57 Old Forge Rd.
Tuxedo, NY 10987
Dr. Qu''s research interests have been mainly focused on: 1) biomarker application and risk assessment in human populations exposed to occupational or environmental pollutants; and 2) identification of genetic susceptibility factors in human diseases with environmental origins. Previous studies have shown that both urinary S-phenylmercapturic acid (S-PMA) and t,t-muconic acid, especially S-PMA, are the most sensitive and reliable exposure markers for low level benzene exposure in workers. In addition, the genotypes of CYP2E1, NQO1, MPO, and GSTT1 genes were identified in all recruited subjects, including both healthy benzene exposed and poisoned workers. The healthy exposed workers with NQO1 variant alleles showed significantly lower WBC and neutrophil counts than those who have homozygous wild type alleles, especially after adjusting for smoking, gender, and benzene exposure. Comparison between healthy exposed and poisoned workers further confirmed the finding that variant alleles of NQO1 gene may make people more susceptible to benzene-associated hematotoxicity. One of the ongoing projects has been conducted in a Chinese occupational population to validate the biomarkers of polycyclic aromatic hydrocarbons (PAHs) exposure, including 1-hydroxypyrene (1-OH-P) in urine, DNA adducts, DNA damage detected by comet assay in lymphocytes, albumin adducts of PAHs metabolites, and identification of polymorphisms of metabolic genes, such as CYP1A1, GSTM1, microsomal epoxide hydrolase (mEH). Another newly funded project focuses on the biomarker applications and risk assessment for Cr(VI) in humans with broad range of exposures to chromium. In this study, The Cr levels in erythrocytes, lymphocytes, DNA-protein crosslinks, DNA damage detected by comet assay in lymphocytes, and 8-hydroxy-2!?-deoxyguanosine are being measured and evaluated as both exposure and biological effect markers.
Metal rich particulate matter impairs acetylcholine-mediated vasorelaxation of microvessels in mice
Cuevas, Azita K; Niu, Jingping; Zhong, Mianhua; Liberda, Eric N; Ghio, Andrew; Qu, Qingshan; Chen, Lung Chi. Metal rich particulate matter impairs acetylcholine-mediated vasorelaxation of microvessels in mice. Particle & fibre toxicology. 2015 Jun 4;12:14-14 (1616592)
Improving Knowledge about Children's Environmental Health in Northwest China
Niu, Jingping; Qu, Qingshan; Li, Juansheng; Liu, Xingrong; Zhang, Benzhong; Li, Zhilan; Ding, Guowu; Sun, Yingbiao; Shi, Yanrong; Wan, Yaxiong; Hu, Xiaobin; Chen, Lung-Chi; Mendelsohn, Alan; Chen, Yu; Trasande, Leonardo. Improving Knowledge about Children's Environmental Health in Northwest China. International journal of environmental research & public health. 2015 Dec 25;13(1):80-80 (1894472)
Micro-RNA regulation by exposure to air pollution and antigen
Grunig, G; Lucas, B; Kazeros, A; Reibman, J; Rom, W N; Qu, Q; Park, S -H. Micro-RNA regulation by exposure to air pollution and antigen [Meeting Abstract]. American journal of respiratory & critical care medicine. 2014 2014;189:- (1824422)
The acute exposure effects of inhaled nickel nanoparticles on murine endothelial progenitor cells
Liberda, Eric N; Cuevas, Azita K; Qu, Qingshan; Chen, Lung Chi. The acute exposure effects of inhaled nickel nanoparticles on murine endothelial progenitor cells. Inhalation toxicology. 2014 Aug ;26(10):588-597 (1161512)
Regulation of microRNA expression in the lungs by exposure to air pollution & antigen
Lucas, B; Chen, W -C; Bleck, B; Reibman, J; Rom, W; Narayanan, N; Qu, Q; Park, S -H; Grunig, G. Regulation of microRNA expression in the lungs by exposure to air pollution & antigen [Meeting Abstract]. Journal of immunology (1950). 2014 01 May;192(1):?-? (1058342)