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Extensive mechanical, histological, and biochemical evaluations show that the regenerated cartilage has properties nearly identical to those of the normal cartilage. Furthermore, this neocartilage showed no sign of arthritic deterioration 6 mo after implantation. We continue to investigate the use of growth factors to enhance the repair induced by cell transplants, as well as cell-free devices. We have extended our studies to large animal models (dogs, goats) to replicate the clinical situation. Our most recent studies are testing the use of stem cells and gene therapy techniques to regenerate damaged articular surfaces.
The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling
Zhao, Yun-Peng; Tian, Qing-Yun; Frenkel, Sally; Liu, Chuan-Ju
2013-06-24; 0142-9612,Biomaterials - id: 394052, year: 2013 Journal Article
Adenosine A2A Receptor Activation Prevents Wear Particle-Induced Osteolysis
Mediero, Aranzazu; Frenkel, Sally R; Wilder, Tuere; He, Wenjie; Mazumder, Amitabha; Cronstein, Bruce N
2012-05-28; 1946-6234,Science translational medicine - id: 167513, year: 2012 Journal Article
The BioDigital Human: A Web-based 3D Platform for Medical Visualization and Education
Qualter, John; Sculli, Frank; Oliker, Aaron; Napier, Zachary; Lee, Sabrina; Garcia, Julio; Frenkel, Sally; Harnik, Victoria; Triola, Marc
2012-02-27; 0926-9630,Studies in health technology & informatics - id: 157490, year: 2012 Journal Article
Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis
Feng, Jian Q; Guo, Feng-Jin; Jiang, Bai-Chun; Zhang, Yan; Frenkel, Sally; Wang, Da-Wei; Tang, Wei; Xie, Yixia; Liu, Chuan-Ju
2012-02-23; 0892-6638,FASEB journal - id: 156179, year: 2010 Journal Article; Research Support, N.I.H., Extramural
Adenosine A2A receptor agonists: Can they prevent/treat joint prosthesis loosening?
Mediero A.; Frenkel S.R.; Wilder T.; Immerman I.; Hadley S.; Howell R.D.; Hawly M.
2012-02-05; 0004-3591,Arthritis & rheumatism - id: 130923, year: 2010