225 East 34th Street
New York, NY 10016
The Comprehensive Epilepsy Center, directed by Orrin Devinsky, M.D., offers multidisciplinary evaluation, medical treatment and surgical intervention for epilepsies by a team of epileptologists, neuropsychologists, neurosurgeons, psychiatrists, and other specially trained support personnel. The major goal of the Center is to provide comprehensive care to people with epilepsy. Routine and advanced diagnostic studies, 10 clinical pharmacologic trials, and a variety of therapeutic interventions are carried out to better understand the disorder and improve treatment.
Dr. Devinsky and his co-investigators are presently conducting studies of several investigational antiepileptic medications such as topiramate, tiagabine, lamotrigine, vigabatrin, oxcarbazepine, and remacemide, as well as vagal nerve stimulator implantation. The Comprehensive Epilepsy Center offers 16 inpatient video-EEG-monitored beds in a specialized Epilepsy Monitoring Unit. Each bed has the capacity for 64 channels of EEG data with on-line computer analysis for 24-hour seizure and spike detection.
Preoperative neuropsychological assessment, invasive monitoring including depth and subdural electrode studies, intraoperative electrocorticography and functional localization of language, motor and sensory areas permits precise surgical approaches to remove epileptic tissue while sparing necessary brain areas.
A major miss in prognostication after cardiac arrest: Burst suppression and brain healing
Becker, Danielle A; Schiff, Nicholas D; Becker, Lance B; Holmes, Manisha G; Fins, Joseph J; Horowitz, James M; Devinsky, Orrin. A major miss in prognostication after cardiac arrest: Burst suppression and brain healing. Epilepsy & behavior case reports. 2017 ;7:1-5 (2386742)
Parahippocampal and Entorhinal Resection Extent Predicts Verbal Memory Decline in an Epilepsy Surgery Cohort
Lu, Anil; Thesen, Thomas; Barr, William; Morrison, Chris; Dugan, Patricia; Wang, Xiuyuan; Meager, Michael; Doyle, Werner; Kuzniecky, Ruben; Devinsky, Orrin; Blackmon, Karen. Parahippocampal and Entorhinal Resection Extent Predicts Verbal Memory Decline in an Epilepsy Surgery Cohort. Journal of cognitive neuroscience. 2016 Dec 19;:1-12 (2374262)
Musical hallucinations: a brief review of functional neuroimaging findings
Bernardini, Francesco; Attademo, Luigi; Blackmon, Karen; Devinsky, Orrin. Musical hallucinations: a brief review of functional neuroimaging findings. CNS spectrums. 2016 Dec 19;:1-7 (2396662)
Manipulating stored phonological input during verbal working memory
Cogan, Gregory B; Iyer, Asha; Melloni, Lucia; Thesen, Thomas; Friedman, Daniel; Doyle, Werner; Devinsky, Orrin; Pesaran, Bijan. Manipulating stored phonological input during verbal working memory. Nature neuroscience. 2016 Dec 12;:?-? (2363302)
De novo mutations of KIAA2022 in females cause intellectual disability and intractable epilepsy
de Lange, Iris M; Helbig, Katherine L; Weckhuysen, Sarah; Moller, Rikke S; Velinov, Milen; Dolzhanskaya, Natalia; Marsh, Eric; Helbig, Ingo; Devinsky, Orrin; Tang, Sha; Mefford, Heather C; Myers, Candace T; van Paesschen, Wim; Striano, Pasquale; van Gassen, Koen; van Kempen, Marjan; de Kovel, Carolien G F; Piard, Juliette; Minassian, Berge A; Nezarati, Marjan M; Pessoa, Andre; Jacquette, Aurelia; Maher, Bridget; Balestrini, Simona; Sisodiya, Sanjay; Warde, Marie Therese Abi; De St Martin, Anne; Chelly, Jamel; van 't Slot, Ruben; Van Maldergem, Lionel; Brilstra, Eva H; Koeleman, Bobby P C. De novo mutations of KIAA2022 in females cause intellectual disability and intractable epilepsy. Journal of medical genetics. 2016 Dec;53(12):850-858 (2167052)