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Biosketch / Results /

Veronica M. Catanese, M.D.

Adjunct Associate Professor;
Department of Medicine (Endocrinology Div) [1]

Clinical Addresses

560 FIRST AVENUE, 441
NEW YORK, NY 10016
Phone: 212-263-7839
[3]

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Medical Specialties

Endocrinology & Metabolism, Internal Medicine

Dr. Catanese is Chair of the NIH Special Study Section on Bioengineering and Physiology, a member of the Institute of Medicine's Clinical Research Roundtable, and a co-leader of the NIH director's Clinical Research Roadmap Advisory Group's Subcommittee on Training. She is also Associate Editor of the Journal of Investigative Medicine.

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Board Certification

1982 — Ab Internal Medicine - Internal Medicine
1985 — Ab Internal Medicine (Endocrinology, Diabetes & Metabolism)

Education

1979 — New York University School of Medicine, Medical Education
1979-1980 — Bellevue Hospital Center, Internship
1979-1980 — NYU Medical Center, Internship
1980-1984 — NYU Medical Center, Residency Training
1980-1984 — Bellevue Hospital Center, Residency Training
1982-1983 — NYU Medical Center (Endocrinology & Meta), Clinical Fellowships
1982-1983 — Bellevue Hospital Center (Endocrinology & Meta), Clinical Fellowships
1984-1986 — Joslin Diabetes Center (Endocrinology & Meta), Clinical Fellowships
1984-1986 — Brigham And Women'S Hospital (Endocrinology & Meta), Clinical Fellowships

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Research Summary

The physiological stimuli of changing pressure and flow promote compensatory hypertrophy in several organ systems in humans and animals. Renal glomeruli in diabetes and left ventricular myocytes in hypertension display such post-mitotic tissue growth. While these result in initial adaptive benefits to the organism, fibrosis and loss of function of the organ eventually ensue, thereby leading directly to morbidity and mortality from these disease processes. Insulin-like growth factor I (IGF-I) is a peptide structurally and functionally very similar to insulin. IGF-I is less potent than insulin as a metabolic hormone but much more potent than insulin as a mitogenic agent. Unlike insulin, however, IGF-I protein is made in almost all organs, raising the possibility that it might function locally to control tissue growth. Our laboratory identified tissue-specific enhancement of IGF-I gene expression early in both these models of adaptive growth, suggesting that it participates in initiating the hypertrophic response in tissues no longer capable of cell division. We also identified differential regulation of a tissue-specific panel of IGF-binding proteins capable of restricting or promoting access of IGF-I to its receptor.

Current objectives are to: 1) identify the hormonal and physiological stimuli responsible for induction of the IGF-I growth factor axis in vivo and in vitro; 2) elucidate the mechanisms by which these factors regulate expression of the IGF-I and IGF binding protein genes; 3) define the structural and functional consequences of IGF-I overexpression in vivo and in vitro; and 4) determine if tissue-specific expression of IGF-I is necessary and/or sufficient to initiate hypertrophy. To achieve these aims, we combine physiological, molecular, and cell biological techniques and use both intact animal adenoviral expression systems and targeted cell culture for molecular analysis.

Research Interests

Molecular Regulation of Post-Mitotic Tissue Growth

Research Keywords

gene regulation, growth factors, paracrine/autocrine mechanisms of tissue growth

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search [9]

The many missions of medical schools
Smith, Lawrence G; Catanese, Veronica M
2010 Jun 15;152(12):818-819, Annals of internal medicine
— id: 133616, year: 2010, vol: 152, page: 818, stat: Journal Article,

A case of student cheating
Catanese, Veronica; Aronson, Paul
2005 ;7(4):?-?, Virtual mentor : VM
— id: 203992, year: 2005, vol: 7, page: ?, stat: Journal Article,

Creating a new structure for research on health care effectiveness
Kupersmith, Joel; Sung, Nancy; Genel, Myron; Slavkin, Harold; Califf, Robert; Bonow, Robert; Sherwood, Louis; Reame, Nancy; Catanese, Veronica; Baase, Catherine; Feussner, John; Dobs, Adrian; Tilson, Hugh; Reece, E Albert
2005 Mar;53(2):67-72, Journal of investigative medicine
— id: 164320, year: 2005, vol: 53, page: 67, stat: Journal Article,

