550 First Avenue
New York, NY 10016
Our laboratory investigates the mechanisms of oncogene activation, tumor suppressor gene inactivation and the function that these genes have in malignant transformation and normal cellular processes. Specifically, we study the ras family genes, which are activated in a significant percentage of human tumors. Working with animal model systems, we have induced several types of tumors and analyzed them at the molecular level. To determine the exact role of the N-ras oncogene in these tumors, we constructed several lines of transgenic mice that develop different types of neoplasias, mimicking the phenotype of the tumors from where the oncogene was originally isolated. Moreover, with mutant mice lacking the N-ras gene (knockout) we are determining the cellular pathways in which this gene is specifically involved.
In addition, we are characterizing a new oncogene identified in the laboratory, rsc, that is a homologue of the activator for another member of the ras extended gene family, Ral, and we are continuing our studies on the mechanisms of inactivation of p15 in murine thymic lymphomas.
The differential palmitoylation States of N-ras and h-ras determine their distinct Golgi subcompartment localizations
Lynch, Stephen J; Snitkin, Harriet; Gumper, Iwona; Philips, Mark R; Sabatini, David; Pellicer, Angel. The differential palmitoylation States of N-ras and h-ras determine their distinct Golgi subcompartment localizations. Journal of cellular physiology. 2015 Mar;230(3):610-619 (1360222)
In TCR-Stimulated T-cells, N-ras Regulates Specific Genes and Signal Transduction Pathways
Lynch, Stephen J; Zavadil, Jiri; Pellicer, Angel. In TCR-Stimulated T-cells, N-ras Regulates Specific Genes and Signal Transduction Pathways. PLoS one. 2014 ;8(6):e63193-e63193 e63193 (394082)
Sindbis viral vectors target hematopoietic malignant cells
Suzme, R; Tseng, J-C; Levin, B; Ibrahim, S; Meruelo, D; Pellicer, A. Sindbis viral vectors target hematopoietic malignant cells. Cancer gene therapy. 2012 Nov;19(11):757-766 (180084)
Wild type N-ras displays anti-malignant properties, in part by downregulating decorin
Benet M; Dulman RY; Suzme R; de Miera EV; Vega ME; Nguyen T; Zavadil J; Pellicer A. Wild type N-ras displays anti-malignant properties, in part by downregulating decorin. Journal of cellular physiology. 2012 Jun;227(6):2341-2351 (137054)
p15INK4b plays a crucial role in murine lymphoid development and tumorigenesis
Osei-Sarfo, Kwame; Perez de Castro, Ignacio; Pellicer, Angel. p15INK4b plays a crucial role in murine lymphoid development and tumorigenesis. Carcinogenesis. 2012 Mar;33(3):708-713 (158582)