Microdissection and culture of murine pancreatic ductal epithelial cells
Pylayeva-Gupta, Yuliya; Lee, Kyoung Eun; Bar-Sagi, Dafna
2013 ;980:267-279, Methods in molecular biology
— id: 214132, year: 2013, vol: 980, page: 267, stat: Journal Article,

Regulating the regulator: post-translational modification of RAS
Ahearn, Ian M; Haigis, Kevin; Bar-Sagi, Dafna; Philips, Mark R
2012 Jan;13(1):39-51, Nature reviews. Molecular cell biology
— id: 147707, year: 2012, vol: 13, page: 39, stat: Journal Article,

VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression
Cao, Ying; E, Guangqi; Wang, Enfeng; Pal, Krishnendu; Dutta, Shamit K; Bar-Sagi, Dafna; Mukhopadhyay, Debabrata
2012 Aug;72(16):3912-3918, Cancer research
— id: 174384, year: 2012, vol: 72, page: 3912, stat: Journal Article,

Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis
Jeng, Hao-Hsuan; Taylor, Laura J; Bar-Sagi, Dafna
2012 ;3:1168-1168, Nature communications
— id: 202202, year: 2012, vol: 3, page: 1168, stat: Journal Article,

EZH2 couples pancreatic regeneration to neoplastic progression
Mallen-St Clair, Jon; Soydaner-Azeloglu, Rengin; Lee, Kyoung Eun; Taylor, Laura; Livanos, Alexandra; Pylayeva-Gupta, Yuliya; Miller, George; Margueron, Raphael; Reinberg, Danny; Bar-Sagi, Dafna
2012 Mar;26(5):439-444, Genes & development
— id: 159852, year: 2012, vol: 26, page: 439, stat: Journal Article,

MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells
Ochi, Atsuo; Nguyen, Andrew H; Bedrosian, Andrea S; Mushlin, Harry M; Zarbakhsh, Saman; Barilla, Rocky; Zambirinis, Constantinos P; Fallon, Nina C; Rehman, Adeel; Pylayeva-Gupta, Yuliya; Badar, Sana; Hajdu, Cristina H; Frey, Alan B; Bar-Sagi, Dafna; Miller, George
2012 Aug;209(9):1671-1687, Journal of experimental medicine
— id: 177029, year: 2012, vol: 209, page: 1671, stat: Journal Article,

Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia
Pylayeva-Gupta, Yuliya; Lee, Kyoung Eun; Hajdu, Cristina H; Miller, George; Bar-Sagi, Dafna
2012 Jun;21(6):836-847, Cancer cell
— id: 169485, year: 2012, vol: 21, page: 836, stat: Journal Article,

Regulation of RAS oncogenicity by acetylation
Yang, Moon Hee; Nickerson, Seth; Kim, Eric T; Liot, Caroline; Laurent, Gaelle; Spang, Robert; Philips, Mark R; Shan, Yibing; Shaw, David E; Bar-Sagi, Dafna; Haigis, Marcia C; Haigis, Kevin M
2012 Jul;109(27):10843-10848, Proceedings of the National Academy of Sciences of the United States of America
— id: 173075, year: 2012, vol: 109, page: 10843, stat: Journal Article,

CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling
Zheng, Z-Y; Cheng, C-M; Fu, X-R; Chen, L-Y; Xu, L; Terrillon, S; Wong, S T; Bar-Sagi, D; Songyang, Z; Chang, E C
2012 Oct;31(43):4630-4638, Oncogene
— id: 184602, year: 2012, vol: 31, page: 4630, stat: Journal Article,

Escorting ras
Zheng, Ze-Yi; Xu, Lizhong; Bar-Sagi, Dafna; Chang, Eric C
2012 Oct;3(4):236-239, Small GTPases
— id: 210812, year: 2012, vol: 3, page: 236, stat: Journal Article,

Fibronectin growth factor-binding domains are required for fibroblast survival
Lin, Fubao; Ren, Xiang-Dong; Pan, Zhi; Macri, Lauren; Zong, Wei-Xing; Tonnesen, Marcia G; Rafailovich, Miriam; Bar-Sagi, Dafna; Clark, Richard A F
2011 Jan;131(1):84-98, Journal of investigative dermatology
— id: 138146, year: 2011, vol: 131, page: 84, stat: Journal Article,

An orthosteric inhibitor of the Ras-Sos interaction
Patgiri, Anupam; Yadav, Kamlesh K; Arora, Paramjit S; Bar-Sagi, Dafna
2011 ;7(9):585-587, Nature Chemical Biology
— id: 137095, year: 2011, vol: 7, page: 585, stat: Journal Article,

RAS oncogenes: weaving a tumorigenic web
Pylayeva-Gupta, Yuliya; Grabocka, Elda; Bar-Sagi, Dafna
2011 ;11(11):761-774, Nature reviews. Cancer
— id: 139741, year: 2011, vol: 11, page: 761, stat: Journal Article,

Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor
Connolly, Michael K; Mallen-St Clair, Jon; Bedrosian, Andrea S; Malhotra, Ashim; Vera, Valery; Ibrahim, Junaid; Henning, Justin; Pachter, H Leon; Bar-Sagi, Dafna; Frey, Alan B; Miller, George
2010 Apr;87(4):713-725, Journal of leukocyte biology
— id: 108918, year: 2010, vol: 87, page: 713, stat: Journal Article,

Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless
Gureasko, Jodi; Kuchment, Olga; Makino, Debora Lika; Sondermann, Holger; Bar-Sagi, Dafna; Kuriyan, John
2010 Feb 23;107(8):3430-3435, Proceedings of the National Academy of Sciences of the United States of America
— id: 111558, year: 2010, vol: 107, page: 3430, stat: Journal Article,

