1 Park Avenue
New York, NY 10016
A major focus of Dr. Pomara’s research has been to elucidate pharmacokinetic and pharmacodynamic factors that may contribute to individual vulnerability to drug induced cognitive and psychomotor toxicity in the elderly. He has shown that certain variants of the APOE and TOMM40 genes increase risk for drug-induced adverse events unrelated to pharmacokinetic factors and likely reflecting pharmacodynamic mechanisms.
Other important contributions include his early reports of increased activity in the HPA axis associated with both aging and AD, as determined by studies of baseline cortisol and dexamethasone response. These results led to the first pilot clinical trial that examined the cognitive effects of the glucocorticoid receptor antagonist, RU486, in AD. Dr. Pomara also provided the first report on an absence of a cortisol response to naltrexone and an elevation in CSF-glutamate in Alzheimer’s patients.
Dr. Pomara additionally presented the first evidence that late life depression, a condition associated with increased risk for Alzheimer’s disease (AD) or prodromal phase, may be accompanied by disturbances in central and peripheral metabolism of amyloid-beta, a peptide implicated in AD. More recently, he has been collaborating with the NYU Cohen Veterans Center to identify biomarkers for PTSD/TBI.
Selective and state-dependent changes in CSF abeta42 levels in cognitively-intact elderly with late life major depression
Pomara, N; Nierenberg, J; Bruno, D; Reichert, C; Osorio, R; Sarreal, A; Hernando, R; Marmar, C; Wisniewski, T; Zetterberg, H; Blennow, K. Selective and state-dependent changes in CSF abeta42 levels in cognitively-intact elderly with late life major depression [Meeting Abstract]. Neuropsychopharmacology. 2016 December;Conference:(55th):S544- (2397672)
The recency ratio as an index of cognitive performance and decline in elderly individuals
Bruno, Davide; Reichert, Chelsea; Pomara, Nunzio. The recency ratio as an index of cognitive performance and decline in elderly individuals. Journal of clinical & experimental neuropsychology. 2016 Nov;38(9):967-973 (2236382)
Neuronal correlates of serial position performance in amnestic mild cognitive impairment
Kasper, Elisabeth; Brueggen, Katharina; Grothe, Michel J; Bruno, Davide; Pomara, Nunzio; Unterauer, Elisabeth; Duering, Marco; Ewers, Michael; Teipel, Stefan; Buerger, Katharina. Neuronal correlates of serial position performance in amnestic mild cognitive impairment. Neuropsychology. 2016 Nov;30(8):906-914 (2312402)
State-dependent alterations in cerebrospinal fluid Abeta42 levels in cognitively intact elderly with late-life major depression
Pomara, Nunzio; Bruno, Davide; Osorio, Ricardo S; Reichert, Chelsea; Nierenberg, Jay; Sarreal, Antero S; Hernando, Raymundo T; Marmar, Charles R; Wisniewski, Thomas; Zetterberg, Henrik; Blennow, Kaj. State-dependent alterations in cerebrospinal fluid Abeta42 levels in cognitively intact elderly with late-life major depression. Neuroreport. 2016 Sep 28;27(14):1068-1071 (2213652)
Major Depression May Lead to Elevations in Potentially Neurotoxic Amyloid Beta Species Independently of Alzheimer Disease
Pomara, Nunzio; Bruno, Davide. Major Depression May Lead to Elevations in Potentially Neurotoxic Amyloid Beta Species Independently of Alzheimer Disease [Editorial]. American journal of geriatric psychiatry. 2016 Sep;24(9):773-775 (2231782)