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Studies in these specific areas have been ongoing at NYU Medical Center since 1967. Dr. Nachtigall conducted a comprehensive ten year prospective double blind placebo controlled study of estrogen replacement therapy and the relationship to carcinoma, cardiovascular disease, and osteoporosis in a sample of hospitalized women. From the 300 women recruited, 168 were followed as matched pairs. This study was the first to demonstrate the increased survival of patients on ERT, of lipid patterns as a significant risk factor, and of a reduction in breast cancer incidence in treated patients as compared to the controls. Moreover, a ten year follow-up with single photon densitometer measurements found continued increase in bone density in treated women who had their last menstrual period within three years or less, while those on placebo continued to lose bone. In addition, treated women who had their last menstrual period more than three years previously, kept their bone at a steady level, while their placebo controlled matched pairs continued to lose bone. Dr. Nachtigall subsequently conducted a 22 year follow-up on these studies, losing only five patients to follow-up or breast cancer.
Studies are continuing to address such issues as the efficacy of transdermal versus oral estrogen, the use of progesterone in prevention of endometrial cancer, the ability to decrease the side effects of progesterone therapy and on cardiovascular disease in older women, with and without hormones.
Long term hormone replacement therapy (HT) does not affect post-menopausal total body composition
Bayer, A H; Goldman, K N; Mauricio, R; Nachtigall, M J; Naftolin, F; Nachtigall, L E. Long term hormone replacement therapy (HT) does not affect post-menopausal total body composition [Meeting Abstract]. Fertility & sterility. 2015 September 2015;104(3):e5-e6 (1806592)
DXA assessment of adiposity is a better predictor of metabolic risk than BMI
Goldstein, Steven R; Hirsch, Jacqueline; Oh, Cheongeun; Nachtigall, Richard; Nachtigall, Lila. DXA assessment of adiposity is a better predictor of metabolic risk than BMI [Meeting Abstract]. Menopause. 2015 DEC;22(12):1397-1397 (1989382)
Is Percentile Body Fat by Dual-Energy X-Ray Absorptiometry a Better Surrogate for Metabolic Health Than Body Mass Index?
Goldstein, Steven Robert; Nachtigall, Lila E; Nachtigall, Richard. Is Percentile Body Fat by Dual-Energy X-Ray Absorptiometry a Better Surrogate for Metabolic Health Than Body Mass Index? [Meeting Abstract]. Obstetrics & gynecology. 2015 MAY;125:98S-99S (1610192)
Hormone therapy and ovarian cancer
Naftolin, Frederick; Friedenthal, Jenna; Blakemore, Jennifer; Nachtigall, Lila. Hormone therapy and ovarian cancer [Letter]. Lancet. 2015 Sep 12;386(9998):1037-1037 (1779392)
Hot flashes: is a hot flash just a hot flash?
Nachtigall, Lila. Hot flashes: is a hot flash just a hot flash?. Menopause. 2014 Jun ;21(6):551-552 (1004902)