Clinical research in the United States at a crossroads: proposal for a novel public-private partnership to establish a national clinical research enterprise
Crowley, William F Jr; Sherwood, Louis; Salber, Patricia; Scheinberg, David; Slavkin, Hal; Tilson, Hugh; Reece, E Albert; Catanese, Veronica; Johnson, Stephen B; Dobs, Adrian; Genel, Myron; Korn, Allan; Reame, Nancy; Bonow, Robert; Grebb, Jack; Rimoin, David
2004 Mar;291(9):1120-1126, JAMA
— id: 164319, year: 2004, vol: 291, page: 1120, stat: Journal Article,

Medical humanities at New York University School of Medicine: an array of rich programs in diverse settings
Krackov, Sharon K; Levin, Richard I; Catanese, Veronica; Rey, Mariano; Aull, Felice; Blagev, Denitza; Dreyer, Benard; Grieco, Anthony J; Hebert, Cristy; Kalet, Adina; Lipkin, Mack Jr; Lowenstein, Jerome; Ofri, Danielle; Stevens, David
2003 Oct;78(10):977-982, Academic medicine
— id: 39038, year: 2003, vol: 78, page: 977, stat: Journal Article,

Central challenges facing the national clinical research enterprise
Sung, Nancy S; Crowley, William F Jr; Genel, Myron; Salber, Patricia; Sandy, Lewis; Sherwood, Louis M; Johnson, Stephen B; Catanese, Veronica; Tilson, Hugh; Getz, Kenneth; Larson, Elaine L; Scheinberg, David; Reece, E Albert; Slavkin, Harold; Dobs, Adrian; Grebb, Jack; Martinez, Rick A; Korn, Allan; Rimoin, David
2003 Mar;289(10):1278-1287, JAMA
— id: 164318, year: 2003, vol: 289, page: 1278, stat: Journal Article,

Academic medicine in the 21st century: lessons from the dinosaurs
Catanese VM
1997 Aug;45(6):362-365, Journal of investigative medicine
— id: 12292, year: 1997, vol: 45, page: 362, stat: Journal Article,

Antihypertensive agents that limit ventricular hypertrophy inhibit cardiac expression of insulin-like growth factor-I
Donohue TJ; Dworkin LD; Ma J; Lango MN; Catanese VM
1997 Dec;45(9):584-591, Journal of investigative medicine
— id: 57375, year: 1997, vol: 45, page: 584, stat: Journal Article,

Correlation of glioma cell regression with inhibition of insulin-like growth factor 1 and insulin-like growth factor-binding protein-2 expression
Wang ZH; Ma J; Zeng BJ; Catanese VM; Samuels S; Gama Sosa MA; Kolodny EH
1997 Sep;66(3):203-211, Neuroendocrinology
— id: 9851, year: 1997, vol: 66, page: 203, stat: Journal Article,

Transforming growth factor-beta (TGF-beta) and insulin-like growth factor-I (IGF-I) regulate IGF binding protein expression in human mesangial cells by distinct pre- and post-translational mechanisms
Ma, JX; Catanese, VM
1996 MAR ;44(3):A307-A307, Journal of investigative medicine
— id: 52965, year: 1996, vol: 44, page: A307, stat: Journal Article,

Insulin-like growth factor-I (IGF-I) stimulates transforming growth factor-beta (TGF-beta) production by mesangial cells: A molecular mechanism for coupling cellular proliferation and matrix expansion
Ma, JX; Munger, J; Catanese, VM
1996 MAR ;44(3):A231-A231, Journal of investigative medicine
— id: 52944, year: 1996, vol: 44, page: A231, stat: Journal Article,

Secondary diabetes
Catanese VM; Kahn CR
Principles and practice of endocrinology and metabolism Philadelphia : J.B. Lippincott Co., 1995,
— id: 3523, year: 1995, vol: , page: 1220, stat: Chapter,

Pre- and post-translational regulation of renal insulin-like growth factor binding protein-1 in insulin-deficient diabetes
Kaufman CR; Catanese VM
1995 Apr;43(2):178-186, Journal of investigative medicine
— id: 56665, year: 1995, vol: 43, page: 178, stat: Journal Article,

