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Biosketch / Results /

Erika Bach, Ph.D.

Associate Professor; Graduate Director
Department of Biochemistry and Molecular Pharmacology [1]

Contact Info

Address
550 First Avenue
Floor 4 Room 497B
Medical Science Building
New York, NY 10016

212-263-7133
Erika.Bach@nyumc.org


[3]

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Education

— Dr. Bach was a postdoctoral fellow in the Genetics Department at Harvard Medical School., PostDoctoral Training
— Dr. Bach received her Ph.D. in Immunology from Washington University in St. Louis., Graduate Education

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Research Summary

1. How does the JAK/STAT pathway regulate stem cells numbers? Regulating the number of stem cells is a primary mechanism by which homeostasis is maintained and oncogenesis is prevented. Stem cells divide to produce daughter cells that renew the stem cell pool or that regenerate tissue by differentiating. The choice between self-renewal and differentiation must be tightly controlled as increasing the stem cell pool provides a condition for oncogenesis. Tumors have cancer stem cells that self-renew and establish new tumors at low numbers. One of the critical regulators of stem cell numbers in mammals is the JAK/STAT pathway. Furthermore, dominant-active mutations in jak and stat genes cause cancer, and Stat3 is a target for therapeutic intervention since its ablation blocks the growth of human cancer cells. Despite these compelling observations, the mechanisms utilized by this pathway to regulate stem cell numbers in mammals have not yet been elucidated, in part due to the redundancy of 4 jak and 7 stat genes. Drosophila provides an ideal system to study how JAK/STAT signaling regulates stem cell numbers, as this function is conserved in several Drosophila tissues, including testis and eye. Unlike the redundancy of the mammalian system, Drosophila has only one jak and one stat gene (called stat92E), which allows facile in vivo analysis. Despite these advantages, nothing is known mechanistically about how this pathway controls stem cell populations in Drosophila. Previous work has shown that over-expression of the cytokine Unpaired, which activates JAK/STAT signaling, leads to an expansion of stem/progenitor cells in the eye and testis. We find that these overgrowths depend on activation of Stat92E within stem cells. Our current hypothesis is that Stat92E must regulate three distinct processes in stem cells in order to regulate their numbers: it must increase cellular mass and accelerate cell cycle progression and, after mitosis, promote self-renewal in some daughter cells. Since Stat92E is a transcription factor, discrete Stat92E target genes should mediate its effects on these processes. We have identified several genes with human homologs that may lie directly downstream of Stat92E and may regulate self-renewal, cellular growth and cell cycle in stem cells.

Research Interests

JAK/STAT signaling; cancer; stem cell self renewal; development JAK/STAT signaling; cancer; stem cell self renewal; development JAK/STAT signaling; cancer; stem cell self renewal; development JAK/STAT signaling; cancer; stem cell self renewal; development

Research Keywords

Drosophila, genetics, growth control, signal transduction

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search [8]

Hedgehog is required for CySC self-renewal but does not contribute to the GSC niche in the Drosophila testis
Amoyel, Marc; Sanny, Justina; Burel, Michael; Bach, Erika A
2013 Jan;140(1):56-65, Development
— id: 202312, year: 2013, vol: 140, page: 56, stat: Journal Article,

Functions of the drosophila JAK-STAT pathway: Lessons from stem cells
Amoyel, M; Bach, E A
2012 2012;1(3):176-183, JAK-STAT
— id: 288402, year: 2012, vol: 1, page: 176, stat: Journal Article,

Activated STAT regulates growth and induces competitive interactions independently of Myc, Yorkie, Wingless and ribosome biogenesis
Rodrigues, Aloma B; Zoranovic, Tamara; Ayala-Camargo, Aidee; Grewal, Savraj; Reyes-Robles, Tamara; Krasny, Michelle; Wu, D Christine; Johnston, Laura A; Bach, Erika A
2012 Nov;139(21):4051-4061, Development
— id: 179271, year: 2012, vol: 139, page: 4051, stat: Journal Article,

Inhibition of the signalling kinase JAK3 alleviates inflammation in monoarthritic rats
Kim, Byung-Hak; Kim, Myunghwan; Yin, Chang-Hong; Jee, Jun-Goo; Sandoval, Claudio; Lee, Hyejung; Bach, Erika A; Hahm, Dae-Hyun; Baeg, Gyeong-Hun
2011 Sep;164(1):106-118, British journal of pharmacology
— id: 136507, year: 2011, vol: 164, page: 106, stat: Journal Article,

Development of a high-throughput cell-based reporter assay for screening of JAK3 inhibitors
Yin, Chang-Hong; Bach, Erika A; Baeg, Gyeong-Hun
2011 Apr;16(4):443-449, Journal of Biomolecular Screening
— id: 134234, year: 2011, vol: 16, page: 443, stat: Journal Article,

