852, stat: Journal Article,

Production of Gastrointestinal Tumors in Mice by Modulating Latent TGF-beta1 Activation
Shibahara, Kotaro; Ota, Mitsuhiko; Horiguchi, Masahito; Yoshinaga, Keiji; Melamed, Jonathan; Rifkin, Daniel B
2013 Jan;73(1):459-468, Cancer research
— id: 211062, year: 2013, vol: 73, page: 459, stat: Journal Article,

F-SPONDIN (SPONDIN-1) NULL MICE EXHIBIT INCREASED BONE FORMATION, DECREASED OSTEOCLAST FUNCTION AND ACCELERATED OSTEOARTHRITIS
Attur, M.; Palmer, C.; Liu, J.; Qing, Y.; Rifkin, D.; Bryce, D.; Beier, F.; Abramson, S. B.
2012 APR;20 1 1:S59-S59, Osteoarthritis & cartilage
— id: 166902, year: 2012, vol: 20 1 1, page: S59, stat: Journal Article,

Matrix control of transforming growth factor-beta function
Horiguchi, Masahito; Ota, Mitsuhiko; Rifkin, Daniel B
2012 Oct;152(4):321-329, Journal of biochemistry (Tokyo)
— id: 179083, year: 2012, vol: 152, page: 321, stat: Journal Article,

Is losartan the drug for all seasons?
Ramirez, Francesco; Rifkin, Daniel B
2012 Apr;12(2):223-224, Current opinion in pharmacology
— id: 169635, year: 2012, vol: 12, page: 223, stat: Journal Article,

Thrombospondin-1 (TSP-1) Analogs ABT-510 and ABT-898 Inhibit Prolactinoma Growth and Recover Active Pituitary Transforming Growth Factor-beta1 (TGF-beta1)
Recouvreux, M Victoria; Camilletti, M Andrea; Rifkin, Daniel B; Becu-Villalobos, Damasia; Diaz-Torga, Graciela
2012 Aug;153(8):3861-3871, Endocrinology
— id: 174582, year: 2012, vol: 153, page: 3861, stat: Journal Article,

An Osteoblast-Derived Proteinase Controls Tumor Cell Survival via TGF-beta Activation in the Bone Microenvironment
Thiolloy, Sophie; Edwards, James R; Fingleton, Barbara; Rifkin, Daniel B; Matrisian, Lynn M; Lynch, Conor C
2012 ;7(1):e29862-e29862, PLoS ONE
— id: 149981, year: 2012, vol: 7, page: e29862, stat: Journal Article,

LTBPs, more than just an escort service
Todorovic, Vesna; Rifkin, Daniel B
2012 Feb;113(2):410-418, Journal of cellular biochemistry
— id: 149808, year: 2012, vol: 113, page: 410, stat: Journal Article,

Specificity of latent TGF-beta binding protein (LTBP) incorporation into matrix: Role of fibrillins and fibronectin
Zilberberg, Lior; Todorovic, Vesna; Dabovic, Branka; Horiguchi, Masahito; Courousse, Thomas; Sakai, Lynn Y; Rifkin, Daniel B
2012 Dec;227(12):3828-3836, Journal of cellular physiology
— id: 177016, year: 2012, vol: 227, page: 3828, stat: Journal Article,

F-spondin (spondin-1) null mice exhibit increased bone formation
Attur, M; Palmer, G; Liu, J; Qing, Y; Rifkin, D; Beier, F; Abramson, S B
2011 October 2011;63(10):-, Arthritis & rheumatism
— id: 170463, year: 2011, vol: 63, page: , stat: Journal Article,

Binding of Anti-SSA Antibodies to Apoptotic Fetal Cardiocytes Stimulates Urokinase Plasminogen Activator (uPA)/uPA Receptor-Dependent Activation of TGF-beta and Potentiates Fibrosis
Briassouli, Paraskevi; Rifkin, Daniel; Clancy, Robert M; Buyon, Jill P
2011 Nov 15;187(10):5392-5401, Journal of immunology
— id: 140530, year: 2011, vol: 187, page: 5392, stat: Journal Article,

Control of lung development by latent TGF-beta binding proteins
Dabovic, Branka; Chen, Yan; Choi, Jiwon; Davis, Elaine C; Sakai, Lynn Y; Todorovic, Vesna; Vassallo, Melinda; Zilberberg, Lior; Singh, Amanjot; Rifkin, Daniel B
2011 Jun;226(6):1499-1509, Journal of cellular physiology
— id: 138140, year: 2011, vol: 226, page: 1499, stat: Journal Article,

Development of a novel multiplexed-TGFbeta assay
Hardee M.E.; Marciscano A.E.; Rifkin D.B.; Barcellos-Hoff M.
2011 ;81(2 SUPPL 1):S755-S755, International journal of radiation oncology biology physics
— id: 150889, year: 2011, vol: 81, page: S755, stat: Journal Article,

Active and total transforming growth factor-{beta}1 are differentially regulated by dopamine and estradiol in the pituitary
Recouvreux, M Victoria; Guida, M Clara; Rifkin, Daniel B; Becu-Villalobos, Damasia; Diaz-Torga, Graciela
2011 Jul;152(7):2722-2730, Endocrinology
— id: 136472, year: 2011, vol: 152, page: 2722, stat: Journal Article,

Long form of latent TGF-beta binding protein 1 (Ltbp1L) regulates cardiac valve development
Todorovic, Vesna; Finnegan, Erin; Freyer, Laina; Zilberberg, Lior; Ota, Mitsuhiko; Rifkin, Daniel B
2011 Jan;240(1):176-187, Developmental dynamics
— id: 116226, year: 2011, vol: 240, page: 176, stat: Journal Article,

Binding of apoptotic fetal cardiocytes by anti-Ro/La antibodies stimulates uPA/uPAR-dependent activation of TGFbeta and potentiates fibrosis
Briassouli P.; Rifkin D.; Buyon J.P.; Clancy R.M.
2010 ;62:489-489, Arthritis & rheumatism
— id: 130926, year: 2010, vol: 62, page: 489, stat: Journal Article,

Microfibril structure masks fibrillin-2 in postnatal tissues
Charbonneau, Noe L; Jordan, C Diana; Keene, Douglas R; Lee-Arteaga, Sui; Dietz, Harry C; Rifkin, Daniel B; Ramirez, Francesco; Sakai, Lynn Y
2010 Jun;285(26):20242-20251, Journal of biological chemistry
— id: 163510, year: 2010, vol: 285, page: 20242, stat: Journal Article,

Differential effects of alendronate and losartan therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome
Nistala, Harikiran; Lee-Arteaga, Sui; Carta, Luca; Cook, Jason R; Smaldone, Silvia; Siciliano, Gabriella; Rifkin, Aaron N; Dietz, Harry C; Rifkin, Daniel B; Ramirez, Francesco
2010 Dec 15;19(24):4790-4798, Human molecular genetics
— id: 140040, year: 2010, vol: 19, page: 4790, stat: Journal Article,

Bone matrix to growth factors: location, location, location
Rifkin, Daniel B; Todorovic, Vesna
2010 Sep 20;190(6):949-951, Journal of cell biology
— id: 112559, year: 2010, vol: 190, page: 949, stat: Journal Article,

E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta
Yang, Tao; Mendoza-Londono, Roberto; Lu, Huifang; Tao, Jianning; Li, Kaiyi; Keller, Bettina; Jiang, Ming Ming; Shah, Rina; Chen, Yuqing; Bertin, Terry K; Engin, Feyza; Dabovic, Branka; Rifkin, Daniel B; Hicks, John; Jamrich, Milan; Beaudet, Arthur L; Lee, Brendan
2010 Jul 1;120(7):2474-2485, Journal of clinical investigation
— id: 146002, year: 2010, vol: 120, page: 2474, stat: Journal Article,

F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-beta activation
Attur, Mukundan G; Palmer, Glyn D; Al-Mussawir, Hayf E; Dave, Mandar; Teixeira, Cristina C; Rifkin, Daniel B; Appleton, C Thomas G; Beier, Frank; Abramson, Steven B
2009 Jan;23(1):79-89, FASEB journal
— id: 156956, year: 2009, vol: 23, page: 79, stat: Journal Article,

p38 MAPK is an early determinant of promiscuous Smad2/3 signaling in the aortas of fibrillin-1 (Fbn1)-null mice
Carta, Luca; Smaldone, Silvia; Zilberberg, Lior; Loch, David; Dietz, Harry C; Rifkin, Daniel B; Ramirez, Francesco
2009 Feb 27;284(9):5630-5636, Journal of biological chemistry
— id: 135228, year: 2009, vol: 284, page: 5630, stat: Journal Article,

Dual functions for LTBP in lung development: LTBP-4 independently modulates elastogenesis and TGF-beta activity
Dabovic, Branka; Chen, Yan; Choi, Jiwon; Vassallo, Melinda; Dietz, Harry C; Ramirez, Francesco; von Melchner, Harald; Davis, Elaine C; Rifkin, Daniel B
2009 Apr;219(1):14-22, Journal of cellular physiology
— id: 92147, year: 2009, vol: 219, page: 14, stat: Journal Article,

Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites
Ono, Robert N; Sengle, Gerhard; Charbonneau, Noe L; Carlberg, Valerie; Bachinger, Hans Peter; Sasaki, Takako; Lee-Arteaga, Sui; Zilberberg, Lior; Rifkin, Daniel B; Ramirez, Francesco; Chu, Mon-Li; Sakai, Lynn Y
2009 Jun;284(25):16872-16881, Journal of biological chemistry
— id: 163506, year: 2009, vol: 284, page: 16872, stat: Journal Article,

Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling
Ramirez, Francesco; Rifkin, Daniel B
2009 Oct;21(5):616-622, Current opinion in cell biology
— id: 133719, year: 2009, vol: 21, page: 616, stat: Journal Article,

Mutations in LTBP4 cause a syndrome of impaired pulmonary, gastrointestinal, genitourinary, musculoskeletal, and dermal development
Urban, Zsolt; Hucthagowder, Vishwanathan; Schurmann, Nura; Todorovic, Vesna; Zilberberg, Lior; Choi, Jiwon; Sens, Carla; Brown, Chester W; Clark, Robin D; Holland, Kristen E; Marble, Michael; Sakai, Lynn Y; Dabovic, Branka; Rifkin, Daniel B; Davis, Elaine C
2009 Nov;85(5):593-605, American journal of human genetics
— id: 120525, year: 2009, vol: 85, page: 593, stat: Journal Article,

Latent transforming growth factor-beta-binding protein-4 regulates transforming growth factor-beta1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin
Zhou, Yong; Koli, Katri; Hagood, James S; Miao, Mi; Mavalli, Mahendra; Rifkin, Daniel B; Murphy-Ullrich, Joanne E
2009 Jan;174(1):21-33, American journal of pathology
— id: 135218, year: 2009, vol: 174, page: 21, stat: Journal Article,

In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta 1
Ahamed, J; Burg, N; Yoshinaga, K; Janczak, CA; Rifkin, DB; Coller, BS
2008 NOV 1 ;112(9):3650-3660, Blood
— id: 90068, year: 2008, vol: 112, page: 3650, stat: Journal Article,

F-spondin, a neuroregulatory protein, is upregulated in human and surgically-induced osteoarthritis: Evidence for regulation of cartilage metabolism via latent tgf-b1 activation
Attur, M; Palmer, G; Al-Mussawir, HE; Rifkin, DB; Teixeira, CC; Appleton, CTG; Beier, F; Abramson, SB
2008 SEP ;58(9):S895-S895, Arthritis & rheumatism
— id: 88578, year: 2008, vol: 58, page: S895, stat: Journal Article,

Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
Ivanov, Ivaylo I; Frutos, Rosa de Llanos; Manel, Nicolas; Yoshinaga, Keiji; Rifkin, Daniel B; Sartor, R Balfour; Finlay, B Brett; Littman, Dan R
2008 Oct 16;4(4):337-349, Cell Host & Microbe
— id: 93379, year: 2008, vol: 4, page: 337, stat: Journal Article,

Report of the National Heart, Lung, and Blood Institute and National Marfan Foundation working group on research in Marfan syndrome and related disorders
Pearson, GD; Devereux, R; Loeys, B; Maslen, C; Milewicz, D; Pyeritz, R; Ramirez, F; Rifkin, D; Sakai, L; Svensson, L; Wessels, A; Van Eyk, J; Dietz, HC
2008 AUG 12 ;118(7):785-791, Circulation
— id: 86820, year: 2008, vol: 118, page: 785, stat: Journal Article,

Perturbation of transforming growth factor (TGF)-beta1 association with latent TGF-beta binding protein yields inflammation and tumors
Yoshinaga, Keiji; Obata, Hiroto; Jurukovski, Vladimir; Mazzieri, Roberta; Chen, Yan; Zilberberg, Lior; Huso, David; Melamed, Jonathan; Prijatelj, Petra; Todorovic, Vesna; Dabovic, Branka; Rifkin, Daniel B
2008 Dec 2;105(48):18758-18763, Proceedings of the National Academy of Sciences of the United States of America
— id: 92146, year: 2008, vol: 105, page: 18758, stat: Journal Article,

