522 First Avenue
New York, NY 10016
Dr Berger's research primarily focuses on discovering novel mechanisms of heart disease, peripheral vascular disease, and stroke. He is also interested in 1) the etiology of unexplained thromboembolic (clotting) disease; 2) the clinical and cellular response to antithrombotic agents in cardiovascular disease; and 3) sex differences in the pathophysiology and treatment response of cardiovascular disease.
Dr. Berger has a particular interest in the field of platelet and hypercoagulable mechanisms of cardiovascular disease, with research interests that include: (1) the role of platelet activity in patients with different high risk vascular phenotypes, such as cardiac and peripheral atherosclerosis, aneurysmal disease, venous disease, kidney disease, and HIV; (2) regulation of platelet activity during the perioperative period; (3) the clinical and platelet response to antiplatelet and antithrombotic therapeutics; and (4) the study of personalized medicine using the platelet phenotype to guide therapeutics. Dr. Berger has set up a platelet lab to measure platelet activity using various techniques, including whole blood and platelet rich plasma aggregometry, flow cytometry, hematology analysis, and molecular biology using the platelet transcriptome. The overall goal of the lab is to use the platelet phenotype in understanding who is at risk for developing cardiovascular disease and to determine whether modification of the platelet phenotype can ultimately lower the risk of adverse cardiovascular events.
Hyperglycemia enhances arsenic-induced platelet and megakaryocyte activation
Newman, Jonathan D; Echagarruga, Christina T; Ogando, Yoscar M; Montenont, Emilie; Chen, Yu; Fisher, Edward A; Berger, Jeffrey S. Hyperglycemia enhances arsenic-induced platelet and megakaryocyte activation. Journal of translational medicine. 2017 Mar 06;15(1):55-55 (2476162)
Activated Platelets Induce Endothelial Cell Activation via an Interleukin-1beta Pathway in Systemic Lupus Erythematosus
Nhek, Sokha; Clancy, Robert; Lee, Kristen A; Allen, Nicole M; Barrett, Tessa J; Marcantoni, Emanuela; Nwaukoni, Janet; Rasmussen, Sara; Rubin, Maya; Newman, Jonathan D; Buyon, Jill P; Berger, Jeffrey S. Activated Platelets Induce Endothelial Cell Activation via an Interleukin-1beta Pathway in Systemic Lupus Erythematosus. Arteriosclerosis, thrombosis, & vascular biology. 2017 Feb 2;37(4):707-716 (2437182)
Perioperative Major Adverse Cardiovascular and Cerebrovascular Events Associated With Noncardiac Surgery
Smilowitz, Nathaniel R; Gupta, Navdeep; Ramakrishna, Harish; Guo, Yu; Berger, Jeffrey S; Bangalore, Sripal. Perioperative Major Adverse Cardiovascular and Cerebrovascular Events Associated With Noncardiac Surgery. JAMA cardiology. 2017 Feb 1;2(2):181-187 (2383672)
Diabetes mellitus is a coronary heart disease risk equivalent for peripheral vascular disease
Newman, Jonathan D; Rockman, Caron B; Kosiborod, Mikhail; Guo, Yu; Zhong, Hua; Weintraub, Howard S; Schwartzbard, Arthur Z; Adelman, Mark A; Berger, Jeffrey S. Diabetes mellitus is a coronary heart disease risk equivalent for peripheral vascular disease. American heart journal. 2017 Feb;184:114-120 (2455482)
Increased Prevalence of Moderate and Severe PAD in the Native American/Alaskan Native Population; a study of 96,000 NA/AN
Baxter, Andrew R; Jacobowitz, Glenn R; Guo, Yu; Maldonado, Thomas; Adelman, Mark A; Berger, Jeffery S; Rockman, Caron B. Increased Prevalence of Moderate and Severe PAD in the Native American/Alaskan Native Population; a study of 96,000 NA/AN. Annals of vascular surgery. 2017 Jan;38:177-183 (2221502)