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Biosketch / Results /

Jayne Raper, Ph.D.

Adjunct Professor;
Departments of Microbiology (Microbiology ) [1] and Medical Parasitology (MP Division ) [2]

Contact Info

Address
550 1st Avenue
Floor 2 Room MSB 228
Medical Science Building
New York, NY 10016

212-263-7632
212-263-8276
Jayne.Raper@nyumc.org


[4]

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Education

1985-1989 — Cambridge University, Graduate Education

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Research Summary

Trypanosome Lytic Factor (TLF) has emerged as a novel arm of innate immunity that is only present in humans and select non-human primates. TLF was originally discovered in human blood as a minor form of HDL that rapidly kills the African trypanosome, Trypanosoma brucei brucei, thereby making humans resistant to infection. However, two other trypanosome species, T. b. rhodesiense and T. b. gambiense, resist killing by human TLF, thereby infecting humans and causing sleeping sickness. Interestingly, baboons can kill these human infective trypanosomes, thereby rendering baboons resistant to all trypanosome species. We have recently shown that this is due to baboon TLF. We have also recently shown that TLF can also ameliorate disease for other pathogens such as Leishmania, which is an intracellular parasite that grows inside a specialized vesicle in macrophages. Our long-term objective is to understand the overall broader role of TLF in innate immunity. Toward this goal,seek to understand the detailed mechanism by which TLF can bind to and kill an intracellular parasite like Leishmania, as well as how differences in the sequences of the components of baboon and human TLFs can give rise to protection from a broader range of pathogens. Understanding these mechanism will provide insights as to other pathogens that TLF should kill, as well as offer potential avenues to therapeutically augment or mimic TLF action.

Research Interests

African trypanosome lytic factors: novel mediators of human innate immunity

Research Keywords

endocytosis, low-density lipoprotein (LDL), receptors, sleeping sickness, trypanosome lytic factors (TLF), trypanosome

Grant Keywords

Disease Control, Biodefense, Hematology, Foodborne Pathogens, Cholesterol, Animal Model, Blood/Blood Products/Transfusions, Disease Prevention, Infectious Diseases/Agents, Fungal Diseases, Cardiovascular Diseases, Blood Diseases, Autoimmunity, Biomedical Research, Multidisciplinary

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search [9]

Early invasion of brain parenchyma by african trypanosomes
Frevert, Ute; Movila, Alexandru; Nikolskaia, Olga V; Raper, Jayne; Mackey, Zachary B; Abdulla, Maha; McKerrow, James; Grab, Dennis J
2012 ;7(8):e43913-e43913 e43913, PLoS ONE
— id: 177170, year: 2012, vol: 7, page: e43913, stat: Journal Article,

Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by trypanolytic factor 1
Capewell, Paul; Veitch, Nicola J; Turner, C Michael R; Raper, Jayne; Berriman, Matthew; Hajduk, Stephen L; MacLeod, Annette
2011 Sep;5(9):e1287-e1287, PLoS neglected tropical diseases
— id: 141721, year: 2011, vol: 5, page: e1287, stat: Journal Article,

Prophylactic Antiparasitic Transgenesis for Human Parasitic Disease?
Lukes, Julius; Raper, Jayne
2010 OCT ;18(10):1745-1747, Molecular therapy
— id: 113909, year: 2010, vol: 18, page: 1745, stat: Journal Article,

Primate evolution of antimicrobial high-density lipoprotein
Raper, J; Thomson, R; Carrington, M
2010 MAY ;119(5):194-194, American journal of physical anthropology
— id: 109835, year: 2010, vol: 119, page: 194, stat: Journal Article,

Identification of Three Classes of Heteroaromatic Compounds with Activity against Intracellular Trypanosoma cruzi by Chemical Library Screening
Bettiol, Esther; Samanovic, Marie; Murkin, Andrew S; Raper, Jayne; Buckner, Frederick; Rodriguez, Ana
2009 ;3(2):e384-e384, PLoS neglected tropical diseases
— id: 96764, year: 2009, vol: 3, page: e384, stat: Journal Article,

Trypanosome lytic factor, an antimicrobial high-density lipoprotein, ameliorates Leishmania infection
Samanovic, Marie; Molina-Portela, Maria Pilar; Chessler, Anne-Danielle C; Burleigh, Barbara A; Raper, Jayne
2009 Jan;5(1):e1000276-e1000276, PLoS pathogens
— id: 96765, year: 2009, vol: 5, page: e1000276, stat: Journal Article,