Extracellular microfibrils in development and disease
Ramirez, F; Sakai, LY; Rifkin, DB; Dietz, HC
2007 SEP ;64(18):2437-2446, Cellular & molecular life sciences: CMLS
— id: 74193, year: 2007, vol: 64, page: 2437, stat: Journal Article,

Long form of latent TGF-{beta} binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling
Todorovic, Vesna; Frendewey, David; Gutstein, David E; Chen, Yan; Freyer, Laina; Finnegan, Erin; Liu, Fangyu; Murphy, Andrew; Valenzuela, David; Yancopoulos, George; Rifkin, Daniel B
2007 Oct;134(20):3723-3732, Development
— id: 74213, year: 2007, vol: 134, page: 3723, stat: Journal Article,

Myofibroblast contraction activates latent TGF-beta 1 from the extracellular matrix
Wipff, PJ; Rifkin, DB; Meister, JJ; Hinz, B
2007 DEC 17 ;179(6):1311-1323, Journal of cell biology
— id: 75633, year: 2007, vol: 179, page: 1311, stat: Journal Article,

E-Selectin Ligand 1 negatively regulates TGF beta in the Golgi during skeletogenesis
Yang, T; Mendoza-Londono, R; Lu, H; Li, K; Keller, B; Jiang, M; Chen, Y; Bertin, T; Dabovic, B; Rifkin, DB; Hick, J; Beaudet, AL; Lee, B
2007 SEP ;22(1):S105-S105, Journal of bone & mineral research
— id: 75797, year: 2007, vol: 22, page: S105, stat: Journal Article,

A rapid and sensitive bioassay to measure bone morphogenetic protein activity
Zilberberg, Lior; ten Dijke, Peter; Sakai, Lynn Y; Rifkin, Daniel B
2007 ;8:41-41, BMC Cell Biology
— id: 75377, year: 2007, vol: 8, page: 41, stat: Journal Article,

Phenotype of mice that cannot form TGF beta 1 large latent complex
Dabovic, B; Jurukovski, V; Obata, H; Chen, Y; Zilberberg, L; Mazzieri, R; Yoshinaga, K; Rifkin, D
2006 NOV ;25(2):S87-S87, Matrix biology
— id: 70621, year: 2006, vol: 25, page: S87, stat: Journal Article,

Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
Habashi, Jennifer P; Judge, Daniel P; Holm, Tammy M; Cohn, Ronald D; Loeys, Bart L; Cooper, Timothy K; Myers, Loretha; Klein, Erin C; Liu, Guosheng; Calvi, Carla; Podowski, Megan; Neptune, Enid R; Halushka, Marc K; Bedja, Djahida; Gabrielson, Kathleen; Rifkin, Daniel B; Carta, Luca; Ramirez, Francesco; Huso, David L; Dietz, Harry C
2006 Apr;312(5770):117-121, Science
— id: 163436, year: 2006, vol: 312, page: 117, stat: Journal Article,

Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species
Jobling, Michael F; Mott, Joni D; Finnegan, Monica T; Jurukovski, Vladimir; Erickson, Anna C; Walian, Peter J; Taylor, Scott E; Ledbetter, Steven; Lawrence, Catherine M; Rifkin, Daniel B; Barcellos-Hoff, Mary Helen
2006 Dec;166(6):839-848, Radiation research
— id: 83229, year: 2006, vol: 166, page: 839, stat: Journal Article,

Cardiac outflow tract defects in mice lacking LTBP-1L
Todorovic, V; Freyer, L; Gutstein, D; Frendewey, D; Rifkin, D
2006 NOV ;25(2):S26-S26, Matrix biology
— id: 70620, year: 2006, vol: 25, page: S26, stat: Journal Article,

Amino acid requirements for formation of the TGF-beta-latent TGF-beta binding protein complexes
Chen, Yan; Ali, Tariq; Todorovic, Vesna; O'leary, Joanne M; Kristina Downing, A; Rifkin, Daniel B
2005 Jan 7;345(1):175-186, Journal of molecular biology
— id: 48106, year: 2005, vol: 345, page: 175, stat: Journal Article,

Lung alveolar septation defects in Ltbp-3-null mice
Colarossi, Cristina; Chen, Yan; Obata, Hiroto; Jurukovski, Vladimir; Fontana, Laura; Dabovic, Branka; Rifkin, Daniel B
2005 Aug;167(2):419-428, American journal of pathology
— id: 58066, year: 2005, vol: 167, page: 419, stat: Journal Article,

Osteopetrosis-like phenotype in latent TGF-beta binding protein 3 deficient mice
Dabovic, B; Levasseur, R; Zambuto, L; Chen, Y; Karsenty, G; Rifkin, D B
2005 Jul;37(1):25-31, Bone
— id: 146003, year: 2005, vol: 37, page: 25, stat: Journal Article,

Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1
Fontana, Laura; Chen, Yan; Prijatelj, Petra; Sakai, Takao; Fassler, Reinhard; Sakai, Lynn Y; Rifkin, Daniel B
2005 Nov;19(13):1798-1808, FASEB journal
— id: 62742, year: 2005, vol: 19, page: 1798, stat: Journal Article,

Methods for measuring TGF-b using antibodies, cells, and mice
Jurukovski, Vladimir; Dabovic, Branka; Todorovic, Vesna; Chen, Yan; Rifkin, Daniel B
2005 ;117:161-175, Methods in molecular medicine
— id: 67921, year: 2005, vol: 117, page: 161, stat: Journal Article,

A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2
Loeys, BL; Chen, JJ; Neptune, ER; Judge, DP; Podowski, M; Holm, T; Meyers, J; Leitch, CC; Katsanis, N; Sharifi, N; Xu, FL; Myers, LA; Spevak, PJ; Cameron, DE; De Backer, J; Hellemans, J; Chen, Y; Davis, EC; Webb, CL; Kress, W; Coucke, P; Rifkin, DB; De Paepe, AM; Dietz, HC
2005 MAR ;37(3):275-281, Nature genetics
— id: 48922, year: 2005, vol: 37, page: 275, stat: Journal Article,

Expression of truncated latent TGF-beta-binding protein modulates TGF-beta signaling
Mazzieri, Roberta; Jurukovski, Vladimir; Obata, Hiroto; Sung, Joanne; Platt, Alec; Annes, Eric; Karaman-Jurukovska, Nevena; Gleizes, Pierre-Emmanuel; Rifkin, Daniel B
2005 May 15;118(Pt 10):2177-2187, Journal of cell science
— id: 56144, year: 2005, vol: 118, page: 2177, stat: Journal Article,

Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability
Rifkin, Daniel B
2005 Mar 4;280(9):7409-7412, Journal of biological chemistry
— id: 50631, year: 2005, vol: 280, page: 7409, stat: Journal Article,

Latent TGF-beta binding proteins
Todorovic, V; Jurukovski, V; Chen, Y; Fontana, L; Dabovic, B; Rifkin, D B
2005 Jan;37(1):38-41, International journal of biochemistry & cell biology
— id: 48101, year: 2005, vol: 37, page: 38, stat: Journal Article,

Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1
Annes, Justin P; Chen, Yan; Munger, John S; Rifkin, Daniel B
2004 Jun 7;165(5):723-734, Journal of cell biology
— id: 44942, year: 2004, vol: 165, page: 723, stat: Journal Article,

A genetic screen to identify latent transforming growth factor beta activators
Annes, Justin; Vassallo, Melinda; Munger, John S; Rifkin, Daniel B
2004 Apr 1;327(1):45-54, Analytical biochemistry
— id: 42347, year: 2004, vol: 327, page: 45, stat: Journal Article,

Annexin II-mediated plasmin generation activates TGF-beta3 during epithelial-mesenchymal transformation in the developing avian heart
Krishnan, Suba; Deora, Arunkumar B; Annes, Justin P; Osoria, Jerelyn; Rifkin, Daniel B; Hajjar, Katherine A
2004 Jan 1;265(1):140-154, Developmental biology (Orlando)
— id: 42348, year: 2004, vol: 265, page: 140, stat: Journal Article,

Fibrillin microfibrils: multipurpose extracellular networks in organismal physiology
Ramirez, F; Sakai, LY; Dietz, HC; Rifkin, DB
2004 OCT 4 ;19(2):151-154, Physiological genomics
— id: 46487, year: 2004, vol: 19, page: 151, stat: Journal Article,

Making sense of latent TGFbeta activation
Annes, Justin P; Munger, John S; Rifkin, Daniel B
2003 Jan 15;116(Pt 2):217-224, Journal of cell science
— id: 35175, year: 2003, vol: 116, page: 217, stat: Journal Article,

Growth retardation as well as spleen and thymus involution in latent TGF-beta binding protein (Ltbp)-3 null mice
Chen, Yan; Dabovic, Branka; Colarossi, Cristina; Santori, Fabio R; Lilic, Mirjana; Vukmanovic, Stanislav; Rifkin, Daniel B
2003 Aug;196(2):319-325, Journal of cellular physiology
— id: 39195, year: 2003, vol: 196, page: 319, stat: Journal Article,

Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein
Isogai, Zenzo; Ono, Robert N; Ushiro, Shin; Keene, Douglas R; Chen, Yan; Mazzieri, Roberta; Charbonneau, Noe L; Reinhardt, Dieter P; Rifkin, Daniel B; Sakai, Lynn Y
2003 Jan 24;278(4):2750-2757, Journal of biological chemistry
— id: 42351, year: 2003, vol: 278, page: 2750, stat: Journal Article,

Solution structure of the third TB domain from LTBP1 provides insight into assembly of the large latent complex that sequesters latent TGF-beta
Lack, Jeremy; O'Leary, Joanne M; Knott, Vroni; Yuan, Xuemei; Rifkin, Daniel B; Handford, Penny A; Downing, A Kristina
2003 Nov 21;334(2):281-291, Journal of molecular biology
— id: 42349, year: 2003, vol: 334, page: 281, stat: Journal Article,

Molecular cloning of the mouse Ltbp-1 gene reveals tissue specific expression of alternatively spliced forms
Noguera, Irene; Obata, Hiroto; Gualandris, Anna; Cowin, Pamela; Rifkin, Daniel B
2003 Apr 10;308(5642):31-41, Gene
— id: 38125, year: 2003, vol: 308, page: 31, stat: Journal Article,

Cell signaling events: a view from the matrix
Ramirez, Francesco; Rifkin, Daniel B
2003 Apr;22(2):101-107, Matrix biology
— id: 42350, year: 2003, vol: 22, page: 101, stat: Journal Article,

The latent-TGFbeta-binding-protein-1 (LTBP-1) is expressed in the organizer and regulates nodal and activin signaling
Altmann, Curtis R; Chang, Chenbei; Munoz-Sanjuan, Ignacio; Bell, Esther; Heke, Michael; Rifkin, Daniel B; Brivanlou, Ali H
2002 Aug 1;248(1):118-127, Developmental biology (Orlando)
— id: 42353, year: 2002, vol: 248, page: 118, stat: Journal Article,

The integrin alphaVbeta6 binds and activates latent TGFbeta3
Annes, Justin P; Rifkin, Daniel B; Munger, John S
2002 Jan 30;511(1-3):65-68, FEBS letters
— id: 28180, year: 2002, vol: 511, page: 65, stat: Journal Article,

Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion
Chen, Yan; Dabovic, Branka; Annes, Justin P; Rifkin, Daniel B
2002 Apr 24;517(1-3):277-280, FEBS letters
— id: 39630, year: 2002, vol: 517, page: 277, stat: Journal Article,

Bone defects in latent TGF-beta binding protein (Ltbp)-3 null mice; a role for Ltbp in TGF-beta presentation
Dabovic, B; Chen, Y; Colarossi, C; Zambuto, L; Obata, H; Rifkin, D B
2002 Oct;175(1):129-141, Journal of endocrinology
— id: 39576, year: 2002, vol: 175, page: 129, stat: Journal Article,

Bone abnormalities in latent TGF-[beta] binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-[beta] bioavailability
Dabovic, Branka; Chen, Yan; Colarossi, Cristina; Obata, Hiroto; Zambuto, Laura; Perle, Mary Ann; Rifkin, Daniel B
2002 Jan 21;156(2):227-232, Journal of cell biology
— id: 27277, year: 2002, vol: 156, page: 227, stat: Journal Article,

Overexpression of the 18 kDa and 22/24 kDa FGF-2 isoforms results in differential drug resistance and amplification potential
Dini, Germana; Funghini, Silvia; Witort, Ewa; Magnelli, Lucia; Fanti, Elena; Rifkin, Daniel B; Del Rosso, Mario
2002 Oct;193(1):64-72, Journal of cellular physiology
— id: 42352, year: 2002, vol: 193, page: 64, stat: Journal Article,

Tamoxifen and Estrogen Effects on TGF-beta Formation: Role of Thrombospondin-1, alphavbeta3, and Integrin-Associated Protein
Harpel JG; Schultz-Cherry S; Murphy-Ullrich JE; Rifkin DB
2001 Jun 1;284(1):11-14, Biochemical & biophysical research communications
— id: 20644, year: 2001, vol: 284, page: 11, stat: Journal Article,

Fibroblast growth factors
Moscatelli D; Rifkin DB
Tumor angiogenesis and microcirculation New York : Dekker, 2001,
— id: 2767, year: 2001, vol: , page: 227, stat: Chapter,

TGF-beta activation; normal and pathological consequence
Rifkin, DB
2001 Dec;41(6):1568-1568, American zoologist
— id: 27511, year: 2001, vol: 41, page: 1568, stat: Journal Article,