Oncogenic KRas Suppresses Inflammation-Associated Senescence of Pancreatic Ductal Cells
Lee, Kyoung Eun; Bar-Sagi, Dafna
2010 Nov 16;18(5):448-458, Cancer cell
— id: 114515, year: 2010, vol: 18, page: 448, stat: Journal Article,

Signaling endosomes: seeing is believing
Miaczynska, Marta; Bar-Sagi, Dafna
2010 Aug;22(4):535-540, Current opinion in cell biology
— id: 111557, year: 2010, vol: 22, page: 535, stat: Journal Article,

Perturbation of cytoskeleton dynamics by the opposing effects of Rac1 and Rac1b
Nimnual AS; Taylor LJ; Nyako M; Jeng HH; Bar-Sagi D
2010 Sep;1(2):89-97, Small GTPases
— id: 138351, year: 2010, vol: 1, page: 89, stat: Journal Article,

Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination
Xu, Lizhong; Lubkov, Veronica; Taylor, Laura J; Bar-Sagi, Dafna
2010 Aug 10;20(15):1372-1377, Current biology. CB
— id: 138182, year: 2010, vol: 20, page: 1372, stat: Journal Article,

Spry2 expression correlates with BRAF mutation in thyroid cancer
Xu, Lizhong; Zhou, Jun Liang; Cohen, Michael; Bar-Sagi, Dafna; Patel, Kepal N
2010 Dec;148(6):1282-7; discussion 1287, Surgery
— id: 115281, year: 2010, vol: 148, page: 1282, stat: Journal Article,

Allosteric gating of Son of sevenless activity by the histone domain
Yadav, Kamlesh K; Bar-Sagi, Dafna
2010 Feb 23;107(8):3436-3440, Proceedings of the National Academy of Sciences of the United States of America
— id: 107379, year: 2010, vol: 107, page: 3436, stat: Journal Article,

In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha
Connolly, Michael K; Bedrosian, Andrea S; Mallen-St Clair, Jon; Mitchell, Aaron P; Ibrahim, Junaid; Stroud, Andrea; Pachter, H Leon; Bar-Sagi, Dafna; Frey, Alan B; Miller, George
2009 Nov;119(11):3213-3225, Journal of clinical investigation
— id: 105172, year: 2009, vol: 119, page: 3213, stat: Journal Article,

Ras/MAPK signaling from endomembranes
Fehrenbacher, Nicole; Bar-Sagi, Dafna; Philips, Mark
2009 Aug;3(4):297-307, Molecular oncology
— id: 101955, year: 2009, vol: 3, page: 297, stat: Journal Article,

Characterization of a Ras mutant with identical GDP- and GTP-bound structures
Ford, Bradley; Boykevisch, Sean; Zhao, Chen; Kunzelmann, Simone; Bar-Sagi, Dafna; Herrmann, Christian; Nassar, Nicolas
2009 Dec 8;48(48):11449-11457, Biochemistry
— id: 105530, year: 2009, vol: 48, page: 11449, stat: Journal Article,

Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas
Frank, Matthew J; Dawson, David W; Bensinger, Steven J; Hong, Jason S; Knosp, Wendy M; Xu, Lizhong; Balatoni, Cynthia E; Allen, Eric L; Shen, Rhine R; Bar-Sagi, Dafna; Martin, Gail R; Teitell, Michael A
2009 Mar 12;113(11):2478-2487, Blood
— id: 95089, year: 2009, vol: 113, page: 2478, stat: Journal Article,

Raf-1 and squamous cell carcinoma: Rok-ing the boat
Grabocka, Elda; Bar-Sagi, Dafna
2009 Aug 4;16(2):85-86, Cancer cell
— id: 101331, year: 2009, vol: 16, page: 85, stat: Journal Article,

Abstracts of papers presented at the 2008 meeting on mechanisms and models of cancer
Bar-Sagi, Dafna; De Pinho, Ronald A; Lees, Jacqueline; Sherr, Charles J
Cold Spring Harbor NY : Cold Spring Harbor Laboratory, 2008,
— id: 2081, year: 2008, vol: , page: , stat: ,

PROLONGED EXPOSURE TO HIGH FAT DIET AND HYPERLIPIDEMIA IN MICE EXACERBATES ACUTE PANCREATITIS
Clair, JMS; Joaquin, VA; Fisher, EA; Bar-Sagi, D
2008 NOV ;37(4):482-483, Pancreas
— id: 91327, year: 2008, vol: 37, page: 482, stat: Journal Article,

Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells
Garcia, Avalon; Zheng, Yang; Zhao, Chen; Toschi, Alfredo; Fan, Judy; Shraibman, Natalie; Brown, H Alex; Bar-Sagi, Dafna; Foster, David A; Arbiser, Jack L
2008 Jul 1;14(13):4267-4274, Clinical cancer research
— id: 95091, year: 2008, vol: 14, page: 4267, stat: Journal Article,

Membrane-dependent signal integration by the Ras activator Son of sevenless
Gureasko, Jodi; Galush, William J; Boykevisch, Sean; Sondermann, Holger; Bar-Sagi, Dafna; Groves, Jay T; Kuriyan, John
2008 May;15(5):452-461, Nature structural & molecular biology
— id: 95093, year: 2008, vol: 15, page: 452, stat: Journal Article,

Design, synthesis, and biological evaluation of new-generation taxoids
Ojima, Iwao; Chen, Jin; Sun, Liang; Borella, Christopher P; Wang, Tao; Miller, Michael L; Lin, Songnian; Geng, Xudong; Kuznetsova, Larisa; Qu, Chuanxing; Gallager, David; Zhao, Xianrui; Zanardi, Ilaria; Xia, Shujun; Horwitz, Susan B; Mallen-St Clair, Jon; Guerriero, Jennifer L; Bar-Sagi, Dafna; Veith, Jean M; Pera, Paula; Bernacki, Ralph J
2008 Jun 12;51(11):3203-3221, Journal of medicinal chemistry
— id: 95092, year: 2008, vol: 51, page: 3203, stat: Journal Article,