Transforming growth factor-beta inhibits synthesis and secretion of insulin-like growth factor binding proteins by emsangial cells
Ma JX; Catanese VM
1995 ;43(Suppll 2):264A-264A, Journal of investigative medicine
— id: 55829, year: 1995, vol: 43, page: 264A, stat: Journal Article,

Estradiol enhances the stimulatory effect of insulin-like growth factor-I (IGF-I) on mammary development and growth hormone-induced IGF-I messenger ribonucleic acid
Ruan, W; Catanese, V; Wieczorek, R; Feldman, M; Kleinberg, D L
1995 Mar;136(3):1296-1302, Endocrinology
— id: 138562, year: 1995, vol: 136, page: 1296, stat: Journal Article,

PRESSURE AND VOLUME OVERLOAD ACTIVATE DISCORDANT PROGRAMS OF GENE-EXPRESSION IN THE HYPERTROPHIC VENTRICLE
BERNSTEIN, NE; MINADEO, J; LANGO, RP; LANGO, MN; DONOHUE, TJ; DWORKIN, LD; CATANESE, VM
1994 APR ;42(2):A169-A169, Clinical research
— id: 52489, year: 1994, vol: 42, page: A169, stat: Journal Article,

Induction of myocardial insulin-like growth factor-I gene expression in left ventricular hypertrophy
Donohue TJ; Dworkin LD; Lango MN; Fliegner K; Lango RP; Benstein JA; Slater WR; Catanese VM
1994 Feb;89(2):799-809, Circulation
— id: 56521, year: 1994, vol: 89, page: 799, stat: Journal Article,

AN EXPLORATION OF THE MOLECULAR-BASIS FOR DIMINISHED GLUCOSE-TRANSPORT IN ALZHEIMERS-DISEASE
MCRAE, T; CATANESE, VM
1994 APR ;42(2):A217-A217, Clinical research
— id: 52495, year: 1994, vol: 42, page: A217, stat: Journal Article,

INSULIN-LIKE GROWTH-FACTOR-I (IGF-I) RECEPTORS ON NORMAL, REMNANT, AND DIABETIC RAT GLOMERULI - EVIDENCE FOR A GLOMERULAR RESPONSE TO INCREASED RENAL IGF-I CONTENT
THOMPSON, N; DWORKIN, LD; TOLBERT, E; CATANESE, VM
1994 APR ;42(2):A143-A143, Clinical research
— id: 98444, year: 1994, vol: 42, page: A143, stat: Journal Article,

Discordant, organ-specific regulation of insulin-like growth factor-I messenger ribonucleic acid in insulin-deficient diabetes in rats
Catanese VM; Sciavolino PJ; Lango MN
1993 Feb;132(2):496-503, Endocrinology
— id: 8455, year: 1993, vol: 132, page: 496, stat: Journal Article,

INSULIN-LIKE GROWTH FACTOR-I (IGF-I) RECEPTORS ON NORMAL AND REMNANT RAT GLOMERULI - EVIDENCE FOR A GLOMERULAR RESPONSE TO INCREASED RENAL IGF-I CONTENT
THOMPSON, N; CATANESE, VM; TOLBERT, E; DWORKIN, LD
1993 OCT ;41(3):A619-A619, Clinical research
— id: 52229, year: 1993, vol: 41, page: A619, stat: Journal Article,

EFFECT OF DIABETES ON RENAL EXPRESSION OF INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEINS
KAUFMAN, CR; CATANESE, VM
1992 APR ;40(2):A221-A221, Clinical research
— id: 51981, year: 1992, vol: 40, page: A221, stat: Journal Article,

INSULIN NEGATIVELY REGULATES PRETRANSLATIONAL AND POSTTRANSLATIONAL RENAL EXPRESSION OF INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-1
KAUFMAN, CR; CATANESE, VM
1992 OCT ;40(3):A657-A657, Clinical research
— id: 51877, year: 1992, vol: 40, page: A657, stat: Journal Article,

HEMODYNAMIC MODULATION OF VENTRICULAR INSULIN-LIKE GROWTH FACTOR-I GENE-EXPRESSION
DONOHUE, TJ; LANGO, M; BENSTEIN, JA; DWORKIN, LD; CATANESE, VM
1991 APR ;39(2):A152-A152, Clinical research
— id: 51602, year: 1991, vol: