522 First Avenue
New York, NY 10016
The goal of the work in the Ernst Laboratory is to contribute to the eradication of tuberculosis, by understanding the mechanisms and limitations of immunity to tuberculosis and developing ways to make the immune response more effective. We develop and apply new tools adapted from immunology and bacterial genomics to study the impact of human immune responses on evolution of the bacteria, and use the information to inform new approaches to vaccine development. We also manipulate the bacterial genome, together with genetically-engineered mice, to obtain a deeper understanding of the mechanisms used by M. tuberculosis to evade recognition and elimination by host immune responses.
Learn more about the Ernst Lab.
Type I interferon is pathogenic during chronic Mycobacterium africanum infection
Wiens, Kirsten E; Ernst, Joel D. Type I interferon is pathogenic during chronic Mycobacterium africanum infection. Journal of infectious diseases. 2016 Dec 15;214(12):1893-1896 (2297212)
Within Host Evolution Selects for a Dominant Genotype of Mycobacterium tuberculosis while T Cells Increase Pathogen Genetic Diversity
Copin, Richard; Wang, Xueying; Louie, Eddie; Escuyer, Vincent; Coscolla, Mireia; Gagneux, Sebastien; Palmer, Guy H; Ernst, Joel D. Within Host Evolution Selects for a Dominant Genotype of Mycobacterium tuberculosis while T Cells Increase Pathogen Genetic Diversity. PLoS pathogens. 2016 Dec 14;12(12):e1006111-e1006111 e1006111 (2363052)
Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4+ T-cell activation
Portal-Celhay, Cynthia; Tufariello, JoAnn M; Srivastava, Smita; Zahra, Aleena; Klevorn, Thais; Grace, Patricia S; Mehra, Alka; Park, Heidi S; Ernst, Joel D; Jacobs, William R Jr; Philips, Jennifer A. Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4+ T-cell activation. Nature microbiology. 2016 Dec 05;2:16232-16232 (2353402)
The Challenge of Latent TB Infection
Blumberg, Henry M; Ernst, Joel D. The Challenge of Latent TB Infection [Comment]. JAMA. 2016 Sep 06;316(9):931-933 (2238052)
The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent
Wiens, Kirsten E; Ernst, Joel D. The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent. PLoS pathogens. 2016 Aug;12(8):e1005809-e1005809 e1005809 (2211652)