The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways
Qi, Jianfei; Nakayama, Koh; Gaitonde, Supriya; Goydos, James S; Krajewski, Stan; Eroshkin, Alexey; Bar-Sagi, Dafna; Bowtell, David; Ronai, Ze'ev
2008 Oct 28;105(43):16713-16718, Proceedings of the National Academy of Sciences of the United States of America
— id: 95090, year: 2008, vol: 105, page: 16713, stat: Journal Article,

Compartmentalization-dependent ubiquitination of oncogenic Ras regulates transforming activity
Terrillon, S; Bar-Sagi, D
2008 JUN ;275(1):320-320, FEBS journal
— id: 86954, year: 2008, vol: 275, page: 320, stat: Journal Article,

Biochemical and biophysical analyses of Ras modification by ubiquitin
Terrillon, Sonia; Bar-Sagi, Dafna
2008 ;438:259-276, Methods in enzymology
— id: 79302, year: 2008, vol: 438, page: 259, stat: Journal Article,

Hyperlipidemia causes pancreatic inflammation and ductal proliferation in Apolipoprotein E deficient mice
Clair, JMS; Joaquin, VA; Fisher, EA; Bar-Sagi, D
2007 NOV ;35(4):414-415, Pancreas
— id: 75691, year: 2007, vol: 35, page: 414, stat: Journal Article,

Spatial Regulation of EGFR Signaling by Sprouty2
Kim, Hong Joo; Taylor, Laura J; Bar-Sagi, Dafna
2007 Mar 6;17(5):455-461, Current biology. CB
— id: 70959, year: 2007, vol: 17, page: 455, stat: Journal Article,

Corrigendum: Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome
Tartaglia, Marco; Pennacchio, Len A; Zhao, Chen; Yadav, Kamlesh K; Fodale, Valentina; Sarkozy, Anna; Pandit, Bhaswati; Oishi, Kimihiko; Martinelli, Simone; Schackwitz, Wendy; Ustaszewska, Anna; Martin, Joel; Bristow, James; Carta, Claudio; Lepri, Francesca; Neri, Cinzia; Vasta, Isabella; Gibson, Kate; Curry, Cynthia J; Siguero, Juan Pedro Lopez; Digilio, Maria Cristina; Zampino, Giuseppe; Dallapiccola, Bruno; Bar-Sagi, Dafna; Gelb, Bruce D
2007 Feb;39(2):276-276, Nature genetics
— id: 70960, year: 2007, vol: 39, page: 276, stat: Journal Article,

Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome
Tartaglia, Marco; Pennacchio, Len A; Zhao, Chen; Yadav, Kamlesh K; Fodale, Valentina; Sarkozy, Anna; Pandit, Bhaswati; Oishi, Kimihiko; Martinelli, Simone; Schackwitz, Wendy; Ustaszewska, Anna; Martin, Joel; Bristow, James; Carta, Claudio; Lepri, Francesca; Neri, Cinzia; Vasta, Isabella; Gibson, Kate; Curry, Cynthia J; Siguero, Juan Pedro Lopez; Digilio, Maria Cristina; Zampino, Giuseppe; Dallapiccola, Bruno; Bar-Sagi, Dafna; Gelb, Bruce D
2007 Jan;39(1):75-79, Nature genetics
— id: 70962, year: 2007, vol: 39, page: 75, stat: Journal Article,

Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors
Yeh, Brian J; Rutigliano, Robert J; Deb, Anrica; Bar-Sagi, Dafna; Lim, Wendell A
2007 May 31;447(7144):596-600, Nature
— id: 95094, year: 2007, vol: 447, page: 596, stat: Journal Article,

Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos
Zhao, Chen; Du, Guangwei; Skowronek, Karl; Frohman, Michael A; Bar-Sagi, Dafna
2007 Jun;9(6):706-712, Nature cell biology
— id: 95095, year: 2007, vol: 9, page: 706, stat: Journal Article,

Pancreatic duct epithelial cell isolation and cultivation in two-dimensional and three-dimensional culture systems
Agbunag, Cristina; Lee, Kyoung Eun; Buontempo, Serena; Bar-Sagi, Dafna
2006 ;407:703-710, Methods in enzymology
— id: 70966, year: 2006, vol: 407, page: 703, stat: Journal Article,

A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen
Archer, Herbert; Jura, Natalia; Keller, James; Jacobson, Matthew; Bar-Sagi, Dafna
2006 Dec;131(6):1844-1855, Gastroenterology
— id: 70963, year: 2006, vol: 131, page: 1844, stat: Journal Article,

Regulation of ras signaling dynamics by Sos-mediated positive feedback
Boykevisch, Sean; Zhao, Chen; Sondermann, Holger; Philippidou, Polyxeni; Halegoua, Simon; Kuriyan, John; Bar-Sagi, Dafna
2006 Nov 7;16(21):2173-2179, Current biology. CB
— id: 70964, year: 2006, vol: 16, page: 2173, stat: Journal Article,

Regulation of sprouty stability by Mnk1-dependent phosphorylation
DaSilva, John; Xu, Lizhong; Kim, Hong Joo; Miller, W Todd; Bar-Sagi, Dafna
2006 Mar;26(5):1898-1907, Molecular & cellular biology
— id: 62919, year: 2006, vol: 26, page: 1898, stat: Journal Article,

