57 Old Forge Rd.
Tuxedo, NY 10987
The eukaryotic genome is organized into higher order chromatin structures. The structure of chromatin and DNA accessibility is regulated, in part, by epigenetic features such as DNA methylation and histone modifications. The goal of our research is to understand the epigenetic regulation of chromatin structure and gene expression programs during differentiation and disease manifestation. We are particularly interested in understanding the causes for aberrant silencing of tumor suppressor genes, which contribute to malignancies. Understanding how and why certain genes are turned off will help unravel the disease mechanism. Aberration in the chromatin structure is one of the causes for mis-regulation of gene expression. Currently, we are investigating the role of transcription factors and epigenetic features of the genome that are involved in maintaining normal chromatin architecture and the anomalies that lead to aberrant gene silencing. In addition, we are also interested in understanding the alterations in epigenetic regulation due to pathogenesis, which in turn may favor disease progression.
Rapid Recall Ability of Memory T cells is Encoded in their Epigenome
Barski, Artem; Cuddapah, Suresh; Kartashov, Andrey V; Liu, Chong; Imamichi, Hiromi; Yang, Wenjing; Peng, Weiqun; Lane, H Clifford; Zhao, Keji. Rapid Recall Ability of Memory T cells is Encoded in their Epigenome. Scientific reports. 2017 Jan 05;7:39785-39785 (2386792)
Lineage relationship of CD8 T cell subsets is revealed by progressive changes in the epigenetic landscape
Crompton, Joseph G; Narayanan, Manikandan; Cuddapah, Suresh; Roychoudhuri, Rahul; Ji, Yun; Yang, Wenjing; Patel, Shashank J; Sukumar, Madhusudhanan; Palmer, Douglas C; Peng, Weiqun; Wang, Ena; Marincola, Francesco M; Klebanoff, Christopher A; Zhao, Keji; Tsang, John S; Gattinoni, Luca; Restifo, Nicholas P. Lineage relationship of CD8 T cell subsets is revealed by progressive changes in the epigenetic landscape. Cellular & molecular immunology. 2016 Jul;13(4):502-513 (1556902)
Nuclear Factor kappaB1/RelA Mediates Inflammation in Human Lung Epithelial Cells at Atmospheric Oxygen Levels
Jagannathan, Lakshmanan; Jose, Cynthia C; Arita, Adriana; Kluz, Thomas; Sun, Hong; Zhang, Xiaoru; Yao, Yixin; Kartashov, Andrey V; Barski, Artem; Costa, Max; Cuddapah, Suresh. Nuclear Factor kappaB1/RelA Mediates Inflammation in Human Lung Epithelial Cells at Atmospheric Oxygen Levels. Journal of cellular physiology. 2016 Jul;231(7):1611-1620 (1848872)
Oxidative stress under ambient and physiological oxygen tension in tissue culture
Jagannathan, Lakshmanan; Cuddapah, Suresh; Costa, Max. Oxidative stress under ambient and physiological oxygen tension in tissue culture. Current pharmacology reports. 2016 Apr;2(2):64-72 (2059342)
Epigenetic dysregulation by nickel through repressive chromatin domain disruption
Jose, Cynthia C; Xu, Beisi; Jagannathan, Lakshmanan; Trac, Candi; Mallela, Ramya K; Hattori, Takamitsu; Lai, Darson; Koide, Shohei; Schones, Dustin E; Cuddapah, Suresh. Epigenetic dysregulation by nickel through repressive chromatin domain disruption. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2014 Oct 07;111(40):14631-14636 (1259292)