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Biosketch / Results /

Claudia Plottel, M.D.

Clinical Associate Professor;
Department of Medicine (Health Info+Bioinformatics) [1]

Clinical Addresses

550 FIRST AVENUE, OBV C/D 640
NEW YORK, NY 10016
Handicap Access: yes
Phone: 212-263-0862
Fax: 212-263-0596
[3]

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Medical Specialties

Pulmonary Medicine, Internal Medicine

Languages

French, Spanish

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Board Certification

1987 — Ab Internal Medicine - Internal Medicine
2000 — Ab Internal Medicine (Pulmonary Disease)

Education

1984 — Medical College of Pennsylvania, Philadelphia, PA, Medical Education
1984-1988 — NYU Medical Center (Internal Medicine), Residency Training
1988-1990 — NYU Medical Center (Pulmonary & Critical), Clinical Fellowships

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Research Summary

Study of the gut microbiome and estrogen metabolism in women with and without Type I endometrioid endometrial carcinoma. Antibiotic-induced gut microbiota perturbation and estrogen metabolism. Estrogen metabolism, gut microbiome, and estrogen-driven neoplasia.

Research Interests

Estrogen, essential for human health and reproduction, plays a role in malignancies such as Type I endometrial carcinoma, and forms of breast and ovarian cancer. The clinical success of anti-estrogen therapies including tamoxifen and aromatase-inhibitors, speaks to the centrality of estrogens in estrogen receptor-expressing breast cancers. Epidemiologic data has similarly implicated states of estrogen excess, such as obesity, nulliparity, early menarche, and late age at menopause as risks for the development of estrogen-related cancers. Estrogen exposure begins in utero and is lifelong. Circulating estrogens are subject to hepatic metabolism; hepatic conjugation reactions allow for biliary excretion of estrogen conjugates. Estrogens that enter the gut via bile are then either excreted in feces primarily as conjugates, or recirculated via the enterohepatic circulation. We are interested in characterizing the ?switch? that allows for greater or lesser estrogen recirculation as women with the highest levels of circulating estrogens are known to be at increased risk of developing estrogen-related cancers. The composition and functioning of the huge intestinal community of metabolically active microorganisms that constitute a woman?s intestinal microbiome may impact her lifetime endogenous estrogen exposure. Our current research focus in both humans and in murine models is the estrobolome, the aggregate of enteric bacterial genes whose products are capable of metabolizing estrogens.

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search [9]

100 questions & answers about asthma
Plottel, Claudia S
Sudbury MA : Jones & Bartlett, 2011,
— id: 2165, year: 2011, vol: , page: , stat: ,

Microbiome and malignancy
Plottel, Claudia S; Blaser, Martin J
2011 Oct 4;10(4):324-335, Cell Host & Microbe
— id: 139747, year: 2011, vol: 10, page: 324, stat: Journal Article,

100 preguntas y respuestas acerca del asma en los ninos = [100 questions & answers about your child's asthma]
Plottel, Claudia S; Feldman, B Robert
Alcala de Guadaira, Sevilla MAD, 2008 ,
— id: 2166, year: 2008, vol: , page: , stat: ,

100 questions & answers about your child's asthma
Plottel, Claudia S; Feldman, Bernard R
Sudbury MA : Jones & Bartlett, 2008,
— id: 1354, year: 2008, vol: , page: , stat: ,

Miat sual wa jawab hawla marad al-rabu = [100 questions & answers about asthma]
Plottel, Claudia S
Bayrut : al-Dar al-'arabiyah lil-'ulum, 2006,
— id: