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Biosketch / Results /

Lawrence B. Gardner, M.D.

Saul J. Farber Associate Professor of Medicine; Associate Professor;
Departments of Medicine (Hematology Div) [1] and Biochemistry and Molecular Pharmacology [2]
NYU Hematology Associates

Clinical Addresses

240 EAST 38TH STREET
19TH FLOOR
NEW YORK, NY 10016
Handicap Access: yes
Phone: 212-731-5650
Fax: 212-731-5540
[4]

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Medical Specialties

Cancer, Hematology

Medical Expertise

Anemia, Hematologic Cancer, Hematology, Platelet Disease

Insurance

AETNA HMO, AETNA INDEMNITY, AETNA MEDICARE, AETNA POS, AETNA PPO, AFFINITY, Cigna HMO/POS, Cigna PPO, EBCBS EPO, EBCBS HLTHY NY, EBCBS HMO, EBCBS INDEMNITY, EBCBS MEDIBLUE, EBCBS POS, EBCBS PPO, GHI CBP, HEALTHPLUS CHLD HLTH (AMERIGROUP), HEALTHPLUS FAM HLTH (AMERIGROUP), HEALTHPLUS MEDICAID (AMERIGROUP), HIP ACCESS I, HIP ACCESS II, HIP CHLD HLTH, HIP EPO/PPO, HIP FAM HLTH, HIP HMO, HIP MEDICAID, HIP MEDICARE, HIP POS, LOCAL 1199 PPO, MAGNACARE PPO, MULTIPLAN/PHCS PPO, Medicare, NYS EMPIRE PLAN, OXFORD FREEDOM, Oxford Liberty, Oxford Medicare, UHC COMMUNITY & STATE PLAN, UHC EPO, UHC HMO, UHC POS, UHC PPO, UHC TOP TIER

Insurance Disclaimer: Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have changed.

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Board Certification

2001 — Ab Internal Medicine (Hematology)

Education

1993 — Yale University School of Medicine, Medical Education
1993-1994 — Johns Hopkins Hospital (Internal Medicine), Residency Training
1993-1994 — Johns Hopkins University (Medicine), Internship
1996-2000 — Johns Hopkins University (Oncology), Clinical Fellowships
1996-2000 — Johns Hopkins Hospital (Hematology), Clinical Fellowships

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Research Summary

We study the effect of low oxygen (hypoxia) on cell cycle regulation, apoptosis, cellular metabolism, and development. Many tumors are severely hypoxic, and hypoxic tumors have a poorer prognosis than non-hypoxic tumors. While most normal cells growth arrest when hypoxic, we have demonstrated that some neoplastic cells, as well as cells we have manipulated with oncogenes, can proliferate even when hypoxic. Using biochemistry, molecular biology, and cell biology techniques we have delineated two specific cell cycle checkpoints that are activated in hypoxic cells: an Rb mediated G1 arrest, and an S phase arrest that is due to the suppression of the initiation step of DNA replication. We are determining how the DNA initiation complex is altered in hypoxic cells, and the role of the ATR kinase (which we have observed is activated in hypoxic cells) in this alteration. We have also determined that the helix-loop-helix inhibitor, Id-1, is transcriptionally down-regulated in hypoxic cells. This down-regulation is dependent on activation of the activation of the unfolded-protein response, and we and are exploring the mechanism and significance of this observation.

Research Interests

Mechanism and Significance of Hypoxic Regulation of Cell Cycle

Research Keywords

Hypoxia, Cell Cycle, Apoptosis, ATR, HIF-1

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search [10]

Therapeutic Hemoglobin Levels after Gene Transfer in beta-Thalassemia Mice and in Hematopoietic Cells of beta-Thalassemia and Sickle Cells Disease Patients
Breda, Laura; Casu, Carla; Gardenghi, Sara; Bianchi, Nicoletta; Cartegni, Luca; Narla, Mohandas; Yazdanbakhsh, Karina; Musso, Marco; Manwani, Deepa; Little, Jane; Gardner, Lawrence B; Kleinert, Dorothy A; Prus, Eugenia; Fibach, Eitan; Grady, Robert W; Giardina, Patricia J; Gambari, Roberto; Rivella, Stefano
2012 ;7(3):e32345-e32345 e32345, PLoS ONE
— id: 164514, year: 2012, vol: 7, page: e32345, stat: Journal Article,

Hypoxic activation of ATR and the suppression of the initiation of DNA replication through cdc6 degradation
Martin, L; Rainey, M; Santocanale, C; Gardner, L B
2012 Sep;31(36):4076-4084, Oncogene
— id: 178043, year: 2012, vol: 31, page: 4076, stat: Journal Article,

The human ankyrin insulator supports production of therapeutic levels of adult hemoglobin following beta-globin gene transfer in hematopoietic cells derived from thalassemic and sickle cell patients
Breda, L; Casu, C; Bianchi, N; Cartegni, L; Yazdanbakhsh, K; Manwani, D; Mohandas, N; Jelinic, P; David, G; Gardner, L B; Kleinert, D A; Prus, E; Fibach, E; Giardina, P; Gambari, R; Rivella, S
2011 18 Nov 2011;118(21):-, Blood
— id: 169672, year: 2011, vol: 118, page: , stat: Journal Article,

The sarcoplasmic reticulum luminal thiol oxidase ERO1 regulates cardiomyocyte excitation-coupled calcium release and response to hemodynamic load
Chin, King-Tung; Kang, Guoxin; Qu, Jiaxiang; Gardner, Lawrence B; Coetzee, William A; Zito, Ester; Fishman, Glenn I; Ron, David
2011 Aug;25(8):2583-2591, FASEB journal
— id: 135555, year: 2011, vol: 25, page: 2583, stat: Journal Article,

Hypoxia is present in murine atherosclerotic plaques and has multiple adverse effects on macrophage lipid metabolism
Parathath, Sajesh; Mick, Stephanie L; Feig, Jonathan E; Joaquin, Victor; Grauer, Lisa; Habiel, David M; Gassmann, Max; Gardner, Lawrence B; Fisher, Edward A
2011 Oct 28;109(10):1141-1152, Circulation research
— id: 140525, year: 2011, vol: 109, page: 1141, stat: Journal Article,

Perifosine Plus Bortezomib and Dexamethasone in Relapsed/Refractory Multiple Myeloma Patients Previously Treated with Bortezomib: Final Results of a Phase I/II Trial
Richardson, P G; Wolf, J L; Jakubowiak, A J; Zonder, J A; Lonial, S; Irwin, D; Densmore, J; Krishnan, A; Raje, N S; Bar, M H; Schlossman, R; Ghobrial, I M; Munshi, N C; Martin, T; Laubach, J P; Allerton, J P; Hideshima, T; Sportelli, P; Gardner, L; Anderson, K C
2011 18 Nov 2011;118(21):-, Blood
— id: 169657, year: 2011, vol: 118, page: , stat: Journal Article,

Overexpression of the c-myc Oncogene Inhibits Nonsense-mediated RNA Decay in B Lymphocytes
Wang, Ding; Wengrod, Jordan; Gardner, Lawrence B
2011 Nov 18;286(46):40038-40043, Journal of biological chemistry
— id: 145775, year: 2011, vol: 286, page: 40038, stat: Journal Article,

Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis
Wang, Ding; Zavadil, Jiri; Martin, Leenus; Parisi, Fabio; Friedman, Eugene; Levy, David; Harding, Heather; Ron, David; Gardner, Lawrence B
2011 Sep;31(17):3670-3680, Molecular & cellular biology
— id: 136513, year: 2011, vol: 31, page: 3670, stat: Journal Article,

Nonsense-mediated RNA decay regulation by cellular stress: implications for tumorigenesis
Gardner, Lawrence B
2010 Mar;8(3):295-308, Molecular cancer research
— id: 108429, year: 2010, vol: 8, page: 295, stat: Journal Article,

Regulation of the unfolded protein response by eif2bdelta isoforms
Martin, Leenus; Kimball, Scot R; Gardner, Lawrence B
2010 Oct 15;285(42):31944-31953, Journal of biological chemistry
— id: 113943, year: 2010, vol: 285, page: 31944, stat: Journal Article,

The Presence of Hypoxia in Murine Atherosclerotic Plaques and Its Adverse Effects on Macrophage Lipid Metabolism
Parathath, Saj; Mick, Stephanie L.; Feig, Jonathan E.; Lisa, Grauer; Joaquin, Victor; Gassmann, Max; Gardner, Lawrence B.; Fisher, Edward A.
2010 NOV ;30(11):E253-E253, Arteriosclerosis, thrombosis, & vascular biology
— id: 117307, year: 2010, vol: 30, page: E253, stat: Journal Article,

