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Exposure to airborne pollutants and cigarette smoke are major causes of chronic inflammation in the lungs. The lungs also become more susceptible to infection with viruses or bacteria. The result is the dysfunction of the bronchi that transport air to and from the alveoli, and to the blood vessels that circulate the blood through the lungs. The major focus point of research in the laboratory is to define the role of secreted proteins by which immune cells communicate with the cells that make up the structure of the lungs. This research has identified one of these mediators, called Interleukin-13 (IL-13), to directly initiate the processes that induce the cardinal signs of asthma: bronchial constriction, inflammation and increased mucus production. At the present time, we have a grant from the National Institute of Health that has the goal to help to develop a drug that inhibits Interleukin-13 and a few other key mediators of asthma. We have most recently begun to investigate the blood vessels in the lungs. We have shown for the first time experimentally that the immune response can induce severe wall-thickening of arteries (structure stained in brown by labeling with a smooth muscle specific antibody) in the lungs. In addition, the studies showed that Interleukin-13 (IL-13) is a critical, indirect communicator in the process that leads to the severe thickening of the pulmonary arterial walls. This thickening of the pulmonary arterial walls has been described in patients who have pulmonary hypertension, a debilitating disease that frequently accompanies chronic lung disease caused by smoking. This research might aid in developing new methods to follow disease progression and tailor treatment strategies in patients with pulmonary hypertension.
Aberrant immune response with consequent vascular and connective tissue remodeling - causal to scleroderma and associated syndromes such as Raynaud phenomenon and other fibrosing syndromes?
Durmus, Nedim; Park, Sung-Hyun; Reibman, Joan; Grunig, Gabriele. Aberrant immune response with consequent vascular and connective tissue remodeling - causal to scleroderma and associated syndromes such as Raynaud phenomenon and other fibrosing syndromes?. Current opinion in rheumatology. 2016 Nov;28(6):571-576 (2221422)
Progranulin Recruits HSP70 to beta-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease
Jian, Jinlong; Tian, Qing-Yun; Hettinghouse, Aubryanna; Zhao, Shuai; Liu, Helen; Wei, Jianlu; Grunig, Gabriele; Zhang, Wujuan; Setchell, Kenneth D R; Sun, Ying; Overkleeft, Herman S; Chan, Gerald L; Liu, Chuan-Ju. Progranulin Recruits HSP70 to beta-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease. EBioMedicine. 2016 Nov;13:212-224 (2288842)
[Pathobiology, pathology and genetics of pulmonary hypertension: Recommendations of the Cologne Consensus Conference 2016]
Olschewski, A; Berghausen, E M; Eichstaedt, C A; Fleischmann, B K; Grunig, E; Grunig, G; Hansmann, G; Harbaum, L; Hennigs, J K; Jonigk, D; Kubler, W M; Kwapiszewska, G; Pullamsetti, S S; Stacher, E; Weissmann, N; Wenzel, D; Schermuly, R T. [Pathobiology, pathology and genetics of pulmonary hypertension: Recommendations of the Cologne Consensus Conference 2016]. Deutsche medizinische Wochenschrift (1946). 2016 Oct;141(S 01):S4-S9 (2292922)
Association Between Progranulin and Gaucher Disease
Jian, Jinlong; Zhao, Shuai; Tian, Qing-Yun; Liu, Helen; Zhao, Yunpeng; Chen, Wen-Chi; Grunig, Gabriele; Torres, Paola A; Wang, Betty C; Zeng, Bai; Pastores, Gregory; Tang, Wei; Sun, Ying; Grabowski, Gregory A; Kong, Max Xiangtian; Wang, Guilin; Chen, Ying; Liang, Fengxia; Overkleeft, Herman S; Saunders-Pullman, Rachel; Chan, Gerald L; Liu, Chuan-Ju. Association Between Progranulin and Gaucher Disease. EBioMedicine. 2016 Sep;11:127-137 (2219102)
Spotlight on Inflammation in Pulmonary Hypertension
Grunig, Gabriele; Durmus, Nedim. Spotlight on Inflammation in Pulmonary Hypertension. American journal of respiratory & critical care medicine. 2015 Oct 15;192(8):913-915 (1809842)