A Ras-induced conformational switch in the Ras activator Son of sevenless
Freedman, Tanya S; Sondermann, Holger; Friedland, Gregory D; Kortemme, Tanja; Bar-Sagi, Dafna; Marqusee, Susan; Kuriyan, John
2006 Nov 7;103(45):16692-16697, Proceedings of the National Academy of Sciences of the United States of America
— id: 70965, year: 2006, vol: 103, page: 16692, stat: Journal Article,

Mapping cellular routes of Ras: a ubiquitin trail
Jura, Natalia; Bar-Sagi, Dafna
2006 Dec;5(23):2744-2747, Cell cycle
— id: 70961, year: 2006, vol: 5, page: 2744, stat: Journal Article,

Differential modification of ras proteins by ubiquitination
Jura, Natalia; Scotto-Lavino, Elizabeth; Sobczyk, Aleksander; Bar-Sagi, Dafna
2006 Mar 3;21(5):679-687, Molecular cell
— id: 62917, year: 2006, vol: 21, page: 679, stat: Journal Article,

The role of boundary conditions in the experimental model of wound healing
Nikolic, Djordje L; Boettiger, Alistair N; Bar-Sagi, Dafna; Carbeck, Jeffrey D; Shvartsman, Stanislav Y
2006 Jul;291(1):C68-C75, American journal of physiology. Cell physiology
— id: 62918, year: 2006, vol: 291, page: C68, stat: Journal Article,

Structure of the G60A mutant of Ras: implications for the dominant negative effect
Ford, Bradley; Skowronek, Karlheinz; Boykevisch, Sean; Bar-Sagi, Dafna; Nassar, Nicolas
2005 Jul 8;280(27):25697-25705, Journal of biological chemistry
— id: 62923, year: 2005, vol: 280, page: 25697, stat: Journal Article,

Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between
Jura, Natalia; Archer, Herbert; Bar-Sagi, Dafna
2005 Jan;15(1):72-77, Cell research
— id: 62924, year: 2005, vol: 15, page: 72, stat: Journal Article,

Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless
Sondermann, Holger; Nagar, Bhushan; Bar-Sagi, Dafna; Kuriyan, John
2005 Nov 15;102(46):16632-16637, Proceedings of the National Academy of Sciences of the United States of America
— id: 62921, year: 2005, vol: 102, page: 16632, stat: Journal Article,

Analysis of Ras:RasGEF interactions by phage display and static multi-angle light scattering
Sondermann, Holger; Zhao, Chen; Bar-Sagi, Dafna
2005 Oct;37(2):197-202, Methods
— id: 62920, year: 2005, vol: 37, page: 197, stat: Journal Article,

Ras oncogene and inflammation: partners in crime
Sparmann, Anke; Bar-Sagi, Dafna
2005 Jun;4(6):735-736, Cell cycle
— id: 62922, year: 2005, vol: 4, page: 735, stat: Journal Article,

Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells
Agbunag, Cristina; Bar-Sagi, Dafna
2004 Aug 15;64(16):5659-5663, Cancer research
— id: 62927, year: 2004, vol: 64, page: 5659, stat: Journal Article,

Identification of the Role of MnSOD in EGFR-Positive Breast Cancer Development
Kim, Hong J; Bar-Sagi, Dafna
Ft. Belvoir Defense Technical Information Center MAY 2004,
— id: 2307, year: 2004, vol: , page: , stat: ,

Modulation of signalling by Sprouty: a developing story
Kim, Hong Joo; Bar-Sagi, Dafna
2004 Jun;5(6):441-450, Nature reviews. Molecular cell biology
— id: 62928, year: 2004, vol: 5, page: 441, stat: Journal Article,

Structural analysis of autoinhibition in the Ras activator Son of sevenless
Sondermann, Holger; Soisson, Stephen M; Boykevisch, Sean; Yang, Shao-Song; Bar-Sagi, Dafna; Kuriyan, John
2004 Oct 29;119(3):393-405, Cell
— id: 62926, year: 2004, vol: 119, page: 393, stat: Journal Article,

Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
Sparmann, Anke; Bar-Sagi, Dafna
2004 Nov;6(5):447-458, Cancer cell
— id: 62925, year: 2004, vol: 6, page: 447, stat: Journal Article,

Cell phenotype specific kinetics of expression of intratracheally injected manganese superoxide dismutase-plasmid/liposomes (MnSOD-PL) during lung radioprotective gene therapy
Epperly, M W; Guo, H L; Jefferson, M; Nie, S; Gretton, J; Bernarding, M; Bar-Sagi, D; Archer, H; Greenberger, J S
2003 Jan;10(2):163-171, Gene therapy
— id: 62935, year: 2003, vol: 10, page: 163, stat: Journal Article,

Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene
Guo, Hongliang; Seixas-Silva, Jose A Jr; Epperly, Michael W; Gretton, Joan E; Shin, Dong M; Bar-Sagi, Dafna; Archer, Herbert; Greenberger, Joel S
2003 Mar;159(3):361-370, Radiation research
— id: 62932, year: 2003, vol: 159, page: 361, stat: Journal Article,

hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl
Hall, Amy B; Jura, Natalia; DaSilva, John; Jang, Yeon Joo; Gong, Delquin; Bar-Sagi, Dafna
2003 Feb 18;13(4):308-314, Current biology. CB
— id: 62934, year: 2003, vol: 13, page: 308, stat: Journal Article,

Suppression of Ras-stimulated transformation by the JNK signal transduction pathway
Kennedy, Norman J; Sluss, Hayla K; Jones, Stephen N; Bar-Sagi, Dafna; Flavell, Richard A; Davis, Roger J
2003 Mar 1;17(5):629-637, Genes & development
— id: 62930, year: 2003, vol: 17, page: 629, stat: Journal Article,

