540-562 First Avenue
New York, NY 10016
Dr. Placantonakis obtained his MD/PhD degree in Neuroscience from NYU School of Medicine and completed a postdoctoral fellowship in human embryonic stem cell biology with Drs. Lorenz Studer and Viviane Tabar at Memorial Sloan-Kettering. He was also trained in Neurosurgery at Weill Cornell Medical College and Memorial Sloan-Kettering. At NYU, he is a tenure-track physician-scientist dividing his time between his neurosurgical practice and the laboratory. Dr. Placantonakis has an interest in the treatment of gliomas and brain tumors in general. The Neurosurgical Laboratory for Stem Cell Research, which is headed by Dr. Placantonakis, studies stem cell biology in the context of glioma, a malignant brain tumor. We adapt human embryonic stem cell and genetic technologies to model oncogenic processes, with the goal of understanding the early steps in glioma formation and developing translational applications, such as high-throughput drug screening and biomarker identification. Furthermore, we use genetic approaches and patients' tissue to generate models for high-grade gliomas, with emphasis on the role of stem cells in pathogenesis and new therapeutic approaches that directly target them. Our ultimate goal is to translate our laboratory findings to new therapies and diagnostic tests for patients with glioma.
Dr. Placantonakis' laboratory is funded by the National Institutes of Health (NIH) and private foundations.
GPR133 (ADGRD1), an adhesion G-protein-coupled receptor, is necessary for glioblastoma growth
Bayin, N S; Frenster, J D; Kane, J R; Rubenstein, J; Modrek, A S; Baitalmal, R; Dolgalev, I; Rudzenski, K; Scarabottolo, L; Crespi, D; Redaelli, L; Snuderl, M; Golfinos, J G; Doyle, W; Pacione, D; Parker, E C; Chi, A S; Heguy, A; MacNeil, D J; Shohdy, N; Zagzag, D; Placantonakis, D G. GPR133 (ADGRD1), an adhesion G-protein-coupled receptor, is necessary for glioblastoma growth. Oncogenesis. 2016 Oct 24;5:e263-e263 e263 (2281812)
144 GPR133 Promotes Glioblastoma Growth in Hypoxia
Bayin, Nermin Sumru; Frenster, Joshua; Kane, J Robert; Modrek, Aram; Shohdy, Nadim; MacNeil, Douglas J; Zagzag, David; Placantonakis, Dimitris G. 144 GPR133 Promotes Glioblastoma Growth in Hypoxia. Neurosurgery. 2016 Aug;63 Suppl 1:158-159 (2263492)
Adult Primary Spinal Epidural Extraosseous Ewing's Sarcoma: A Case Report and Review of the Literature
Bustoros, Mark; Thomas, Cheddhi; Frenster, Joshua; Modrek, Aram S; Bayin, N Sumru; Snuderl, Matija; Rosen, Gerald; Schiff, Peter B; Placantonakis, Dimitris G. Adult Primary Spinal Epidural Extraosseous Ewing's Sarcoma: A Case Report and Review of the Literature. Case reports in neurological medicine. 2016 ;2016:1217428-1217428 (2238732)
Traumatic brain injury and subsequent glioblastoma development: Review of the literature and case reports
Tyagi, Vineet; Theobald, Jason; Barger, James; Bustoros, Mark; Bayin, N Sumru; Modrek, Aram S; Kader, Michael; Anderer, Erich G; Donahue, Bernadine; Fatterpekar, Girish; Placantonakis, Dimitris G. Traumatic brain injury and subsequent glioblastoma development: Review of the literature and case reports. Surgical neurology international. 2016 ;7:78-78 (2246622)
Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells
Basu-Roy, Upal; Bayin, N Sumru; Rattanakorn, Kirk; Han, Eugenia; Placantonakis, Dimitris G; Mansukhani, Alka; Basilico, Claudio. Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells. Nature communications. 2015 Apr 2;6:6411-6411 (1519512)