the philips lab
departments of medicine, cell biology and pharmacology, NYU cancer institute, Division of Rheumatology, NYU School of Medicine
GTPase Trafficking
GTPase Trafficking
The Ras trafficking pathway from synthesis in the cytosol to reversible association with the plasma membrane. more detail

GTPase Trafficking
Localization of GFP-tagged H-Ras, one of the two palmitoylated isoforms, on the plasma membrane and Golgi apparatus. more detail

CAAX processing allows engagement of several trafficking pathways, including those regulated by palmitoylation.  We seek to understand the pathways that deliver GTPases to target membranes, how these pathways are regulated and how they relate to signaling.