Evidence that the integrin alpha(v)beta(6) activates TGF-beta 3
Annes, JP; Rifkin, DB; Munger, JS
2000 DEC ;11(2):263A-264A, Molecular biology of the cell
— id: 55207, year: 2000, vol: 11, page: 263A, stat: Journal Article,

The latent transforming growth factor-beta-binding protein-1 promotes in vitro differentiation of embryonic stem cells into endothelium
Gualandris A; Annes JP; Arese M; Noguera I; Jurukovski V; Rifkin DB
2000 Dec;11(12):4295-4308, Molecular biology of the cell
— id: 39508, year: 2000, vol: 11, page: 4295, stat: Journal Article,

Biochemical analysis of the arginine methylation of high molecular weight fibroblast growth factor-2
Klein S; Carroll JA; Chen Y; Henry MF; Henry PA; Ortonowski IE; Pintucci G; Beavis RC; Burgess WH; Rifkin DB
2000 Feb 4;275(5):3150-3157, Journal of biological chemistry
— id: 8561, year: 2000, vol: 275, page: 3150, stat: Journal Article,

Measurement of active TGF-beta generated by cultured cells
Mazzieri R; Munger JS; Rifkin DB
2000 ;142:13-27, Methods in molecular biology
— id: 11706, year: 2000, vol: 142, page: 13, stat: Journal Article,

Blocking LTBP-mediated matrix incorporation in vivo results in increased TGF-beta activation in mouse epidermis and hair follicles
Mazzieri, R; Obata, H; Sung, JJ; Gleizes, PE; Platt, AB; Dabovic, B; Rifkin, DB
2000 DEC ;11(2):28A-28A, Molecular biology of the cell
— id: 55206, year: 2000, vol: 11, page: 28A, stat: Journal Article,

Nonenzymatic interactions between proteinases and the cell surface: novel roles in normal and malignant cell physiology
Mignatti P; Rifkin DB
2000 ;78(1):103-157, Advances in cancer research
— id: 27868, year: 2000, vol: 78, page: 103, stat: Journal Article,

LTBP-1 is an organizer gene which acts as an activin agonist in mesoderm induction and axis formation
Quarto, N; Rifkin, DB; Hemmati-Brivanlou, A
2000 DEC ;11(2):275A-275A, Molecular biology of the cell
— id: 55208, year: 2000, vol: 11, page: 275A, stat: Journal Article,

Hybrid and complex glycans are linked to the conserved N-glycosylation site of the third eight-cysteine domain of LTBP-1 in insect cells
Rudd PM; Downing AK; Cadene M; Harvey DJ; Wormald MR; Weir I; Dwek RA; Rifkin DB; Gleizes PE
2000 Feb 22;39(7):1596-1603, Biochemistry
— id: 57557, year: 2000, vol: 39, page: 1596, stat: Journal Article,

Nuclear activities of basic fibroblast growth factor: potentiation of low-serum growth mediated by natural or chimeric nuclear localization signals
Arese M; Chen Y; Florkiewicz RZ; Gualandris A; Shen B; Rifkin DB
1999 May;10(5):1429-1444, Molecular biology of the cell
— id: 6112, year: 1999, vol: 10, page: 1429, stat: Journal Article,

Melanoma growth in wild-type, urokinase-type plasminogen activator knockout and tissue-type plasminogen activator knockout mice
Chuang N; Shamamian P; Roses DF; Rifkin DB; Shapiro RL
1999 ;60:367-368, Surgical forum
— id: 25206, year: 1999, vol: 60, page: 367, stat: Journal Article,

[Activation of latent TGF-beta. A required mechanism for vascular integrity]
Gleizes PE; Rifkin DB
1999 Apr;47(4):322-329, Pathologie biologie
— id: 42355, year: 1999, vol: 47, page: 322, stat: Journal Article,

Modulation of cell growth and transformation by doxycycline-regulated FGF-2 expression in NIH-3T3 cells
Gualandris A; Arese M; Shen B; Rifkin DB
1999 Nov;181(2):273-284, Journal of cellular physiology
— id: 6212, year: 1999, vol: 181, page: 273, stat: Journal Article,

Diltiazem reduces retinal neovascularization in a mouse model of oxygen induced retinopathy
Higgins RD; Yu K; Sanders RJ; Nandgaonkar BN; Rotschild T; Rifkin DB
1999 Jan;18(1):20-27, Current eye research
— id: 7345, year: 1999, vol: 18, page: 20, stat: Journal Article,

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
Munger JS; Huang X; Kawakatsu H; Griffiths MJ; Dalton SL; Wu J; Pittet JF; Kaminski N; Garat C; Matthay MA; Rifkin DB; Sheppard D
1999 Feb 5;96(3):319-328, Cell
— id: 7411, year: 1999, vol: 96, page: 319, stat: Journal Article,

Proteolytic control of growth factor availability
Rifkin DB; Mazzieri R; Munger JS; Noguera I; Sung J
1999 Jan;107(1):80-85, Apmis
— id: 6074, year: 1999, vol: 107, page: 80, stat: Journal Article,

Cellular glycosylphosphatidylinositol-specific phospholipase D regulates urokinase receptor shedding and cell surface expression
Wilhelm OG; Wilhelm S; Escott GM; Lutz V; Magdolen V; Schmitt M; Rifkin DB; Wilson EL; Graeff H; Brunner G
1999 Aug;180(2):225-235, Journal of cellular physiology
— id: 35194, year: 1999, vol: 180, page: 225, stat: Journal Article,

Inhibition of angiogenesis and matrix metalloproteinase-2 activity by dexrazoxane (zinecard) may mediate its antitumor effects
Chuang JN; Ren CJ; Mendoza S; Shamamian P; Roses DF; Rifkin DB; Chachoua A; Shapiro RL
1998 ;49:424-426, Surgical forum
— id: 25210, year: 1998, vol: 49, page: 424, stat: Journal Article,

Hyperoxia stimulates endothelin-1 secretion from endothelial cells; modulation by captopril and nifedipine
Higgins RD; Hendricks-Munoz KD; Caines VV; Gerrets RP; Rifkin DB
1998 May;17(5):487-493, Current eye research
— id: 42356, year: 1998, vol: 17, page: 487, stat: Journal Article,

Transforming growth factor-beta 1 latency associated peptide binds to and signals through the integrin alpha v beta 6
Kawakatsu, H; Munger, JS; Rifkin, DB; Sheppard, D
1998 NOV ;9(11):297A-297A, Molecular biology of the cell
— id: 53646, year: 1998, vol: 9, page: 297A, stat: Journal Article,

Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1
Munger JS; Harpel JG; Giancotti FG; Rifkin DB
1998 Sep;9(9):2627-2638, Molecular biology of the cell
— id: 12078, year: 1998, vol: 9, page: 2627, stat: Journal Article,

Cells expressing the integrin alpha v beta g can activate latent TGF-beta
Munger, JS; Kawakatsu, H; Dalton, S; Rifkin, DB; Sheppard, D
1998 NOV ;9(11):417A-417A, Molecular biology of the cell
— id: 53648, year: 1998, vol: 9, page: 417A, stat: Journal Article,

Structure and activation of the large latent transforming growth factor-Beta complex
Nunes I; Munger J; Harpel JG; Nagano Y; Shapiro R; Gleizes PE; Rifkin DB
1998 Oct;69(10):643-648, Journal of the American Optometric Association
— id: 6041, year: 1998, vol: 69, page: 643, stat: Journal Article,

Irsogladine maleate inhibits angiogenesis in wild-type and plasminogen activator-deficient mice
Ren CJ; Ueda F; Roses DF; Harris MN; Mignatti P; Rifkin DB; Shapiro RL
1998 Jul 1;77(2):126-131, Journal of surgical research
— id: 12076, year: 1998, vol: 77, page: 126, stat: Journal Article,

Activation of latent TGF-beta: Participation of proteases
Rifkin, DB; Munger, J; Mazzieri, R; Sung, J; Harpel, JG
1998 NOV ;9(11):6A-6A, Molecular biology of the cell
— id: 53639, year: 1998, vol: 9, page: 6A, stat: Journal Article,

Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis
Seghezzi G; Patel S; Ren CJ; Gualandris A; Pintucci G; Robbins ES; Shapiro RL; Galloway AC; Rifkin DB; Mignatti P
1998 Jun 29;141(7):1659-1673, Journal of cell biology
— id: 7787, year: 1998, vol: 141, page: 1659, stat: Journal Article,

Intracellular association of FGF-2 with the ribosomal protein L6/TAXREB107
Shen B; Arese M; Gualandris A; Rifkin DB
1998 Nov 18;252(2):524-528, Biochemical & biophysical research communications
— id: 7791, year: 1998, vol: 252, page: 524, stat: Journal Article,

Biological roles of fibroblast growth factor-2
Bikfalvi A; Klein S; Pintucci G; Rifkin DB
1997 Feb;18(1):26-45, Endocrine reviews
— id: 9010, year: 1997, vol: 18, page: 26, stat: Journal Article,

TGF-beta latency: biological significance and mechanisms of activation
Gleizes PE; Munger JS; Nunes I; Harpel JG; Mazzieri R; Noguera I; Rifkin DB
1997 ;15(3):190-197, Stem cells
— id: 7154, year: 1997, vol: 15, page: 190, stat: Journal Article,

Fibroblast growth factors as angiogenesis factors: new insights into their mechanism of action
Klein S; Roghani M; Rifkin DB
1997 ;79:159-192, Experientia. Supplementum
— id: 12428, year: 1997, vol: 79, page: 159, stat: Journal Article,

Latent transforming growth factor-beta: structural features and mechanisms of activation
Munger JS; Harpel JG; Gleizes PE; Mazzieri R; Nunes I; Rifkin DB
1997 May;51(5):1376-1382, Kidney international
— id: 35177, year: 1997, vol: 51, page: 1376, stat: Journal Article,

Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta
Nunes I; Gleizes PE; Metz CN; Rifkin DB
1997 Mar 10;136(5):1151-1163, Journal of cell biology
— id: 12354, year: 1997, vol: 136, page: 1151, stat: Journal Article,

Plasminogen/plasminogen activator and growth factor activation
Rifkin DB; Gleizes PE; Harpel J; Nunes I; Munger J; Mazzieri R; Noguera I
1997 ;212:105-15; discussion 116, CIBA Foundation symposium
— id: 12147, year: 1997, vol: 212, page: 105, stat: Journal Article,

Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: An autocrine mechanism of angiogenesis
Seghezzi, G; Patel, S; Ren, CJ; Pintucci, G; Gualandris, A; Robbins, E; Shapiro, RL; Galloway, AC; Rifkin, DB; Mignatti, P
1997 NOV ;8(5):1335-1335, Molecular biology of the cell
— id: 53166, year: 1997, vol: 8, page: 1335, stat: Journal Article,

Urokinase-type plasminogen activator-deficient mice are predisposed to staphylococcal botryomycosis, pleuritis, and effacement of lymphoid follicles
Shapiro RL; Duquette JG; Nunes I; Roses DF; Harris MN; Wilson EL; Rifkin DB
1997 Jan;150(1):359-369, American journal of pathology
— id: 12426, year: 1997, vol: 150, page: 359, stat: Journal Article,

Inhibition of glycosylphosphatidylinositol (GPI) phospholipase D by suramin-like compounds
Brunner G; Zalkow L; Burgess E; Rifkin DB; Wilson EL; Gruszecka-Kowalik E; Powis G
1996 Sep-Oct;16(5A):2513-2516, Anticancer research
— id: 12546, year: 1996, vol: 16, page: 2513, stat: Journal Article,

FGF suppresses apoptosis and induces differentiation of fiber cells in the mouse lens
Chow, RL; Roux, GD; Roghani, M; Palmer, MA; Rifkin, DB; Moscatelli, DA; Lang, RA
1996 FEB 15 ;37(3):4509-4509, Investigative ophthalmology & visual science. IOVS
— id: 53037, year: 1996, vol: 37, page: 4509, stat: Journal Article,

The regulation of TGF-beta activity by hematopoietic cells
Coetzee, S; Burger, P; Rifkin, D; Wilson, EL
1996 NOV 15 ;88(10):2150-2150, Blood
— id: 52712, year: 1996, vol: 88, page: 2150, stat: Journal Article,

Identification and characterization of an eight-cysteine repeat of the latent transforming growth factor-beta binding protein-1 that mediates bonding to the latent transforming growth factor-beta1
Gleizes PE; Beavis RC; Mazzieri R; Shen B; Rifkin DB
1996 Nov 22;271(47):29891-29896, Journal of biological chemistry
— id: 12468, year: 1996, vol: 271, page: 29891, stat: Journal Article,

Integrin regulation by endogenous expression of 18-kDa fibroblast growth factor-2
Klein S; Bikfalvi A; Birkenmeier TM; Giancotti FG; Rifkin DB
1996 Sep 13;271(37):22583-22590, Journal of biological chemistry
— id: 8012, year: 1996, vol: 271, page: 22583, stat: Journal Article,

Characterization of fibroblast growth factor-2 binding to ribosomes
Klein S; Morimoto T; Rifkin DB
1996 ;13(3-4):219-228, Growth factors
— id: 12671, year: 1996, vol: 13, page: 219, stat: Journal Article,