Perifosine in combination with bortezomib and dexamethasone extends progression-free survival and overall survival in relapsed/refractory multiple myeloma patients previously treated with bortezombib: Updated phase I/II trial results
Richardson P.; Lee Wolf J.; Jakubowiak A.; Zonder J.A.; Lonial S.; Irwin D.H.; Krishnan A.; Densmore J.; Raje N.; Bar M.H.; Schlossman R.L.; Ghobrial I.; Munshi N.C.; Martin T.; Laubach J.; Allerton J.P.; Hideshima T.; Gardner L.; Sportelli P.; Anderson K.C.
2009 ;114(22):?-? #1868, Blood
— id: 112213, year: 2009, vol: 114, page: ?, stat: Journal Article,

Regression of HIV-related diffuse large B-cell lymphoma in response to antiviral therapy alone
Amengual, Jennifer E; Zhang, Xinmin; Ibrahim, Sherif; Gardner, Lawrence B
2008 Nov 15;112(10):4359-4360, Blood
— id: 95588, year: 2008, vol: 112, page: 4359, stat: Journal Article,

Heparin-induced antibodies and cardiovascular risk in patients on dialysis
Asmis, Lars M; Segal, Jodi B; Plantinga, Laura C; Fink, Nancy E; Kerman, Jonathan S; Kickler, Thomas S; Coresh, Josef; Gardner, Lawrence B
2008 Sep;100(3):498-504, Thrombosis & haemostasis
— id: 115357, year: 2008, vol: 100, page: 498, stat: Journal Article,

Hypoxic inhibition of nonsense-mediated RNA decay regulates gene expression and the integrated stress response
Gardner, Lawrence B
2008 Jun;28(11):3729-3741, Molecular & cellular biology
— id: 79298, year: 2008, vol: 28, page: 3729, stat: Journal Article,

Hypoxic regulation of mRNA expression
Gardner, Lawrence B; Corn, Paul G
2008 Jul 1;7(13):1916-1924, Cell cycle
— id: 86650, year: 2008, vol: 7, page: 1916, stat: Journal Article,

Role of hypoxia and cAMP in the transdifferentiation of human fetal cardiac fibroblasts: implications for progression to scarring in autoimmune-associated congenital heart block
Clancy, Robert M; Zheng, Ping; O'Mahony, Marguerita; Izmirly, Peter; Zavadil, Jiri; Gardner, Lawrence; Buyon, Jill P
2007 Dec;56(12):4120-4131, Arthritis & rheumatism
— id: 75771, year: 2007, vol: 56, page: 4120, stat: Journal Article,

Inhibition of nonsense mediated RNA decay in hypoxic cells; Implications for thalassemia
Gardner, LB
2007 NOV 16 ;110(11):528A-528A, Blood
— id: 76179, year: 2007, vol: 110, page: 528A, stat: Journal Article,

Hypoxic regulation of Id-1 and activation of the unfolded protein response are aberrant in neuroblastoma
Nemetski, S Maureen; Gardner, Lawrence B
2007 Jan 5;282(1):240-248, Journal of biological chemistry
— id: 70311, year: 2007, vol: 282, page: 240, stat: Journal Article,

Hypoxia-inducible factor-1alpha promotes nonhypoxia-mediated proliferation in colon cancer cells and xenografts
Dang, Duyen T; Chen, Fang; Gardner, Lawrence B; Cummins, Jordan M; Rago, Carlo; Bunz, Fred; Kantsevoy, Sergey V; Dang, Long H
2006 Feb 1;66(3):1684-1936, Cancer research
— id: 115358, year: 2006, vol: 66, page: 1684, stat: Journal Article,

Severe macrophage hypoxia alters expression of genes of cholesterol metabolism and transport and converts them to a foam-cell like phenotype
Mick, SL; Feig, JE; Habiel, DM; Gardner, LB; Fisher, EA
2006 MAY ;26(5):E79-E79, Arteriosclerosis, thrombosis, & vascular biology
— id: 63869, year: 2006, vol: 26, page: E79, stat: Journal Article,

Hypoxia, an environmental stress, in initiation and progression of the pathologic cascade to congenital heart block
Clancy, R; Zheng, P; Gardner, L; Buyon, JP
2005 SEP ;52(9):S303-S303, Arthritis & rheumatism
— id: 59276, year: 2005, vol: 52, page: S303, stat: Journal Article,

The novel cyclophilin binding compound, sanglifehrin A, disassociates G1 cell cycle arrest from tolerance induction