Characterization of a dominant-active STAT that promotes tumorigenesis in Drosophila
Ekas, Laura A; Cardozo, Timothy J; Flaherty, Maria Sol; McMillan, Elizabeth A; Gonsalves, Foster C; Bach, Erika A
2010 Aug 15;344(2):621-636, Developmental biology (Orlando)
— id: 111584, year: 2010, vol: 344, page: 621, stat: Journal Article,

chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila
Flaherty, Maria Sol; Salis, Pauline; Evans, Cory J; Ekas, Laura A; Marouf, Amine; Zavadil, Jiri; Banerjee, Utpal; Bach, Erika A
2010 Apr 20;18(4):556-568, Developmental cell
— id: 109515, year: 2010, vol: 18, page: 556, stat: Journal Article,

NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3
Kim, BH; Jee, JG; Yin, CH; Sandoval, C; Jayabose, S; Kitamura, D; Bach, EA; Baeg, GH
2010 FEB 11 ;9(2):-, Molecular cancer
— id: 108777, year: 2010, vol: 9, page: , stat: Journal Article,

MS-1020 is a novel small molecule that selectively inhibits JAK3 activity
Kim, Byung-Hak; Oh, Sei-Ryang; Yin, Chang-Hong; Lee, Sangku; Kim, Eun-Ah; Kim, Min-Seok; Sandoval, Claudio; Jayabose, Somasundaram; Bach, Erika A; Lee, Hyeong-Kyu; Baeg, Gyeong-Hun
2010 Jan;148(1):132-143, British journal of haematology
— id: 133451, year: 2010, vol: 148, page: 132, stat: Journal Article,

Cytosolic ras supports eye development in Drosophila
Sung, Pamela J; Rodrigues, Aloma B; Kleinberger, Andrew; Quatela, Steven; Bach, Erika A; Philips, Mark R
2010 Dec;30(24):5649-5657, Molecular & cellular biology
— id: 114824, year: 2010, vol: 30, page: 5649, stat: Journal Article,

Genome-wide expression profiling in the Drosophila eye reveals unexpected repression of notch signaling by the JAK/STAT pathway
Flaherty, Maria Sol; Zavadil, Jiri; Ekas, Laura A; Bach, Erika A
2009 Sep;238(9):2235-2253, Developmental dynamics
— id: 101887, year: 2009, vol: 238, page: 2235, stat: Journal Article,

A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cells
Kim, Byung Hak; Yin, Chang-Hong; Guo, Qianxu; Bach, Erika A; Lee, Haeryun; Sandoval, Claudio; Jayabose, Somasundaram; Ulaczyk-Lesanko, Agnieszka; Hall, Dennis G; Baeg, Gyeong-Hun
2008 Sep;7(9):2672-2680, Molecular cancer therapeutics
— id: 95067, year: 2008, vol: 7, page: 2672, stat: Journal Article,

The JAK/STAT pathway regulates proximo-distal patterning in Drosophila
Ayala-Camargo, Aidee; Ekas, Laura A; Flaherty, Maria Sol; Baeg, Gyeong-Hun; Bach, Erika A
2007 Oct;236(10):2721-2730, Developmental dynamics
— id: 75448, year: 2007, vol: 236, page: 2721, stat: Journal Article,

GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo
Bach, Erika A; Ekas, Laura A; Ayala-Camargo, Aidee; Flaherty, Maria Sol; Lee, Haeryun; Perrimon, Norbert; Baeg, Gyeong-Hun
2007 Jan;7(3):323-331, Gene expression patterns
— id: 71860, year: 2007, vol: 7, page: 323, stat: Journal Article,

Ken & barbie selectively regulates the expression of a subset of Jak/STAT pathway target genes
Arbouzova, Natalia I; Bach, Erika A; Zeidler, Martin P
2006 Jan 10;16(1):80-88, Current biology. CB
— id: 95068, year: 2006, vol: 16, page: 80, stat: Journal Article,

JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila
Ekas, Laura A; Baeg, Gyeong-Hun; Flaherty, Maria Sol; Ayala-Camargo, Aidee; Bach, Erika A
2006 Dec;133(23):4721-4729, Development
— id: 70533, year: 2006, vol: 133, page: 4721, stat: Journal Article,

Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways
Read, Renee D; Bach, Erika A; Cagan, Ross L
2004 Aug;24(15):6676-6689, Molecular & cellular biology
— id: 95069, year: 2004, vol: 24, page: 6676, stat: Journal Article,

Prime time for the Drosophila JAK/STAT pathway
Bach EA; Perrimon N
Signal transducers and activators of transcription (STATs): activation and biology Boston : Kluwer, 2003,
— id: 3143, year: 2003, vol: , page: 87, stat: Chapter,

A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway
Bach, Erika A; Vincent, Stephane; Zeidler, Martin P; Perrimon, Norbert
2003 Nov;165(3):1149-1166, Genetics
— id: 42001, year: 2003, vol: 165, page: 1149, stat: Journal Article,

Mechanism of activation of the Drosophila EGF Receptor by the TGFalpha ligand Gurken during oogenesis
Ghiglione, Christian; Bach, Erika A; Paraiso, Yolande; Carraway, Kermit L 3rd; Noselli, Stephane; Perrimon, Norbert
2002 Jan;129(1):175-186, Development
— id: 32562, year: 2002, vol: 129, page: 175, stat: Journal Article,

The roles of the Drosophila JAK/STAT pathway
Zeidler MP; Bach EA; Pe