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS
Margarit, S Mariana; Sondermann, Holger; Hall, Brian E; Nagar, Bhushan; Hoelz, Andre; Pirruccello, Michelle; Bar-Sagi, Dafna; Kuriyan, John
2003 Mar 7;112(5):685-695, Cell
— id: 62931, year: 2003, vol: 112, page: 685, stat: Journal Article,

Redox-dependent downregulation of Rho by Rac
Nimnual, Anjaruwee S; Taylor, Laura J; Bar-Sagi, Dafna
2003 Mar;5(3):236-241, Nature cell biology
— id: 62933, year: 2003, vol: 5, page: 236, stat: Journal Article,

Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless
Sondermann, Holger; Soisson, Stephen M; Bar-Sagi, Dafna; Kuriyan, John
2003 Dec;11(12):1583-1593, Structure
— id: 62929, year: 2003, vol: 11, page: 1583, stat: Journal Article,

Ras and Rac as activators of reactive oxygen species (ROS)
Archer, Herbert; Bar-Sagi, Dafna
2002 ;189:67-73, Methods in molecular biology
— id: 62940, year: 2002, vol: 189, page: 67, stat: Journal Article,

The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins
Egan, James E; Hall, Amy B; Yatsula, Bogdan A; Bar-Sagi, Dafna
2002 Apr 30;99(9):6041-6046, Proceedings of the National Academy of Sciences of the United States of America
— id: 62943, year: 2002, vol: 99, page: 6041, stat: Journal Article,

Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy
Epperly, Michael W; Sikora, Christine A; DeFilippi, Stacy J; Gretton, Joan E; Bar-Sagi, Dafna; Archer, Herbert; Carlos, Timothy; Guo, HongLiang; Greenberger, Joel S
2002 ;8(4):175-187, Biology of blood & marrow transplantation
— id: 62942, year: 2002, vol: 8, page: 175, stat: Journal Article,

The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation
Farhang-Fallah, Janet; Randhawa, Varinder K; Nimnual, Anjaruwee; Klip, Amira; Bar-Sagi, Dafna; Rozakis-Adcock, Maria
2002 Oct;22(20):7325-7336, Molecular & cellular biology
— id: 62937, year: 2002, vol: 22, page: 7325, stat: Journal Article,

The structural basis for the transition from Ras-GTP to Ras-GDP
Hall, Brian E; Bar-Sagi, Dafna; Nassar, Nicolas
2002 Sep 17;99(19):12138-12142, Proceedings of the National Academy of Sciences of the United States of America
— id: 62938, year: 2002, vol: 99, page: 12138, stat: Journal Article,

Autoinhibition of Sos by intramolecular interactions
Hall, Brian E; Yang, Shao-Song; Bar-Sagi, Dafna
2002 Jan 1;7:d288-d294, Frontiers in biosciences
— id: 62944, year: 2002, vol: 7, page: d288, stat: Journal Article,

The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase
Lei, Kui; Nimnual, Anjaruwee; Zong, Wei-Xing; Kennedy, Norman J; Flavell, Richard A; Thompson, Craig B; Bar-Sagi, Dafna; Davis, Roger J
2002 Jul;22(13):4929-4942, Molecular & cellular biology
— id: 62941, year: 2002, vol: 22, page: 4929, stat: Journal Article,

Direct coupling of the cell cycle and cell death machinery by E2F
Nahle, Zaher; Polakoff, Julia; Davuluri, Ramana V; McCurrach, Mila E; Jacobson, Matthew D; Narita, Masashi; Zhang, Michael Q; Lazebnik, Yuri; Bar-Sagi, Dafna; Lowe, Scott W
2002 Nov;4(11):859-864, Nature cell biology
— id: 62936, year: 2002, vol: 4, page: 859, stat: Journal Article,

The two hats of SOS
Nimnual, Anjaruwee; Bar-Sagi, Dafna
2002 Aug 13;2002(145):pe36-pe36, Science's STKE
— id: 62939, year: 2002, vol: 2002, page: pe36, stat: Journal Article,

A Ras by any other name
Bar-Sagi D
2001 Mar;21(5):1441-1443, Molecular & cellular biology
— id: 62950, year: 2001, vol: 21, page: 1441, stat: Journal Article,

Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation
Epperly MW; Kagan VE; Sikora CA; Gretton JE; Defilippi SJ; Bar-Sagi D; Greenberger JS
2001 Aug 20;96(4):221-231, International journal of cancer
— id: 62946, year: 2001, vol: 96, page: 221, stat: Journal Article,

Rac1 mediates STAT3 activation by autocrine IL-6
Faruqi TR; Gomez D; Bustelo XR; Bar-Sagi D; Reich NC
2001 Jul 31;98(16):9014-9019, Proceedings of the National Academy of Sciences of the United States of America
— id: 62947, year: 2001, vol: 98, page: 9014, stat: Journal Article,

Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange
Hall BE; Yang SS; Boriack-Sjodin PA; Kuriyan J; Bar-Sagi D
2001 Jul 20;276(29):27629-27637, Journal of biological chemistry
— id: 62948, year: 2001, vol: 276, page: 27629, stat: Journal Article,

Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling
Lu W; Gong D; Bar-Sagi D; Cole PA
2001 Oct;8(4):759-769, Molecular cell
— id: 62945, year: 2001, vol: 8, page: 759, stat: Journal Article,

Differential activation of the Rac pathway by Ha-Ras and K-Ras
Walsh AB; Bar-Sagi D
2001 May 11;276(19):15609-15615, Journal of biological chemistry
— id: 62949, year: 2001, vol: 276, page: 15609, stat: Journal Article,

Ras and Rho GTPases: a family reunion
Bar-Sagi D; Hall A
2000 Oct 13;103(2):227-238, Cell
— id: 62951, year: 2000, vol: 103, page: 227, stat: Journal Article,