Characterization of different forms of cell-associated matrix metalloproteinase-9 (MMP-9)
Mazzieri, R; Zanetta, L; Monea, S; Galloway, AC; Rifkin, DB; Mignatti, P
1996 DEC ;7(3):350-350, Molecular biology of the cell
— id: 53347, year: 1996, vol: 7, page: 350, stat: Journal Article,

Plasminogen activators and angiogenesis
Mignatti P; Rifkin DB
1996 4 March;213(Pt.1):33-50, Current topics in microbiology & immunology
— id: 42357, year: 1996, vol: 213, page: 33, stat: Journal Article,

Plasminogen activators and matrix metalloproteinases in angiogenesis
Mignatti P; Rifkin DB
1996 ;49(1-3):117-137, Enzyme & protein
— id: 57369, year: 1996, vol: 49, page: 117, stat: Journal Article,

Latency-associated peptide (LAP), which binds and confers latency upon transforming growth factor-beta (TGF-beta), is a substrate for protein kinase C and thrombin-stimulated platelet kinase(s)
Munger, JS; Harpel, JG; Rom, WN; Rifkin, DB
1996 MAR ;44(3):A231-A231, Journal of investigative medicine
— id: 52943, year: 1996, vol: 44, page: A231, stat: Journal Article,

Effects of endogenously activated transforming growth factor-beta on growth and differentiation of retinoic acid-treated HL-60 cells
Nunes I; Kojima S; Rifkin DB
1996 Feb 1;56(3):495-499, Cancer research
— id: 56835, year: 1996, vol: 56, page: 495, stat: Journal Article,

Structure and activation of the large latent transforming growth factor-beta complex
Nunes I; Munger JS; Harpel JG; Nagano Y; Shapiro RL; Gleizes PE; Rifkin DB
1996 Mar;20 Suppl 3:S4-S8, International journal of obesity & related metabolic disorders
— id: 12639, year: 1996, vol: 20 Suppl 3, page: S4, stat: Journal Article,

Angiogenesis and the fibrinolytic system
Pintucci G; Bikfalvi A; Klein S; Rifkin DB
1996 ;22(6):517-524, Seminars in thrombosis & hemostasis
— id: 9012, year: 1996, vol: 22, page: 517, stat: Journal Article,

Methylation of high molecular weight fibroblast growth factor-2 determines post-translational increases in molecular weight and affects its intracellular distribution
Pintucci G; Quarto N; Rifkin DB
1996 Aug;7(8):1249-1258, Molecular biology of the cell
— id: 9011, year: 1996, vol: 7, page: 1249, stat: Journal Article,

Autocrine regulation of vascular endothelial growth factor (VEGF) expression by fibroblast growth factor-2 (FGF-2)
Seghezzi, G; Patel, S; Pintucci, G; Galloway, A; Rifkin, D; Mignatti, P
1996 DEC ;7(3):2045-2045, Molecular biology of the cell
— id: 53358, year: 1996, vol: 7, page: 2045, stat: Journal Article,

Induction of primary cutaneous melanocytic neoplasms in urokinase-type plasminogen activator (uPA)-deficient and wild-type mice: cellular blue nevi invade but do not progress to malignant melanoma in uPA-deficient animals
Shapiro RL; Duquette JG; Roses DF; Nunes I; Harris MN; Kamino H; Wilson EL; Rifkin DB
1996 Aug 1;56(15):3597-3604, Cancer research
— id: 12575, year: 1996, vol: 56, page: 3597, stat: Journal Article,

Differential modulation of cell phenotype by different molecular weight forms of basic fibroblast growth factor: possible intracellular signaling by the high molecular weight forms
Bikfalvi A; Klein S; Pintucci G; Quarto N; Mignatti P; Rifkin DB
1995 Apr;129(1):233-243, Journal of cell biology
— id: 6578, year: 1995, vol: 129, page: 233, stat: Journal Article,

FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens
Chow RL; Roux GD; Roghani M; Palmer MA; Rifkin DB; Moscatelli DA; Lang RA
1995 Dec;121(12):4383-4393, Development
— id: 6894, year: 1995, vol: 121, page: 4383, stat: Journal Article,

Transforming growth factor-beta 1 regulates axon/Schwann cell interactions
Einheber S; Hannocks MJ; Metz CN; Rifkin DB; Salzer JL
1995 Apr;129(2):443-458, Journal of cell biology
— id: 7896, year: 1995, vol: 129, page: 443, stat: Journal Article,

POTENT 2'-AMINO-2'-DEOXYPYRIMIDINE RNA INHIBITORS OF BASIC FIBROBLAST GROWTH-FACTOR
JELLINEK, D; GREEN, LS; BELL, C; LYNOTT, CK; GILL, N; VARGEESE, C; KIRSCHENHEUTER, G; MCGEE, DPC; ABESINGHE, P; PIEKEN, WA; SHAPIRO, R; RIFKIN, DB; MOSCATELLI, D; JANJIC, N
1995 SEP 12 ;34(36):11363-11372, Biochemistry
— id: 86739, year: 1995, vol: 34, page: 11363, stat: Journal Article,

Lipopolysaccharide inhibits activation of latent transforming growth factor-beta in bovine endothelial cells
Kojima S; Vernooy R; Moscatelli D; Amanuma H; Rifkin DB
1995 Apr;163(1):210-219, Journal of cellular physiology
— id: 6662, year: 1995, vol: 163, page: 210, stat: Journal Article,

Characterization of latent TGF-beta activation by murine peritoneal macrophages
Nunes I; Shapiro RL; Rifkin DB
1995 Aug 1;155(3):1450-1459, Journal of immunology
— id: 6852, year: 1995, vol: 155, page: 1450, stat: Journal Article,

Basic fibroblast growth factor (bFGF) transfected stromal cells promote the growth of Dami leukemic cells
Ogilvie, V; Coetzee, S; Rifkin, D; Quesenberry, P; Wilson, EL
1995 NOV 15 ;86(10):1229-1229, Blood
— id: 53118, year: 1995, vol: 86, page: 1229, stat: Journal Article,

Effects of a single administration of fibroblast growth factor on vascular wall reaction to injury
Parish MA; Grossi EA; Baumann FG; Asai T; Rifkin DB; Colvin SB; Galloway AC
1995 Apr;59(4):948-954, Annals of thoracic surgery
— id: 56694, year: 1995, vol: 59, page: 948, stat: Journal Article,

An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct
Abe M; Harpel JG; Metz CN; Nunes I; Loskutoff DJ; Rifkin DB
1994 Feb 1;216(2):276-284, Analytical biochemistry
— id: 6305, year: 1994, vol: 216, page: 276, stat: Journal Article,

An endogenous glycosylphosphatidylinositol-specific phospholipase D releases basic fibroblast growth factor-heparan sulfate proteoglycan complexes from human bone marrow cultures
Brunner G; Metz CN; Nguyen H; Gabrilove J; Patel SR; Davitz MA; Rifkin DB; Wilson EL
1994 Apr 15;83(8):2115-2125, Blood
— id: 56502, year: 1994, vol: 83, page: 2115, stat: Journal Article,

GROWTH-FACTOR REGULATION OF THE GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)-SPECIFIC PHOSPHOLIPASE-D IN BONE-MARROW STROMAL CELLS
BRUNNER, G; GULATI, M; GABRILOVE, JL; RIFKIN, DB; WILSON, EL
1994 NOV 15 ;84(10):A564-A564, Blood
— id: 52291, year: 1994, vol: 84, page: A564, stat: Journal Article,

BASIC FIBROBLAST GROWTH-FACTOR (BFGF) TRANSFECTED STROMAL CELLS SUPPORT SURVIVAL OF MO7E CELLS
COETZEE, S; OGILVIE, V; BRUNNER, G; QUARTO, N; RIFKIN, D; QUESENBERRY, P; WILSON, EL
1994 NOV 15 ;84(10):A279-A279, Blood
— id: 52284, year: 1994, vol: 84, page: A279, stat: Journal Article,

MODULATION OF THE PRODUCTION AND THE ACTIVATION OF LATENT TGF-BETA BY RETINOID AND LIPOPOLYSACCHARIDE IN BOVINE ENDOTHELIAL-CELLS
KOJIMA, S; RIFKIN, DB
1994 JAN 4 ;269(6):317-317, Journal of cellular biochemistry
— id: 52587, year: 1994, vol: 269, page: 317, stat: Journal Article,

Release of GPI-anchored membrane proteins by a cell-associated GPI-specific phospholipase D
Metz CN; Brunner G; Choi-Miura NH; Nguyen H; Gabrilove J; Caras IW; Altszuler N; Rifkin DB; Wilson EL; Davitz MA
1994 Apr 1;13(7):1741-1751, EMBO journal
— id: 7885, year: 1994, vol: 13, page: 1741, stat: Journal Article,

Mammary artery versus saphenous vein grafts: assessment of basic fibroblast growth factor receptors
Nguyen HC; Grossi EA; LeBoutillier M 3rd; Steinberg BM; Rifkin DB; Baumann FG; Colvin SB; Galloway AC
1994 Aug;58(2):308-10; discussion 310, Annals of thoracic surgery
— id: 12923, year: 1994, vol: 58, page: 308, stat: Journal Article,

Suppression of neointimal lesions after vascular injury: a role for polyclonal anti-basic fibroblast growth factor antibody
Nguyen HC; Steinberg BM; LeBoutillier M 3rd; Baumann FG; Rifkin DB; Grossi EA; Galloway AC
1994 Aug;116(2):456-61; discussion 461, Surgery
— id: 12925, year: 1994, vol: 116, page: 456, stat: Journal Article,

Requirement for receptor-bound urokinase in plasmin-dependent cellular conversion of latent TGF-beta to TGF-beta
Odekon LE; Blasi F; Rifkin DB
1994 Mar;158(3):398-407, Journal of cellular physiology
— id: 6473, year: 1994, vol: 158, page: 398, stat: Journal Article,

Tumor cells secrete an angiogenic factor that stimulates basic fibroblast growth factor and urokinase expression in vascular endothelial cells
Peverali FA; Mandriota SJ; Ciana P; Marelli R; Quax P; Rifkin DB; Della Valle G; Mignatti P
1994 Oct;161(1):1-14, Journal of cellular physiology
— id: 42358, year: 1994, vol: 161, page: 1, stat: Journal Article,

Studies on FGF-2: nuclear localization and function of high molecular weight forms and receptor binding in the absence of heparin
Rifkin DB; Moscatelli D; Roghani M; Nagano Y; Quarto N; Klein S; Bikfalvi A
1994 Sep;39(1):102-4; discussion 104, Molecular reproduction & development
— id: 6730, year: 1994, vol: 39, page: 102, stat: Journal Article,

MECHANISMS AND CONSEQUENCE OF TGF-BETA FORMATION BY VASCULAR CELLS
RIFKIN, DB
1994 JAN 4 ;269(6):307-307, Journal of cellular biochemistry
— id: 52586, year: 1994, vol: 269, page: 307, stat: Journal Article,

Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding
Roghani M; Mansukhani A; Dell'Era P; Bellosta P; Basilico C; Rifkin DB; Moscatelli D
1994 Feb 11;269(6):3976-3984, Journal of biological chemistry
— id: 6499, year: 1994, vol: 269, page: 3976, stat: Journal Article,

Mechanism of action of angiostatic steroids: suppression of plasminogen activator activity via stimulation of plasminogen activator inhibitor synthesis
Blei F; Wilson EL; Mignatti P; Rifkin DB
1993 Jun;155(3):568-578, Journal of cellular physiology
— id: 8234, year: 1993, vol: 155, page: 568, stat: Journal Article,

Basic fibroblast growth factor expression in human bone marrow and peripheral blood cells
Brunner G; Nguyen H; Gabrilove J; Rifkin DB; Wilson EL
1993 Feb 1;81(3):631-638, Blood
— id: 13270, year: 1993, vol: 81, page: 631, stat: Journal Article,

MOBILIZATION OF BFGF-PROTEOGLYCAN COMPLEXES IN HUMAN BONE-MARROW CULTURES BY A GPI-SPECIFIC PHOSPHOLIPASE-D
BRUNNER, G; NGUYEN, H; RIFKIN, DB; GABRILOVE, J; WILSON, EL
1993 NOV 15 ;82(10):A370-A370, Blood
— id: 52146, year: 1993, vol: 82, page: A370, stat: Journal Article,

Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells
Flaumenhaft R; Abe M; Sato Y; Miyazono K; Harpel J; Heldin CH; Rifkin DB
1993 Feb;120(4):995-1002, Journal of cell biology
— id: 13266, year: 1993, vol: 120, page: 995, stat: Journal Article,

Activation of latent transforming growth factor beta
Flaumenhaft R; Kojima S; Abe M; Rifkin DB
1993 ;24:51-76, Advances in pharmacology (New York)
— id: 13286, year: 1993, vol: 24, page: 51, stat: Journal Article,

High-affinity RNA ligands to basic fibroblast growth factor inhibit receptor binding
Jellinek D; Lynott CK; Rifkin DB; Janjic N
1993 Dec 1;90(23):11227-11231, Proceedings of the National Academy of Sciences of the United States of America
— id: 42359, year: 1993, vol: 90, page: 11227, stat: Journal Article,

Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells
Klein S; Giancotti FG; Presta M; Albelda SM; Buck CA; Rifkin DB
1993 Oct;4(10):973-982, Molecular biology of the cell
— id: 56551, year: 1993, vol: 4, page: 973, stat: Journal Article,

Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cells
Kojima S; Nara K; Rifkin DB
1993 Apr;121(2):439-448, Journal of cell biology
— id: 8221, year: 1993, vol: 121, page: 439, stat: Journal Article,

Mechanism of retinoid-induced activation of latent transforming growth factor-beta in bovine endothelial cells
Kojima S; Rifkin DB
1993 May;155(2):323-332, Journal of cellular physiology
— id: 13175, year: 1993, vol: 155, page: 323, stat: Journal Article,

Bovine urokinase-type plasminogen activator and its receptor: cloning and induction by retinoic acid
Kratzschmar J; Haendler B; Kojima S; Rifkin DB; Schleuning WD
1993 Mar 30;125(2):177-183, Gene
— id: 42360, year: 1993, vol: 125, page: 177, stat: Journal Article,

Biology and biochemistry of proteinases in tumor invasion
Mignatti P; Rifkin DB
1993 Jan;73(1):161-195, Physiological reviews
— id: 56423, year: 1993, vol: 73, page: 161, stat: Journal Article,

INTERLEUKIN-1 (IL-1) INHIBITS THE MIGRATORY RESPONSE OF HUMAN UMBILICAL VEIN ENDOTHELIAL-CELLS (HUVEC) TO BASIC FIBROBLAST GROWTH-FACTOR (BFGF)
ODEKON, LE; ROGHANI, M; MOSCATELLI, DA; LEVIN, RI; RIFKIN, DB
1993 FEB 19 ;7(3):A193-A193, FASEB journal
— id: 54346, year: 1993, vol: 7, page: A193, stat: Journal Article,

TGF-beta: structure, function, and formation
Rifkin DB; Kojima S; Abe M; Harpel JG
1993 Jul 1;70(1):177-179, Thrombosis & haemostasis
— id: 56578, year: 1993, vol: 70, page: 177, stat: Journal Article,

MECHANISM OF ACTIVATION OF LATENT TGF-BETA
RIFKIN, DB; KOJIMA, S; ABE, M; HARPEL, J; NUNES, I
1993 MAR 29 ;43(4):105-105, Journal of cellular biochemistry
— id: 54219, year: 1993, vol: 43, page: 105, stat: Journal Article,

PHOSPHOLIPASE-C RELEASE OF BIOLOGICALLY-ACTIVE BASIC FIBROBLAST GROWTH FACTOR-HEPARAN SULFATE PROTEOGLYCAN COMPLEXES FROM HUMAN BONE-MARROW CULTURES
BRUNNER, G; GABRILOVE, J; RIFKIN, DB; WILSON, EL
1992 JAN ;20(1):107-107, Experimental hematology
— id: 52124, year: 1992, vol: 20, page: 107, stat: Journal Article,

Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity
Flaumenhaft R; Abe M; Mignatti P; Rifkin DB
1992 Aug;118(4):901-909, Journal of cell biology
— id: 13507, year: 1992, vol: 118, page: 901, stat: Journal Article,

Cell density dependent effects of TGF-beta demonstrated by a plasminogen activator-based assay for TGF-beta
Flaumenhaft R; Rifkin DB
1992 Jul;152(1):48-55, Journal of cellular physiology
— id: 13527, year: 1992, vol: 152, page: 48, stat: Journal Article,

The extracellular regulation of growth factor action
Flaumenhaft R; Rifkin DB
1992 Oct;3(10):1057-1065, Molecular biology of the cell
— id: 13406, year: 1992, vol: 3, page: 1057, stat: Journal Article,

THE REGULATION OF PLASMINOGEN-ACTIVATOR ACTIVITY IN HUMAN BONE-MARROW STROMAL CELLS
HANNOCKS, MJ; RIFKIN, DB; OLIVER, L; GABRILOVE, J; WILSON, EL
1992 JAN ;20(1):108-108, Experimental hematology
— id: 52125, year: 1992, vol: 20, page: 108, stat: Journal Article,

Control of transforming growth factor-beta activity: latency vs. activation
Harpel JG; Metz CN; Kojima S; Rifkin DB
1992 ;4(4):321-335, Progress in growth factor research
— id: 56539, year: 1992, vol: 4, page: 321, stat: Journal Article,

Immunohistochemical localization of basic fibroblast growth factor in wound healing sites of mouse skin
Kurita Y; Tsuboi R; Ueki R; Rifkin DB; Ogawa H
1992 ;284(4):193-197, Archives of dermatological research
— id: 42363, year: 1992, vol: 284, page: 193, stat: Journal Article,

Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum-Golgi complex
Mignatti P; Morimoto T; Rifkin DB
1992 Apr;151(1):81-93, Journal of cellular physiology
— id: 42362, year: 1992, vol: 151, page: 81, stat: Journal Article,

Urokinase-type plasminogen activator mediates basic fibroblast growth factor-induced bovine endothelial cell migration independent of its proteolytic activity
Odekon LE; Sato Y; Rifkin DB
1992 Feb;150(2):258-263, Journal of cellular physiology
— id: 13697, year: 1992, vol: 150, page: 258, stat: Journal Article,

Plasminogen activator expression and matrix degradation
Rifkin DB
1992 ;1:20-22, Matrix. Supplement
— id: 13771, year: 1992, vol: 1, page: 20, stat: Journal Article,

A wound healing model using healing-impaired diabetic mice
Tsuboi R; Shi CM; Rifkin DB; Ogawa H
1992 Nov;19(11):673-675, Journal of dermatology
— id: 42361, year: 1992, vol: 19, page: 673, stat: Journal Article,

ANGIOSTATIC STEROIDS INHIBIT ENDOTHELIAL-CELL PLASMINOGEN-ACTIVATOR ACTIVITY
BLEI, F; WILSON, EL; RIFKIN, DB
1991 APR ;29(4):A137-A137, Pediatric research
— id: 51662, year: 1991, vol: 29, page: A137, stat: Journal Article,

Phospholipase C release of basic fibroblast growth factor from human bone marrow cultures as a biologically active complex with a phosphatidylinositol-anchored heparan sulfate proteoglycan
Brunner G; Gabrilove J; Rifkin DB; Wilson EL
1991 Sep;114(6):1275-1283, Journal of cell biology
— id: 13933, year: 1991, vol: 114, page: 1275, stat: Journal Article,

Direct evidence for methylation of arginine residues in high molecular weight forms of basic fibroblast growth factor
Burgess WH; Bizik J; Mehlman T; Quarto N; Rifkin DB
1991 Feb;2(2):87-93, Cell regulation
— id: 42368, year: 1991, vol: 2, page: 87, stat: Journal Article,

Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor
Dennis PA; Rifkin DB
1991 Jan 15;88(2):580-584, Proceedings of the National Academy of Sciences of the United States of America
— id: 14155, year: 1991, vol: 88, page: 580, stat: Journal Article,

Extracellular matrix regulation of growth factor and protease activity
Flaumenhaft R; Rifkin DB
1991 Oct;3(5):817-823, Current opinion in cell biology
— id: 13877, year: 1991, vol: 3, page: 817, stat: Journal Article,

Lipoprotein (a) inhibits the generation of transforming growth factor beta: an endogenous inhibitor of smooth muscle cell migration
Kojima S; Harpel PC; Rifkin DB
1991 Jun;113(6):1439-1445, Journal of cell biology
— id: 14009, year: 1991, vol: 113, page: 1439, stat: Journal Article,

Expression of the urokinase receptor in vascular endothelial cells is stimulated by basic fibroblast growth factor
Mignatti P; Mazzieri R; Rifkin DB
1991 Jun;113(5):1193-1201, Journal of cell biology
— id: 42364, year: 1991, vol: 113, page: 1193, stat: Journal Article,

Basic fibroblast growth factor released by single, isolated cells stimulates their migration in an autocrine manner
Mignatti P; Morimoto T; Rifkin DB
1991 Dec 15;88(24):11007-11011, Proceedings of the National Academy of Sciences of the United States of America
— id: 13815, year: 1991, vol: 88, page: 11007, stat: Journal Article,

Release of basic fibroblast growth factor, an angiogenic factor devoid of secretory signal sequence: a trivial phenomenon or a novel secretion mechanism?
Mignatti P; Rifkin DB
1991 Nov;47(3):201-207, Journal of cellular biochemistry
— id: 13859, year: 1991, vol: 47, page: 201, stat: Journal Article,

Immunoreactive basic fibroblast growth factor-like proteins in chromaffin granules
Presta M; Rifkin DB
1991 Mar;56(3):1087-1088, Journal of neurochemistry
— id: 42366, year: 1991, vol: 56, page: 1087, stat: Journal Article,

The NH2-terminal extension of high molecular weight bFGF is a nuclear targeting signal
Quarto N; Finger FP; Rifkin DB
1991 May;147(2):311-318, Journal of cellular physiology
— id: 42365, year: 1991, vol: 147, page: 311, stat: Journal Article,

Selective expression of high molecular weight basic fibroblast growth factor confers a unique phenotype to NIH 3T3 cells
Quarto N; Talarico D; Florkiewicz R; Rifkin DB
1991 Sep;2(9):699-708, Cell regulation
— id: 13931, year: 1991, vol: 2, page: 699, stat: Journal Article,

Mechanisms controlling the extracellular activity of basic fibroblast growth factor and transforming growth factor
Rifkin DB; Moscatelli D; Flaumenhaft R; Sato Y; Saksela O; Tsuboi R
1991 ;614:250-258, Annals of the New York Academy of Sciences
— id: 14164, year: 1991, vol: 614, page: 250, stat: Journal Article,

New observations on the intracellular localization and release of bFGF
Rifkin DB; Quarto N; Mignatti P; Bizik J; Moscatelli D
1991 ;638:204-206, Annals of the New York Academy of Sciences
— id: 14216, year: 1991, vol: 638, page: 204, stat: Journal Article,

The stimulatory effect of PDGF on vascular smooth muscle cell migration is mediated by the induction of endogenous basic FGF
Sato Y; Hamanaka R; Ono J; Kuwano M; Rifkin DB; Takaki R
1991 Feb 14;174(3):1260-1266, Biochemical & biophysical research communications
— id: 42367, year: 1991, vol: 174, page: 1260, stat: Journal Article,

Basic fibroblast growth factor stimulates myelopoiesis in long-term human bone marrow cultures
Wilson EL; Rifkin DB; Kelly F; Hannocks MJ; Gabrilove JL
1991 Mar 1;77(5):954-960, Blood
— id: 57423, year: 1991, vol: 77, page: 954, stat: Journal Article,

Expression of tissue factor procoagulant activity: regulation by cytosolic calcium
Bach R; Rifkin DB
1990 Sep;87(18):6995-6999, Proceedings of the National Academy of Sciences of the United States of America
— id: 42369, year: 1990, vol: 87, page: 6995, stat: Journal Article,

Studies on the role of basic fibroblast growth factor in vivo: inability of neutralizing antibodies to block tumor growth
Dennis PA; Rifkin DB
1990 Jul;144(1):84-98, Journal of cellular physiology
— id: 42373, year: 1990, vol: 144, page: 84, stat: Journal Article,

Heparin and heparan sulfate increase the radius of diffusion and action of basic fibroblast growth factor
Flaumenhaft R; Moscatelli D; Rifkin DB
1990 Oct;111(4):1651-1659, Journal of cell biology
— id: 25414, year: 1990, vol: 111, page: 1651, stat: Journal Article,

THE EFFECT OF RECOMBINANT BASIC FIBROBLAST GROWTH-FACTOR ON THE WOUND-HEALING AND ITS LOCALIZATION IN HEALING IMPAIRED DB DB MICE
Kurita, Y; Tsuboi, R; Ogawa, H; Rifkin, DB
1990 Apr;94(4):545-545, Journal of investigative dermatology
— id: 31999, year: 1990, vol: 94, page: 545, stat: Journal Article,

THE EFFECT OF RECOMBINANT BASIC FIBROBLAST GROWTH-FACTOR ON THE WOUND-HEALING AND ITS LOCALIZATION IN HEALING IMPAIRED DB/DB MICE
Kurita, Y; Tsuboi, R; Ogawa, H; Rifkin, DB
1990 Apr;38(2):A611-A611, Clinical research
— id: 31979, year: 1990, vol: 38, page: A611, stat: Journal Article,

UREMIC LEVELS OF OXALIC-ACID SUPPRESS REPLICATION OF HUMAN ENDOTHELIAL-CELLS INDUCED BY FIBROBLAST GROWTH-FACTORS
Lewin, RI; Moscatelli, DA; Recht, PA; Lee, SY; Rifkin, DB; Ekundayo, CI
1990 Apr;38(2):A233-A233, Clinical research
— id: 32064, year: 1990, vol: 38, page: A233, stat: Journal Article,

Long-term culture of human bone marrow stromal cells in the presence of basic fibroblast growth factor
Oliver LJ; Rifkin DB; Gabrilove J; Hannocks MJ; Wilson EL
1990 ;3(3):231-236, Growth factors
— id: 35203, year: 1990, vol: 3, page: 231, stat: Journal Article,

Nuclear and cytoplasmic localization of different basic fibroblast growth factor species
Renko M; Quarto N; Morimoto T; Rifkin DB
1990 Jul;144(1):108-114, Journal of cellular physiology
— id: 42374, year: 1990, vol: 144, page: 108, stat: Journal Article,

Growth factor control of extracellular proteolysis
Rifkin DB; Moscatelli D; Bizik J; Quarto N; Blei F; Dennis P; Flaumenhaft R; Mignatti P
1990 Dec 2;32(3):313-318, Cell differentiation & development
— id: 14245, year: 1990, vol: 32, page: 313, stat: Journal Article,

Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity
Saksela O; Rifkin DB
1990 Mar;110(3):767-775, Journal of cell biology
— id: 42375, year: 1990, vol: 110, page: 767, stat: Journal Article,

Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system
Sato Y; Tsuboi R; Lyons R; Moses H; Rifkin DB
1990 Aug;111(2):757-763, Journal of cell biology
— id: 42370, year: 1990, vol: 111, page: 757, stat: Journal Article,

Bimodal relationship between invasion of the amniotic membrane and plasminogen activator activity
Tsuboi R; Rifkin DB
1990 Jul 15;46(1):56-60, International journal of cancer
— id: 42371, year: 1990, vol: 46, page: 56, stat: Journal Article,

Recombinant basic fibroblast growth factor stimulates wound healing in healing-impaired db/db mice
Tsuboi R; Rifkin DB
1990 Jul 1;172(1):245-251, Journal of experimental medicine
— id: 42372, year: 1990, vol: 172, page: 245, stat: Journal Article,

Correlation of cell migration, cell invasion, receptor number, proteinase production, and basic fibroblast growth factor levels in endothelial cells
Tsuboi R; Sato Y; Rifkin DB
1990 Feb;110(2):511-517, Journal of cell biology
— id: 42376, year: 1990, vol: 110, page: 511, stat: Journal Article,

INVERSE RELATIONSHIP BETWEEN INVASION OF THE AMNIOTIC MEMBRANE AND PLASMINOGEN-ACTIVATOR ACTIVITY
Tsuboi, R; Ogawa, H; Rifkin, DB
1990 Apr;38(2):A614-A614, Clinical research
— id: 31981, year: 1990, vol: 38, page: A614, stat: Journal Article,

INVERSE RELATIONSHIP BETWEEN INVASION OF THE AMNIOTIC MEMBRANE AND PLASMINOGEN-ACTIVATOR ACTIVITY
Tsuboi, R; Ogawa, H; Rifkin, DB
1990 Apr;94(4):586-586, Journal of investigative dermatology
— id: 32003, year: 1990, vol: 94, page: 586, stat: Journal Article,

Immunohistochemical localization of basic fibroblast growth factor in astrocytomas
Zagzag D; Miller DC; Sato Y; Rifkin DB; Burstein DE
1990 Nov 15;50(22):7393-7398, Cancer research
— id: 8224, year: 1990, vol: 50, page: 7393, stat: Journal Article,

Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair
Broadley KN; Aquino AM; Woodward SC; Buckley-Sturrock A; Sato Y; Rifkin DB; Davidson JM
1989 Nov;61(5):571-575, Laboratory investigation
— id: 42377, year: 1989, vol: 61, page: 571, stat: Journal Article,

Alpha 2-macroglobulin is a binding protein for basic fibroblast growth factor
Dennis PA; Saksela O; Harpel P; Rifkin DB
1989 May 5;264(13):7210-7216, Journal of biological chemistry
— id: 10622, year: 1989, vol: 264, page: 7210, stat: Journal Article,

Role of extracellular matrix in the action of basic fibroblast growth factor: matrix as a source of growth factor for long-term stimulation of plasminogen activator production and DNA synthesis
Flaumenhaft R; Moscatelli D; Saksela O; Rifkin DB
1989 Jul;140(1):75-81, Journal of cellular physiology
— id: 10556, year: 1989, vol: 140, page: 75, stat: Journal Article,

In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases
Mignatti P; Tsuboi R; Robbins E; Rifkin DB
1989 Feb;108(2):671-682, Journal of cell biology
— id: 10740, year: 1989, vol: 108, page: 671, stat: Journal Article,

Transformation by basic fibroblast growth factor requires high levels of expression: comparison with transformation by hst/K-fgf
Quarto N; Talarico D; Sommer A; Florkiewicz R; Basilico C; Rifkin DB
1989 ;5(2):101-110, Oncogene research
— id: 10813, year: 1989, vol: 5, page: 101, stat: Journal Article,

Recent developments in the cell biology of basic fibroblast growth factor
Rifkin DB; Moscatelli D
1989 Jul;109(1):1-6, Journal of cell biology
— id: 10568, year: 1989, vol: 109, page: 1, stat: Journal Article,

The role of proteases in matrix breakdown during cellular invasion
Rifkin DB; Tsuboi R; Mignatti P
1989 Oct;140(4):1112-1113, American review of respiratory disease
— id: 10476, year: 1989, vol: 140, page: 1112, stat: Journal Article,

GROWTH-FACTOR CONTROL OF ENDOTHELIAL-CELL FIBRINOLYSIS
Rifkin, DB
1989 Aug 19;62(1):458-458, Thrombosis & haemostasis
— id: 31666, year: 1989, vol: 62, page: 458, stat: Journal Article,

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture
Sato Y; Rifkin DB
1989 Jul;109(1):309-315, Journal of cell biology
— id: 10572, year: 1989, vol: 109, page: 309, stat: Journal Article,

An amino-terminally extended and post-translationally modified form of a 25kD basic fibroblast growth factor
Sommer A; Moscatelli D; Rifkin DB
1989 May 15;160(3):1267-1274, Biochemical & biophysical research communications
— id: 25416, year: 1989, vol: 160, page: 1267, stat: Journal Article,

Interaction of heparin with human basic fibroblast growth factor: protection of the angiogenic protein from proteolytic degradation by a glycosaminoglycan
Sommer A; Rifkin DB
1989 Jan;138(1):215-220, Journal of cellular physiology
— id: 42378, year: 1989, vol: 138, page: 215, stat: Journal Article,

COORDINATE CONTROL OF CELL-MIGRATION AND INVASION IN CAPILLARY ENDOTHELIAL-CELLS BY ENDOGENOUS BASIC FIBROBLAST GROWTH-FACTOR
Tsuboi, R; Sato, Y; Rifkin, DB
1989 Apr;37(2):A641-A641, Clinical research
— id: 31721, year: 1989, vol: 37, page: A641, stat: Journal Article,

COORDINATE CONTROL OF CELL-MIGRATION AND INVASION IN CAPILLARY ENDOTHELIAL-CELLS BY ENDOGENOUS BASIC FIBROBLAST GROWTH-FACTOR
Tsuboi, R; Sato, Y; Rifkin, DB
1989 Mar;92(3):534-534, Journal of investigative dermatology
— id: 31740, year: 1989, vol: 92, page: 534, stat: Journal Article,

Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential
Delli-Bovi P; Curatola AM; Newman KM; Sato Y; Moscatelli D; Hewick RM; Rifkin DB; Basilico C
1988 Jul;8(7):2933-2941, Molecular & cellular biology
— id: 11053, year: 1988, vol: 8, page: 2933, stat: Journal Article,

In vitro neurite extension by granule neurons is dependent upon astroglial-derived fibroblast growth factor
Hatten ME; Lynch M; Rydel RE; Sanchez J; Joseph-Silverstein J; Moscatelli D; Rifkin DB
1988 Feb;125(2):280-289, Developmental biology (Orlando)
— id: 11190, year: 1988, vol: 125, page: 280, stat: Journal Article,

The development of a quantitative RIA for basic fibroblast growth factor using polyclonal antibodies against the 157 amino acid form of human bFGF. The identification of bFGF in adherent elicited murine peritoneal macrophages
Joseph-Silverstein J; Moscatelli D; Rifkin DB
1988 Jun 13;110(2):183-192, Journal of immunological methods
— id: 11065, year: 1988, vol: 110, page: 183, stat: Journal Article,

Multiple forms of an angiogenesis factor: basic fibroblast growth factor
Moscatelli D; Joseph-Silverstein J; Presta M; Rifkin DB
1988 Jan;70(1):83-87, Biochimie
— id: 11285, year: 1988, vol: 70, page: 83, stat: Journal Article,

Membrane and matrix localization of proteinases: a common theme in tumor cell invasion and angiogenesis
Moscatelli D; Rifkin DB
1988 Aug 3;948(1):67-85, Biochimica & biophysica acta
— id: 10990, year: 1988, vol: 948, page: 67, stat: Journal Article,

New aspects of blood vessel growth: tumor and tissue-derived angiogenesis factors
Presta M; Rifkin DB
1988 ;18(1):6-17, Haemostasis
— id: 11290, year: 1988, vol: 18, page: 6, stat: Journal Article,

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation
Saksela O; Moscatelli D; Sommer A; Rifkin DB
1988 Aug;107(2):743-751, Journal of cell biology
— id: 11021, year: 1988, vol: 107, page: 743, stat: Journal Article,

Cell-associated plasminogen activation: regulation and physiological functions
Saksela O; Rifkin DB
1988 ;4:93-126, Annual review of cell biology
— id: 11259, year: 1988, vol: 4, page: 93, stat: Journal Article,

Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis
Sato Y; Rifkin DB
1988 Sep;107(3):1199-1205, Journal of cell biology
— id: 10962, year: 1988, vol: 107, page: 1199, stat: Journal Article,

Endothelial cell growth factors and the vessel wall
Joseph-Silverstein J; Rifkin DB
1987 Oct;13(4):504-513, Seminars in thrombosis & hemostasis
— id: 11355, year: 1987, vol: 13, page: 504, stat: Journal Article,

Angiogenesis : mechanisms and pathobiology
Klagsbrun, Michael; Rifkin, Daniel B
Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory, 1987,
— id: 61, year: 1987, vol: , page: , stat: ,

Mr 25,000 heparin-binding protein from guinea pig brain is a high molecular weight form of basic fibroblast growth factor
Moscatelli D; Joseph-Silverstein J; Manejias R; Rifkin DB
1987 Aug;84(16):5778-5782, Proceedings of the National Academy of Sciences of the United States of America
— id: 25417, year: 1987, vol: 84, page: 5778, stat: Journal Article,

The opposing effects of basic fibroblast growth factor and transforming growth factor beta on the regulation of plasminogen activator activity in capillary endothelial cells
Saksela O; Moscatelli D; Rifkin DB
1987 Aug;105(2):957-963, Journal of cell biology
— id: 25418, year: 1987, vol: 105, page: 957, stat: Journal Article,

THE OPPOSING EFFECTS OF BASIC FIBROBLAST GROWTH-FACTOR AND TRANSFORMING GROWTH-FACTOR-BETA ON THE REGULATION OF PLASMINOGEN-ACTIVATOR ACTIVITY IN CAPILLARY ENDOTHELIAL-CELLS
Saksela, O; Moscatelli, D; Rifkin, DB
1987 Jul 6;58(1):505-505, Thrombosis & haemostasis
— id: 31143, year: 1987, vol: 58, page: 505, stat: Journal Article,

A form of human basic fibroblast growth factor with an extended amino terminus
Sommer A; Brewer MT; Thompson RC; Moscatelli D; Presta M; Rifkin DB
1987 Apr 29;144(2):543-550, Biochemical & biophysical research communications
— id: 25419, year: 1987, vol: 144, page: 543, stat: Journal Article,

Tumor invasion through the human amniotic membrane: requirement for a proteinase cascade
Mignatti P; Robbins E; Rifkin DB
1986 Nov 21;47(4):487-498, Cell
— id: 42379, year: 1986, vol: 47, page: 487, stat: Journal Article,

A PROTEASE CASCADE IN MELANOMA INVASION
MIGNATTI, P; RIFKIN, DB
1986 APR ;34(2):A768-A768, Clinical research
— id: 41419, year: 1986, vol: 34, page: A768, stat: Journal Article,

A PROTEASE CASCADE IN MELANOMA INVASION
MIGNATTI, P; RIFKIN, DB
1986 APR ;86(4):494-494, Journal of investigative dermatology
— id: 41473, year: 1986, vol: 86, page: 494, stat: Journal Article,

INHIBITORS OF SERINE PROTEINASES AND METALLOPROTEINASES BLOCK INVITRO INVASION BY B-16 MELANOMA-CELLS
Mignatti, P; Rifkin, DB
1986 Mar;27(2):57-57, Proceedings (American Association for Cancer Research)
— id: 31055, year: 1986, vol: 27, page: 57, stat: Journal Article,

Identification of a pituitary factor responsible for enhancement of plasminogen activator activity in breast tumor cells
Mira-y-Lopez R; Joseph-Silverstein J; Rifkin DB; Ossowski L
1986 Oct;83(20):7780-7784, Proceedings of the National Academy of Sciences of the United States of America
— id: 42380, year: 1986, vol: 83, page: 7780, stat: Journal Article,

Both normal and tumor cells produce basic fibroblast growth factor
Moscatelli D; Presta M; Joseph-Silverstein J; Rifkin DB
1986 Nov;129(2):273-276, Journal of cellular physiology
— id: 25422, year: 1986, vol: 129, page: 273, stat: Journal Article,

Purification of a factor from human placenta that stimulates capillary endothelial cell protease production, DNA synthesis, and migration
Moscatelli D; Presta M; Rifkin DB
1986 Apr;83(7):2091-2095, Proceedings of the National Academy of Sciences of the United States of America
— id: 25424, year: 1986, vol: 83, page: 2091, stat: Journal Article,

Purification and biological activities of an angiogenesis factor from human placenta
Moscatelli DA; Presta M; Mignatti P; Mullins DE; Crowe RM; Rifkin DB
1986 Jul-Aug;6(4):861-863, Anticancer research
— id: 25423, year: 1986, vol: 6, page: 861, stat: Journal Article,

BASIC FIBROBLAST GROWTH-FACTOR (BFGF)-LIKE MOLECULES ARE PRODUCED BY A VARIETY OF CULTURED-CELLS
MOSCATELLI, D; PRESTA, M; JOSEPHSILVERSTEIN, J; RIFKIN, DB
1986 MAY ;45(6):1718-1718, Federation Proceedings (Federation of American Societies for Experimental Biology)
— id: 41448, year: 1986, vol: 45, page: 1718, stat: Journal Article,

Purification from a human hepatoma cell line of a basic fibroblast growth factor-like molecule that stimulates capillary endothelial cell plasminogen activator production, DNA synthesis, and migration
Presta M; Moscatelli D; Joseph-Silverstein J; Rifkin DB
1986 Nov;6(11):4060-4066, Molecular & cellular biology
— id: 25421, year: 1986, vol: 6, page: 4060, stat: Journal Article,

MOLECULES CONTROLLING CELLULAR INVASION
Rifkin, DB
1986 Aug;58(8):539-539, Seikagaku
— id: 31014, year: 1986, vol: 58, page: 539, stat: Journal Article,

PROTEINS REGULATING CELLULAR INVASION
Rifkin, DB
1986 Nov;14(3):235-235, Journal of cellular biochemistry
— id: 31090, year: 1986, vol: 14, page: 235, stat: Journal Article,

IDENTIFICATION OF BFGF IN CONDITIONED MEDIA AND EXTRACTS OF CULTURED-CELLS - DEVELOPMENT OF A SOLID-PHASE RIA FOR BFGF USING ANTI-HUMAN BFGF IGG
SILVERSTEIN, JJ; MOSCATELLI, D; RIFKIN, DB
1986 NOV ;103(5):A297-A297, Journal of cell biology
— id: 41321, year: 1986, vol: 103, page: A297, stat: Journal Article,

MECHANISMS FOR REGULATING TISSUE FACTOR INITIATED COAGULATION BY CULTURED BOVINE CELLS
Bach, R; Rifkin, DB
1985 ;54(1):225-225, Thrombosis & haemostasis
— id: 30718, year: 1985, vol: 54, page: 225, stat: Journal Article,

Production of latent collagenase by human umbilical vein endothelial cells in response to angiogenic preparations
Moscatelli DA; Rifkin DB; Jaffe EA
1985 Feb;156(2):379-390, Experimental cell research
— id: 25426, year: 1985, vol: 156, page: 379, stat: Journal Article,

PURIFICATION AND BIOLOGICAL-ACTIVITIES OF AN ANGIOGENIC FACTOR FROM HUMAN-PLACENTA
Moscatelli, DA; Presta, M; Mignetti, P; Ossowski, L; Mullins, DE; Crowe, RM; Rifkin, DB
1985 ;5(6):618-618, Anticancer research
— id: 30821, year: 1985, vol: 5, page: 618, stat: Journal Article,

Purification and characterization of a low molecular mass cysteine proteinase inhibitor from human amniotic fluid
Rohrlich ST; Levy H; Rifkin DB
1985 ;180(2):239-241, Progress in clinical & biological research
— id: 42382, year: 1985, vol: 180, page: 239, stat: Journal Article,

Purification and characterization of a low molecular mass cysteine proteinase inhibitor from human amniotic fluid
Rohrlich ST; Levy H; Rifkin DB
1985 Feb;366(2):147-155, Biological chemistry Hoppe-Seyler
— id: 42381, year: 1985, vol: 366, page: 147, stat: Journal Article,

GENERATION OF PLASMIN-INHIBITOR-PLASMIN COMPLEXES IN PLASMA BY TISSUE PLASMINOGEN-ACTIVATOR AND UROKINASE
HARPEL, PC; WEIL, D; LEVIN, RI; RIFKIN, DB
1984 ;14(1):67-67, Haemostasis
— id: 40843, year: 1984, vol: 14, page: 67, stat: Journal Article,

Aspirin inhibits vascular plasminogen activator activity in vivo. Studies utilizing a new assay to quantify plasminogen activator activity
Levin RI; Harpel PC; Weil D; Chang TS; Rifkin DB
1984 Aug;74(2):571-580, Journal of clinical investigation
— id: 57531, year: 1984, vol: 74, page: 571, stat: Journal Article,

Synthesis of collagenase and plasminogen activator by endothelial cells
Moscatelli D; Gross JL; Jaffe EA; Rifkin DB
Biology of endothelial cells Boston : Kluwer, 1984,
— id: 2766, year: 1984, vol: , page: 429, stat: Chapter,

Stimulation of motility in cultured bovine capillary endothelial cells by angiogenic preparations
Mullins DE; Rifkin DB
1984 May;119(2):247-254, Journal of cellular physiology
— id: 42383, year: 1984, vol: 119, page: 247, stat: Journal Article,

PROTEASE PRODUCTION BY CULTURED ENDOTHELIAL-CELLS
RIFKIN, D; MOSCATELLI, D
1984 ;43(3):587-587, Federation Proceedings (Federation of American Societies for Experimental Biology)
— id: 41010, year: 1984, vol: 43, page: 587, stat: Journal Article,

PLASMINOGEN-ACTIVATOR PRODUCTION BY ENDOTHELIAL-CELLS EXPOSED TO ANGIOGENIC STIMULI
RIFKIN, DB; MOSCATELLI, D
1984 ;14(1):128-128, Haemostasis
— id: 40994, year: 1984, vol: 14, page: 128, stat: Journal Article,

A polypeptide secreted by transformed cells that modulates human plasminogen activator production
Davies RL; Rifkin DB; Tepper R; Miller A; Kucherlapati R
1983 Jul 8;221(4606):171-173, Science
— id: 42384, year: 1983, vol: 221, page: 171, stat: Journal Article,

PURIFICATION AND CHARACTERIZATION OF A CARTILAGE DERIVED COLLAGENASE INHIBITOR
GABRIELIDES, C; RIFKIN, DB
1983 ;97(5):A460-A460, Journal of cell biology
— id: 40611, year: 1983, vol: 97, page: A460, stat: Journal Article,

Down-regulation of epidermal growth factor receptor correlates with plasminogen activator activity in human A431 epidermoid carcinoma cells
Gross JL; Krupp MN; Rifkin DB; Lane MD
1983 Apr;80(8):2276-2280, Proceedings of the National Academy of Sciences of the United States of America
— id: 42387, year: 1983, vol: 80, page: 2276, stat: Journal Article,

Increased capillary endothelial cell protease activity in response to angiogenic stimuli in vitro
Gross JL; Moscatelli D; Rifkin DB
1983 May;80(9):2623-2627, Proceedings of the National Academy of Sciences of the United States of America
— id: 27429, year: 1983, vol: 80, page: 2623, stat: Journal Article,

Plasminogen activator in differentiating mouse keratinocytes
Isseroff RR; Fusenig NE; Rifkin DB
1983 Apr;80(4):217-222, Journal of investigative dermatology
— id: 42385, year: 1983, vol: 80, page: 217, stat: Journal Article,

Plasminogen is present in the basal layer of the epidermis
Isseroff RR; Rifkin DB
1983 Apr;80(4):297-299, Journal of investigative dermatology
— id: 42386, year: 1983, vol: 80, page: 297, stat: Journal Article,

PRODUCTION OF A UROKINASE INHIBITOR BY HUMAN CHORIOCARCINOMA CELLS
MULLINS, DE; RIFKIN, DB
1983 ;97(5):A117-A117, Journal of cell biology
— id: 40495, year: 1983, vol: 97, page: A117, stat: Journal Article,

Proteases, angiogenesis, and invasion
Rifkin DB; Moscatelli D; Gross J; Jaffe E
1983 ;36(9):187-200, Symposium on fundamental cancer research
— id: 27430, year: 1983, vol: 36, page: 187, stat: Journal Article,

Plasminogen activator and collagenase production by cultured capillary endothelial cells
Gross JL; Moscatelli D; Jaffe EA; Rifkin DB
1982 Dec;95(3):974-981, Journal of cell biology
— id: 27434, year: 1982, vol: 95, page: 974, stat: Journal Article,

Binding of developing mouse cerebellar cells to fibronectin: a possible mechanism for the formation of the external granular layer
Hatten ME; Furie MB; Rifkin DB
1982 Sep;2(9):1195-1206, Journal of neuroscience
— id: 42388, year: 1982, vol: 2, page: 1195, stat: Journal Article,

Biochemistry of granule cell migration in developing mouse cerebellum
Hatten ME; Rifkin DB; Furie MB; Mason CA; Liem RK
1982 ;85 Pt B(9):509-519, Progress in clinical & biological research
— id: 42389, year: 1982, vol: 85 Pt B, page: 509, stat: Journal Article,

PLASMINOGEN IS PRESENT IN THE BASAL LAYER OF THE EPIDERMIS
Isseroff, RR; Rifkin, DB
1982 ;30(2):A605-A605, Clinical research
— id: 30563, year: 1982, vol: 30, page: A605, stat: Journal Article,

PLASMINOGEN IS PRESENT IN THE BASAL LAYER OF THE EPIDERMIS
Isseroff, RR; Rifkin, DB
1982 ;78(4):359-359, Journal of investigative dermatology
— id: 30565, year: 1982, vol: 78, page: 359, stat: Journal Article,

EGF-RECEPTOR DOWN-REGULATION IS CORRELATED WITH PLASMINOGEN-ACTIVATOR SYNTHESIS
Krupp, MN; Gross, JL; Rifkin, DB; Lane, MD
1982 ;95(2):A416-A416, Journal of cell biology
— id: 30363, year: 1982, vol: 95, page: A416, stat: Journal Article,

Phorbol esters stimulate protease production by human endothelial cells
Moscatelli D; Jaffe EA; Rifkin DB
1982 ;7(3):401-404, Carcinogenesis: a comprehensive survey
— id: 27435, year: 1982, vol: 7, page: 401, stat: Journal Article,

COLLAGENASE PRODUCTION BY HUMAN UMBILICAL VEIN ENDOTHELIAL- CELLS IN RESPONSE TO ANGIOGENIC PREPARATIONS
Moscatelli, D; Rifkin, DB; Jaffe, EA
1982 ;95(2):A206-A206, Journal of cell biology
— id: 30351, year: 1982, vol: 95, page: A206, stat: Journal Article,

STIMULATION OF MOTILITY IN BOVINE CAPILLARY ENDOTHELIAL-CELLS BY ANGIOGENIC PREPARATIONS
Mullins, DE; Moscatelli, DA; Rifkin, DB
1982 ;95(2):A187-A187, Journal of cell biology
— id: 30513, year: 1982, vol: 95, page: A187, stat: Journal Article,

COLLAGENASE AND PLASMINOGEN-ACTIVATOR PRODUCTION BY CULTURED CAPILLARY ENDOTHELIAL-CELLS
Gross, JL; Moscatelli, D; Jaffe, EA; Rifkin, DB
1981 ;91(2):A34-A34, Journal of cell biology
— id: 30402, year: 1981, vol: 91, page: A34, stat: Journal Article,

PLASMINOGEN-ACTIVATOR IN DIFFERENTIATING KERATINOCYTES
Isseroff, RR; Rifkin, DB; Fusenig, NE
1981 ;29(2):A600-A600, Clinical research
— id: 30271, year: 1981, vol: 29, page: A600, stat: Journal Article,

PLASMINOGEN-ACTIVATOR IN DIFFERENTIATING KERATINOCYTES
Isseroff, RR; Rifkin, DB; Fusenig, NE
1981 ;76(4):332-333, Journal of investigative dermatology
— id: 30258, year: 1981, vol: 76, page: 332, stat: Journal Article,

ANGIOGENIC FACTORS STIMULATE PLASMINOGEN-ACTIVATOR AND COLLAGENASE PRODUCTION BY CAPILLARY ENDOTHELIAL-CELLS
Moscatelli, D; Gross, JL; Rifkin, DB
1981 ;91(2):A201-A201, Journal of cell biology
— id: 30405, year: 1981, vol: 91, page: A201, stat: Journal Article,

The involvement of proteases and protease inhibitors in neovascularization
Rifkin DB; Gross JL; Moscatelli D; Gabrielides C
1981 ;40(10-11):1259-1263, Acta biologica & medica Germanica
— id: 27436, year: 1981, vol: 40, page: 1259, stat: Journal Article,

Isolation of the major serine protease inhibitor from the 5-day serum-free conditioned medium of human embryonic lung cells and demonstration that it is fetuin
Rohrlich ST; Rifkin DB
1981 Oct;109(1):1-15, Journal of cellular physiology
— id: 42390, year: 1981, vol: 109, page: 1, stat: Journal Article,

