540-562 First Avenue
New York, NY 10016
Dr. Harmony Reynolds' current research is targeted to women and includes studies of acute coronary syndromes with non-obstructive coronary artery disease and of apical ballooning cardiomyopathy (tako-tsubo syndrome). Dr. Reynolds is an investigator in the Clinical Coordinating Center of OAT, the Occluded Artery Trial and principal investigator for CUE-HF that evaluates carotid artery intimal medical thickness as a screening tool to determine the etiology of ejection fraction as well as SWAN, a study of women with acute coronary syndrome using new imaging techniques to help determine the causes. She is also a site principal investigator for TACT, a trial to assess chelation therapy for treatment of coronary heart disease in patients who survived a heart attack.
Dr. Reynolds' research group is studying why women with acute myocardial infarction are more likely than men to have reinfarction, bleeding or death. This difference has been hypothesized to be due to older age, treatment delay and comorbidities in women as well as the use of diagnostic and therapeutic modalities. The research team is also looking at cardiogenic shock (CS) which occurs in ~5-8% of patients hospitalized with ST elevation MI. Recent research has suggested that the peripheral vasculature and neurohormonal and cytokine systems play a role in the pathogenesis and persistence of CS. Early revascularization improves survival substantially and new mechanical approaches to treatment are available as well as the feasibility of clinical trials even in this high risk population. Reynolds' group is participating in a large scale trial using rigorous scientific methods to validate or debunk the use of chelation for coronary heart disease. Chelation is widely practiced in the alternative medicine community with little evidence to show that it is effective or ineffective, safe or harmful.
Go Red for Women Strategically Focused Research Network Centers
Mosca, Lori; Ouyang, Pamela; Hubel, Carl A; Reynolds, Harmony R; Allison, Matthew A. Go Red for Women Strategically Focused Research Network Centers. Circulation. 2017 Feb 07;135(6):609-611 (2435892)
ESC working group position paper on myocardial infarction with non-obstructive coronary arteries
Agewall, Stefan; Beltrame, John F; Reynolds, Harmony R; Niessner, Alexander; Rosano, Giuseppe; Caforio, Alida L P; De Caterina, Raffaele; Zimarino, Marco; Roffi, Marco; Kjeldsen, Keld; Atar, Dan; Kaski, Juan C; Sechtem, Udo; Tornvall, Per. ESC working group position paper on myocardial infarction with non-obstructive coronary arteries. European heart journal. 2017 Jan 14;38(3):143-153 (2435942)
Postoperative Tachycardia: Clinically Meaningful or Benign Consequence of Orthopedic Surgery?
Sigmund, Alana E; Fang, Yixin; Chin, Matthew; Reynolds, Harmony R; Horwitz, Leora I; Dweck, Ezra; Iturrate, Eduardo. Postoperative Tachycardia: Clinically Meaningful or Benign Consequence of Orthopedic Surgery?. Mayo Clinic proceedings. 2016 Nov 24;92(1):98-105 (2329172)
Stress Cardiac MRI in Women With Myocardial Infarction and Nonobstructive Coronary Artery Disease
Mauricio, Rina; Srichai, Monvadi B; Axel, Leon; Hochman, Judith S; Reynolds, Harmony R. Stress Cardiac MRI in Women With Myocardial Infarction and Nonobstructive Coronary Artery Disease. Clinical cardiology. 2016 Oct;39(10):596-602 (2191502)
Platelet FcgammaRIIA polymorphism H131R associates with subclinical atherosclerosis and increased platelet activity in SLE
Rasmussen, S; Reynolds, H; Buyon, J P; Nhek, S; Newman, J; Berger, J; Clancy, R M. Platelet FcgammaRIIA polymorphism H131R associates with subclinical atherosclerosis and increased platelet activity in SLE [Meeting Abstract]. Arthritis & rheumatology. 2016 October;Conference:(American):2663-2664 (2398072)