Induction of the cellular E2F-1 promoter by the adenovirus E4-6/7 protein
Schaley J; O'Connor RJ; Taylor LJ; Bar-Sagi D; Hearing P
2000 Mar;74(5):2084-2093, Journal of virology
— id: 62955, year: 2000, vol: 74, page: 2084, stat: Journal Article,

Single cell assays for Rac activity
Taylor LJ; Walsh AB; Hearing P; Bar-Sagi D
2000 ;325:327-334, Methods in enzymology
— id: 62952, year: 2000, vol: 325, page: 327, stat: Journal Article,

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
Tournier C; Hess P; Yang DD; Xu J; Turner TK; Nimnual A; Bar-Sagi D; Jones SN; Flavell RA; Davis RJ
2000 May 5;288(5467):870-874, Science
— id: 62953, year: 2000, vol: 288, page: 870, stat: Journal Article,

Workshop on specificity in Ras and Rho-mediated signalling events
Bos JL; Lacal, Juan Carlos; Hall, A; Bar-Sagi, D
[Madrid] : Instituto Juan March de Estudios e Investigaciones, 1999,
— id: 2203, year: 1999, vol: , page: , stat: ,

Suppression of Ras-induced apoptosis by the Rac GTPase
Joneson T; Bar-Sagi D
1999 Sep;19(9):5892-5901, Molecular & cellular biology
— id: 62957, year: 1999, vol: 19, page: 5892, stat: Journal Article,

SCH 51344, an inhibitor of RAS/RAC-mediated cell morphology pathway
Kumar CC; Ohashi K; Nagata K; Walsh A; Bar-Sagi D; Mizuno K
1999 ;886:122-131, Annals of the New York Academy of Sciences
— id: 62954, year: 1999, vol: 886, page: 122, stat: Journal Article,

Nucleolar Arf sequesters Mdm2 and activates p53
Weber JD; Taylor LJ; Roussel MF; Sherr CJ; Bar-Sagi D
1999 May;1(1):20-26, Nature cell biology
— id: 62956, year: 1999, vol: 1, page: 20, stat: Journal Article,

Transmembrane signaling protocols
Bar-Sagi, Dafna
Totowa NJ : Humana Press, 1998,
— id: 1087, year: 1998, vol: , page: , stat: ,

The structural basis of the activation of Ras by Sos
Boriack-Sjodin PA; Margarit SM; Bar-Sagi D; Kuriyan J
1998 Jul 23;394(6691):337-343, Nature
— id: 62959, year: 1998, vol: 394, page: 337, stat: Journal Article,

Regulation of Sos activity by intramolecular interactions
Corbalan-Garcia S; Margarit SM; Galron D; Yang SS; Bar-Sagi D
1998 Feb;18(2):880-886, Molecular & cellular biology
— id: 62963, year: 1998, vol: 18, page: 880, stat: Journal Article,

A Rac1 effector site controlling mitogenesis through superoxide production
Joneson T; Bar-Sagi D
1998 Jul 17;273(29):17991-17994, Journal of biological chemistry
— id: 62960, year: 1998, vol: 273, page: 17991, stat: Journal Article,

Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors
Joneson T; Fulton JA; Volle DJ; Chaika OV; Bar-Sagi D; Lewis RE
1998 Mar 27;273(13):7743-7748, Journal of biological chemistry
— id: 62961, year: 1998, vol: 273, page: 7743, stat: Journal Article,

Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos
Nimnual AS; Yatsula BA; Bar-Sagi D
1998 Jan 23;279(5350):560-563, Science
— id: 62962, year: 1998, vol: 279, page: 560, stat: Journal Article,

Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein
Soisson SM; Nimnual AS; Uy M; Bar-Sagi D; Kuriyan J
1998 Oct 16;95(2):259-268, Cell
— id: 62958, year: 1998, vol: 95, page: 259, stat: Journal Article,

The role of the PH domain in the signal-dependent membrane targeting of Sos
Chen RH; Corbalan-Garcia S; Bar-Sagi D
1997 Mar 17;16(6):1351-1359, EMBO journal
— id: 62967, year: 1997, vol: 16, page: 1351, stat: Journal Article,

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization
Colley WC; Sung TC; Roll R; Jenco J; Hammond SM; Altshuller Y; Bar-Sagi D; Morris AJ; Frohman MA
1997 Mar 1;7(3):191-201, Current biology. CB
— id: 62968, year: 1997, vol: 7, page: 191, stat: Journal Article,

Ras effectors and their role in mitogenesis and oncogenesis
Joneson T; Bar-Sagi D
1997 Aug;75(8):587-593, Journal of Molecular Medicine (Berlin)
— id: 62966, year: 1997, vol: 75, page: 587, stat: Journal Article,

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
Kouhara H; Hadari YR; Spivak-Kroizman T; Schilling J; Bar-Sagi D; Lax I; Schlessinger J
1997 May 30;89(5):693-702, Cell
— id: 56961, year: 1997, vol: 89, page: 693, stat: Journal Article,

SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway
Walsh AB; Dhanasekaran M; Bar-Sagi D; Kumar CC
1997 Nov 20;15(21):2553-2560, Oncogene
— id: 62965, year: 1997, vol: 15, page: 2553, stat: Journal Article,

The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains
Zheng J; Chen RH; Corblan-Garcia S; Cahill SM; Bar-Sagi D; Cowburn D
1997 Nov 28;272(48):30340-30344, Journal of biological chemistry
— id: 62964, year: 1997, vol: 272, page: 30340, stat: Journal Article,

Insulin-induced dissociation of Sos from Grb2 does not contribute to the down regulation of Ras activation
Corbalan-Garcia S; Degenhardt KR; Bar-Sagi D
1996 Mar 7;12(5):1063-1068, Oncogene
— id: 62973, year: 1996, vol: 12, page: 1063, stat: Journal Article,

Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2
Corbalan-Garcia S; Yang SS; Degenhardt KR; Bar-Sagi D
1996 Oct;16(10):5674-5682, Molecular & cellular biology
— id: 62970, year: 1996, vol: 16, page: 5674, stat: Journal Article,

RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase
Joneson T; McDonough M; Bar-Sagi D; Van Aelst L
1996 Nov 22;274(5291):1374-1376, Science
— id: 62969, year: 1996, vol: 274, page: 1374, stat: Journal Article,

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS
Joneson T; White MA; Wigler MH; Bar-Sagi D
1996 Feb 9;271(5250):810-812, Science
— id: 62974, year: 1996, vol: 271, page: 810, stat: Journal Article,

The Ras superfamily of GTPases
Macara IG; Lounsbury KM; Richards SA; McKiernan C; Bar-Sagi D
1996 Apr;10(5):625-630, FASEB journal
— id: 62972, year: 1996, vol: 10, page: 625, stat: Journal Article,

Identification of a novel Rac1-interacting protein involved in membrane ruffling
Van Aelst L; Joneson T; Bar-Sagi D
1996 Aug 1;15(15):3778-3786, EMBO journal
— id: 62971, year: 1996, vol: 15, page: 3778, stat: Journal Article,

Mammalian cell microinjection assay
Bar-Sagi D
1995 ;255:436-442, Methods in enzymology
— id: 62977, year: 1995, vol: 255, page: 436, stat: Journal Article,

Purification of baculovirus-expressed human Sos1 protein
Frech M; Cussac D; Chardin P; Bar-Sagi D
1995 ;255:125-129, Methods in enzymology
— id: 62978, year: 1995, vol: 255, page: 125, stat: Journal Article,

Inhibition of ras-induced proliferation and cellular transformation by p16INK4
Serrano M; Gomez-Lahoz E; DePinho RA; Beach D; Bar-Sagi D
1995 Jan 13;267(5195):249-252, Science
— id: 62976, year: 1995, vol: 267, page: 249, stat: Journal Article,

Differential interactions of human Sos1 and Sos2 with Grb2
Yang SS; Van Aelst L; Bar-Sagi D
1995 Aug 4;270(31):18212-18215, Journal of biological chemistry
— id: 62975, year: 1995, vol: 270, page: 18212, stat: Journal Article,

The Sos (Son of sevenless) protein
Bar-Sagi, D
1994 May-Jun;5(4):165-169, Trends in endocrinology & metabolism
— id: 105531, year: 1994, vol: 5, page: 165, stat: Journal Article,

Crosslinking of the surface immunoglobulin receptor in B lymphocytes induces a redistribution of neurofibromin but not p120-GAP
Boyer MJ; Gutmann DH; Collins FS; Bar-Sagi D
1994 Feb;9(2):349-357, Oncogene
— id: 62981, year: 1994, vol: 9, page: 349, stat: Journal Article,

An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane
Rotin D; Bar-Sagi D; O'Brodovich H; Merilainen J; Lehto VP; Canessa CM; Rossier BC; Downey GP
1994 Oct 3;13(19):4440-4450, EMBO journal
— id: 62980, year: 1994, vol: 13, page: 4440, stat: Journal Article,

Activation of Ras and other signaling pathways by receptor tyrosine kinases
Schlessinger J; Bar-Sagi D
1994 ;59:173-179, Cold Spring Harbor symposia on quantitative biology
— id: 56846, year: 1994, vol: 59, page: 173, stat: Journal Article,

Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1
Sun H; Tonks NK; Bar-Sagi D
1994 Oct 14;266(5183):285-288, Science
— id: 62979, year: 1994, vol: 266, page: 285, stat: Journal Article,

SH3 domains direct cellular localization of signaling molecules
Bar-Sagi D; Rotin D; Batzer A; Mandiyan V; Schlessinger J
1993 Jul 16;74(1):83-91, Cell
— id: 35758, year: 1993, vol: 74, page: 83, stat: Journal Article,

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
Chardin P; Camonis JH; Gale NW; van Aelst L; Schlessinger J; Wigler MH; Bar-Sagi D
1993 May 28;260(5112):1338-1343, Science
— id: 62984, year: 1993, vol: 260, page: 1338, stat: Journal Article,

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras
Gale NW; Kaplan S; Lowenstein EJ; Schlessinger J; Bar-Sagi D
1993 May 6;363(6424):88-92, Nature
— id: 62985, year: 1993, vol: 363, page: 88, stat: Journal Article,

Degranulation of individual mast cells in response to Ca2+ and guanine nucleotides: an all-or-none event
Hide I; Bennett JP; Pizzey A; Boonen G; Bar-Sagi D; Gomperts BD; Tatham PE
1993 Nov;123(3):585-593, Journal of cell biology
— id: 62982, year: 1993, vol: 123, page: 585, stat: Journal Article,

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling
Li N; Batzer A; Daly R; Yajnik V; Skolnik E; Chardin P; Bar-Sagi D; Margolis B; Schlessinger J
1993 May 6;363(6424):85-88, Nature
— id: 57448, year: 1993, vol: 363, page: 85, stat: Journal Article,

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts
Quelle DE; Ashmun RA; Shurtleff SA; Kato JY; Bar-Sagi D; Roussel MF; Sherr CJ
1993 Aug;7(8):1559-1571, Genes & development
— id: 62983, year: 1993, vol: 7, page: 1559, stat: Journal Article,

Mechanisms of signal transduction by Ras
Bar-Sagi D
1992 Apr;3(2):93-98, Seminars in cell biology
— id: 62986, year: 1992, vol: 3, page: 93, stat: Journal Article,