SV40 mutants with an altered small-t protein are tumorigenic in newborn hamsters
Topp WC; Rifkin DB; Sleigh MJ
1981 Jun;111(2):341-350, Virology
— id: 42391, year: 1981, vol: 111, page: 341, stat: Journal Article,

Characterization of a temperature-sensitive membrane alteration in chick embryo fibroblasts infected with a temperature-sensitive mutant of Rous sarcoma virus
Eger, R; Rifkin, D
1980 Aug 4;600(2):313-319, Biochimica & biophysica acta
— id: 135297, year: 1980, vol: 600, page: 313, stat: Journal Article,

Requirement for the large T and small T proteins of SV40 in the maintenance of the transformed state
Frisque RJ; Rifkin DB; Topp WC
1980 ;44 Pt 1,(7):325-331, Cold Spring Harbor symposia on quantitative biology
— id: 42399, year: 1980, vol: 44 Pt 1,, page: 325, stat: Journal Article,

Transformation of primary hamster brain cells with JC virus and its DNA
Frisque RJ; Rifkin DB; Walker DL
1980 Jul;35(1):265-269, Journal of virology
— id: 42395, year: 1980, vol: 35, page: 265, stat: Journal Article,

Location of a gelatin-binding region of human plasma fibronectin
Furie MB; Frey AB; Rifkin DB
1980 May 25;255(10):4391-4394, Journal of biological chemistry
— id: 42396, year: 1980, vol: 255, page: 4391, stat: Journal Article,

Proteolytically derived fragments of human plasma fibronectin and their localization within the intact molecule
Furie MB; Rifkin DB
1980 Apr 10;255(7):3134-3140, Journal of biological chemistry
— id: 42397, year: 1980, vol: 255, page: 3134, stat: Journal Article,

Early mutants of polyoma virus (dl8 and dl23) with altered transformation properties: is polyoma virus middle T antigen a transforming gene product?
Griffin BE; Ito Y; Novak U; Spurr N; Dilworth S; Smolar N; Pollack R; Smith K; Rifkin DB
1980 ;44 Pt 1,(7):271-283, Cold Spring Harbor symposia on quantitative biology
— id: 42400, year: 1980, vol: 44 Pt 1,, page: 271, stat: Journal Article,

Transformation of rat embryo fibroblasts by cloned polyoma virus DNA fragments containing only part of the early region
Hassell JA; Topp WC; Rifkin DB; Moreau PE
1980 Jul;77(7):3978-3982, Proceedings of the National Academy of Sciences of the United States of America
— id: 42394, year: 1980, vol: 77, page: 3978, stat: Journal Article,

PHENOTYPE OF POLYOMA-INDUCED HAMSTER TUMOR-CELL LINES
Israel, MA; Martin, MA; Miyamura, T; Takemoto, KK; Rifkin, D; Pollack, R
1980 ;35(1):252-255, Journal of virology
— id: 27982, year: 1980, vol: 35, page: 252, stat: Journal Article,

PLASMINOGEN-ACTIVATOR IN DIFFERENTIATING KERATINOCYTES
Isseroff, RR; Rifkin, DB; Fusenig, NE
1980 ;87(2):A28-A28, Journal of cell biology
— id: 28086, year: 1980, vol: 87, page: A28, stat: Journal Article,

Tetradecanoyl phorbol acetate stimulates latent collagenase production by cultured human endothelial cells
Moscatelli D; Jaffe E; Rifkin DB
1980 Jun;20(2):343-351, Cell
— id: 27437, year: 1980, vol: 20, page: 343, stat: Journal Article,

Regulation of plasminogen activator synthesis in chick embryo fibroblasts infected with avian retroviruses
Rifkin DB
1980 ;44 Pt 1,(7):665-668, Cold Spring Harbor symposia on quantitative biology
— id: 42398, year: 1980, vol: 44 Pt 1,, page: 665, stat: Journal Article,

Studies on the control of plasminogen activator production by cultured human embryonic lung cells: requirements for inhibition by corticosteroids
Rifkin DB; Crowe RM
1980 Dec;105(3):417-422, Journal of cellular physiology
— id: 42392, year: 1980, vol: 105, page: 417, stat: Journal Article,

The small-t protein of SV40 is required for loss of actin cable networks and plasminogen activator synthesis in transformed rat cells
Topp WC; Rifkin DB
1980 Oct 30;106(2):282-291, Virology
— id: 42393, year: 1980, vol: 106, page: 282, stat: Journal Article,

REQUIREMENT FOR THE LARGE T-PROTEINS AND SMALL T-PROTEINS OF SV40 IN THE MAINTENANCE OF THE TRANSFORMED STATE
Frisque, RJ; Rifkin, DB; Topp, WC
1979 ;44(2):325-331, Cold Spring Harbor symposia on quantitative biology
— id: 28055, year: 1979, vol: 44, page: 325, stat: Journal Article,

PROTEOLYTICALLY-DERIVED FRAGMENTS OF HUMAN-PLASMA FIBRONECTIN AND THEIR LOCALIZATION WITHIN THE INTACT MOLECULE
Furie, MB; Rifkin, DB
1979 ;32(4):193-193, Journal of supramolecular structure
— id: 30028, year: 1979, vol: 32, page: 193, stat: Journal Article,

EARLY MUTANTS OF POLYOMA-VIRUS (DL8 AND DL23) WITH ALTERED TRANSFORMATION PROPERTIES - IS POLYOMA-VIRUS MIDDLE T-ANTIGEN A TRANSFORMING GENE-PRODUCT
Griffin, BE; Ito, Y; Novak, U; Spurr, N; Dilworth, S; Smolar, N; Pollack, R; Smith, K; Rifkin, DB
1979 ;44(2):271-283, Cold Spring Harbor symposia on quantitative biology
— id: 28054, year: 1979, vol: 44, page: 271, stat: Journal Article,

The effect of avian retroviruses on limb bud chondrogenesis in vitro
Gross JL; Rifkin DB
1979 Nov;18(3):707-718, Cell
— id: 42401, year: 1979, vol: 18, page: 707, stat: Journal Article,

Tumor promoters induce changes in the chick embryo fibroblast cytoskeleton
Rifkin DB; Crowe RM; Pollack R
1979 Oct;18(2):361-368, Cell
— id: 42402, year: 1979, vol: 18, page: 361, stat: Journal Article,

REGULATION OF PLASMINOGEN-ACTIVATOR SYNTHESIS IN CHICK-EMBRYO FIBROBLASTS INFECTED WITH AVIAN RETROVIRUSES
Rifkin, DB
1979 ;44(2):665-668, Cold Spring Harbor symposia on quantitative biology
— id: 28056, year: 1979, vol: 44, page: 665, stat: Journal Article,

TUMORIGENICITY OF REVERTANTS FROM AN SV40-TRANSFORMED LINE
Steinberg, BM; Rifkin, D; Shin, S; Boone, C; Pollack, R
1979 ;11(4):539-546, Journal of supramolecular structure
— id: 28076, year: 1979, vol: 11, page: 539, stat: Journal Article,

Fibronectin from chicken embryo fibroblasts contains covalently bound phosphate
Teng MH; Rifkin DB
1979 Mar;80(3):784-791, Journal of cell biology
— id: 42403, year: 1979, vol: 80, page: 784, stat: Journal Article,

ORDERING OF PROTEOLYTIC FRAGMENTS OF HUMAN COLD-INSOLUBLE GLOBULIN (CIG)
Furie, M; Rifkin, DB
1978 ;79(2):A54-A54, Journal of cell biology
— id: 29870, year: 1978, vol: 79, page: A54, stat: Journal Article,

Clonal sublines of rat neurotumor RT4 and cell differentiation. II. A conversion coupling of tumorigenicity and a glial property
Imada M; Sueoka N; Rifkin DB
1978 Sep;66(1):109-116, Developmental biology (Orlando)
— id: 42405, year: 1978, vol: 66, page: 109, stat: Journal Article,

Plasminogen activator synthesis by cultured human embryonic lung cells: characterization of the suppressive effect of corticosteroids
Rifkin DB
1978 Dec;97(3 Pt 2 Suppl 1):421-428, Journal of cellular physiology
— id: 42404, year: 1978, vol: 97, page: 421, stat: Journal Article,

The preparation and use of pyridoxal [32P]phosphate as a labeling reagent for proteins on the outer surface of membranes
Eger R; Rifkin DB
1977 Oct 3;470(1):70-83, Biochimica & biophysica acta
— id: 42407, year: 1977, vol: 470, page: 70, stat: Journal Article,

A sensitive assay for elastase employing radioactive elastin coupled to sepharose
Rifkin DB; Crowe RM
1977 May 1;79(1-2):268-275, Analytical biochemistry
— id: 42409, year: 1977, vol: 79, page: 268, stat: Journal Article,

Isolation of a protease inhibitor from tissues resistant to tumor invasion
Rifkin DB; Crowe RM
1977 Dec;358(12):1525-1531, Hoppe-Seylers zeitschrift fur physiologische Chemie
— id: 42406, year: 1977, vol: 358, page: 1525, stat: Journal Article,

Production of plasminogen activator by established cell lines of mouse origin
Rifkin DB; Pollack R
1977 Apr;73(1):47-55, Journal of cell biology
— id: 42410, year: 1977, vol: 73, page: 47, stat: Journal Article,

Patterns of plasminogen activator production in cultured normal embryonic cells
Rohrlich ST; Rifkin DB
1977 Oct;75(1):31-42, Journal of cell biology
— id: 42408, year: 1977, vol: 75, page: 31, stat: Journal Article,

The organization of the proteins of vesicular stomatitis virions: labeling with pyridoxal phosphate
Eger R; Compans RW; Rifkin DB
1975 Aug;66(2):610-615, Virology
— id: 42412, year: 1975, vol: 66, page: 610, stat: Journal Article,

Plasma membrane alteration associated with malignant transformation in culture
Gilula NB; Eger RR; Rifkin DB
1975 Sep;72(9):3594-3598, Proceedings of the National Academy of Sciences of the United States of America
— id: 42411, year: 1975, vol: 72, page: 3594, stat: Journal Article,

Proteases and biological control
Reich, Edward; Rifkin, Daniel B.; Shaw, Elliott
[Cold Spring Harbor, N.Y.] : Cold Spring Harbor Laboratory, 1975,
— id: 215, year: 1975, vol: , page: , stat: ,

Properties of plasminogen activators formed by neoplastic human cell cultures
Rifkin DB; Loeb JN; Moore G; Reich E
1974 May 1;139(5):1317-1328, Journal of experimental medicine
— id: 42413, year: 1974, vol: 139, page: 1317, stat: Journal Article,

Virus-induced modification of cellular membranes related to viral structure
Rifkin DB; Quigley JP
1974 ;28(0):325-351, Annual review of microbiology
— id: 42414, year: 1974, vol: 28, page: 325, stat: Journal Article,

Studies of Rous sarcoma virus. Effects of nucleoside analogues on virus synthesis
Brdar B; Rifkin DB; Reich E
1973 Apr 10;248(7):2397-2408, Journal of biological chemistry
— id: 42416, year: 1973, vol: 248, page: 2397, stat: Journal Article,

An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. II. Mammalian fibroblast cultures transformed by DNA and RNA tumor viruses
Ossowski L; Unkeless JC; Tobia A; Quigley JP; Rifkin DB; Reich E
1973 Jan 1;137(1):112-126, Journal of experimental medicine
— id: 42418, year: 1973, vol: 137, page: 112, stat: Journal Article,

The project-grant application of the National Institutues of Health. A beginning scientist's first project-grant application
Rifkin DB
1973 May;32(5):1543-1543, Federation Proceedings (Federation of American Societies for Experimental Biology)
— id: 42415, year: 1973, vol: 32, page: 1543, stat: Journal Article,

An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. I. Chick embryo fibroblast cultures transformed by avian RNA tumor viruses
Unkeless JC; Tobia A; Ossowski L; Quigley JP; Rifkin DB; Reich E
1973 Jan 1;137(1):85-111, Journal of experimental medicine
— id: 42417, year: 1973, vol: 137, page: 85, stat: Journal Article,

Specificity of Rous sarcoma virus synthesis
Brdar B; Rifkin DB; Reich E
1972 Aug 15;24(3):347-350, FEBS letters
— id: 42354, year: 1972, vol: 24, page: 347, stat: Journal Article,

Isolation and characterization of ribonucleoprotein substructures from Rous sarcoma virus
Quigley JP; Rifkin DB; Compans RW
1972 Oct;50(1):65-75, Virology
— id: 42421, year: 1972, vol: 50, page: 65, stat: Journal Article,

Determination of phospholipid composition of RNA tumor viruses by 32 P labeling of infected cell cultures
Quigley JP; Rifkin DB; Einhorn MH
1972 Jun;47(2):614-619, Analytical biochemistry
— id: 42422, year: 1972, vol: 47, page: 614, stat: Journal Article,

Lipid studies of Rous sarcoma virus and host cell membranes
Quigley JP; Rifkin DB; Reich E
1972 Nov;50(2):550-557, Virology
— id: 42419, year: 1972, vol: 50, page: 550, stat: Journal Article,

A specific labeling procedure for proteins on the outer surface of membranes
Rifkin DB; Compans RW; Reich E
1972 Oct 25;247(20):6432-6437, Journal of biological chemistry
— id: 42420, year: 1972, vol: 247, page: 6432,

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Daniel B. Rifkin, Ph.D.

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