Hydrodynamic gene delivery of baboon trypanosome lytic factor eliminates both animal and human-infective African trypanosomes
Thomson, Russell; Molina-Portela, Pilar; Mott, Helen; Carrington, Mark; Raper, Jayne
2009 Nov 17;106(46):19509-19514, Proceedings of the National Academy of Sciences of the United States of America
— id: 105362, year: 2009, vol: 106, page: 19509, stat: Journal Article,

Activity of trypanosome lytic factor: a novel component of innate immunity
Thomson, Russell; Samanovic, Marie; Raper, Jayne
2009 Sep;4:789-796, Future microbiology
— id: 101964, year: 2009, vol: 4, page: 789, stat: Journal Article,

Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model
Molina-Portela, Maria Pilar; Samanovic, Marie; Raper, Jayne
2008 Aug 4;205(8):1721-1728, Journal of experimental medicine
— id: 96766, year: 2008, vol: 205, page: 1721, stat: Journal Article,

Trypanosome lytic factor, a subclass of high-density lipoprotein, forms cation-selective pores in membranes
Molina-Portela, Maria del Pilar; Lugli, Elena B; Recio-Pinto, Esperanza; Raper, Jayne
2005 Dec;144(2):218-226, Molecular & biochemical parasitology
— id: 62362, year: 2005, vol: 144, page: 218, stat: Journal Article,

Characterization of primate trypanosome lytic factors
Lugli, Elena B; Pouliot, Michael; Portela, Maria Del Pilar Molina; Loomis, Michael R; Raper, Jayne
2004 Nov;138(1):9-20, Molecular & biochemical parasitology
— id: 46466, year: 2004, vol: 138, page: 9, stat: Journal Article,

Evidence for a Trypanosoma brucei lipoprotein scavenger receptor
Green, Heather P; Del Pilar Molina Portela, Maria; St Jean, Emmanuelle N; Lugli, Elena B; Raper, Jayne
2003 Jan 3;278(1):422-427, Journal of biological chemistry
— id: 39381, year: 2003, vol: 278, page: 422, stat: Journal Article,

Natural immunity to human African trypanosomiasis: trypanosome lytic factors and the blood incubation infectivity test
Raper, Jayne; Portela Molina, Maria Pilar; Redpath, Maria; Tomlinson, Stephen; Lugli, Elena; Green, Heather
2002 Apr;96 Suppl 1(6):S145-S150, Transactions of the Royal Society of Tropical Medicine & Hygiene
— id: 39632, year: 2002, vol: 96 Suppl 1, page: S145, stat: Journal Article,

Trypanosome lytic factors: novel mediators of human innate immunity
Raper J; Portela MP; Lugli E; Frevert U; Tomlinson S
2001 Aug;4(4):402-408, Current opinion in microbiology
— id: 26706, year: 2001, vol: 4, page: 402, stat: Journal Article,

An investigation into the mechanism of trypanosome lysis by human serum factors
Molina Portela MP; Raper J; Tomlinson S
2000 Oct;110(2):273-282, Molecular & biochemical parasitology
— id: 21262, year: 2000, vol: 110, page: 273, stat: Journal Article,

Characterization of a novel trypanosome lytic factor from human serum
Raper J; Fung R; Ghiso J; Nussenzweig V; Tomlinson S
1999 Apr;67(4):1910-1916, Infection & immunity
— id: 6065, year: 1999, vol: 67, page: 1910, stat: Journal Article,

The purification and characterization of a novel high density lipoprotein immune complex from human serum
Raper, J
1999 APR 23 ;13(7):A1476-A1476, FASEB journal
— id: 53939, year: 1999, vol: 13, page: A1476, stat: Journal Article,

Reply [In Process Citation]
Tomlinson S; Raper J
1999 Jun;15(6):252-252, Parasitology today
— id: 12004, year: 1999, vol: 15, page: 252, stat: Journal Article,

Natural human immunity to trypanosomes
Tomlinson, S; Raper, J
1998 Sep;14(9):354-359, Parasitology today
— id: 105898, year: 1998, vol: 14, page: 354, stat: Journal Article,

Haptoglobin-related protein and apolipoprotein AI are components of the two trypanolytic factors in human serum
Tomlinson S; Muranjan M; Nussenzweig V; Raper J
1997 May;86(1):117-120, Molecular & biochemical parasitology
— id: 7272, year: 1997, vol: 86, page: 117, stat: Journal Article,

An M(r) 145,000 low-density lipoprotein (LDL)-binding protein is conserved throughout the Kinetoplastida order
Bastin P; Stephan A; Raper J; Saint-Remy JM; Opperdoes FR; Courtoy PJ
1996 Feb-Mar;76(1-2):43-56, Molecular & biochemical parasitology
— id: 18804, year: 1996,