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
Lowenstein EJ; Daly RJ; Batzer AG; Li W; Margolis B; Lammers R; Ullrich A; Skolnik EY; Bar-Sagi D; Schlessinger J
1992 Aug 7;70(3):431-442, Cell
— id: 13480, year: 1992, vol: 70, page: 431, stat: Journal Article,

Anoxia induces phospholipase A2 activation in rabbit renal proximal tubules
Portilla D; Mandel LJ; Bar-Sagi D; Millington DS
1992 Mar;262(3 Pt 2):F354-F360, American journal of physiology
— id: 62987, year: 1992, vol: 262, page: F354, stat: Journal Article,

Phospholipase A2: microinjection and cell localization techniques
Bar-Sagi D
1991 ;197:269-279, Methods in enzymology
— id: 62990, year: 1991, vol: 197, page: 269, stat: Journal Article,

Introduction of unlabeled proteins into living cells by electroporation and isolation of viable protein-loaded cells using dextran-fluorescein isothiocyanate as a marker for protein uptake
Graziadei L; Burfeind P; Bar-Sagi D
1991 Apr;194(1):198-203, Analytical biochemistry
— id: 62989, year: 1991, vol: 194, page: 198, stat: Journal Article,

Association of p21ras with cellular polypeptides
Kaplan S; Bar-Sagi D
1991 Oct 5;266(28):18934-18941, Journal of biological chemistry
— id: 62988, year: 1991, vol: 266, page: 18934, stat: Journal Article,

Effect of H-ras proteins on the activity of polyphosphoinositide phospholipase C in HL60 membranes
Cockcroft S; Bar-Sagi D
1990 ;2(3):227-234, Cellular signalling
— id: 62992, year: 1990, vol: 2, page: 227, stat: Journal Article,

Co-capping of ras proteins with surface immunoglobulins in B lymphocytes
Graziadei L; Riabowol K; Bar-Sagi D
1990 Sep 27;347(6291):396-400, Nature
— id: 62991, year: 1990, vol: 347, page: 396, stat: Journal Article,

ras proteins: biological effects and biochemical targets (review)
Bar-Sagi D
1989 Sep-Oct;9(5):1427-1437, Anticancer research
— id: 62993, year: 1989, vol: 9, page: 1427, stat: Journal Article,

G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2
Kim D; Lewis DL; Graziadei L; Neer EJ; Bar-Sagi D; Clapham DE
1989 Feb 9;337(6207):557-560, Nature
— id: 62994, year: 1989, vol: 337, page: 557, stat: Journal Article,

Stimulation of exocytotic degranulation by microinjection of the ras oncogene protein into rat mast cells
Bar-Sagi D; Gomperts BD
1988 Oct;3(4):463-469, Oncogene
— id: 62995, year: 1988, vol: 3, page: 463, stat: Journal Article,

Localization of phospholipase A2 in normal and ras-transformed cells
Bar-Sagi D; Suhan JP; McCormick F; Feramisco JR
1988 May;106(5):1649-1658, Journal of cell biology
— id: 62996, year: 1988, vol: 106, page: 1649, stat: Journal Article,

Regulation of membrane turnover by ras proteins
Bar-Sagi D; Fernandez A; Feramisco JR
1987 May;7(5):427-434, Bioscience reports
— id: 62997, year: 1987, vol: 7, page: 427, stat: Journal Article,

Inhibition of cell surface ruffling and fluid-phase pinocytosis by microinjection of anti-ras antibodies into living cells
Bar-Sagi D; McCormick F; Milley RJ; Feramisco JR
1987 ;Suppl 5:69-73, Journal of cellular physiology. Supplement
— id: 62998, year: 1987, vol: Suppl 5, page: 69, stat: Journal Article,

Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins
Bar-Sagi D; Feramisco JR
1986 Sep 5;233(4768):1061-1068, Science
— id: 62999, year: 1986, vol: 233, page: 1061, stat: Journal Article,

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation
Bar-Sagi D; Feramisco JR
1985 Oct;42(3):841-848, Cell
— id: 63000, year: 1985, vol: 42, page: 841, stat: Journal Article,

Negative modulation of sodium channels in cultured chick muscle cells by the channel activator batrachotoxin
Bar-Sagi D; Prives J
1985 Apr 25;260(8):4740-4744, Journal of biological chemistry
— id: 63001, year: 1985, vol: 260, page: 4740, stat: Journal Article,

Regulation of surface properties in cultured muscle cells
Bar-Sagi, Dafna
[S.l. : s.n.], 1984,
— id: 2082, year: 1984, vol: , page: , stat: ,

Trifluoperazine, a calmodulin antagonist, inhibits muscle cell fusion
Bar-Sagi D; Prives J
1983 Nov;97(5 Pt 1):1375-1380, Journal of cell biology
— id: 63002, year: 1983, vol: 97, page: 1375, stat: Journal Article,

Tunicamycin inhibits the expression of surface Na+ channels in cultured muscle cells
Bar-Sagi D; Prives J
1983 Jan;114(1):77-81, Journal of cellular physiology
— id: 63005, year: 1983, vol: 114, page: 77, stat: Journal Article,

Effect of tunicamycin, an inhibitor of protein glycosylation, on the biological properties of acetylcholine receptor in cultured muscle cells
Prives J; Bar-Sagi D
1983 Feb 10;258(3):1775-1780, Journal of biological chemistry
— id: 63004, year: 1983, vol: 258, page: 1775, stat: Journal Article,

Differential expression of sodium channel activities during the development of chick skeletal muscle cells in culture
Strichartz G; Bar-Sagi D; Prives J
1983 Sep;82(3):365-384, Journal of general physiology
— id: 63003, year: 1983, vol: 82, page: 365, stat: Journal Article,